Cosmeceutical Critique: Idebenone
BAUMANN LS, Skin & Allergy News- 2005 12 (Vol. 36, Issue 12)
"Synthesized for the first time a little more than 20 years ago, 2,3-dimethoxy-5-methyl-6-(10′-hydroxydecyl)-1,4-benzoquinone—also known as CV-2619, QSA-10, or idebenone—is similar in structure to the potent antioxidant coenzyme Q10, an integral cell membrane nutrient and contributor to the adenosine triphosphate-producing mitochondrial electron transport chain (Altern. Med. Rev. 2001;6:83–6).
Extensive research has been conducted on this benzoquinone compound for more than 2 decades, mostly to compare it with other drugs for treating patients with Alzheimer's disease, for ameliorating the symptoms of Friedreich's ataxia, and for use in organ transplant solutions.
Studies on rats paved the way to hypotheses regarding the compound's neurologic, cardiologic, and antiaging indications. Those studies ascertained that idebenone inhibits lipid peroxidation, protecting cell membranes and mitochondria from oxidative damage and, in particular, brain mitochondria from swelling (Altern. Med. Rev. 2001;6:83–6; Neurosci. Lett. 1993;163:219–22; Arch. Gerontol. Geriatr. 1989;8:299–305)."
"The synthetic coenzyme Q10 analogue, idebenone, has been investigated extensively over the past 2 decades. Its antioxidant and other health benefits are well established, as is its use for various indi-cations outside the United States.
Patients in my practice who used the initial Prevage formulation by Allergan reported acne and contact dermatitis. It is my understanding that the Prevage MD product by Allergan and the Prevage product by Elizabeth Arden have been reformulated, and the new formulations are less likely to result in those side effects.
It is important to remember that this ingredient, like all antioxidants, may prevent signs of aging with consistent use. However, there is no evidence that it will affect wrinkles that already exist beyond increasing skin hydration."
Return to product page
anti-acne
anti-androgenetic
alopecia
anti-inflammatory
antioxidant
cellular
energy production
collagen
production (reduce fine lines and wrinkles)
chelating
agents
containers
& packaging
Categories
We accept payment via PayPal
 | |
|
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
New & Updates
Attention: BulkActives is a part-time
business.
Orders are processed on Saturdays and mailed on Mondays at the
latest, usually earlier.
Social networking:
Follow us on Twitter for updates or read our blog for skin care articles.
Free original software: Recipe creator database and HLB calculator
We now offer a range of NON-formaldehyde releasing preservatives:
phenoxyethanol (paraben free) & paraben and phenoxyethanol combo
Back in stock!!
Out of stock:
Pantothenic acid (replaced with d-Panthenol)
Xanthan Gum
abstracts menu: Ascorbyl Tetraisopalmitate, alpha bisabolol, L-Ascorbic Acid, Beta 1-3 Glucan (Yeast), Beta 1-3, 1-4 Glucan (Oat), Boswellia serrata, Carnitine (-L), Coconut Endosperm, Co Q10, DMAE bitartrate, Centella Asiatica, Dimethyl isosorbide, Ellagic acid, Ferulic Acid, Gamma oryzanol, Ginkgo Biloba, Glucosamine (N-acetyl-D),Grape Seed Proanthocyanidins, Green Tea Extract (EGCG), Gynostemma extract, Idebenone, Lecithin (liquid),Magnesium Ascorbyl Phosphate (MAP), Niacinamide, Pomegranate extract, Quercetin ,Resveratrol, Silymarin, Soy Isoflavones, Wild Yam (Diosgenin)