Skin Care Research: Magnesium Ascorbyl Phosphate in DIY Skin Care Recipes

Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo.
Kameyama K, Sakai C, Kondoh S, Yonemoto K, Nishiyama S, Tagawa M, Murata T, Ohnuma T, Quigley J, Dorsky A, Bucks D, Blanock K., Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan.

"BACKGROUND: An inhibitory effect of ascorbic acid (AsA) on melanogenesis has been described. However, AsA is quickly oxidized and decomposed in aqueous solution and thus is not generally useful as a depigmenting agent.

OBJECTIVE: Our purpose was to examine the effect on pigmentation of magnesium-L-ascorbyl-2-phosphate (VC-PMG), a stable derivative of AsA.

METHODS: Percutaneous absorption of VC-PMG was examined in dermatomed human skin, and its effect on melanin production by mammalian tyrosinase and human melanoma cells in culture was also measured. A 10% VC-PMG cream was applied to the patients.

RESULTS: VC-PMG suppressed melanin formation by tyrosinase and melanoma cells. In situ experiments demonstrated that VC-PMG cream was absorbed into the epidermis and that 1.6% remained 48 hours after application. The lightening effect was significant in 19 of 34 patients with chloasma or senile freckles and in 3 of 25 patients with normal skin.

CONCLUSION: magnesium ascorbyl phosphate (VC-PMG) is effective in reducing skin hyperpigmentation in some patients." Read more

Regulation of collagen synthesis in human dermal fibroblasts by the sodium and magnesium salts of ascorbyl-2-phosphate.
Geesin JC, Gordon JS, Berg RA., Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854.

"In order to provide a more stable alternative to ascorbic acid, two salts of ascorbyl-2-phosphate, having a greater chemical stability than ascorbic acid, were tested for their ability to stimulate collagen synthesis in monolayer fibroblast cultures. ...The magnesium salt of ascorbyl-2-phosphate (magnesium ascorbyl phosphate) was found to be equivalent to ascorbic acid in stimulating collagen synthesis in these assays..." Read more

Stability of vitamin C derivatives in solution and topical formulations.
Austria R, Semenzato A, Bettero A., Universita di Padova, Dipartimento di Scienze Farmaceutiche, Italy.

"The stability of ascorbic acid, ascorbyl palmitate and magnesium ascorbyl phosphate (VC-PMG) in both standard solutions and topical formulations was investigated...Conversely, the introduction of the phosphoric group in 2 position protected the molecule from break-up of the enediol system, confirming VC-PMG (magnesium ascorbyl phosphate ) as a very stable derivative of vitamin C that may be easily used in various types of cosmetic products." Read more

Postadministration protective effect of magnesium-L-ascorbyl-phosphate on the development of UVB-induced cutaneous damage in mice.
Kobayashi S, Takehana M, Kanke M, Itoh S, Ogata E., Kyoritsu College of Pharmacy, Tokyo, Japan.

These results suggest that postadministration of MAP delays progression of skin damage induced by UVB irradiation. It is presumed that MAP, once converted to As, exhibits such inhibitory effects by scavenging hydroxyl and lipid radicals generated as a direct or indirect result of UVB exposure. Read more

Protective effect of magnesium-L-ascorbyl-2 phosphate against skin damage induced by UVB irradiation.
Kobayashi S, Takehana M, Itoh S, Ogata E., Kyoritsu College of Pharmacy, Tokyo, Japan.

"We found, in an in vitro experiment, that MAP was converted to AS as it crossed the epidermis, but that AS-Na did not pass through the epidermis. Furthermore, MAP was also converted to AS in serum. These results suggest that the protective effect of MAP on UVB-induced cutaneous damage is due to conversion of MAP to AS." Read more

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Advanced skin care research on Magnesium Ascorbyl Phosphate (MAP) shows that it is useful for: antioxidants, anti-inflammatories, promoting collagen production, skin lightening and skin brightening, and for UV protection/sun damage repair.

Magnesium Ascorbyl Phosphate research

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