Skin Care Research: Resveratrol for Homemade Skin Care Formulas

"Resveratrol (3,4′,5-trihydroxystilbene) is a polyphenolic phytoalexin compound present in the skin and seeds of grapes, berries, peanuts, and other foods. The preponderance of data on resveratrol is very recent, with increased research activity following a seminal report in the journal Science in 1997 (Science 1997;275:218–20; Biochem. Biophys. Res. Commun. 2005;331:993–1000; Cancer Res. 2001;61:1604–10).

In the 1997 study, purified resveratrol was found to exhibit major inhibitory activity against cancer initiation, promotion, and progression. Specifically, its antioxidant and antimutagenic potency and induction of phase II drug-metabolizing enzymes were seen as counter to carcinogenic initiation. Resveratrol hindered cyclooxygenase and hydroperoxidase and initiated anti-inflammatory effects, thereby demonstrating antipromotion activity. The induction of human promyelocytic leukemia cell differentiation by this newly discovered botanical ingredient also thwarted the progress of carcinogenic activity. In addition, resveratrol demonstrated significant inhibitory effects in vitro with carcinogen-induced preneoplastic lesions in mouse mammary glands, and in vivo with tumorigenesis in the two-stage mouse skin cancer model (Science 1997;275:218–20).

Since then, copious research has been performed on this compound, which has developed a strong reputation as a potent antioxidant, anti-inflammatory, and antiproliferative agent (Toxicol. Appl. Pharmacol. 2003;186:28–37; Biochem. Pharmacol. 2002;63:99–104; Biomed. Papers 2003;147:137–45). Most importantly, it is considered to act as a chemopreventive agent against skin cancer and to exert an antiproliferative influence on oral-squamous, breast, colon, and prostate cancer cells, in which it triggers apoptosis (Pancreas 2002;25:e71–6; J. Biol. Chem. 2003;278:41482–90). Research has confirmed its inhibitory effects on tumor initiation, promotion, and progression (Biomed. Papers 2003;147:137–45; Front. Biosci. 2002;7:784–92; Skin Pharmacol. Appl. Skin Physiol. 2002;15:297–306).

The most recent data indicate that resveratrol protects against UVB-mediated cutaneous damage in SKH-1 hairless mice, particularly by inhibiting survivin, the overexpression of which is associated with various cancers (Photochem. Photobiol. 2005;81:25–31; FASEB J. 2005;19:1193–5)." BAUMANN LS, Skin & Allergy News- 2006 06 (Vol. 37, Issue 6)

Resveratrol: an original mechanism on tyrosinase inhibition

Bernard, Berthon (2000), International Journal of Cosmetic Science 22 (3), 219–226.

"The aim of our work was to present resveratrol as an original substrate for tyrosinase with very promising cosmetic perspectives. This study was based on several spectrophotometric analyses with minor adaptations. These analyses suggested that resveratrol is biotransformed by tyrosinase into an oxydated form, becoming a powerful inhibitor of tyrosinase. Furthermore, we show that resveratrol can be used as an additive compound in whitening cosmetics, particularly with a Morus alba extract. These results may help in understanding tyrosinase active site structure and mechanism." Read more

Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm.
Sen CK, Khanna S, Gordillo G, Bagchi D, Bagchi M, Roy S., Laboratory of Molecular Medicine, Dorothy M. Davis Heart and Lung Research Institute, Department of Surgery (CMIS), The Ohio State University Medical Center

"Disrupted vasculature and high energy-demand by regenerating tissue results in wound hypoxia. Wound repair may be facilitated by oxygen therapy. Evidence supporting the mode of action of hyperbaric oxygen in promoting wound healing is sketchy, however. Topical oxygen therapy involves local administration of pure oxygen. The advantages of topical oxygen therapy include low cost, the lack of systemic oxygen toxicity, and possibility of home treatment. While this modality of wound care is of outstanding interest, it clearly lacks the support of mechanism-oriented studies. The search for mechanisms by which oxygen supports wound healing has now taken another step. Respiratory burst-derived oxidants support healing. Oxidants serve as cellular messengers to promote healing. Although this information is of outstanding significance to the practice of oxygen therapy, it remains largely unexplored. The search for "natural remedies" has drawn attention to herbals. Proanthocyanidins or condensed tannins are a group of biologically active polyphenolic bioflavonoids that are synthesized by many plants. Proanthocyanidins and other tannins facilitate wound healing. A combination of grape seed proanthocyanidin extract and resveratrol facilitates inducible VEGF expression, a key element supporting wound angiogenesis. Strategies to manipulate the redox environment in the wound are likely to be of outstanding significance in wound healing." Read more

Effect of topically applied resveratrol on cutaneous herpes simplex virus infections in hairless mice.

Docherty, J.J., Smith, J.S., Fu, M.M., Stoner, T., Booth, T. Antiviral Research, 2004 Jan;61(1):19-26.

"Resveratrol (3,5,4'-trihydroxystilbene) is a natural component of certain foods, such as grapes, that has been shown to have anti-herpes simplex virus (HSV) activity in vitro. To determine if it is active in vivo, the abraded epidermis of SKH1 mice were infected with HSV-1 and topically treated with 12.5 or 25% resveratrol cream or cream only. Initial studies demonstrated that: (1). 25% resveratrol cream topically applied two, three, or five times a day effectively suppressed lesion development whereas 12.5% resveratrol cream effectively suppressed lesion formation when applied five times a day starting 1h after infection; (2). when treatment was begun 1, 6, or 12h after infection, both 12.5 and 25% resveratrol were effective at 1 and 6h after infection, but not if applied 12h after infection. Comparative studies between resveratrol cream, 10% docosanol cream (Abreva) and 5% acyclovir ointment (Zovirax) were also carried out. When treatment was begun 1h after infection and repeated every 3h five times a day for 5 days, 12.5 and 25% resveratrol significantly (P=0.0001) inhibited the development of HSV-1 induced skin lesions. Acyclovir was as effective (P=0.0001) as resveratrol. Animals that were topically treated with docosanol were not protected and developed lesions in a manner indistinguishable from cream only controls. These studies were repeated with an HSV-1 acyclovir-resistant virus. As before, 12.5 and 25% resveratrol cream effectively suppressed lesion formation. The skin of resveratrol-treated animals showed no apparent dermal toxicity such as erythema, scaling, crusting, lichenification, or excoriation. These studies demonstrate that topically applied resveratrol inhibits HSV lesion formation in the skin of mice."

Click here for our NEW

White Resveratrol (98%)

Return to product page

Resveratrol research has shown resveratrol to be an effective antioxidant, and an anti-inflammatory. It also has qualities that make it useful in sun damage repair, and for color correction in the skin.

Resveratrol research

Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and cosmeceuticals, for DIY skin care and cosmetics, and homemade skin care products.

view cart

checkout

all products

BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.

New & Updates

Attention: BulkActives is a part-time business.
Orders are processed on Saturdays and mailed on Mondays at the latest, usually earlier.

Social networking:

Free original software: Recipe creator database and HLB calculator

We now offer a range of NON-formaldehyde releasing preservatives:

phenoxyethanol (paraben free) & paraben and phenoxyethanol combo

NEW

Sea kelp ferment

White Willow - bark extract 80%...more salicin and a light beige color!

Out of stock:

Idebenone

Alpha Bisabolol natural

Oat Beta Glucan

Lecithin

Last website update: