Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
About BulkActives

BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.

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BulkActives is a part-time business. Orders are processed on Saturdays and mailed on Mondays at the latest, usually earlier.

Alpha Lipoic Acid (RS-ALA)

Alpha Lipoic Acid in skin care:  antioxidant, anti-inflammatory, reduce fine lines and possibly wrinkles, sun damage repair, active ingredient in Perricone MD products

Alpha Lipoic Acid is a powerful antioxidant with anti aging properties. It is often used in skin care products intended to reduce inflammation, improve cellular energy production, and for neutralizing heavy metals and free radicals. It shows much promise for reducing fine lines and wrinkles. Alpha Lipoic Acid is also a main ingredient in Perricone MD skin care products

 

Product Code: Alpha Lipoic Acid (RS-ALA)
Reward Points: 2
Assay: 99.83%
CAS#: 1077-28-7
Gross weight: 30g /1.06oz
Availability: In Stock ( 5+ Available )
Price: $9.20
Price in reward points: 184

Alpha Lipoic Acid (RS-ALA)

About Alpha Lipoic Acid in DIY Skin Care


Alpha Lipoic acid is an antioxidant used to treat and prevent the aging of skin, fine lines, and pigmentation abnormalities. Lipoic acid  may decrease the inflammation that leads to accelerated skin aging.

The effectiveness of Alpa Lipoic acid is believed to be due to its by-product, dihydrolipoic acid (DHLA).

Although DHLA has a more powerful antioxidative effect than Alpa Lipoic acid, it is very unstable and is oxidized in the skin within minutes of application.

Alpa Lipoic acid has become popular due to the fact that it is absorbed in a stable form and after entrance into cells, is immediately converted to DHLA

Researchers have identified and emphasized four principal antioxidative properties of Alpa Lipoic acid:

  • The capacity to chelate metals.

  • The ability to scavenge reactive oxygen species.

  • The ability to regenerate endogenous antioxidants such as vitamins C and E.

  • The ability to repair oxidative

Topical application of 3% Alpa Lipoic acid in a lecithin base has been shown to reduce UVB-induced erythema .

Topical application of lipoic acid could prevent free radical damage to skin, reducing the effects of photoaging and carcinogenesis.

However, it should be noted that research has also indicated that Alpa Lipoic acid is sensitive to UV radiation. 

Alpa Lipoic acid should therefore be used as a sun damage treatment, NOT a sun damage prevention product.

 

From alpha Lipoic Acid to dihydrolipoic acid

  • Alpha Lipoic acid is an example of an existing drug whose therapeutic effect has been related to its antioxidant activity. [3]
  • Dihydrolipoic acid [DHLA], formed by reduction of lipoic acid, has more antioxidant properties than does lipoic acid. [3]
  • Both dihydrolipoic acid [DHLA],  and Alpha lipoic acid  have metal-chelating capacity and scavenge ROS, whereas only DHLA is able to regenerate endogenous antioxidants and to repair oxidative damage. [3]
  • Alpha lipoic acid  can act as an antioxidant against the pro-oxidant activity produced by dihydrolipoic acid [DHLA]. [3]
  • Dihydrolipoic acid [DHLA],  has the capacity to regenerate the endogenous antioxidants vitamin E, vitamin C and Glutathione. [3]
  • Alpha lipoic acid  topically applied to skin penetrated readily, and was reduced to  [2]
  • Alpha lipoic acid  was converted rapidly by the cells to dihydrolipoic acid. [1]
Alpha Lipoic Acid is an acid and it may irritate. Start of with small amounts. A slight tingling/burning feeling upon application is common, this should go away after a few minutes. If not, remove from face and use a smaller percentage.
Assay: 99.83%
CAS#:1077-28-7
INCI: 1,2-dithiolane-3-pentanoic acid (thioctic acid)
Solubility: oil (mixes in a cream), propolyne glycol
Suggested percentage:3% to 5%

Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China

NOTE: We are often asked to stock the R form of ALA, instead of  the R/S (racemix) product we currently stock.  At this stage we are not prepared to do so. As far as we know (and if we are wrong please send us the info) there is no solid published evidence to support the negative comments circulating the use of the S form in skin care products. In addition, the problem with the R form, once isolated from the S, is that it is unstable and extremely sensitive to heat, thus making it entirely unsuitable for shipping (unless send refrigerated) and most importantly DIY skin care.

Topically applied Alpha Lipoic Acid may:

  • prevent or reduce UVA and UVB sun damage: [11] [9] [7] [5] [4]
  • act as an anti oxidant [12] [10] [8] [4] [3]
  • increase collagen production [11]
  • act as an anti inflammatory [8]
12. Matsugo S, Bito T, Konishi T.. Photochemical stability of lipoic acid and its impact on skin ageing. Free Radic Res. 2011 Aug;45(8):918-24. Epub 2011 Jun 9. PMID: 21651453 

11. Tsuji-Naito K, Ishikura S, Akagawa M, Saeki H.  α-Lipoic acid induces collagen biosynthesis involving prolyl hydroxylase expression via activation of TGF-β-Smad signaling in human dermal fibroblasts. Connect Tissue Res. 2010 Oct;51(5):378-87. PMID: 20604712

10. Wada N, Wakami H, Konishi T, Matsugo S.  The Degradation and Regeneration of alpha-Lipoic Acid under the Irradiation of UV Light in the Existence of Homocysteine. J Clin Biochem Nutr. 2009 May;44(3):218-22. Epub 2009 Apr 25. PMID: 19430609 

9. Davis GD, Masilamoni JG, Arul V, Kumar MS, Baraneedharan U, Paul SF, Sakthivelu IV, Jesudason EP, Jayakumar R. Radioprotective effect of DL-alpha-lipoic acid on mice skin fibroblasts.. Cell Biol Toxicol. 2009 Aug;25(4):331-40. Epub 2008 Jun 13. PMID: 18553143

8. Petersen Shay K, Moreau RF, Smith EJ, Hagen TM.  Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. IUBMB Life. 2008 Jun;60(6):362-7. PMID: 18409172 

7. Ho YS, Lai CS, Liu HI, Ho SY, Tai C, Pan MH, Wang YJ. Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and anti-oxidation. Biochem Pharmacol. 2007 Jun 1;73(11):1786-95. Epub 2006 Dec 10. PMID: 17403519

6. Lin JY, Lin FH, Burch JA, Selim MA, Monteiro-Riviere NA, Grichnik JM, Pinnell SR. Alpha-lipoic acid is ineffective as a topical antioxidant for photoprotection of  skin.  J Invest Dermatol. 2004 Nov;123(5):996-8. PMID: 15482491 

5.  Beitner H. Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin. Br J Dermatol. 2003 Oct;149(4):841-9. PMID: 14616378

4. Podda M, Zollner TM, Grundmann-Kollmann M, Thiele JJ, Packer L, Kaufmann R. Activity of alpha-lipoic acid in the protection against oxidative stress in skin. Curr Probl Dermatol. 2001;29:43-51. PMID: 11225200 

3.  Biewenga GP, Haenen GR, Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol. 1997 Sep;29(3):315-31. PMID: 9378235 

2. Podda M, Rallis M, Traber MG, Packer L, Maibach HI. Kinetic study of cutaneous and subcutaneous distribution following topical application of [7,8-14C]rac-alpha-lipoic acid onto hairless mice. Biochem Pharmacol. 1996 Aug 23;52(4):627-33. PMID: 8759036 

1.  Handelman GJ, Han D, Tritschler H, Packer L. Alpha-lipoic acid reduction by mammalian cells to the dithiol form, and release into the culture medium. Biochem Pharmacol. 1994 May 18;47(10):1725-30. PMID: 8204089

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