Oat Beta Glucan (Beta 1-3, 1-4 Glucan)
Beta 1-3, 1-4 Glucan (Oat) is used as an anti-inflammatory, for the promotion of collagen production, to reduce fine lines and wrinkles, and for scar and wound care. This skin care ingredient has the ability to penetrate deep into the skin, and has long been used for its healing affects.
About Beta Glucan Oat (Beta 1-3, 1-4 Glucan) in DIY Skin Care
Beta glucan is best known for the way it is able to enhance the body's complex immune-response the face of attacks by pathogens and other compounds. It stimulates and affects the macrophage release of cytokines that are involved in the immune system response. Beta glucan also stimulates the production of precursor cells in bone marrow, which is where all the major immune responses and reactions originate from. This is particularly powerful when the body is under major attack for example from cancers, where the body’s immune response is weakened and exhausted by such treatments as radiation and chemotherapy.
It is this same powerful regeneration ability that Beta glucan has when it is used as a topical application. Not only does it have impressive penetrating ability, going right into the dermis where it is needed, but once there Beta glucan stimulates the generation and rebuilding of collagen which results in the restoration of wrinkled, lined skin and the revitalization of the skin structure giving it firmness, tone and smoothness. In this way beta glucan plays its role as a powerful anti-aging agent that ensures that skin return to a youthful luster, tone and firmness. It also happens to do this after a relatively short while and has been proven to show impressive results in reducing skin wrinkles, both deep and shallow over an 8 week period.
In addition the ability to counter the effects of known cancer causing agents, beta glucan also works to actually beat the effects of cancer at the cell level. Cancer normally attacks vital cells such as the immune cells including macrophages, white blood cells, dendritic and NK cells. Beta glucan influences the macrophages and NK cells to overcome and destroy tumor cells.
Beta glucan also has various powerful effects in the prevention of infection as well as treatment and healing of wounds. This it does by strengthening the body’s healing powers by attaching to the protector cells and ensuring that their ability is not compromised by pathogens and other infection inducing agents.
Beta glucan's effect on combating free radicals also enables it to be a powerful photoprotective agent has good application in the manufacture of sunscreens. Its use has been shown to result in reduction of UV induced erythema as well as preserving and enhancing the power of the Langerhans cells in the epidermis.
Beta glucan is therefore a most powerful and efficient antioxidant available to the body and the skin.
A study by a University of Alberta spin-off company showed that oat beta glucan can penetrate the skin despite years of doctors and scientists believing that the large molecule was too big.
The finding is significant, not only in the treatment of skin disorders and removing fine lines and wrinkles, but in the promotion of wound healing and reduction in scaring following surgical procedures.
The study showed that glucan works through the inter-cellular lipid matrix, or the cells' cement, to enter the lower levels of the skin. Of medical significance is the fact that beta glucan creams promote wound healing and reduction in scaring following surgical procedures.
The research team measured the depth of the skin that the glucan penetrated and photographs showed the actual reduction of wrinkles and consumers. Beta glucan is already used in a number of products available to consumers including brand name products from Johnson and Johnson and Schering Plough. The proof provided in this paper and other research conducted is that glucan can have a specific and measurable effect on skin
"Oat (1,4; 1,3) beta-glucan is a natural active ingredient offering significant performance-enhancing properties for personal care applications. studies have shown that the molecule, despite its considerable molecular weight, is able to enter the stratum corneum and epidermis and penetrate deep into the dermis. The observed effects of beta-glucan on tissue restructuring and wrinkle reduction are most likely effects mediated by fibroblast stimulation and collagen deposition in the dermis. These unique properties make oat beta-glucan a promising and effective ingredient for cosmetics." Read more (PDF)
Todorov, G., Oat beta-glucan's anti-wrinkle promise. smartskincare
"preliminary research indicates that a biopolymer from oat called beta-glucan may be capable of both penetrating deep into the skin and delivering significant skin benefits. Beta-glucan is a linear polymer consisting of glucose molecules linked together in a particular fashion. It has a long history of safe use in skin care and dermatology as a long-lasting, film-forming moisturizer. It has also been shown to work as anti-irritant and to speed up healing of shallow abrasions and partial thickness burns. Beta-glucan appears to enhance wound healing through several mechanisms including the stimulation of collagen deposition, activation of immune cells and so forth." Todorov, G., Oat beta-glucan's anti-wrinkle promise. smartskincare