About DMAE in DIY Skin Care
When skin loses its firmness, this signifies thinning collagen, compromised membranes, and cellular dehydration. The result is a visible sagging, with a wrinkling tendency.
In a human study, scientists found that topical application of dimethylaminoethanol (DMAE) increased both the thickness of collagen fibers, and skin hydration.(Tadini KA, Campos PM. In vivo skin effects of a dimethyla-minoethanol (DMAE) based formulation. Pharmazie. 2009 Dec;64(12):818-22.
Another controlled study showed DMAE produces an anti-inflammatory effect and a clear increase in skin firmness. .Also, when DMAE was topically tested on humans in a randomized clinical trial, researchers found it resulted in mitigation of lines in the forehead and around the eyes. There was a beneficial effect on the appearance of coarse wrinkles, under-eye dark circles, nasolabial folds (“laugh lines”), and neck skin, which was noticeably firmed. These effects were observed in just 16 weeks! (Grossman R. The role of dimethylaminoethanol in cosmetic dermatology. Am J Clin Dermatol. 2005;6(1):39-47.
Scientists also observed that DMAE exerts a general firming action on skin cells, likely explained by the fact that, as a precursor of acetylcholine, DMAE alters muscle contraction. (Gragnani A, Giannoccaro FB, Sobral CS, et al. Dimethylaminoethanol affects the viability of human cultured fibroblasts. Aesthetic Plast Surg. 2007 Nov-Dec;31(6):711-8.)
The acute skin-firming effects of DMAE were further confirmed in a randomized, double-blind, split-face study on 30 humans,16 and by quantitative measures of cutaneous tensile strength (the force required to pull the skin). (Tadini KA, Campos PM. In vivo skin effects of a dimethyla-minoethanol (DMAE) based formulation. Pharmazie. 2009 Dec;64(12):818-22.)
Daily skin application for an entire year showed no adverse effects. (Tadini KA, Campos PM. In vivo skin effects of a dimethyla-minoethanol (DMAE) based formulation. Pharmazie. 2009 Dec;64(12):818-22.)
Dr. G. Todorov. Will DMAE lift your face, or just your wallet?,
"It has been demonstrated that DMAE causes some degree of skin tightening.
However, despite speculation it remains unclear how DMAE firms the skin -- whether by stabilizing the membranes, boosting acetylcholine, reducing lipofuscin deposits or none of the above.
Whatever the mechanism, the effect of DMAE is often noticeable although seldom dramatic.
Besides, even though DMAE can't fully reverse the existing facial sag, it may reduce its further progression. Some people report a cumulative effect with continued use of DMAE."Dr. G. Todorov. Will DMAE lift your face, or just your wallet?, Smartskincare.com.
DMAE is the active ingredient in Tricutan.Scientists investigate anti-ageing attributes of Tricutan
"Swedish scientists say that dermatological research they have carried out on the anti-ageing ingredient Tricutan confirms that it can improve skin firmness and elasticity"
- Tricutan is the 'secret sauce' in Dermyn Active Serum
- Dermyn retails at US$59.- for a 30ml bottle.
- DMAE is VERY water soluble,
- It is easy to DIY your own Dermyn! Just click on the FORMULATIONS/RECIPES tab!
Ingredients in Dermyn
|Dimethyl Monoaminoethanol Bitartrate (DMAE)||Dimethyl Monoaminoethanol Bitartrate (DMAE)|
|Polyglycerin- 6|| |
|PEG-16 Macadamia Glycerides|| |
|Ammonium Acryloyldimethyltaurate/VP Copolymer||Gelmaker Ultra|
|Centella asiatica extract||Centella asiatica extract|
|Butylene Glycol|| |
|DMDM Hydantoin||Preservative (optional)|
|Sorbic Acid|| |
|Dehydroacetic Acid|| |