Grape Seed (95% Proanthocyanidins)
About Grape Seed Proanthocyanidins in DIY Skin Care
Grape seed extract is a great source of proanthocyanidins.
Proanthocyanidins are flavonoids that protect capillary walls and inhibit the enzymes that break down collagen (collagenase), hyaluronic acid (hyaluronidase) and elastin (elastase).
Also acts as anti-inflammatory, antihistamines, antiallergenic, and as major free radical scavengers.
Proanthocyanidins also help promote tissue elasticity, help heal injuries, reduce swelling and edema, restore collagen and improve peripheral circulation.
Proanthocyanidins also prevent bruising, strengthen weak blood vessels and reduce histamine production.
Topically applied Grape Seed Proanthocyandins may:
- act as an anti-inflammatory:     
- act as an anti oxidant:        
- repair and treat sun damage:     
- prevent or reduce UVA and UVB sun damage:          
- increase skin elasticity: 
- support wound healing:   
14: Yuan XY, Liu W, Hao JC, Gu WJ, Zhao YS. Topical Grape Seed Proanthocyandin Extract Reduces Sunburn Cells and Mutant p53 Positive Epidermal Cell Formation, and Prevents Depletion of Langerhans Cells in an Acute Sunburn Model. Photomed Laser Surg. 2011 Nov 21. [Epub ahead of print] PubMed PMID: 22103910.
13: Afaq F, Katiyar SK. Polyphenols: Skin Photoprotection and Inhibition of Photocarcinogenesis. Mini Rev Med Chem. 2011 Oct 28. [Epub ahead of print] PubMed PMID: 22070679.
12: Hemmati AA, Aghel N, Rashidi I, Gholampur-Aghdami A. Topical grape (Vitis vinifera) seed extract promotes repair of full thickness wound in rabbit. Int Wound J. 2011 Oct;8(5):514-20. doi: 10.1111/j.1742-481X.2011.00833.x. Epub 2011 Aug 4. PubMed PMID: 21816000.
11: Filip A, Daicoviciu D, Clichici S, Mocan T, Muresan A, Postescu ID. Photoprotective effects of two natural products on ultraviolet B-induced oxidative stress and apoptosis in SKH-1 mouse skin. J Med Food. 2011 Jul-Aug;14(7-8):761-6. Epub 2011 Apr 6. PubMed PMID: 21470043.
10: Hanausek M, Spears E, Walaszek Z, Kowalczyk MC, Kowalczyk P, Wendel C, Slaga TJ. Inhibition of murine skin carcinogenesis by freeze-dried grape powder and other grape-derived major antioxidants. Nutr Cancer. 2011;63(1):28-38. PubMed PMID: 21108125.
9: Nichols JA, Katiyar SK. Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms. Arch Dermatol Res. 2010 Mar;302(2):71-83. Epub 2009 Nov 7. Review. PubMed PMID: 19898857; PubMed Central PMCID: PMC2813915.
8: Vitseva O, Varghese S, Chakrabarti S, Folts JD, Freedman JE. Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates. J Cardiovasc Pharmacol. 2005 Oct;46(4):445-51. PubMed PMID: 16160595.
7: Shi J, Yu J, Pohorly JE, Kakuda Y. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food. 2003 Winter;6(4):291-9. Review. PubMed PMID: 14977436.
6: Khanna S, Venojarvi M, Roy S, Sharma N, Trikha P, Bagchi D, Bagchi M, Sen CK. Dermal wound healing properties of redox-active grape seed proanthocyanidins. Free Radic Biol Med. 2002 Oct 15;33(8):1089-96. PubMed PMID: 12374620.
5: Sen CK, Khanna S, Gordillo G, Bagchi D, Bagchi M, Roy S. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm. Ann N Y Acad Sci. 2002 May;957:239-49. Review. PubMed PMID: 12074976.
4: Bagchi D, Bagchi M, Stohs SJ, Das DK, Ray SD, Kuszynski CA, Joshi SS, Pruess HG. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology. 2000 Aug 7;148(2-3):187-97. PubMed PMID: 10962138.
3: Bomser J, Singletary K, Meline B. Inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin ornithine decarboxylase and protein kinase C by polyphenolics from grapes. Chem Biol Interact. 2000 Jun 15;127(1):45-59. PubMed PMID: 10903418.
2: Zhao J, Wang J, Chen Y, Agarwal R. Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent. Carcinogenesis. 1999 Sep;20(9):1737-45. PubMed PMID: 10469619.
1: Bomser JA, Singletary KW, Wallig MA, Smith MA. Inhibition of TPA-induced tumor promotion in CD-1 mouse epidermis by a polyphenolic fraction from grape seeds. Cancer Lett. 1999 Jan 29;135(2):151-7. PubMed PMID: 10096423.