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About BulkActives

BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.

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Buy Niacinamide (Vitamin B3) For DIY Skin Care

Niacinamide in skin care:  anti-acne, anti-inflammatory, oil sebum control, lightening & brightening, sun damage repair & protection, prevent water loss in skin, reduce fine lines and wrinkles, improve skin elasticity

Niacinamide (Vitamin B3) has many qualities that make it useful for acne medications, and for anti aging formulations. It has properties that make it effective for: anti contol, as an anti-inflammatory,  oil control, skin lightening, skin brightening, to increase ceramide levels, to prevent water loss in skin, and for its anti aging effects to reduce fine lines and wrinkles and improve skin elasticity.
 
Product Code: Niacinamide (Vitamin B3)
Reward Points: 1
CAS#: 99%
Net weight: 30g /1.06oz
Availability: In Stock ( 5+ Available )
Price: $5.10
Reward Points: 255
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Niacinamide (Vitamin B3)

About Niacinamide and N-acetyl Glucosamine  in DIY Skin Care

Application of Niacinamide topically has been shown to benefit skin color, decrease melanin synthesis (important for hyperpigmentation), and decrease inflammation and itching (pruritus).

The biochemical effects of Niacinamide include increased concentration of NADPH, the donor of reducing power in cell biosynthesis, an effect that translates into increased synthesis of collagen, involucrin, filaggrin, and keratin.

Topical application of Niacinamide also decreases UV-induced skin cancers and prevented immunosuppression by UV irradiation.

This molecule is one of the components of NADPH (reduced niacinamide adenine dinucleotide phosphate) the coenzyme that provides the reducing power required to build new molecules in the human body. Niacinamide and niacin are not synthesized in the human body and therefore must be supplied externally (these is why we call niacin a vitamin), either through the diet or through topical application (or better, both).

Niacinamide is also part of NAD (like NADP but without the extra phosphate), the molecule that is wherever carbohydrates and other foodstuffs are oxidized (respired) to make energy. Even when following a normal healthy diet, topical application of niacinamide will result in increased synthesis of collagen, keratin, involucrin and flaggrin. Topical application of niacinamide will decrease pruritus and inflammation, help acne affected skin, decrease oiliness, alleviate atopic dermatitis, decrease UV-induced skin cancers and help decrease facial pigmentation. These are just a few of the beneficial effects of topical application of niacinamide to the skin, and it would be suspicious that there are so many were it not for the crucial role of this chemical in human metabolism.

 

Topical Formulation Containing N-Acetyl Glucosamine and Niacinamide Reduces the Appearance of Hyperpigmented Spots on Human Facial Skin

"Glucosamine has been shown to reduce production of melanin in melanocyte cell culture .  The reported mechanism is inhibition of maturation of tyrosinase, specifically inhibiting the glycosylation of pro-tyrosinase to active tyrosinase.  Clinical pigmentation effects of topical glucosamine have not been reported.  We have investigated the effectiveness of a stable derivative of glucosamine, N-acetyl glucosamine (NAG), alone and in combination with a previously demonstrated effective material, niacinamide (N) , for clinically reducing the appearance of facial hyperpigmented spots."

 

Topical N-Acetyl Glucosamine and Niacinamide Increase Hyaluronan

"In in vitro human skin cultures, topical application of N-acetyl glucosamine and niacinamide stimulated hyaluronan synthesis. •These treatments also led to an increase in collagen (procollagen-1) expression. •Twice daily use of a facial moisturizer containing a combination of 2% N-acetyl glucosamine and 4% niacinamide for 4 to 8 weeks by women with moderate to severe fine and wrinkles reduced the appearance of facial fine lines and wrinkles, particularly in the eye area of the face. •The in vitro hyaluronan results suggest that this effacement of fine lines and wrinkles is due at least in part to improved hydration of the skin. References 1.Sayo T, Sakai S, Inoue S.  Synergistic effect of N-acetylglucosamine and retinoids on hyaluronan production in human keratinocytes."

 

A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma.

(what is melasma?)


"The therapeutic effect of topical niacinamide versus hydroquinone (HQ) in melasma patients was evaluated.
Twenty-seven melasma patients were randomized to receive for eight weeks 4% niacinamide cream on one side of the face, and 4% HQ cream on the other.
All patients showed pigment improvement with both treatments.
Good to excellent improvement was observed with niacinamide in 44% of patients, compared to 55% with HQ.
Niacinamide induces a decrease in pigmentation, inflammatory infiltrate, and solar elastosis.
Niacinamide is a safe and effective therapeutic agent for melasma."

Assay: 99%
CAS#: 98-92-0 
Chemical Name: pyridine-3-carboxamide
Other names: 3-pyridinecarboxamide, niacinamide, nicotinamide, nicotinic acid amide, Vitamin PP
INCI: Niacinamide
Solubility: water
Suggested percentage: 5%
Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China

 Topically applied  Niacinamide may:

  • act as an anti-inflammatory: [18] [17] [12] [11] [8] [6] [5] [3]
  • lighten and brighten skin (treat melsama/hyper pigmentation): [18] [16] [15] [14] [11] [9] [6] [5] [3] [2] [1]
  • repair and treat sun damage:  [18] [16] [15] [14] [10] [1]
  • prevent or reduce UVA and UVB sun damage:[14]  [13] [10]
  • prevent and treat acne: [18] [17] [12] [4] [1]
  • control oil/sebum levels: [8]
  • repair the skin barrier:[1]
  • increase hyaluroninic acid production: [18]
  • moisturize and prevent water loss: [18] [1]
  • reduce fine lines and wrinkles: [6] [2]
  • increase skin elasticity: [6]

18.      Navarrete-Solís J, Castanedo-Cázares JP, Torres-?lvarez B, Oros-Ovalle C, Fuentes-Ahumada C, González FJ, Martínez-Ramírez JD, Moncada B. A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatol Res Pract. 2011;2011:379173. Epub 2011 Jul 21.  PMCID: PMC3142702 PMID: 21822427  [PubMed]
 
17.         Iraji F, Banan L. Dermatol Ther. The efficacy of nicotinamide gel 4% as an adjuvant therapy in the treatment of cutaneous erosions of pemphigus vulgaris. 2010 May-Jun;23(3):308-11. PMID: 20597951 
 
16.         Jerajani HR, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ. The effects of a daily facial lotion containing vitamins B3 and E and provitamin  B5 on the facial skin of Indian women: a randomized, double-blind trial. Indian J Dermatol Venereol Leprol. 2010 Jan-Feb;76(1):20-6. PMID:  20061726
 
15.         Bissett DL, Robinson LR, Raleigh PS, Miyamoto K, Hakozaki T, Li J, Kelm GR.  J Cosmet. Reduction in the appearance of facial hyperpigmentation by topical N-undecyl-10-enoyl-L-phenylalanine and its combination with niacinamide. Dermatol. 2009 Dec;8(4):260-6. PMID: 19958429 
 
14.         Kimball AB, Kaczvinsky JR, Li J, Robinson LR, Matts PJ, Berge CA, Miyamoto K, Bissett DL. Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a  randomized, double-blind, vehicle-controlled trial. Br J Dermatol. 2010 Feb 1;162(2):435-41. Epub 2009 Aug 28. PMID: 19845667 
 
13.         Sivapirabu G, Yiasemides E, Halliday GM, Park J, Damian DL. Topical nicotinamide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppression in humans. Br J Dermatol. 2009 Dec;161(6):1357-64. Epub 2009 Apr 20. PMID: 19804594 
 
12.         Grange PA, Raingeaud J, Calvez V, Dupin N. Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-kappaB and MAPK pathways. J Dermatol Sci. 2009 Nov;56(2):106-12. Epub 2009 Sep 1. PMID: 19726162 
 
11.         Kawada A, Konishi N, Oiso N, Kawara S, Date A. Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide. J Dermatol. 2008 Oct;35(10):637-42. PMID: 19017042 
 
10.         Damian DL, Patterson CR, Stapelberg M, Park J, Barnetson RS, Halliday GM. UV radiation-induced immunosuppression is greater in men and prevented by topical nicotinamide. J Invest Dermatol. 2008 Feb;128(2):447-54. Epub 2007 Sep 20. PMID: 17882270 
 
9.         Bissett DL, Robinson LR, Raleigh PS, Miyamoto K, Hakozaki T, Li J, Kelm GR. Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine. J Cosmet Dermatol. 2007 Mar;6(1):20-6. PMID: 17348991 
 
 8.       Draelos ZD, Matsubara A, Smiles K.The effect of 2% niacinamide on facial sebum production. J Cosmet Laser Ther. 2006 Jun;8(2):96-101. PMID: 16766489 
 
 7.      R. Osborne, Ph.D., L. A. Mullins, B.S. and L. R. Robinson, Ph.D. Topical N-Acetyl Glucosamine and Niacinamide Increase Hyaluronan. The Procter & Gamble Company, Cincinnati, Ohio USA
 
6.       Bissett DL, Oblong JE, Berge CA. Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatol Surg. 2005 Jul;31(7 Pt 2):860-5; discussion 865. PMID: 16029679 
 
5.       Hakozaki T, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K, Greatens A,Hillebrand GG, Bissett DL, Boissy RE. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol. 2002 Jul;147(1):20-31. PMID: 12100180 
 
4.       Shalita AR, Smith JG, Parish LC, Sofman MS, Chalker DK. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. Int J Dermatol. 1995 Jun;34(6):434-7. PMID: 7657446 
 
3.       Greatens A, Hakozaki T, Koshoffer A, Epstein H, Schwemberger S, Babcock G, Bissett D, Takiwaki H, Arase S, Wickett RR, Boissy RE. Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible. Exp Dermatol. 2005 Jul;14(7):498-508. PMID: 15946237
 
 2.       Bissett DL, Miyamoto K, Sun P, Li J, Berge CA. Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin. Int J Cosmet Sci. 2004 Oct;26(5):231-8. PMID: 18492135
 
1.       Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol. 2004 Apr;3(2):88-93. PMID: 17147561
 

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