Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
I am following the moisturizing cream + Zinc dispersion recipe and I am extremely satisfied. I do allow for a little time for it to absorb in & then I dab off anything that I feel looks a little white - but that's because I initially use a fairly thick coating on myself. I use a bit of foundation at times on top and there are no issues as far as weird colors or texture issues. I am so grateful for this entire website as a one-stop-shop for such effective skin care products, and now we can.. ...»
I purposely waited a few months before writing my review. I am happy to report this product is great! I combined the DMAE product with the base creams resulting in tighter skin and lessened wrinkles, including areas around underarms... ...»
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The inflammatory response evolved as a way for the body to defend itself. Inflammation is initiated in response to the presence of an antigen, which may be an infectious agent or damaged tissue [including damage by UV irradiation]. Following recognition of an antigen by local immune cells [leukocytes], blood vessels may either dilate or constrict, depending on the context. This leads to increased vascular permeability and the accumulation of plasma proteins at the site of the antigen which can recruit circulating leukocytes to extravagate and respond to the insult. Through this mechanism a positive feedback loop is established as the immune cells secrete inflammatory signaling molecules [cytokines],recruiting more leukocytes from circulation [1, 2]. The “leaky” vasculature combined with the presence of leukocytes causes skin to appear flushed, a condition known as erythema. Further, the secretion of cytokines and pro-inflammatory compounds can cause itchiness and discomfort .
When phagocytic leukocytes such as macrophages respond during inflammation the phagocytic process causes reactive oxygen species [ROS] to be released. ROS can also be produced independently of leukocytes by UV irradiation. This is significant because ROS can damage cell membranes, and since the cells of the skin are rich in polyunsaturated fatty acids they are particularly susceptible to oxidative damage. ROS-induced cell death can thus initiate or contribute to a pro-inflammatory state, increasing leukocyte recruitment [4, 5]. Both ROS and cytokines can lead to cellular production of proteolytic enzymes which degrade the extracellular matrix, increasing the appearance of fine lines and wrinkles while decreasing the elasticity or the skin . Together, inflammation resulting from environmental assaults [such as smoking or pollution], UV photodamage, or infection [such as acne vulgaris] results in aging of the skin and in skin abnormalities such as flushing and irritation.
Anti-inflammatory agents are now commonly being incorporated into skin care products to improve skin tone and texture while reducing the appearance of aging. Many plant extracts have been shown to attenuate inflammation, including boswelic acid which can inhibit the enzymatic pathway in leukocytes that produces leukotrienes, important inflammatory mediators. This blocks loss of collagen and elastic fibers while increasing fibroblastic synthesis of collagen [7, 8].
Dipotassium glycyerhizinate is a salt of an extract from the white licorice plant which can also inhibit leukotriene synthesis. Additionally, this compound slows down the metabolism of cortisol, a potent proinflammatory mediator and also can inhibit the synthesis of inflammatory histamines. Studies have demonstrate this compound is useful in treating both atopic dermatitis [AD] and psoriasis [9-13].
Fucoidan, a brown seaweed extract, also has implications for treatment of AD, allergic reactions, and wound healing. Fucoidans inhibit several enzymes involved in the inflammatory pathway while simultaneously stimulating dermal cells to synthesize collagen and accelerate re-epithelialization [14-21].
Pomegranate extracts, though widely known for their antioxidant properties, also have powerful anti-inflammatory effects. They have been shown to reduce erythema, decrease UV-induced cell death and protect against UV-induced inflammation via ROS [22, 23].
Soy isoflavones are also known mediators of UV-induced ROS and can inhibit the activity of certain enzymes which drive inflammation [24-26]. Plant sterols, hesperidin methyl chalcone [extracted from citrus fruits], and ginkgo biloba extracts are all known to regulate blood flow through skin capillaries which can decrease redness of the skin and reduce the recruitment of circulating leukocytes to the site of the stimulus [27-30].
Gynostemma, or jiaogulan, are polysaccharides extracted from a plant belonging to the cucumber family which decreases synthesis of inflammatory cytokines and is useful for treatment of psoriasis [31, 32]. Pine bark extracts, white willow bark salicylic acid extract, and grape extracts [resveratrol] are capable of acting as a skin protectant from UV light, both reducing damage if used as a pre-treatment and for alleviating the inflammation induced by UV irradiation [33-36].
Certain vitamins or vitamin-like compounds can also act as anti-inflammatory agents. Coenzyme Q10 is a vitamin-like compound which is oil-soluble and naturally synthesized by the body. Q10 levels naturally decline with age, but topical application of this compound to the skin have been shown to decrease inflammation induced by UV irradiation and other environmental hazards, increase collagen synthesis, and promote wound healing [37-39].
Provitamin B5, or D-panthenol, is involved in skin maintenance and growth. This compound has been shown to be beneficial for atopic dermatitis as it is protective against skin irritants and is as effective at treating AD as corticosteroids, the current standard of therapy [40, 41]. Further, D-panthenol is effective in reducing UV-induced erythema and thus can decrease redness in the skin .
Niacinamine [vitamin B3], supports barrier function and reduces leukocyte infiltration to the site of inflammation and has been shown to be beneficial in treatment of rosacea [43, 44]. Vitamin E, or mixed tocopherols, is a lipid-soluble vitamin with known sun-protectant properties also capable of neutralizing UV-induced oxidative damage. Mixed tocopherols can also inhibit the enzymes which produce reactive oxygen species in response to stress in both macrophages and epithelial cells [45, 46].
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 Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454:428-35.
 Hoffmann R, Schmelz M. Time course of UVA‐and UVB‐induced inflammation and hyperalgesia in human skin. European Journal of Pain. 1999;3:131-9.
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 Trenam CW, Blake DR, Morris CJ. Skin Inflammation: Reactive Oxygen Species and the Role of Iron. J Investig Dermatol. 1992;99:675-82.
 Pillai S, Oresajo C, Hayward J. Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation-induced matrix degradation – a review. International Journal of Cosmetic Science. 2005;27:17-34.
 Calzavara‐Pinton P, Zane C, Facchinetti E, Capezzera R, Pedretti A. Topical Boswellic acids for treatment of photoaged skin. Dermatologic therapy. 2010;23[s1]:S28-S32.
 Siddiqui M. Boswellia serrata, a potential antiinflammatory agent: an overview. Indian journal of pharmaceutical sciences. 2011;73:255.
 Panel CIRE. Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate. International journal of toxicology. 2007;26:79.
 Ojima M, Satoh K, Gomibuchi T, Itoh N, Kin S, Fukuchi S, et al. [The inhibitory effects of glycyrrhizin and glycyrrhetinic acid on the metabolism of cortisol and prednisolone--in vivo and in vitro studies]. Nihon Naibunpi Gakkai Zasshi. 1990;66:584-96.
 Noriaki I, Hiroshi K, Yasuhiro H, Kimio Y, Atsushi I. Effects of glycyrrhizin and glycyrrhetinic acid on dexamethasone-induced changes in histamine synthesis of mouse mastocytoma P-815 cells and in histamine release from rat peritoneal mast cells. Biochemical pharmacology. 1989;38:2521-6.
 Saeedi M, Morteza-Semnani K, Ghoreishi M. The treatment of atopic dermatitis with licorice gel. Journal of Dermatological Treatment. 2003;14:153-7.
 Xiong H, Xu Y, Tan G, Han Y, Tang Z, Xu W, et al. Glycyrrhizin Ameliorates Imiquimod-Induced Psoriasis-like Skin Lesions in BALB/c Mice and Inhibits TNF-α-Induced ICAM-1 Expression via NF-κB/MAPK in HaCaT Cells. Cellular Physiology and Biochemistry. 2015;35:1335-46.
 Ferrao AV, Mason RM. The effect of heparin on cell proliferation and type-I collagen synthesis by adult human dermal fibroblasts. Biochimica et Biophysica Acta [BBA]-Molecular Basis of Disease. 1993;1180:225-30.
 Iwamoto K, Hiragun T, Takahagi S, Yanase Y, Morioke S, Mihara S, et al. Fucoidan suppresses IgE production in peripheral blood mononuclear cells from patients with atopic dermatitis. Arch Dermatol Res. 2011;303:425-31.
 Kim TH, Lee EK, Lee MJ, Kim JH, Yang WS. Fucoidan inhibits activation and receptor binding of transforming growth factor-β1. Biochemical and Biophysical Research Communications. 2013;432:163-8.
 Nakamura T, Suzuki H, Wada Y, Kodama T, Doi T. Fucoidan induces nitric oxide production via p38 mitogen-activated protein kinase and NF-κB-dependent signaling pathways through macrophage scavenger receptors. Biochemical and Biophysical Research Communications. 2006;343:286-94.
 O’Leary R, Rerek M, Wood EJ. Fucoidan modulates the effect of transforming growth factor [TGF]-b1 on fibroblast proliferation and wound repopulation in in vitro models of dermal wound repair. Biol Pharm Bull. 2004;27:266-70.
 Robert L, Fodil-Bourahla I, Bizbiz L, Robert AM. Effects of L-fucose and fucose-rich oligo- and polysaccharides [FROP-s] on collagen biosynthesis by human skin fibroblasts. Modulation of the effect of retinol, ascorbate and α-tocopherol. Biomedicine & Pharmacotherapy. 2004;58:65-70.
 Sezer AD, Cevher E, Hatıpoğlu F, Oğurtan Z, Baş AL, Akbuğa J. Preparation of fucoidan-chitosan hydrogel and its application as burn healing accelerator on rabbits. Biological and Pharmaceutical Bulletin. 2008;31:2326-33.
 Yang J-H. Topical Application of Fucoidan Improves Atopic Dermatitis Symptoms in NC/Nga Mice. Phytotherapy Research. 2012;26:1898-903.
 Parveen R, Akhtar N, Mahmood T. Topical microemulsion containing Punica granatum extract: its control over skin erythema and melanin in healthy Asian subjects. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii. 2014;31:351.
 Pacheco-Palencia LA, Noratto G, Hingorani L, Talcott ST, Mertens-Talcott SU. Protective effects of standardized pomegranate [Punica granatum L.] polyphenolic extract in ultraviolet-irradiated human skin fibroblasts. Journal of agricultural and food chemistry. 2008;56:8434-41.
 Chan W-H, Yu J-S. Inhibition of UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermal carcinoma A 431 cells by genistein. Journal of cellular biochemistry. 2000;78:73-84.
 Isoherranen K, Punnonen K, Jansen C, Uotila P. Ultraviolet irradiation induces cyclooxygenase-2 expression in keratinocytes. British journal of dermatology. 1999;140:1017-22.
 Miller CC, Hale P, Pentland AP. Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Evidence for UVB-induced epidermal growth factor receptor activation. Journal of Biological Chemistry. 1994;269:3529-33.
 HIBATALLAH J, CARDUNER C, POELMAN MC. In‐vivo and In‐vitro Assessment of the Free‐radical‐scavenger Activity of Ginkgo Flavone Glycosides at High Concentration. Journal of pharmacy and pharmacology. 1999;51:1435-40.
 Boelsma E, Lamers R, Hendriks HF, van Nesselrooij JH, Roza L. Evidence of the regulatory effect of Ginkgo biloba extract on skin blood flow and study of its effects on urinary metabolites in healthy humans. Planta medica. 2004;70:1052-7.
 Bouskela E, Cyrino FZ, Marcelon G. Inhibitory effect of the Ruscus extract and of the flavonoid hesperidine methylchalcone on increased microvascular permeability induced by various agents in the hamster cheek pouch. Journal of cardiovascular pharmacology. 1993;22:225-30.
 Boller S, Soldi C, Marques MC, Santos EP, Cabrini DA, Pizzolatti MG, et al. Anti-inflammatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation. Journal of ethnopharmacology. 2010;130:262-6.
 Aktan F, Henness S, Roufogalis BD, Ammit AJ. Gypenosides derived from Gynostemma pentaphyllum suppress NO synthesis in murine macrophages by inhibiting iNOS enzymatic activity and attenuating NF-κB-mediated iNOS protein expression. Nitric oxide. 2003;8:235-42.
 Li X-L, Wang Z-H, Zhao Y-X, Luo S-J, Zhang D-W, Xiao S-X, et al. Purification of a polysaccharide from Gynostemma pentaphyllum Makino and its therapeutic advantages for psoriasis. Carbohydrate polymers. 2012;89:1232-7.
 Sime S, Reeve VE. Protection from Inflammation, Immunosuppression and Carcinogenesis Induced by UV Radiation in Mice by Topical Pycnogenol®¶. Photochemistry and photobiology. 2004;79:193-8.
 Jackson RL, Greiwe JS, Schwen RJ. Ageing skin: oestrogen receptor β agonists offer an approach to change the outcome. Experimental dermatology. 2011;20:879-82.
 Nwachukwu JC, Srinivasan S, Bruno NE, Parent AA, Hughes TS, Pollock JA, et al. Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. Elife. 2014;3:e02057.
 Khayyal MT, El-Ghazaly MA, Abdallah DM, Okpanyi SN, Kelber O, Weiser D. Mechanisms involved in the anti-inflammatory effect of a standardized willow bark extract. Arzneimittel-Forschung. 2004;55:677-87.
 Fasano E, Serini S, Mondella N, Trombino S, Celleno L, Lanza P, et al. Antioxidant and anti-inflammatory effects of selected natural compounds contained in a dietary supplement on two human immortalized keratinocyte lines. BioMed research international. 2014;2014.
 Fuller B, Smith D, Howerton A, Kern D. Anti‐inflammatory effects of CoQ10 and colorless carotenoids. Journal of cosmetic dermatology. 2006;5:30-8.
 Choi BS, Song HS, Kim HR, Park TW, Kim TD, Cho BJ, et al. Effect of coenzyme Q10 on cutaneous healing in skin-incised mice. Archives of pharmacal research. 2009;32:907-13.
 Biro K, ThaÇi D, Ochsendorf FR, Kaufmann R, Boehncke WH. Efficacy of dexpanthenol in skin protection against irritation: a double‐blind, placebo‐controlled study. Contact dermatitis. 2003;49:80-4.
 Udompataikul M, Limpa-o-Vart D. Comparative trial of 5% dexpanthenol in water-in-oil formulation with 1% hydrocortisone ointment in the treatment of childhood atopic dermatitis: a pilot study. Journal of drugs in dermatology: JDD. 2012;11:366-74.
 Baschong W, Hüglin D, Röding J. D-panthenol loaded nanotopes< TM> providing enhanced anti-inflammatory efficacy: A study on human volunteers. SÖFW-journal. 1999;125:18-20.
 Draelos ZD, Ertel K, Berge C, Amburgey M. Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea. CUTIS-NEW YORK-. 2005;76:135.
 Navarrete-Solís J, Castanedo-Cázares JP, Torres-Álvarez B, Oros-Ovalle C, Fuentes-Ahumada C, González FJ, et al. A double-blind, randomized clinical trial of niacinamide 4% versus hydroquinone 4% in the treatment of melasma. Dermatology research and practice. 2011;2011.
 Jiang Q, Elson-Schwab I, Courtemanche C, Ames BN. γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proceedings of the National Academy of Sciences. 2000;97:11494-9.
 Reiter E, Jiang Q, Christen S. Anti-inflammatory properties of α-and γ-tocopherol. Molecular aspects of medicine. 2007;28:668-91.
Zinc Oxide Dispersion is a non-nano, uncoated, homogeneous dispersions of Zinc Oxide in Mineral Oil and Caprylic- Capric Triglyceride. Non-nano Zinc Oxide is safe because there are no nanopartices. The homogeneous Zinc Oxide dispersion makes it easy to process and use in DIY skin care (just add to a cream), no high shear mixing is required. Zinc Oxide is a highly effective inorganic physical sunscreen with broad spectrum UVA and UVB activity and coverage. Zinc Oxide is a physical sun protection sunscreen which absorbs & scatters UV light. Zinc Oxide offers mild and safe, long lasting UV protection, and does not degrade or oxidize. 250 gram of Zinc Oxide dispersion can make 1250 gram of final suncreen product if used at 20%.
Zinc oxide is a mineral produced by oxidation of zinc. Because of its reduced natural availability, zinc oxide is industrially produced. Besides a wide utilization in industrial areas such as semiconductors, textiles and food, zinc oxide used in several medical products, most of them ointments and treatments that are meant for topical use. Due to its physical characteristics that ensure good coating of the stratum corneum, without intracellular invasion zinc oxide is used in rash protection ointments. Zinc also has healing and soothing properties, making it a common ingredient in soothing, calming and antiseptic lotions. One of the most encountered utilisation of zinc oxide is as a component of physical sunscreen lotions due to its full spectrum block properties, ZnO currently being the most effective substance in protecting against UVA and UVB radiation. Last but not least, because zinc is the second most present metal in the human body after iron, and thus part of every structure including stratum corneum, there are a lot of topical solutions against skin disorders such as acne, dandruff, rash, dermatitis.
In order for skin to be healthy we need a well maintained stratum corneum. A healthy stratum corneum offers protection against environmental stress and water loss. BulkActives’ multi lamellar cream imitates the skin’s own lipid structure and enhance the skin's natural barrier function.
BulkActives’ multi lamellar cream is formulated with a new generation, European, sugar based, liquid crystals emulsifying system based on sorbitan stearate with sucrose cocoate. It is formulated specifically for DIY Skin care customers. BulkActives’ multi lamellar cream can be used as is. However, it can easily accept both water, oil, and water soluble and oil soluble powders and liquids. BulkActives’ multi lamellar cream is a great carrier for active skin care ingredients. The multi lamellar structure is ideal for even and effective delivery of skin actives into the skin.
BulkActives’ multi lamellar cream is exclusively and professionally formulated, manufactured and packaged for us by the same biochemist who manufactures our seakelp bioferment, pumpkin bioferment, and lemon bioferment.
NOTE: Based on customer feedback we have reformulated our multi lamellar cream, making it "greener' and even more elegant! In this NEW formulation we have also replaced the xantham gum with Sclerotium Gum, the preservative system combines the extremely safe, yet effective, Sodium Levulinate and Sodium Anisate, with Potassium sorbate and citric acid. This means our cream now does NOT contain parabens or phenoxyethanol.
Multi Lamellar Base Cream with SeaKelp Bioferment and Sclerotium Gum (No Oil and No Polymer):
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
BulkActives is a part-time business. Orders are processed on Saturdays and mailed on Mondays at the latest.