restore barrier function

Ceramides are a type of lipid that is abundant in skin tissue, where it exerts both structural and signaling functions. Its structural function includes maintaining the barrier function and retaining water content and hence integrity of the skin. Its signaling function includes regulating the proliferation, differentiation, and apoptosis of the cells. Ceramides have been used to treat skin conditions that are a result of disrupted barrier function, such as atopic dermatitis, irritant/allergic contact dermatitis, and aged skin, and they might be used against skin cancer as well. Ceramides extracted from plant cells are superior in terms of safety and toxicity and are currently being explored. BulkActives sells safe ceramides, extracted from plant cells, we do NOT sell ceramides extracted from the bovine central nervous system. It is recommended that Ceramides are used in combination with Cholesterol NF and Natural Fatty Acids at a ratio of 3:1:1  cholesterols, ceramides and free fatty acids. Ceramides are used in Elizabeth Arden products, Ceramides in a Liquid Crystal Emulsion are used in Atopalm products.

Ceramide 2, 3, 6II Lamellar Liquid Crystal Emulsion is a stable pre emulsion base containing ceramide 2, ceramide 3, ceramide 6II, and phytosteryl isostearate.  Forms lamellar liquid crystal structure which provides enhanced delivery of the Ceramide 2, 3, 6II in to the skin, moisturize and nourishes the intercellular matrix, and additionally stabilizes the ceramides when diluted with water. after formulaton.

NOTE: To assist you with solubility issues, we now also sell Ceramide 2, 3, 6II Lamellar Liquid Crystal PRE Emulsion as a standardized pre-dissolved solution. Just add the liquid to your cream and mix well.

Key benefits of ceramides in skin care:

• Moisturizing and hydration ^{[24] [25] [26] [27] [28] [29]}
• Restore barrier function ^{[24 ][25] [26] [27] [28] [29]}

Key benefits of cholesterol in skin care:

• restore barrier function [3] [4] [5] [6] [7] [8] [9] [10] [11] 12] [13] [14]
• moisturizing and hydration [5] [8] [14]

Ginkgo biloba is a unique tree species. Its leaf extract contains a diverse variety of molecules useful in cosmetics and pharmacology. Firstly, they are potent antioxidants, and can even activate the production of enzymes that neutralize free radicals. Combined with the anti-inflammatory effects, this extract provides an effective defense against UV radiation and ageing symptoms. Dermal applications of this extract can even lead to protection of other organs. Another major application of Ginkgo biloba is moisturizing the skin, which helps to increase its elasticity and visual appearance, even reducing the amount of wrinkles. Furthermore, this extract helps to maintain the barrier function of the skin – it reduces water loss through epidermis, thus reducing skin dryness and irritation. In combination with green tea extract, Ginkgo shows even stronger benefits in these areas.

NOTE: To assist you with solubility issues, we now also sell Ginkgo Biloba extract as a standardized pre-dissolved solution. Just add the liquid to your cream and mix well.

Key benefits of Ginkgo Biloba in skin care:

• Sun damage protection ^{[1] [6] [8] [10] [11]}
• Sun damage repair ^{[7] [10]}
• Antioxidant ^{[1] [6]}
• Capillary health ^{[6] [14]}
• Increase skin elasticity ^[2]
• Moisturizing & hydration ^{[2] [3] [4]}
• Restore barrier function ^{[2] [3] [4] [5]}
• Reduce fine lines and wrinkles ^{[2] [4] [9]}
• Anti-inflammatory ^{[9] [12] [13]}

• 11% solution gives 1% EGCG content in final product.
• 33% solution gives 3% EGCG content in final product.
• 54% solution gives 5% EGCG content in final product.

Key benefits of Green Tea EGCG in skin care:

• Sun damage protection ^{[1] [2] [3] [4] [5]}
• Sun damage repair ^{[1] [2] [3]}
• Antioxidant ^{[1] [2] [3] [7]}
• Capillary health ^[19]
• Moisturizing & hydration ^{[8] [9] [11]}
• Reduce fine lines and wrinkles ^{[10] [11]}
• Wound healing support ^{[17] [18]}
• Oil/sebum control ^[12]
• Lightening & brightening ^[6]
• Restore barrier function ^{[8] [9]}
• Anti-inflammatory ^[1]
• Anti-acne ^{[12] [13]}
• Anti-bacterial ^{[13] [14] [16]}

• 11% solution gives 1% Hesperidin content in final product.
• 31% solution gives 3% Hesperidin content in final product.
• 51% solution gives 5% Hesperidin content in final product.

Key benefits of Hesperidin methyl chalcone in skin care:

• Sun damage protection ^{[8] [11]}
• Capillary health ^{[4] [5] [12]}
• Lightening & brightening ^{[7] [8]}
• Reduce dark circles under the eyes ^[6]
• Restore barrier function ^{[1] [9] [10]}
• Anti-inflammatory ^{[2] [5]}

Key benefits of Hyaluronic acid in skin care:

• Moisturizing and hydration ^{[2] [6] [7]}
• Reduce fine lines and wrinkles ^{[2] [7] [8]}
• Increase skin elasticity ^{[2] [4] [7]}
• Wound healing support ^{[1] [10] [11]}
• Restoring barrier function ^[9]

Key benefits of Niacinamide in skin care:

• Treat hyperpigmentation ^{[3] [7] [8]}
• Lightening and brightening ^{[3] [7] [8]}
• Reduce fine lines and wrinkles ^[9]
• Anti-inflammatory ^{[5] [6] [8]}
• Anti-oxidant ^{[10] [13]}
• Anti-acne ^{[1] [5] [11]}
• Moisturizing and hydration ^{[2] [5] [12]}
• Restore barrier function ^{[2] [5] [12]}
• Wound healing support ^{[5] [6]}
• Increase skin elasticity ^{[5] [9]}
• Oil/sebum control ^[2]
• Pore refinement ^[2]
• Sun damage repair ^[13]
• Sun damage protection ^[10]
• Stimulate collagen production ^[5]
• Stimulate HA production ^[9]

Phytosterols are a family of plant-produced molecules with diverse health benefits. In cosmetics, the ability to stimulate collagen production is most interesting. Together with antioxidant activity and down-regulation of collagen degrading enzymes, these abilities help repair damage in photoaged skin. Phytosterols also have anti-inflammatory properties, which are useful in UV protection, dermatitis treatment, and even cancer prevention. They are widely used in burn wound care – phytosterols were found to improve healing, improve scar appearance and possess analgesic properties, reducing the need of opiate drugs. Antimicrobial activity of phytosterols is also important in skin care, as it can be utilized in both wound care and general fight against infections, such as Candida. Finally, phytosterols regulate transport of cholesterol and thus sebum production – this may present a good treatment option for acne and other sebum-related conditions.

NOTE: To assist you with solubility issues, we now also sell Phytosterol in a standardized  pre-dissolved solution. Just add the liquid to your cream and mix well.

• 11% solution gives 1% Phytosterols content in final product.
  32% solution gives 3% Phytosterols content in final product.
  53% solution gives 5% Phytosterols content in final product.

Key benefits of Phytosterols in skin care:

• Anti-inflammatory [2], [12]–[14]
• Anti-bacterial [6], [7]
• Oil/sebum control [8]
• Anti-acne [8]
• Sun damage protection [10], [11]
• Stimulate collagen production [9]–[11]
• Restore barrier function [5]
• Matrix metalloproteinase (MMP) inhibitors [9]–[11]
• Wound healing support [3]–[5]
• Scar care [3]–[5]

Key benefits of Sclerotium Gum in skin care:

• moisturizing and hydration [9][12][13]
• anti-inflammatory [6] [10]
• wound healing support [6] [10]
• sun damage protection [10]
• sun damage repair [10]
• stimulate collagen production[11]
• Anti-bacterial [11]
• Antioxidant [10]
• Restore barrier function [9][12][13]

• Emulsion stabilizer
• Improves flow of emulsions
• Wide pH tolerance :: 5 to 12
• Offers a nice feel to products
• Viscosity not affected by high heat
• Stable in extreme physical and chemical conditions
• Creates smooth flowing gels / serums
• Improves natural moisture levels in skin and hair
• Gels the water phase for enhanced viscosity without stiffness
• Outstanding suspending ability
• Alternative to carbopol and Gelmaker Ultra
• Moisturizer

Key Benefits of Vitamin E mixed Tocotrienols in skin care:

• Antioxidant [1-10]
• Sun damage protection [1, 3, 4, 5, 6, 7, 10]
• Sun damage repair [1, 3, 4, 5, 6, 7, 8, 9, 10]
• Anti-inflammatory [4, 6, 9]
• Stimulate collagen production [1, 2, 3]
• Increase skin elasticity [2, 3]
• Restore barrier function [8]
• Treat hyperpigmentation [11]

Glucan is a polymer, produced from glucose molecules in fungi, seaweed and other organisms. Many types of this polymer exist, but yeast beta-glucan has the optimal structure and size for biological activity. It has significant effects in wound healing – glucan is already used to treat burn patients, as it promotes regeneration of the skin, reduces pain and improves scar appearance. Furthermore, it is able to activate the immune system to fight against infections, making it additionally useful in open wound care. Additionally, it helps the skin to maintain its barrier function after damage by chemicals, such as detergents. The antioxidant properties of this polymer help protect the skin cells against UV or other sources of oxidative damage. Skin ageing symptoms, such as darkening, sunburn and collagen degradation, can also be reduced by applying this compound.

Key benefits of Yeast Beta Glucan in skin care:

• Sun damage protection [1], [5], [11]
• Sun damage repair [1], [5], [11]
• Wound healing support [1], [4]–[8]
• Anti-bacterial [9], [10]
• Scar care [8]
• Lightening & brightening [1]
• Antioxidant [1], [5], [11]
• Restore barrier function [5]

Key benefits of ceramides in skin care:

Multi Lamellar Base Cream with SeaKelp Bioferment and Sclerotium Gum (No Oil and No Polymer): 

• Multi-lamellar cream offers outstanding moisturization
• skin barrier repair and maintenance
• optimized delivery of actives

Benefits of Liquid crystal systems:

• Improved dissolution of poorly water soluble actives .
• Liquid crystals can protect and facilitate the transport of fragile molecules e.g. proteins
• Controlled active release:
• Multilayers reduce the interfacial transport of actives dissolved in oil phase
• Active delivery can be tailored depending on the active
• Oleosome structure may enhance delivery of oil soluble ingredients
• Hydrosome structure may enhance delivery of water soluble actives
• Prolonged hydration potential:
• Up to 50% water bound up in swollen water layers.
• This water is less prone to evaporation.
• In-vivo tests moisturization lasts 3 times longer
• Effective Transepidermal Water Loss (TWEL)
• Structure similar to skin