Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
I purposely waited a few months before writing my review. I am happy to report this product is great! I combined the DMAE product with the base creams resulting in tighter skin and lessened wrinkles, including areas around underarms... ...»
This ingredient has done more for my skin than anything else I've ever used.
I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic.
I will use this forever, no question... ...»
I've been using Bulkactives green tea EGCG for four years. No complaints, it blends nicely my DIY anti-aging cream. I can feel a bit of toning and definitely notice the anti-inflammatory effects on my skin. Two observations that keep the rating 4 stars instead of 5: (1) A package of green tea contains significantly less weight/volume than the package of grape seed extract that I order from bulkactives. The two are combined in equal amounts in the anti-aging cream, so I find myself running o.. ...»
We sell COSMETIC RAW MATERIALS, which are meant to be used at an appropriate percentage in a cosmetic formulation of your devising. Please do not order our products unless you know how to formulate creams and lotions with it!
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Coenzyme Q10 is a molecule naturally involved in energy metabolism in all human cells. Among its many benefits, the antioxidant properties are the most researched. This molecule can prevent oxidation damage to water-insoluble molecules, DNA mutations, collagen synthesis decrease, pigmentation, inflammation and other adverse effects associated with UV exposure and ageing. In combination with vitamin E or other antioxidants, an exceedingly strong antioxidative effect can be achieved. Furthermore, coenzyme Q10 has a unique capability to protect against infrared A radiation, which is also found in sunlight. The promotion of collagen synthesis makes this coenzyme useful in treating ageing-associated skin changes, such as wrinkle appearance. Finally, its anti-inflammatory effect is beneficial not only for UV-damaged skin, but also for wound healing support.
Key benefits of Coenzyme Q10 in skin care:
Sun damage protection   
Antioxidant       
Increase cellular energy production 
Stimulate collagen production    
Lightening & brightening 
Sun damage repair   
Reduce fine lines & wrinkles  
Wound healing support 
Anti-inflammatory    
Product Code: BulkActives Reward Points: 5 Assay:
303-98-0 Net weight:
5g / 0.18oz Availability: In Stock
Coenzyme Q10 (also called ubiquinone) is a molecule with great importance for energy production in human cells. Since its role in helping the energy-generating enzymes has been known for almost 50 years, it is rather well researched, yet new benefits of this coenzyme are still being discovered. Besides metabolism, it is very important as an antioxidant – it is the only lipid antioxidant naturally produced in human cells, meaning that it can reach and neutralize oxidation damage in water-insoluble molecules . More recently, it was discovered that coenzyme Q10 acts as a gene regulator, and can control inflammation, cell signaling, nutrient transport and other processes .
Oxidation of cellular components is associated with many negative conditions, among them ageing. Coenzyme Q10 has been proven to protect skin cells from oxidative stress, especially following UV exposure (photoageing). This effect has been shown several times, using the coenzyme in various carriers and formulations –. While the primary target of this antioxidant is the lipids, it can also effectively reduce UV-caused damage to DNA . Even more, coenzyme Q10 promotes the synthesis of enzymes that help neutralize oxidizing agents. After UV exposure, the levels of these enzymes in skin cells fall to around 30 % of normal, and applying coenzyme Q10 restores the levels to 80 % of normal, thus helping the cellular repairs after UV exposure . Due to all these properties, applying coenzyme Q10 ultimately helps to prevent cell death caused by oxidative agents .
In the beginning of 2015, yet another benefit of coenzyme Q10 was discovered. Not only UV, but infrared A radiation from sunlight is also able to cause the photoageing effect and skin damage. However, previously it was not known that protection from this radiation is possible. In the recent study it was shown otherwise – a SPF30 sunscreen containing coenzyme Q10, vitamin C and vitamin E was able to protect the skin from damage, while sunscreen alone had no protective effect against this type of radiation .
The effects of coenzyme Q10 applications also extend to other components damaged by UV exposure. Collagen is among such examples, as oxidative damage promotes its degradation. However, coenzyme Q10 interferes with this degradation . Enhancement of collagen synthesis has also been observed . This molecule also promotes the growth of basal membrane, a collagenous layer underneath the epidermis . It has been shown that coenzyme Q10 applications (in the form of 1% cream) reduce wrinkle depth, and most likely these mechanisms are responsible for this effect , .
Sunlight also induces melanin synthesis in the skin, leading to darkening; this effect can also be counteracted by coenzyme Q10 . Furthermore, this molecule is able to reduce the inflammation caused by sunlight or other causes , . This anti-inflammatory action, together with promotion of collagen synthesis, leads to yet another application of coenzyme Q10 – skin cuts in mice, treated with coenzyme Q10, healed faster and with less signs of inflammation .
As natural production of coenzyme Q10 decreases with age, its use is particularly advised for older patients . Additionally, in patients with Parkinson’s disease, coenzyme Q10 can restore energy production in skin cells . It is suggested to formulate this coenzyme together with vitamin E, as these two molecules can support each other’s activity . Combinations with various other antioxidants also result in enhanced effect, exceeding that of any antioxidant alone .
"What can CoQ10 do for your skin? Theoretically speaking, CoQ10 (in a skin cream, for example) can be helpful. In most people over thirty, levels of CoQ10 in the skin are below optimum, resulting in lesser ability to produce collagen, elastin and other important skin molecules.Besides, CoQ10-depleted skin may be more prone to the damage by free radicals, which are particularly abundant in the skin since it is exposed to the elements.Thus, CoQ10 may boost skin repair and regeneration and reduce free radical damage. Furthermore, CoQ10 is a small molecule that can relatively easily penetrate into skin cells." Todorov, G., Can coenzyme Q10 help protect and repair your skin?, Smartskincare
About CoQ10 for Sun Damage Protection
Pinnell et al.  claim that CoQ10 is NOT as effective for sun protection as Pinnell's Vitamin C+E+Ferulic.
At BuklkActives we are not a big fan of Idebenone or CoQ10 for topical sunprotection as neither are very soluble and bio available.
We strongly suggest that Vitamin C be the main weapon in your fight against sun damage, and that CoQ10 or Idebenone are used at night to help increase cellular energy production.
Storage: Store in a cool and dry place. Store in well closed containers. Country of Origin: China
 G. P. Littarru and L. Tiano, “Bioenergetic and antioxidant properties of coenzyme Q10: recent developments,” Mol. Biotechnol., vol. 37, no. 1, pp. 31–37, Sep. 2007.
 J. Garrido-Maraver, M. D. Cordero, M. Oropesa-Ávila, A. Fernández Vega, M. de la Mata, A. Delgado Pavón, M. de Miguel, C. Pérez Calero, M. Villanueva Paz, D. Cotán, and J. A. Sánchez-Alcázar, “Coenzyme Q10 Therapy,” Mol. Syndromol., vol. 5, no. 3–4, pp. 187–197, Jul. 2014.
 F. Brugè, E. Damiani, C. Puglia, A. Offerta, T. Armeni, G. P. Littarru, and L. Tiano, “Nanostructured lipid carriers loaded with CoQ10: effect on human dermal fibroblasts under normal and UVA-mediated oxidative conditions,” Int. J. Pharm., vol. 455, no. 1–2, pp. 348–356, Oct. 2013.
 S. B. Lohan, S. Bauersachs, S. Ahlberg, N. Baisaeng, C. M. Keck, R. H. Müller, E. Witte, K. Wolk, S. Hackbarth, B. Röder, J. Lademann, and M. C. Meinke, “Ultra-small lipid nanoparticles promote the penetration of coenzyme Q10 in skin cells and counteract oxidative stress,” Eur. J. Pharm. Biopharm. Off. J. Arbeitsgemeinschaft Pharm. Verfahrenstechnik EV, Dec. 2014.
 U. Hoppe, J. Bergemann, W. Diembeck, J. Ennen, S. Gohla, I. Harris, J. Jacob, J. Kielholz, W. Mei, D. Pollet, D. Schachtschabel, G. Sauermann, V. Schreiner, F. Stäb, and F. Steckel, “Coenzyme Q10, a cutaneous antioxidant and energizer,” BioFactors Oxf. Engl., vol. 9, no. 2–4, pp. 371–378, 1999.
 E. Fasano, S. Serini, N. Mondella, S. Trombino, L. Celleno, P. Lanza, A. Cittadini, and G. Calviello, “Antioxidant and Anti-Inflammatory Effects of Selected Natural Compounds Contained in a Dietary Supplement on Two Human Immortalized Keratinocyte Lines,” BioMed Res. Int., vol. 2014, pp. 1–11, 2014.
 Y. Yue, H. Zhou, G. Liu, Y. Li, Z. Yan, and M. Duan, “The advantages of a novel CoQ10 delivery system in skin photo-protection,” Int. J. Pharm., vol. 392, no. 1–2, pp. 57–63, Jun. 2010.
 K. Muta-Takada, T. Terada, H. Yamanishi, Y. Ashida, S. Inomata, T. Nishiyama, and S. Amano, “Coenzyme Q10 protects against oxidative stress-induced cell death and enhances the synthesis of basement membrane components in dermal and epidermal cells,” BioFactors Oxf. Engl., vol. 35, no. 5, pp. 435–441, Oct. 2009.
 S. Grether-Beck, A. Marini, T. Jaenicke, and J. Krutmann, “Effective Photoprotection of Human Skin against Infrared A Radiation by Topically Applied Antioxidants: Results from a Vehicle Controlled, Double-Blind, Randomized Study,” Photochem. Photobiol., vol. 91, no. 1, pp. 248–250, Jan. 2015.
 M. Zhang, L. Dang, F. Guo, X. Wang, W. Zhao, and R. Zhao, “Coenzyme Q(10) enhances dermal elastin expression, inhibits IL-1α production and melanin synthesis in vitro,” Int. J. Cosmet. Sci., vol. 34, no. 3, pp. 273–279, Jun. 2012.
 M. Inui, M. Ooe, K. Fujii, H. Matsunaka, M. Yoshida, and M. Ichihashi, “Mechanisms of inhibitory effects of CoQ10 on UVB-induced wrinkle formation in vitro and in vivo,” BioFactors Oxf. Engl., vol. 32, no. 1–4, pp. 237–243, 2008.
 B. Fuller, D. Smith, A. Howerton, and D. Kern, “Anti-inflammatory effects of CoQ10 and colorless carotenoids,” J. Cosmet. Dermatol., vol. 5, no. 1, pp. 30–38, Mar. 2006.
 B. S. Choi, H. S. Song, H. R. Kim, T. W. Park, T. D. Kim, B. J. Cho, C. J. Kim, and S. S. Sim, “Effect of coenzyme Q10 on cutaneous healing in skin-incised mice,” Arch. Pharm. Res., vol. 32, no. 6, pp. 907–913, Jun. 2009.
 C. Rona, F. Vailati, and E. Berardesca, “The cosmetic treatment of wrinkles,” J. Cosmet. Dermatol., vol. 3, no. 1, pp. 26–34, Jan. 2004.
 K. Winkler-Stuck, F. R. Wiedemann, C.-W. Wallesch, and W. S. Kunz, “Effect of coenzyme Q10 on the mitochondrial function of skin fibroblasts from Parkinson patients,” J. Neurol. Sci., vol. 220, no. 1–2, pp. 41–48, May 2004.
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
BulkActives is a part-time business. Orders are processed on Saturdays and mailed on Mondays at the latest.