Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Reviews
Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
Angela
Very good product! Only been using it for a short time, its already made a difference. .. ...»
Bronwynne
muy satisfecho profesionales, y envio sin problemas ,ya que soy de españa producto bien envasado , un placer ser cliente porque dan comnfianza y calidad.gracias un saludo.. ...»
daniel
Wanting to try this, but.... Angela, what was that about effecting hormones? Could someone explain please..... ...»
Carla
Excellent quality, very fine texture and disperses easily when used correctly. Arrived in just seven days to London, England and with a reasonable postage fee. Very pleased... ...»
D N Bay
I purposely waited a few months before writing my review. I am happy to report this product is great! I combined the DMAE product with the base creams resulting in tighter skin and lessened wrinkles, including areas around underarms... ...»
cjmluv
This ingredient has done more for my skin than anything else I've ever used. I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic. I will use this forever, no question... ...»
Marie
Love the fine powder ascorbic acid. I use it in a recipe for skin care along with hyaluronic acid. I'm 65 years old and absolutely no one believes it 'cause I've been doing this for years... ...»
Kathy
Purchased this some time ago from BulkActives and here to buy some more! Great stuff!!!!.. ...»
Kathy
I've been using Bulkactives green tea EGCG for four years. No complaints, it blends nicely my DIY anti-aging cream. I can feel a bit of toning and definitely notice the anti-inflammatory effects on my skin. Two observations that keep the rating 4 stars instead of 5: (1) A package of green tea contains significantly less weight/volume than the package of grape seed extract that I order from bulkactives. The two are combined in equal amounts in the anti-aging cream, so I find myself running o.. ...»
Theresa Andrews
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Buy Fucoidan For Skin Care

Fucoidan is a dietary fiber extracted from brown seaweed which belongs to a class of fucose-enriched sulphated polysaccharides. Fucoidan has been used for many years in traditional Asian medicine as an anti-coagulant, anti-thrombotic, anti-cancer agent, and to modify immune responses. Topical formulations have recently been investigated for various therapeutic and cosmetic uses.  Due to anti-inflammatory and procollagen synthesis-stimulating properties, fucoidan holds promise for use healing burns, alleviating allergic reactions, and treating atopic dermatitis.  Additionally, fucoidans can increase dermal fibroblast migration and their rate of proliferation.  In several experimental approaches, fucoidan has been shown to successfully reduce the appearance of aging and to promote hair regeneration.  Fucoidan is also present in our seakelp biofermentl, but this powder fucoidan is standardized for 85% of the active ingredient.

NOTE: To assist you with solubility issues, we now also sell Fucoidan as a standardized pre-dissolved solution. Just add the liquid to your cream and mix well.

Key benefits of Fucoidan in skin care:

  • Anti-inflammatory [1] [4] [8] [9] [10] [11]
  • Scar care [5] [6] [7]
  • Wound healing support [5] [6] 7]
  • Stimulate collagen production [2] [15] [16] [18]
  • Reduce fine lines and wrinkles [2, 15, 16, 18]
  • Moisturizing and hydration [15] [16] [18]
  • Increase skin elasticity [6]
  • Sun damage repair [16] [17]
  • Matrix metalloproteinases (MMP) inhibitors [15] [17]
  • Anti-androgenetic alopecia [18]
Fucoidan skin care active ingredients
Product Code: BulkActives
Reward Points: 9
Assay: 85%
CAS#: 9072-19-9
Net weight: 30g /1.06oz & 100g / 3.53oz
Availability:
Standardized preDissolved solution 100g - Options In Stock
Standardized Powder 30g - Options In Stock
Price: $25.10
Reward Points: 875


Available Options


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Fucoidan

About Fucoidan in DIY Skin Care

Fucoidans are a complex group of sulphated polysaccharides, or complex carbohydrates, which are extracted from brown seaweed.  As part of a healthy diet, fucoidans are believed to improve the cardiovascular system, provide immune support, and have anti-oxidant and immunomodulating properties [1].  While the health benefits of dietary fucoidan have long been recognized in Asia, the cosmeceutical benefits of fucoidan to the skin when applied topically have only begun to be understood in the past decade.  Initially investigated for their anti-coagulant roles, fucoidans are now known to interact with and modulate the activities of multiple growth factors and immune cell signaling molecules [cytokines].  Through these actions fucoidans are now recognized as improving skin health in multiple ways, from increasing collagen synthesis and deposition to increasing dermal fibroblasts in the skin [2]. 

Fucoidan solutions are known to stimulate dermal fibroblast proliferation.  As dermal fibroblasts are what produce the collagen in skin, a component which makes up about 70% of the extracellular matrix, benefits of increasing the numbers of these cells include more supple skin, reduced appearance of wrinkles, and decreased thickness of the epidermal layer.  Incorporation of extracellular collagen was increased with fucoidan treatment, and this was further enhanced when fibroblasts were treated with fucoidan in combination with retinol and/or ascorbate [3].  Thus, fucoidan solutions have been investigated for anti-aging effects. 

As people age, collagen levels in the skin decrease and lead to the appearance of fine lines or wrinkles.  Compounding this is that exposure to UV light both decreases the rate of collagen synthesis as well as increases the levels of matrix metalloproteinase 1, or MMP-1, which is responsible for degrading collagen.  Several studies on UV-irradiated skin fibroblasts have demonstrated that following treatment of fucoidin, levels of MMP-1 mRNA and protein were significantly decreased whereas the mRNA and protein levels of procollagen type I were increased dose-dependently manner [4, 5].  In another in vitro trial in which a 1% fucoidan gel formulation was applied to human cheek skin twice daily for five weeks, skin thickness decreased significantly whereas elasticity significantly increased [6].  Such effects indicate that fucoidans may be particularly useful for anti-aging treatments. 

Fucoidans have also been shown to block the effects of transforming growth factor-beta [TGF-β], a growth factor which decreases dermal fibroblast proliferation and which has important roles in tissue remodeling [7].  Studies indicate that fucoidan solutions work to improve the collagen content and collagen incorporation in the matrix of the skin by reversing the effects of TGF- [8].  This makes fucoidan promising for wound healing support and reducing scar formation.  Ointments containing fucoidan have been shown to increase the rate of wound healing in an in vivo dermal burn model [9, 10].   In similar experiments, a fucoidan-chitosan application to dermal wounds had less edema and increased fibroblast migration, collagen synthesis, and accelerated regeneration of the epidermis compared to the control solution [11]. 

Research indicates that the effect of fucoidans on the immune system is not limited to the TGF- β pathways.  Fucoidans have been shown to attenuate white blood cell recruitment and accumulation in the skin [12-14].  This makes fucoidans attractive for use in alleviating allergic hives or angioedema.  Therefore they have recently become extremely attractive for the treatment of atopic eczema, or atopic dermatitis [AD].  AD is characterized by chronic inflammation of the skin and presents with hives.  This disease may affect up to nearly 20% of a given population of children, though it can also affect adults at any age [15].  AD is believed to result from dysregulation of the immune system and/or allergic responses to environmental stimuli [16].  In vivo studies in mice have demonstrated that the dermatitis score in mice treated with fucoidan after the onset of AD was significantly lower.  Further, the skin of the treated animals was significantly less dry, had fewer hives, and appeared to be less irritated compared to the skin of the control animals.  Analyses also indicated decreased epithelial thickness with lower serum histamine levels [17]. 

Finally, low molecular weight fucoidan has recently been demonstrated to promote hair regeneration by stimulating proliferation of the supporting cells.In a zebrafish model, experimental data indicates that, following neomycin treatment to kill mechanosensory hair cells, low molecular weight fucoidan increases cell proliferation and promotes hair growth 18.
 

NOTE: To assist you with solubility issues, we now also sell Fucoidan as a standardized pre-dissolved solution. Just add the liquid to your cream and mix well.

Fucoidan Standardized Powder

Assay: 95%
CAS No.: 9072-19-9
INCI: Fucus vesiculosus
Source: Phaeophyceae or brown algae
Appearance: powder
Solubility: 1,3 Propanediol
Suggested percentage: 1% to 5%

Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China
 

Fucoidan Standardized Pre Dissolved Solution - 10%

Assay: 9.5% Fucoidan
CAS#: 504-63-2, 9072-19-9
INCI: 1,3-Propanediol, Fucus vesiculosus
Appearance: liquid

Solubility: add to cream
Suggested percentages:
11% solution gives 1% Fucoidan content in final product.
32% solution gives 3% Fucoidan content in final product.
53% solution gives 5% Fucoidan content in final product.

Storage: Store in fridge, do not freeze.
Country of origin for raw material: China
Country of manufacture: Taiwan
 
[1]          A. M. Mayer, M. T. Hamann, Marine pharmacology in 2000: marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis, and antiviral activities; affecting the cardiovascular, immune, and nervous systems and other miscellaneous mechanisms of action. Marine Biotechnology 6, 37-52 [2004].
[2]          J. H. Fitton, M. Irhimeh, N. Falk, Macroalgal fucoidan extracts: a new opportunity for marine cosmetics. Cosmetics and toiletries 122, 55 [2007].
[3]          L. Robert, I. Fodil-Bourahla, L. Bizbiz, A. M. Robert, Effects of L-fucose and fucose-rich oligo- and polysaccharides [FROP-s] on collagen biosynthesis by human skin fibroblasts. Modulation of the effect of retinol, ascorbate and α-tocopherol. Biomedicine & Pharmacotherapy 58, 65-70 [2004]; published online Epub1// [http://dx.doi.org/10.1016/j.biopha.2003.06.003].
[4]          H. J. Moon, S. H. Lee, M. J. Ku, B. C. Yu, M. J. Jeon, S. H. Jeong, V. A. Stonik, T. N. Zvyagintseva, S. P. Ermakova, Y. H. Lee, Fucoidan inhibits UVB-induced MMP-1 promoter expression and down regulation of type I procollagen synthesis in human skin fibroblasts. European Journal of Dermatology 19, 129-134 [2009].
[5]          Y. H. Lee, H. J. Moon, S. R. Lee, S. H. Jeong, H. K. Chang, V. A. Stonik, V. A. Rasskazov, T. Zvyagintseva, Protective effects of fucoidan against UVB-induced aging in human skin fibroblasts. The FASEB Journal 21, LB21 [2007].
[6]          T. Fujimura, K. Tsukahara, S. Moriwaki, T. Kitahara, T. Sano, Y. Takema, Treatment of human skin with an extract of Fucus vesiculosus changes its thickness and mechanical properties. Journal of cosmetic science 53, 1-9 [2002]; published online EpubJan-Feb [
[7]          T. H. Kim, E. K. Lee, M. J. Lee, J. H. Kim, W. S. Yang, Fucoidan inhibits activation and receptor binding of transforming growth factor-β1. Biochemical and Biophysical Research Communications 432, 163-168 [2013]; published online Epub3/1/ [http://dx.doi.org/10.1016/j.bbrc.2013.01.055].
[8]          R. O’Leary, M. Rerek, E. J. Wood, Fucoidan modulates the effect of transforming growth factor [TGF]-b1 on fibroblast proliferation and wound repopulation in in vitro models of dermal wound repair. Biol Pharm Bull 27, 266-270 [2004].
[9]          A. D. Sezer, E. Cevher, F. Hatıpoğlu, Z. Oğurtan, A. L. Baş, J. Akbuğa, Preparation of fucoidan-chitosan hydrogel and its application as burn healing accelerator on rabbits. Biological and Pharmaceutical Bulletin 31, 2326-2333 [2008].
[10]        A. D. Sezer, F. Hatipoglu, E. Cevher, Z. Oğurtan, A. L. Bas, J. Akbuğa, Chitosan film containing fucoidan as a wound dressing for dermal burn healing: preparation and in vitro/in vivo evaluation. AAPS PharmSciTech 8, E94-E101 [2007].
[11]        A. Sezer, E. Cevher, F. Hatipoğlu, Z. Oğurtan, A. Baş, J. Akbuğa, The use of fucosphere in the treatment of dermal burns in rabbits. European Journal of Pharmaceutics and Biopharmaceutics 69, 189-198 [2008].
[12]        M. M. Teixeira, P. G. Hellewell, The effect of the selectin binding polysaccharide fucoidin on eosinophil recruitment in vivo. British Journal of Pharmacology 120, 1059-1066 [1997]; published online Epub11/26/received
12/10/accepted [10.1038/sj.bjp.0701024].
13]         T. Nakamura, H. Suzuki, Y. Wada, T. Kodama, T. Doi, Fucoidan induces nitric oxide production via p38 mitogen-activated protein kinase and NF-κB-dependent signaling pathways through macrophage scavenger receptors. Biochemical and Biophysical Research Communications 343, 286-294 [2006]; published online Epub4/28/ [http://dx.doi.org/10.1016/j.bbrc.2006.02.146].
[14]        M.-H. Kim, H.-G. Joo, Immunostimulatory effects of fucoidan on bone marrow-derived dendritic cells. Immunology Letters 115, 138-143 [2008]; published online Epub1/29/ [http://dx.doi.org/10.1016/j.imlet.2007.10.016].
[15]        H. Williams, C. Robertson, A. Stewart, N. Aït-Khaled, G. Anabwani, R. Anderson, I. Asher, R. Beasley, B. Björkstén, M. Burr, T. Clayton, J. Crane, P. Ellwood, U. Keil, C. Lai, J. Mallol, F. Martinez, E. Mitchell, S. Montefort, N. Pearce, J. Shah, B. Sibbald, D. Strachan, E. von Mutius, S. K. Weiland, Worldwide variations in the prevalence of symptoms of atopic eczema in the international study of asthma and allergies in childhood. Journal of Allergy and Clinical Immunology 103, 125-138 [1999]; published online Epub1// [http://dx.doi.org/10.1016/S0091-6749[99]70536-1].
[16]        A. Cantani, Pathogenesis of atopic dermatitis [AD] and the role of allergic factors. European review for medical and pharmacological sciences 5, 95-118 [2001].
[17]        J.-H. Yang, Topical Application of Fucoidan Improves Atopic Dermatitis Symptoms in NC/Nga Mice. Phytotherapy Research 26, 1898-1903 [2012]10.1002/ptr.4658].
[18]        I. S. Moon, J.-H. So, Y.-M. Jung, W.-S. Lee, E. Y. Kim, J.-H. Choi, C.-H. Kim, J. Y. Choi, Fucoidan promotes mechanosensory hair cell regeneration following amino glycoside-induced cell death. Hearing Research 282, 236-242 [2011]; published online Epub12// [http://dx.doi.org/10.1016/j.heares.2011.07.007].
 

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