Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
This is the best product I have ever used on my skin and I tried a LOT of expansive brands. It helps with redness and overall skin tone. Please do not ever stop making this stuff... ...»
Really loving this product. I make the best Centella toner and most concentrated ever. 2 g of centella extract dissolved in 10g of alcohol(you have to stir a lot) plus 88 grams of water and you get a very concentrated toner. Creams, toners, ampoules... all have only 0,1% of triterpenes, this toner i make have 1,4%. I am loving it, will see the results. .. ...»
Just recently ordered this and LOVE! Green Tea EGCG truly is one of the most fantastic skincare actives out there. Very difficult to find good quality product (90%) and even harder to actually solubilize it! Love that it comes in pre-dissolved solution. I enjoy adding it at 1% (so 11% sol) to my serum formulations containing Niacinamide 5% + NAG 3%. Excellent for oily acne prone skin.
*Only gripe... because the Pre-Dissolved Solution is SO heavy in propanediol (10 parts Propanediol for 1 part E.. ...»
The Pre-dissolved solution is excellent. Ferulic Acid is an amazing skincare ingredient (potent antioxidant, protects other sensitive antioxidants from light degradation, UV protection) but is absolutely ineffective if it isn't solubilized correctly.
Makes adding to any Serum Base or w/o emulsion easy. Love using it (at 6%; so active 0.5%) with the Resveratrol Fluid (10%; active 1%) and Green Tea Extr for potent nighttime brightening treatment... ...»
Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
muy satisfecho
profesionales,
y envio sin problemas ,ya que soy de españa
producto bien envasado ,
un placer ser cliente
porque dan comnfianza y calidad.gracias un saludo.. ...»
Any long delivery delays are caused by The Canada Border Services Agency.
I now ONLY offer EMS as a shipping option to Canada.
This appears to have resolved most of the delays caused by The Canada Border Services Agency.
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We sell COSMETIC RAW MATERIALS, which are meant to be used at an appropriate percentage in a cosmetic formulation of your devising. Please do not order our products unless you know how to formulate creams and lotions with it!
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BulkActives has been in business since 2005, we might have disappeared from google search results, but we're still hanging on, just, mainly thanks to the support of some loyal customers.
However, like many, COVID hit us hard, and we're having a lot of trouble recovering.
Right now, we have not restocked many powders, however, are looking at continuing with selling only our flagship products:
seakelp and pre-dissolved powders, and some of the essentials.
Hesperidin is a a plant flavonoid, found naturally in citrus fruits. It has numerous biological benefits, but it is poorly absorbed and transported in the body, hence a modified version, hesperidin methyl chalcone (HMC), is used in cosmetics. The best known effect of HMC is reduction of capillary permeability. This can be used to reduce dark circles and bags under the eyes or even treat varicose veins. It is also known to reduce melanin synthesis, thus lightening the skin, and it also protects skin from UV-caused damage and cell ageing. Furthermore, HMC restores the barrier function of the skin, improving hydration, regulating pH and promoting skin cell proliferation. Finally, it has an anti-inflammatory effect, and can even be used to reduce various types of pain caused by inflammation.
NOTE: To assist you with solubility issues, we now also sell Hesperidin methyl chalcone as a liquid standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
11% solution gives 1% Hesperidin content in final product.
31% solution gives 3% Hesperidin content in final product.
51% solution gives 5% Hesperidin content in final product.
Key benefits of Hesperidin methyl chalcone in skin care:
Sun damage protection [8] [11]
Capillary health [4] [5] [12]
Lightening & brightening [7] [8]
Reduce dark circles under the eyes [6]
Restore barrier function [1] [9] [10]
Anti-inflammatory [2] [5]
Product Code: BulkActives Assay:
98% CAS#:
24292-52-2 Net weight:
30g /1.06oz Availability: In Stock
Plants are the major source of many complex compounds with cosmetical and pharmaceutical benefits called flavonoids. Hesperidin is one such molecule, composed of a flavone hesperetin bound to a sugar. It is found naturally in peels of orange and other citrus fruits. It has a wide range of protective effects, among them anti-inflammatory, antioxidant, antibacterial, antiviral properties, skin whitening effect, epidermal barrier strengthening, and even cancer suppression [1]. Interestingly, many of the benefits of orange juice consumption have been linked to their high hesperidin content [2].
However, pure hesperidin has poor solubility in water, therefore its absorption and distribution inside the body are ineffective [2]. Hesperidin methyl chalcone (HMC) is produced by a simple chemical reaction (adding methyl groups) of hesperidin. Experiments have shown that such changes greatly improve the absorption of related compounds. Furthermore, their health benefits can be even stronger: certain flavones that have a cancer-preventive effect showed 8-10 time stronger effect in the methylated form, likely due to better absorption and transport in the body [3]. Therefore, it is logical that the effects of hesperidin methyl chalcone should be similar to unmodified hesperidin or even more notable.
The action of hesperidin methyl chalcone on capillaries has been known for almost 40 years. It is able to reduce their permeability, thus reducing loss of various molecules through their walls [4]. Many molecules produced during inflammation have an opposite activity, therefore HMC exhibits anti-inflammatory properties [5]. Furthermore, it is able to reduce inflammation-associated pain of various types [2]. In cosmetics, this ability is used in several related products to reduce dark bags and puffiness under the eyes, with reported 65 % reduction of bag volume after 28 days of using HMC [6].
HMC is also a promising cosmeceutical in lightening and brightening skin tone. Hesperidin is able to inhibit melanin synthesis, thus reducing skin darkening, and has an anti-yellowing effect [7]. Hesperetin was also found to be an effective whitening agent, having significant photoprotective effect on the skin [8].
Regarding other uses in cosmetics, hesperidin helps to restore the barrier function of damaged skin. A cream containing 2 % hesperidin restores the hydration of damaged skin up to 50 % of healthy level as soon as 2 hours after damage. Furthermore, it stimulates the proliferation of epidermal cells, resulting in increased skin thickness [1]. This is especially useful for patients using glucocorticoids (steroids), as they can negatively affect the barrier function of skin, and this damage is fully reversed by hesperiding-containing cream [9]. Loss of barrier function is also associated with ageing skin. Additionally, ageing causes skin pH to increase; hesperidin applications can reduce both of these symptoms [10].
The protective effect of hesperetin-related compounds was also shown using fermented citrus peel. UV irradiation of skin cells increases collagen degradation and causes cell ageing. However, application of the fermented peel counteracted these processes, increasing collagen synthesis, decreasing its degradation, and even reducing the levels of markers typically associated with cell senescence [11].
Finally, HMC is useful for patients with varicose veins. Together with Ruscus plant extract, it reduces both the negative symptoms, such as pain and cramps, and the underlying physiological damage associated with this condition [12]. These changes significantly improve the quality of life of the patients [13]. Interestingly, it is believed that HMC is safe to use even in very high doses, since no adverse effects were observed in patients consuming as much as 15 g daily [2].
NOTE: To assist you with solubility issues, we now also sell Hesperidin methyl chalcone as a liquid standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
Hesperidin methyl chalcone Standardized Powder
Assay: 98% CAS No.: 24292-52-2 INCI: Hesperidin methyl chalcone Appearance: powder Solubility: water, propanediol (heated) Suggested percentage: 2 to 10%
Storage: Cool, dry place. Do not freeze. Keep away from light and moisture! Country of origin: China
Hesperidin methyl chalcone Standardized Pre Dissolved Solution - 10%
Solubility: add to cream Suggested percentage:
11% solution gives 1% Hesperidin content in final product.
31% solution gives 3% Hesperidin content in final product.
51% solution gives 5% Hesperidin content in final product.
Storage: Store in fridge, do not freeze Country of origin for raw material: China Country of manufacture: Taiwan
[1] M. Hou, M. Man, W. Man, W. Zhu, M. Hupe, K. Park, D. Crumrine, P. M. Elias, and M.-Q. Man, “Topical hesperidin improves epidermal permeability barrier function and epidermal differentiation in normal murine skin,” Exp. Dermatol., vol. 21, no. 5, pp. 337–340, May 2012.
[2] F. A. Pinho-Ribeiro, M. S. N. Hohmann, S. M. Borghi, A. C. Zarpelon, C. F. S. Guazelli, M. F. Manchope, R. Casagrande, and W. A. Verri Jr., “Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: Role of TRPV1, oxidative stress, cytokines and NF-κB,” Chem. Biol. Interact., vol. 228, pp. 88–99, Feb. 2015.
[3] T. Walle, “Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption,” Mol. Pharm., vol. 4, no. 6, pp. 826–832, Dec. 2007.
[4] J. P. Tarayre and H. Lauressergues, “Advantages of a combination of proteolytic enzymes, flavonoids and ascorbic acid in comparison with non-steroid anti-inflammatory agents,” Arzneimittelforschung., vol. 27, no. 6, pp. 1144–1149, 1977.
[5] E. Bouskela, F. Z. Cyrino, and G. Marcelon, “Inhibitory effect of the Ruscus extract and of the flavonoid hesperidine methylchalcone on increased microvascular permeability induced by various agents in the hamster cheek pouch,” J. Cardiovasc. Pharmacol., vol. 22, no. 2, pp. 225–230, Aug. 1993.
[6] Sederma, “Cosmetic or dermopharmaceutical compositions which are used to reduce bags and circles under the eyes.,” EP1474100.
[7] W. Zhu and J. Gao, “The Use of Botanical Extracts as Topical Skin-Lightening Agents for the Improvement of Skin Pigmentation Disorders,” J. Investig. Dermatol. Symp. Proc., vol. 13, no. 1, pp. 20–24, 2008.
[8] Y.-B. Huang, K.-F. Lee, C.-T. Huang, Y.-H. Tsai, and P.-C. Wu, “The effect of component of cream for topical delivery of hesperetin,” Chem. Pharm. Bull. (Tokyo), vol. 58, no. 5, pp. 611–614, May 2010.
[9] G. Man, T. M. Mauro, P. L. Kim, M. Hupe, Y. Zhai, R. Sun, D. Crumrine, C. Cheung, A. Nuno-Gonzalez, P. M. Elias, and M.-Q. Man, “Topical hesperidin prevents glucocorticoid-induced abnormalities in epidermal barrier function in murine skin,” Exp. Dermatol., vol. 23, no. 9, pp. 645–651, Sep. 2014.
[10] G. Man, T. M. Mauro, Y. Zhai, P. L. Kim, C. Cheung, M. Hupe, D. Crumrine, P. M. Elias, and M.-Q. Man, “Topical Hesperidin Enhances Epidermal Function in an Aged Murine Model,” J. Invest. Dermatol., Nov. 2014.
[11] J. T. Bae, H. J. Ko, G. B. Kim, H. B. Pyo, and G. S. Lee, “Protective effects of fermented Citrus unshiu peel extract against ultraviolet-A-induced photoageing in human dermal fibrobolasts,” Phytother. Res. PTR, vol. 26, no. 12, pp. 1851–1856, Dec. 2012.
[12] P. Boyle, C. Diehm, and C. Robertson, “Meta-analysis of clinical trials of Cyclo 3 Fort in the treatment of chronic venous insufficiency,” Int. Angiol. J. Int. Union Angiol., vol. 22, no. 3, pp. 250–262, Sep. 2003.
[13] J. J. Guex, L. Avril, E. Enrici, E. Enriquez, C. Lis, and C. Taïeb, “Quality of life improvement in Latin American patients suffering from chronic venous disorder using a combination of Ruscus aculeatus and hesperidin methyl-chalcone and ascorbic acid (quality study),” Int. Angiol. J. Int. Union Angiol., vol. 29, no. 6, pp. 525–532, Dec. 2010
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
DISCLAIMER
We do NOT sell ready-made skin care products!
All our products are powders, liquids, flakes or gels, used for making your own skin care products.
All our products are cosmetic / technical grade only.
We do NOT sell pharmaceuticals, prescription drugs or nutritional supplements.
Any statements about our products have not been evaluated by the FDA.
Our active skin care ingredients are not intended to diagnose, treat, cure, or prevent any disease
SHIPPING
Please write your correct address:
We take NO responsibility for delivery issues caused by customers entering the wrong address in the checkout page
Delivery
BulkActives is a part-time business. Orders are processed and mailed on Saturdays.
Canadian Customers:
Any long delivery delays are caused by The Canada Border Services Agency.
I now ONLY offer EMS as a shipping option to Canada.
This appears to have resolved most of the delays caused by The Canada Border Services Agency.