Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
I purposely waited a few months before writing my review. I am happy to report this product is great! I combined the DMAE product with the base creams resulting in tighter skin and lessened wrinkles, including areas around underarms... ...»
This ingredient has done more for my skin than anything else I've ever used.
I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic.
I will use this forever, no question... ...»
I've been using Bulkactives green tea EGCG for four years. No complaints, it blends nicely my DIY anti-aging cream. I can feel a bit of toning and definitely notice the anti-inflammatory effects on my skin. Two observations that keep the rating 4 stars instead of 5: (1) A package of green tea contains significantly less weight/volume than the package of grape seed extract that I order from bulkactives. The two are combined in equal amounts in the anti-aging cream, so I find myself running o.. ...»
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Carnosine is a compound from two amino acids, produced naturally in the human brain and muscles. Most likely, it performs a protective function – carnosine neutralizes metal ions and is a powerful antioxidant. It is used in skin care to combat oxidative damage to DNA and proteins, such as that caused by UV exposure. Furthermore, carnosine can protect proteins, primarily collagen, from glycation. These qualities make it a promising molecule in the fight against ageing, as carnosine not only protects cellular components, but can improve the visual appearance, reduce roughness and fine lines. It also maintains the barrier function of the skin, both by simple hydration and complex effects in wound healing. Carnosine applications are of special importance to diabetes patients, as it helps alleviate several complications of this disease, among them xerosis, rapid AGE production, and impaired wound healing.
Key benefits Carnosine in skin care:
Glycation inhibitor and repair  
Sun damage protection  
Sun damage repair  
Wound healing support  
Moisturizing & hydration  
Antioxidant   
Restore barrier function 
Product Code: BulkActives Reward Points: 7 Assay:
305-84-0 Net weight:
15g / 0.53oz Availability: In Stock
Carnosine is a molecule composed of two amino acids, β-alanine and histidine. It is naturally abundant in brain and muscle tissues, but, although it was discovered in the year 1900, its function in the body is still unclear . It might regulate the pH of muscle cells, neutralize metal ions or act as an antioxidant, and it gained a lot of interest recently as some studies show it might be used in treating cancer, Alzheimer’s disease and even cell ageing .
Carnosine has been shown to protect human skin cells against UV radiation. Together with some other forms of radiation, UV causes mutations in DNA and protein damage that often lead to cancer. To combat this, use of DNA-protecting molecules in skin cosmetics was proposed . Carnosine falls among these molecules due to its antioxidant properties. In a study on human skin cells, carnosine was shown to reduce the oxidative damage caused by the UV on both DNA and proteins . It is also able to activate synthesis of other naturally produced antioxidants, such as glutathione peroxidase . Carnosine and related molecules have even stronger antioxidative capability than vitamin E . However, it is advisable to apply these two antioxidants together, not only for synergistic protective effects – vitamin E improves the delivery of carnosine, resulting in higher levels of this molecule in target tissue .
In the recent years, commercial sunscreen products started to include carnosine, and the benefits of it have been proven in studies of UV-irradiated skin. Compared to traditional sunscreens, carnosine-containing creams successfully prevented UV damage and resulted in a significantly better state of both DNA and protein (less oxidative damage) after the irradiation . In a trial on volunteers with sensitive skin, carnosine showed a protective effect on skin barrier function (reduced water loss and perceived dryness after 28 days of usage). Biochemical experiments suggest that the cream achieved this by improving the skin and neural cell response to UV radiation .
Carnosine is also able to reduce the effects of glycation. This process occurs naturally during ageing and produces damaged forms of proteins, called advanced glycation end products (AGEs). Collagen is among the proteins most affected by this, and its glycation may be responsible for loss of elasticity or other negative consequences of skin ageing. Carnosine is a competitive target for glycation, thus protecting valuable proteins from it , . Results from volunteer studies indicate that carnosine improves skin visual parameters, maintains firmness, reduces roughness, fine lines and oily appearance .
Another major application of carnosine in skin care is wound healing. A preparation with carnosine was shown to promote collagen synthesis, cell proliferation and migration, which result in faster wound closure . Just like glycation protection, this benefit of carnosine is even more important for diabetes patients, as wound healing is impaired under this disease. Skin applications of carnosine have successfully activated healing in diabetic mice wounds . Xerosis, another skin-affecting complication of diabetes, is also alleviated by applying a cream with carnosine, as this molecule has a hydrating effect . This cream also increases skin thickness, blood circulation and quality of life in xerosis patients .
Assay: 99.8% CAS#: 305-84-0 INCI: L Carnosine Appearance: white powder Solubility: water Suggested percentage: 1% to 5%
Storage: Cool, dry place. Do not freeze. Keep away from light and moisture! Country of origin: China
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BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
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