Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
I purposely waited a few months before writing my review. I am happy to report this product is great! I combined the DMAE product with the base creams resulting in tighter skin and lessened wrinkles, including areas around underarms... ...»
This ingredient has done more for my skin than anything else I've ever used.
I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic.
I will use this forever, no question... ...»
I've been using Bulkactives green tea EGCG for four years. No complaints, it blends nicely my DIY anti-aging cream. I can feel a bit of toning and definitely notice the anti-inflammatory effects on my skin. Two observations that keep the rating 4 stars instead of 5: (1) A package of green tea contains significantly less weight/volume than the package of grape seed extract that I order from bulkactives. The two are combined in equal amounts in the anti-aging cream, so I find myself running o.. ...»
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Niacinamide, also known as nicotinamide, is a water soluble form of vitamin B3. Vitamin B3 is essential for maintaining skin health. Niacinamide increases production of important skin structural components such as collagen, ceramide, and keratin. This helps increase moisture and strengthen skin. Niacinamide is known to decrease hyperpigmentation, effectively lightening and brightening skin, especially when used together with n-acetyl glucosamine, a hyaluronic acid precursor. It reduces wrinkles and again, this effect is better with n-acetyl glucosamine. Niacinamide also effectively helps reduce acne and heal wounds. It has anti-oxidant and anti-inflammatory properties. Overall, niacinamide is a compound with many different uses that can increase overall skin health.
Key benefits of Niacinamide in skin care:
Treat hyperpigmentation   
Lightening and brightening   
Reduce fine lines and wrinkles 
Anti-inflammatory   
Anti-oxidant  
Anti-acne   
Moisturizing and hydration   
Restore barrier function   
Wound healing support  
Increase skin elasticity  
Oil/sebum control 
Pore refinement 
Sun damage repair 
Sun damage protection 
Stimulate collagen production 
Stimulate HA production 
Product Code: BulkActives Reward Points: 3 Assay:
98-92-0 Net weight:
30g /1.06oz Availability: In Stock
Niacinamide, also known as nicotinamide, is water soluble vitamin B3 . Vitamin B3 is essential for maintaining the overall health of skin. Vitamin B3 deficiency causes excessive dryness, skin lesions, and sensitivity to sunlight. Niacinamide is a precursor to coenzymes nicotinamide adenine dinucleotide [NAD] and nicotinamide adenine dinucleotide phosphate [NADP]. These are important for many reactions in the body, including those that happen in the skin. NADPH, the hydrogenated form of NADP, is reported to decrease with age . Treatment with niacinamide increases NADP in aged fibroblasts [collagen producing cells] . Thus, niacinamide helps maintain normal amounts of these coenzymes in the skin. Niacinamide is suitable for topical use, as it penetrates easily . It is water soluble and thus, easily used in formulations, and stable. It is tolerated by skin in high concentrations .
Niacinamide stimulates ceramide and fatty acid production, major components of skin that provide barrier function . Topical niacinamide stabilizes skin barrier function and reduces moisture loss . A clinical study using topical niacinamide showed it reduces symptoms of dry skin . Topical niacinamide applied to aging skin improves skin surface structure and smoothes out wrinkles . It also reduces skin yellowing, red facial blotches, and pore size by reducing sebum [oil] excretion .
Niacinamide also helps reduce hyperpigmentation. Hyperpigmentation involves age spots that are clusters of melanin. Researchers believe niacinamide reduces hyperpigmentation by inhibiting the transfer of cell compartments called melanosomes that store melanin . In clinical studies, topical 4% niacinamide inhibits pigmentation [7, 8]. A greater effect was seen when combined with 2% n-acetyl glucosamine, a hyaluronic acid precursor [3, 7]. Both have different mechanisms of reducing pigmentation, so, used together, they produce a better result.
Niacinamide has great potential as an anti-aging treatment. It has shown to increase keratin synthesis . Keratin is an important structural protein in the skin and levels decrease with age. This reduces the structural soundness of skin and water binding capabilities. Overall, niacinamide stimulates cell growth, including collagen . Collagen is another important structural component of the skin that helps maintain elasticity and plays a role in wound healing. Niacinamide is also a cofactor in hyaluronic acid synthesis . Hyaluronic acid is important for retaining moisture in the skin and protecting barrier function. Levels are known to decrease with age, contributing to wrinkle formation. Thus, increasing hyaluronic acid improves skin elasticity and smoothness. An in vitro study shows 4% niacinamide increases hyaluronic acid. Women using a 2% NAG and 4% niacinamide combined showed improved fine lines and wrinkles, especially under the eyes . This shows the anti-aging effects of niacinamide are best when combined with n-acetyl glucosamine.
It also has anti-inflammatory effects . A clinical study using niacinamide showed reduced rosacea symptoms . It also improved facial skin barrier. In a clinical study, niacinamide also reduced immune cell infiltration that promotes inflammation . Topical 4% niacinamide increased cell growth and helped heal skin lesions . It also reduced acne similar to 1% clindamycin, a common topical antibiotic acne treatment . Niacinamide may be a better alternative to clindamycin, as bacteria involved in acne are becoming increasingly resistant to antibiotics.
Niacinamide also has anti-oxidant effects by scavenging free radicals . In an in vitro study, niacinamide helped repair DNA damage due to UV exposure . Overall, niacinamide increases the skin’s capacity to protect itself from damaging agents.
Assay: 99% CAS#: 98-92-0 INCI: Niacinamide Appearance: white powder Solubility: water Suggested percentage: 5%
Storage: Cool, dry place. Do not freeze. Keep away from light and moisture! Country of origin: China
 D.L. Bissett, “Common cosmeceuticals,” Clinics in Dermatology, vol. 27, pp. 435–445, 2009.
 D.L. Bissett, “Topical Niacinamide and Barrier Enhancement,” Proctor and Gamble Company, Cincinnati, Ohio. pp. 8-12.
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 J. Navarrete-Solis, J.P. Castanedo-Cazares, B. Torres-Alvarez, C. Oros-Ovalle, C. Fuentes-Ahumada, F.J. Gonzalez, J.D. Martınez-Ramırez, and B. Moncada, “A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma,” Dermatology Research and Practice, 1-5, 2011.
 R. Osborne, L. A. Mullins, and L. R. Robinson, “Topical N-Acetyl Glucosamine and Niacinamide Increase Hyaluronan,” The Procter & Gamble Company, Cincinnati, Ohio USA.
 N. Otte, C. Borelli, and H.C. Korting, “Nicotinamide – biologic actions of an emerging cosmetic ingredient,” International Journal of Cosmetic Science, vol. 27, pp. 255–261, 2005.
 A.R. Shalita, J.G. Smith, L.C. PARISH, M.S. Sofman, and D.K. Chalker, “Topical Nicotinamide Comparedwith Clindamycin Gel in the Treatment of Inflammatory Acne Vulgaris,” International Journal of Dermatology, vol. 34, no. 6, pp. 434-437, June 1995.
 Y. Soma, M. Kashima, A. Imaizumi, H. Takahama, T. Kawakami, and M. Mizoguchi, “Moisturizing effects of topical nicotinamide on atopic dry skin,” International Journal of Dermatology, vol. 44,pp. 197–202, 2005.
 B.C. Thompson, D. Surjana, G.M. Halliday, and D.L. Damian, “Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in primary melanocytes,” Experimental Dermatology, vol. 23, pp. 509–528, 2014.
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
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