Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
I purposely waited a few months before writing my review. I am happy to report this product is great! I combined the DMAE product with the base creams resulting in tighter skin and lessened wrinkles, including areas around underarms... ...»
This ingredient has done more for my skin than anything else I've ever used.
I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic.
I will use this forever, no question... ...»
I've been using Bulkactives green tea EGCG for four years. No complaints, it blends nicely my DIY anti-aging cream. I can feel a bit of toning and definitely notice the anti-inflammatory effects on my skin. Two observations that keep the rating 4 stars instead of 5: (1) A package of green tea contains significantly less weight/volume than the package of grape seed extract that I order from bulkactives. The two are combined in equal amounts in the anti-aging cream, so I find myself running o.. ...»
Any long delivery delays are caused by The Canada Border Services Agency.
I now ONLY offer EMS as a shipping option to Canada.
This appears to have resolved most of the delays caused by The Canada Border Services Agency.
Please write your correct address:
We take NO responsibility for delivery issues caused by customers entering the wrong address in the checkout page
We sell COSMETIC RAW MATERIALS, which are meant to be used at an appropriate percentage in a cosmetic formulation of your devising. Please do not order our products unless you know how to formulate creams and lotions with it!
Forgotten your password? Not receiving lost password emails? Can't create an account?
NO PROBLEM! Just email me, and I will sort it all out.
Not receiving order status email updates?
Please check your JUNK mail folder for our emails, and mark them as NOT SPAM.
Failing to do so will result in NOT receiving ANY transaction / order status email updates.
Buy Resveratrol (Trans-resveratrol 98) For Skin Care
Resveratrol is a compound found in grapes and many other plants. It is currently investigated in many skincare applications. Resveratrol protects cells from oxidative stress – it is an antioxidant itself, and activates the synthesis of other such compounds. It also regulates inflammatory responses and even aids the distribution of cosmetical sunscreens, thus helping to prevent UV damage to the skin. Similarities in structure allow resveratrol to replace estrogen in post-menopausal women, helping to reduce collagen loss and reduce skin ageing symptoms. Additionally, it counters photoageing by inhibiting melanin synthesis, resulting in lighter skin and less pigmented spots. Even acne can be alleviated by applying resveratrol, as it has antibacterial properties and controls sebaceous cell growth. Finally, it is a promising agent in melanoma prevention, able to delay the emergence and reduce the size of skin tumors.
NOTE:To assist you with solubility issues, we now also sell Resveratrol in a standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
About Resveratrol (Trans-resveratrol 98%) in DIY Skin Care
Resveratrol is a natural plant polyphenol, first isolated from white hellebore, but since then described in many other plant sources, including grapes and red wine. In nature, it protects plants from stress, ultraviolet light and certain fungal infections . In humans, its range of functions is even greater, with implications in anti-ageing, UV protection, cancer prevention and other areas.
Large part of the research on resveratrol is focused on its antioxidative capabilities. It is known to act by two mechanisms: firstly, it directly scavenges free radicals on its own, and secondly, it stimulates the production of enzymatic antioxidants, which naturally occur at lower levels in the human body . This effect is especially important for mitochondria, which are responsible for cellular energy production and undergo higher oxidative stress. Compared with other plant antioxidants, resveratrol is very effective, with deep penetration into the skin . Surprisingly, resveratrol reduces the skin penetration of UV filters. This is desirable, since filters must act on the top layers of the skin, but resveratrol itself is able to exert the antioxidative effects across deeper layers as well . Interestingly, it was also shown to protect skin cells from cigarette smoke-induced damage, namely inflammation and oxidative shock .
The most promising area of resveratrol application is cancer prevention. Combining UVA irradiation with resveratrol leads to controlled cell death, and is suggested as an alternative to surgery for skin cancer treatment . In mice, topical applications of resveratrol delayed the appearance of melanoma, as well as reduced the number and size of tumors . Similar effect was found in other studies where melanoma was induced by UV irradiation. Furthermore, post-irradiation treatment with resveratrol was found to be equally effective, indicating that it is not a simple sunscreen, but truly prevents the cancer initiation processes even after UV damage .
The chemical structure of resveratrol is similar to that of human hormone estrogen, so it can activate estrogen receptors . By doing this, it reduces edema and other symptoms of inflammation after UV exposure, leading to reduced photoageing , . This makes resveratrol particularly useful for post-menopausal women – hormone replacement therapy is used to counter the skin ageing and collagen loss observed at this period in life, and resveratrol is a safe alternative to human estrogens .
Resveratrol also acts as a skin whitener. It is known to inhibit the activity of tyrosinase, an enzyme necessary for melanin synthesis . This effect was confirmed in animals models, where resveratrol applications after UV exposure steadily suppressed the production of melanin and skin darkening . Whitening effects where also investigated using resveratryl triacetate, a compound that is converted into resveratrol once it is absorbed in the body. In volunteers applying this product for 8 weeks, significant lightening of the skin was observed, and the number of hyperpigmented spots was also reduced . In combination with green tea extract, resveratrol is even able to reduce facial redness, after as little as 6 weeks of treament .
However, resveratrol itself is sensitive to UV exposure. It is advised to employ it in combination with other sunscreens, or use in the evening, in order to maintain its effectiveness . For example, resveratrol (at concentration of 1 %) has been used in a nighttime cosmetical blend together with 0.5 % vitamin E and baicalin. This formulation increases synthesis of collagen and other proteins, resulting in reduction of fine lines and wrinkles, less roughness, greater skin firmness and elasticity, and even an increase in dermal thickness .
Currently, resveratrol is investigated for the possibilities in acne treatment. Pilot studies have shown promising results. In a split-face study, volunteers applied resveratrol-containing gel for 60 days, resulting in more than twice reduced acne scores . It is also known to have an antimicrobial effect against Propionibacterium acnes, the bacteria responsible for this disorder . Most recently, it was discovered that resveratrol inhibits the growth of sebocytes (sebaceous gland cells), thus complementing the anti-acne activity .
About BulkActive's Resveratrol
Trans-resveratrol 98% is the most bio active form of resveratrol available. Both Japanese knotweed and giant knotweed are important concentrated sources of resveratrol, replacing grape byproducts. The product BulkActives sells comes from Giant Knotweed. Many large supplement sources of Resveratrol now use Japanese knotweed and use its scientific name in the supplement labels
Although resvertarol may repair and treat sun damage (    ) it should not be used during the day as a preventative, as it is suggested that resveratrol may react negatively with the UVA in sunlight .
NOTE:To assist you with solubility issues, we now also sell Green Tea EGCG in a standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
Solubility: add to cream Suggested percentage:
10% solution gives 1% Resveratrol content in final product.
31% solution gives 3% Resveratrol content in final product.
51% solution gives 5% Resveratrol content in final product.
Storage: Store in fridge, do not freeze. Country of origin for raw material: China Country of manufacture: Taiwan
 P. Farris, J. Krutmann, Y.-H. Li, D. McDaniel, and Y. Krol, “Resveratrol: a unique antioxidant offering a multi-mechanistic approach for treating aging skin,” J. Drugs Dermatol. JDD, vol. 12, no. 12, pp. 1389–1394, Dec. 2013.
 C. Alonso, L. Rubio, S. Touriño, M. Martí, C. Barba, F. Fernández-Campos, L. Coderch, and J. L. Parra, “Antioxidative effects and percutaneous absorption of five polyphenols,” Free Radic. Biol. Med., vol. 75, pp. 149–155, Oct. 2014.
 J. V. Freitas, F. S. G. Praça, M. V. L. B. Bentley, and L. R. Gaspar, “Trans-resveratrol and beta-carotene from sunscreens penetrate viable skin layers and reduce cutaneous penetration of UV-filters,” Int. J. Pharm., vol. 484, no. 1–2, pp. 131–137, Apr. 2015.
 C. Sticozzi, F. Cervellati, X. M. Muresan, C. Cervellati, and G. Valacchi, “Resveratrol prevents cigarette smoke-induced keratinocytes damage,” Food Funct., vol. 5, no. 9, pp. 2348–2356, Sep. 2014.
 J. Z. Boyer, J. Jandova, J. Janda, F. R. Vleugels, D. A. Elliott, and J. E. Sligh, “Resveratrol-sensitized UVA induced apoptosis in human keratinocytes through mitochondrial oxidative stress and pore opening,” J. Photochem. Photobiol. B, vol. 113, pp. 42–50, Aug. 2012.
 P. Roy, N. Kalra, S. Prasad, J. George, and Y. Shukla, “Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways,” Pharm. Res., vol. 26, no. 1, pp. 211–217, Jan. 2009.
 M. H. Aziz, S. Reagan-Shaw, J. Wu, B. J. Longley, and N. Ahmad, “Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?,” FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol., vol. 19, no. 9, pp. 1193–1195, Jul. 2005.
 R. L. Jackson, J. S. Greiwe, and R. J. Schwen, “Ageing skin: oestrogen receptor β agonists offer an approach to change the outcome,” Exp. Dermatol., vol. 20, no. 11, pp. 879–882, Nov. 2011.
 J. C. Nwachukwu, S. Srinivasan, N. E. Bruno, A. A. Parent, T. S. Hughes, J. A. Pollock, O. Gjyshi, V. Cavett, J. Nowak, R. D. Garcia-Ordonez, R. Houtman, P. R. Griffin, D. J. Kojetin, J. A. Katzenellenbogen, M. D. Conkright, and K. W. Nettles, “Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network,” eLife, vol. 3, p. e02057, 2014.
 R. A. Newton, A. L. Cook, D. W. Roberts, J. H. Leonard, and R. A. Sturm, “Post-transcriptional regulation of melanin biosynthetic enzymes by cAMP and resveratrol in human melanocytes,” J. Invest. Dermatol., vol. 127, no. 9, pp. 2216–2227, Sep. 2007.
 T. H. Lee, J. O. Seo, S.-H. Baek, and S. Y. Kim, “Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin,” Biomol. Ther., vol. 22, no. 1, pp. 35–40, Jan. 2014.
 J. H. Ryu, J. K. Seok, S. M. An, J. H. Baek, J. S. Koh, and Y. C. Boo, “A study of the human skin-whitening effects of resveratryl triacetate,” Arch. Dermatol. Res., vol. 307, no. 3, pp. 239–247, Apr. 2015.
 G. Ferzli, M. Patel, N. Phrsai, and N. Brody, “Reduction of facial redness with resveratrol added to topical product containing green tea polyphenols and caffeine,” J. Drugs Dermatol. JDD, vol. 12, no. 7, pp. 770–774, Jul. 2013.
 P. Farris, M. Yatskayer, N. Chen, Y. Krol, and C. Oresajo, “Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin e for treatment of mild to moderately photodamaged skin,” J. Drugs Dermatol. JDD, vol. 13, no. 12, pp. 1467–1472, Dec. 2014.
 G. Fabbrocini, S. Staibano, G. De Rosa, V. Battimiello, N. Fardella, G. Ilardi, M. I. La Rotonda, A. Longobardi, M. Mazzella, M. Siano, F. Pastore, V. De Vita, M. L. Vecchione, and F. Ayala, “Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study,” Am. J. Clin. Dermatol., vol. 12, no. 2, pp. 133–141, Apr. 2011.
 E. J. M. Taylor, Y. Yu, J. Champer, and J. Kim, “Resveratrol Demonstrates Antimicrobial Effects Against Propionibacterium acnes In Vitro,” Dermatol. Ther., vol. 4, no. 2, pp. 249–257, Dec. 2014.
 S. Y. Kim, M. Y. Hyun, K. C. Go, C. C. Zouboulis, and B. J. Kim, “Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K/Akt pathway,” Int. J. Mol. Med., vol. 35, no. 4, pp. 1042–1050, Apr. 2015.
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
BulkActives is a part-time business. Orders are processed on Saturdays and mailed on Mondays at the latest.