Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
I purposely waited a few months before writing my review. I am happy to report this product is great! I combined the DMAE product with the base creams resulting in tighter skin and lessened wrinkles, including areas around underarms... ...»
This ingredient has done more for my skin than anything else I've ever used.
I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic.
I will use this forever, no question... ...»
I've been using Bulkactives green tea EGCG for four years. No complaints, it blends nicely my DIY anti-aging cream. I can feel a bit of toning and definitely notice the anti-inflammatory effects on my skin. Two observations that keep the rating 4 stars instead of 5: (1) A package of green tea contains significantly less weight/volume than the package of grape seed extract that I order from bulkactives. The two are combined in equal amounts in the anti-aging cream, so I find myself running o.. ...»
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This appears to have resolved most of the delays caused by The Canada Border Services Agency.
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Buy Vitamin E Natural Mixed Tocotrienols For Skin Care
Tocotrienol, a form of vitamin E, is known to be a natural powerful antioxidant that is quickly absorbed into the skin. It reduces damage involved with skin aging that is caused by harmful free radicals from UV light and ozone. Symptoms of skin aging include wrinkles, dryness, hyperpigmentation, and loss of elasticity. Tocotrienol increases collagen synthesis, which improves skin elasticity. It can also “unclog” skin burdened by excessive cholesterol. Toctrienol has anti-inflammatory properties and is able to reduce symptoms of allergic skin reactions. It can also help reduce the drying side effects of acne regimens such as benzoyl peroxide.
Natural Vitamin E Mixed Tocotrienols is an active blend of natural alpha tocopherol and alpha tocotrienol, beta tocotrienol, delta tocotrienol, and gamma tocotrienol.These are NATURAL tocotrienols, they are NOT synthetic.
Key Benefits of Vitamin E mixed Tocotrienols in skin care:
About Natural Vitamin E mixed Tocotrienols in DIY Skin Care
Tocotrienol is a form of vitamin E. There are four different forms of tocotrienol—α. β, γ, and δ. The main sources of tocotrienols are palm oil [α and γ] and rice bran oil . Research shows skin contains 15% tocotrienols . The other form of vitamin E, tocopherol, has traditionally received more attention, but researchers are discovering important uses for tocotrienols. Tocotrienols are more unsaturated than tocopherols [the other form of vitamin E], meaning their structures have more double bonds. They are more compact than tocopherol, lending unique properties. Tocotrienols are easily absorbed into the skin and are more quickly incorporated into cell membranes than tocopherols .
Tocotrienols are known to be better antioxidants than tocopherols [5, 7]. Free radicals, which anti-oxidants protect against, cause skin aging with symptoms like wrinkles, hyperpigmentation, dryness, and loss of elasticity. This damage is frequently caused by UV rays [present in sunlight] or ozone.
A study using γ-tocotrienol shows it reduces amounts of harmful free radicals . Studies show tocotrienol decreases free radical damage before or after UV exposure [1, 6]. Free radicals damage lipids, waxy molecules that retain moisture and preserve skin barrier function. A clinical study shows α-tocotrienol reduced levels of lipid degradation associated with free radicals . These lipids include cholesterol, ceramides, and fatty acids that make up the skin barrier.
In a study using human fibroblasts, cells that produce collagen, tocotrienol reduced damage due to free radicals. An in vitro [outside the body] study shows γ-tocotrienol prevents death of fibroblasts exposed to free radicals . Research shows that increased cell death, especially of fibroblasts, is involved in aging.
Tocotrienol was shown to increase collagen [2, 3]. In another study, fibroblasts from old and young people treated with γ-tocotrienol reversed telomere shortening associated with free radicals . Telomeres are “tails” on the end of DNA necessary for proper cell replication. Shortened telomeres have been associated with aging. The study showed γ-tocotrienol had to be applied before free radical exposure to prevent this damage.
Additionally, topical supplementation of 5% α-tocotrienol reduced the unwanted effects of benzoyl peroxide, commonly used to treat acne . Benzoyl peroxide is known to increase the amount of free radicals and regular use causes extreme dryness. Addition of α-tocotrienol reduced the damage due to free radicals. Treatment with benzoyl peroxide depletes 93% of vitamin E in the skin, but addition of α-tocotrienol reduced the loss .
Tocotrienols also have anti-inflammatory properties. They are known to inhibit the action of COX-2, a protein that produces prostaglandins, inflammatory mediators [4, 6]. Lipids damaged by free radicals accumulate on the surface of skin. Studies show they increase inflammation, including the activity of COX-2. Tocotrienol also reduced expression of inflammatory markers. In a study using mice, tocotrienols reduced symptoms of allergic skin reactions, such as itching and inflammation .
Tocotrienols may help prevent hyperpigmentation caused by UV light. In a study using mice, tocotrienols, specifically the γ and δ forms, reduced pigment production . Treating cells with tocotrienols before UV exposure prevented pigmentation. Additionally, tocotrienols may help regulate skin barrier function. It is thought tocotrienols can inhibit the production of cholesterol. Cholesterol is important for retaining barrier function of the skin. When there is a large excess of cholesterol, though, it can reduce skin permeability and essentially “clog” the skin . In this way, tocotrienols can help restore normal function and enhance skin penetration.
Storage: Cool, dry place. Do not freeze. Keep away from light and moisture! Country of origin: Kenya
 S. Makpol, A.Z. Abidin, K. Sairin, M. Mazlan, G. Md. Top, and W.Z.W. Ngah, “γ-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals,” Oxidative Medicine and Cellular Longevity, vol. 3, issue 1, pp. 35-43, January 2010.
 S. Makpol, F.A. Jam, Y.A.M. Yusof, and W.Z.W. Ngah, “Modulation of collagen synthesis and its gene expression in human skin fibroblasts by tocotrienol-rich fraction,” Arch Med Sci, vol. 5, pp. 889- 895, October 2011.
 S. Makpol, N.A. Rahim, C.K. Hui, and W.Z.W. Ngah, “Inhibition of Mitochondrial Cytochrome c Release and Suppression of Caspases by Gamma-Tocotrienol Prevent Apoptosis and Delay Aging in Stress-Induced Premature Senescence of Skin Fibroblasts,” Oxidative Medicine and Cellular Longevity, pp. 1-13, 2012.
 K. Nakagawa, A. Shibata, T. Maruko, P. Sookwong, T. Tsuduki, K. Kawakami, H. Nishida, and T. Miyazawa, “γ-Tocotrienol Reduces Squalene Hydroperoxide-Induced Inflammatory Responses in HaCaT Keratinocytes,” Lipids, vol. 45, pp. 833-841, 2010.
 L. Packer, S.U. Weber, and G. Rimbach, “Molecular Aspects of a-Tocotrienol Antioxidant Action and Cell Signaling,” Symposium: Molecular Mechanisms of Protective Effects of Vitamin E in Atherosclerosis, American Society for Nutritional Sciences, pp. 369S-373S, 2001.
 V.F. Pedrelli, M.M. Lauriola, and P.D. Pigatto, “Clinical evaluation of photoprotective effect by a topical antioxidants combination [tocopherols and tocotrienols],” Journal of the European Academy of Dermatology and Venereology, vol. 26, pp. 1449-1453, 2012.
 C.K. Sen, S. Khanna, and S. Roy, “Tocotrienols in health and disease: The other half of the natural vitamin E family,” Molecular Aspects of Medicine, vol. 28, pp. 692-728, 2007.
 M.G. Traber, M. Podda, C. Weber, J. Thiele, M. Rallis, and L. Packer, “Diet-derived and topically applied tocotrienols accumulate in skin and protect the tissue against ultraviolet light-induced oxidative stress,” Asia Pacific J Clin Nutr, vol. 6, issue 1, pp. 63-67, 1997.
 T. Tsuduki, K. Kuriyama, K. Nakagawa, and T. Miyazawa, “Tocotrienol [Unsaturated Vitamin E] Suppresses Degranulation of Mast Cells and Reduces Allergic Dermatitis in Mice,” J Oleo Sci., vol. 62, issue 10, pp. 825-834, 2013.
 S.U. Weber, J.J. Thiele, N. Han, C. Luu, G. Valacchi, S. Weber, and L. Packer, “Topical α-tocotrienol Supplementation Inhibits Lipid Peroxidation but Fails to Mitigate Increased Transepidermal Water Loss after Benzoyl Peroxide Treatment of Human Skin,” Free Radical Biology & Medicine, vol. 34, no. 2, pp. 170–176, 2003.
 W. N. Yap, N. Zaiden, C. H. Xu, A. Chen, S. Ong, V. Teo and Y. L. Yap, “Gamma- and delta-tocotrienols inhibit skin melanin synthesis by suppressing constitutive and UV-induced tyrosinase activation,” Pigment Cell Melanoma Res., vol. 23, pp. 688–692, 2010.
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
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