Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Reviews
I am 69 and I have used this product for two years almost every day at a high dose, adding it to my antioxidant day cream, with excellent results. For me it has a very high quality and effectiveness: reduction of wrinkles, hydrated skin, unified color without blemishes ... A product of 10, the same score that I give to John for the quality of the products he sells, his excellent description / use and the bibliographic contribution.En .. ...»
María Jesus
Tried this on my week-old rash from flea bites. Got an almost instant relief and rash healed in 2 days. Tried it on my daughter who has eczema for a very long time. The rashes calmed down after a few days and her skin is now healing well. Really great product. Just put in order for another jar.... ...»
Eliz
This is great stuff. I add it to my liquid face soap and it does an excellent job in preventing acne and gently exfoliating the skin... ...»
Marie
Really loving this product. I make the best Centella toner and most concentrated ever. 2 g of centella extract dissolved in 10g of alcohol(you have to stir a lot) plus 88 grams of water and you get a very concentrated toner. Creams, toners, ampoules... all have only 0,1% of triterpenes, this toner i make have 1,4%. I am loving it, will see the results. .. ...»
Francisco
It is true, this product does leave the skin silky smooth! I can highly recommend using it in your masks... ...»
Mati Fuller
Just recently ordered this and LOVE! Green Tea EGCG truly is one of the most fantastic skincare actives out there. Very difficult to find good quality product (90%) and even harder to actually solubilize it! Love that it comes in pre-dissolved solution. I enjoy adding it at 1% (so 11% sol) to my serum formulations containing Niacinamide 5% + NAG 3%. Excellent for oily acne prone skin. *Only gripe... because the Pre-Dissolved Solution is SO heavy in propanediol (10 parts Propanediol for 1 part E.. ...»
Victor
Wonderful base cream! Only multi-lamellar structured cream I've found on the market. Cream itself is lightweight (no oil) yet very conditioning/hydrating. Easily accepts water-soluble active ingredients as well as oil-soluble ones. I've even pushed the additional ingred % up to 20 (meaning 80% this cream, 20% added) without any separation issues. Ideal base cream for delivering actives. Personal favorite recipe calls for 5% straight Grapeseed Oil with 5% SebumREG oil active + Panthenol 1% + E Ac.. ...»
Vic
excellence product, very good and made my skin soft and smooth just like baby's skin. Thank you john.. ...»
nky
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
Jessie Sandford
The Pre-dissolved solution is excellent. Ferulic Acid is an amazing skincare ingredient (potent antioxidant, protects other sensitive antioxidants from light degradation, UV protection) but is absolutely ineffective if it isn't solubilized correctly. Makes adding to any Serum Base or w/o emulsion easy. Love using it (at 6%; so active 0.5%) with the Resveratrol Fluid (10%; active 1%) and Green Tea Extr for potent nighttime brightening treatment... ...»
James
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 All customers PLEASE read:

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Buy Idebenone For Skin Care

Idebenone has qualities that make it a good choice as an antioxidant. Idebenone also promotes cellular energy production. Since it is closely related to CoQ10 it may be used as replacement for CoQ10 in many recipes. Active ingredient in Prevage, MD™ line.

Key benefits of Idebenone in skin care: 

  • antioxidant
  • cellular energy production
  • sun damage repair
Idebenone skin care active ingredients
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Product Code: BulkActives
Assay: 98%
CAS#: 58186-27-9
Net weight: 5g / 0.18oz
Availability: Product Out Of Stock
Price: $0.00


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Idebenone

About Idebenone  in DIY Skin Care


This analog of Coenzyme Q10 is not just an antioxidant but it can help with mitochondrial function and, therefore, with energy production by the skin cells. This is why idebenone is advertised as anti-aging: mitochondria age faster than the rest of the cells and idebenone would aid mitochondrial function. Idebenone, a chemical very similar to Coenzyme Q10 (ubiquinone) is synthetic and can substitute for Coenzyme Q10 in the electron transport chain. The idea is that mitochondrial function can be limited by Coenzyme Q10 and idebenone will help older mitochondria work better. Taking into account that electron transport is a crucial part of respiration and energy production, idebenone makes sense. .

 

Idebenone and your skin

"Idebenone is closely related to CoQ10 in its structure. It can replace CoQ10 in the process of cellular energy production and, just as CoQ10, idebenone is also an antioxidant. There are some important distinctions though. Idebenone is more water-soluble than CoQ10; its cellular distribution and antioxidant profile are somewhat different too. This makes idebenone superior to CoQ10 in neutralizing some types of free radicals and inferior in fighting other types. Notably, idebnone is more effective than CoQ10 in protecting cells from the free radical damage resulting from reduced blood flow. On the other hand, idebenone appears more conducive than CoQ10 to certain types of noxious free-radical leakage in the cell's mitochondria. Unfortunately, there have been very few studies directly comparing CoQ10 and idebenone in the treatment of various conditions."
debenone: a powerful wrinkle-fighter, a copy-cat or both?
Dr. G. Todorov,.Idebenone: a powerful wrinkle-fighter, a copy-cat or both? smartskincare.com

"It is likely, however, that the increased energy production facilitated by CoQ10 will benefit the skin as well."
Dr. G. Todorov.Conditionally essential nutrients in skin rejuvenation. smartskincare.com

"Idebenone has been shown to produce clinically visible improvements in photodamaged skin. In a study of 41 female subjects aged 30-65, applying idebenone to the face in the morning and evening for six weeks reduced skin roughness and dryness by 26%, and decreased fine lines and wrinkles by 29%. The subjects also exhibited a 37% increase in skin hydration and a 33% overall improvement in assessment for photodamaged skin. These improvements were primarily seen in the epidermis, though there was some increase in dermal collagen as well. Skin biopsies revealed decreased levels of an inflammatory protein, a change associated with the stimulation of collagen production. Topically applied idebenone thus improves numerous markers of skin health while reducing the visible signs of aging.Idebenone may protect the skin through its potent antioxidant effects. One research team studied various antioxidants to gauge their protective effects against oxidative stress. They found that idebenone was the most effective antioxidant studied, providing more protection than CoQ10, vitamin E, kinetin, vitamin C, or lipoic acid. This antioxidant quality allows idebenone to inhibit lipid peroxidation, thus protecting skin cell lipids and membranes.

Topical use of idebenone represents an important step forward in scientifically based skin care. Through its antioxidant effects, idebenone helps protect skin from the effects of oxidative stress and photoaging, restoring moisture, refining texture, reducing fine lines and wrinkles, and promoting a more youthful appearance."
Idebenone Fights Photoaging, Improves Skin Health Dave Tuttle, 'Scientifically Advanced Skin Care', LE Magazine January 2007.
 

Note that Pinnell et al. claim that Idebenone is NOT as effective for sun protection as Pinnell's Vitamin C+E+Ferulic. 

A t BulkActives we are not a big fan of Idebenone or CoQ10 for topical sunprotection, as neither are very soluble and bio available.
We strongly suggest that Vitamin C be the main weapon in your fight against sun damage, and that CoQ10 or Idebenone are used at night to help increase cellular energy production.
 
Assay: 98%
CAS#: 58186-27-9
INCI: Hydroxydecyl Ubiquinone
Appearance: orange powder
Solubility: non-denatured ethanol, Propylene glycol (may require gentle heating)
Suggested percentage: .5% to 1%

Storage: Store in cool and dry place. Keep away from direct strong light and heat.
Country of origin: China

Topically applied Idebenone may:

  • prevent or reduce UVA and UVB sun damage: [2]
  • act as an anti- oxidant: [1]
  • increase cellular energy production: as a synthetic analog of Co-Q10
3: Tournas JA, Lin FH, Burch JA, Selim MA, Monteiro-Riviere NA, Zielinski JE, Pinnell SR. Ubiquinone, idebenone, and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acid. J Invest Dermatol. 2006 May;126(5):1185-7. PubMed PMID: 16528359.

2: McDaniel DH, Neudecker BA, DiNardo JC, Lewis JA 2nd, Maibach HI. Clinical efficacy assessment in photodamaged skin of 0.5% and 1.0% idebenone. J Cosmet Dermatol. 2005 Sep;4(3):167-73. PubMed PMID: 17129261. 

1: McDaniel DH, Neudecker BA, DiNardo JC, Lewis JA 2nd, Maibach HI. Idebenone: a  new antioxidant - Part I. Relative assessment of oxidative stress protection capacity compared to commonly known antioxidants. J Cosmet Dermatol. 2005 Jan;4(1):10-7. PubMed PMID: 17134415.  

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