Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Reviews
Just recently ordered this and LOVE! Green Tea EGCG truly is one of the most fantastic skincare actives out there. Very difficult to find good quality product (90%) and even harder to actually solubilize it! Love that it comes in pre-dissolved solution. I enjoy adding it at 1% (so 11% sol) to my serum formulations containing Niacinamide 5% + NAG 3%. Excellent for oily acne prone skin. *Only gripe... because the Pre-Dissolved Solution is SO heavy in propanediol (10 parts Propanediol for 1 part E.. ...»
Victor
The Pre-dissolved solution is excellent. Ferulic Acid is an amazing skincare ingredient (potent antioxidant, protects other sensitive antioxidants from light degradation, UV protection) but is absolutely ineffective if it isn't solubilized correctly. Makes adding to any Serum Base or w/o emulsion easy. Love using it (at 6%; so active 0.5%) with the Resveratrol Fluid (10%; active 1%) and Green Tea Extr for potent nighttime brightening treatment... ...»
James
The best, most potent and most stable form of Vitamin C. Makes quite a difference to the appearance of mature, photo-damaged skin - don't expect results over night but with consistent use your skin will look more even and radiant!.. ...»
Judy
This ingredient has done more for my skin than anything else I've ever used. I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic. I will use this forever, no question... ...»
Marie
Love the fine powder ascorbic acid. I use it in a recipe for skin care along with hyaluronic acid. I'm 65 years old and absolutely no one believes it 'cause I've been doing this for years... ...»
Kathy
Purchased this some time ago from BulkActives and here to buy some more! Great stuff!!!!.. ...»
Kathy
I've been using Bulkactives green tea EGCG for four years. No complaints, it blends nicely my DIY anti-aging cream. I can feel a bit of toning and definitely notice the anti-inflammatory effects on my skin. Two observations that keep the rating 4 stars instead of 5: (1) A package of green tea contains significantly less weight/volume than the package of grape seed extract that I order from bulkactives. The two are combined in equal amounts in the anti-aging cream, so I find myself running o.. ...»
Theresa Andrews
I ordered the 50 gm after being very pleased with the smaller size. Although it's pricey the quality is outstanding. This is the safest way to add Vit C to your formulations as it's not nearly as fussy as the powder. I've made both serums and creams with this product and have been very pleased with the outcomes! Highly recommend!.. ...»
Annabelle
I am very happy with both the quality and packaging of the Ferulic acid I ordered. It came in foil packets (I ordered two). Will buy from them again as I use the product in my Vitamin C serum to maintain the PH needed... ...»
DBallings
I am very happy with this product, and Bulkactives sells it for 1/3 less the price than other suppliers.. ...»
Monica
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Buy Creatine Pyruvate For Skin Care

Creatine is a molecule synthesized naturally in the human body. It is most important in tissues where energy-requiring activities occur, as it is involved in maintaining constant energy flow inside the cell.  It was show to protect skin from degeneration during ageing: creatine activates collagen synthesis, in this way decreasing the amount of wrinkles, and restoring skin firmness, smoothness and elasticity. Cheek sagging can also be reduced by applying creatine-containing cream. Another important benefit of creatine is UV damage protection, as it helps to protect cellular structures (especially mitochondria) from oxidative stress and mutations. Furthermore, creatine-treated skin was shown to regenerate faster. However, to protect creatine itself, pairing with coenzyme Q10 or other antioxidants is advised.

Key benefits of Creatine in skin care:

  • Sun damage protection [6] [7] [8] [9]
  • Sun damage repair [6] [7]
  • Increase cellular energy production [1] [3] [7]
  • Increase skin elasticity  [6]
  • Reduce fine lines and wrinkles [2] [6]
  • Stimulate collagen production [2] [4]
Creatine Pyruvate skin care active ingredients
Product Code: BulkActives
Reward Points: 5
Assay: 99.8
CAS#: 55965-97-4
Net weight: 30g /1.06oz
Availability: In Stock
Price: $6.10
Reward Points: 535


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Creatine Pyruvate

About Creatine Pyruvate in DIY Skin Care

Creatine is a molecule synthesized from amino acids in human liver, kidneys and pancreas. It is well-known for its function in metabolism – it helps to maintain constant energy flow for intense energy-requiring activities, such as muscle contractions during exercise [1]. Therefore, creatine supplements for athletes have been researched in great detail. Recently, however, it has attracted attention as a promising ingredient in cosmetics, since it can be rapidly absorbed through skin [2]. As energy flow occurs in every cell, the benefits of creatine are very diverse. In epithelial skin cells, the functions of this molecule are associated with cell proliferation, hair growth, sebum secretion and even wound healing [3].

It has been suggested that cellular energy metabolism is related to collagen degeneration during ageing. In fact, dermal application of creatine and guarana extract was shown to overcome this problem by activating collagen synthesis [2]. The same effect was found using a mixture of creatine and folic acid, indicating that creatine indeed is the ingredient responsible for these benefits. In this case, increased firmness of the skin was also observed [4].  To investigate the effects on visual skin appearance, volunteers applied a creatine-containing cream for 6 weeks and were evaluated by experts. It was found that the cream significantly reduced cheek sagging, crow’s feet wrinkles and wrinkles under the eyes [2]. Among other ingredients, creatine was used in a complex anti-ageing gel which noteably reduced cellulite symptoms in 81 % of volunteers treated [5].

Creatine is also involved in repairing skin damage after UV exposure or photoageing. Again, applied together with folic acid, creatine caused faster cell proliferation, thus stimulating renewal of the damaged skin tissue. This resulted in increased skin firmness, reduced number of both fine and coarse wrinkles, as well as increased smoothness and elasticity [6]. Additionally, a protective effect of creatine has been documented, for example, it decreases the DNA damage caused by UV radiation [6]. Other research also indicate that creatine is able to both protect the cells from UV and repair the damage caused by it, possibly by providing the energy necessary for these activities [7].

Mitochondria – the cell structures where respiration and energy generation occur – constantly generate oxidants as by-products, and thus are sensitive to irradiation or other oxidizing stresses. Creatine can also be transported to this structure, where it helps to reduce ageing-associated mutations and in this way also functions in tumor prevention [8]. In another study, application of 1 % cream was sufficient to completely negate the damage done to mitochondria by irradiation. This experiment was performed with elderly volunteers (average of 65 years), as additional supplements of creatine were shown to be more important at this age [9].

While creatine is not a known antioxidant, it can help protect certain enzymes and other proteins from oxidative damage [9]. However, this makes creatine itself susceptible to oxidation. Therefore, it is advised to pair it with a strong antioxidant – for example, including coenzyme Q10 in the formulation was shown to protect creatine and such combination results in even higher effectiveness against skin ageing symptoms [10].
 

About Creatine and Carnitine in DIY Skin Care

A newly issued patent, entitled, “Use of Creatine or Creatine Compounds for Skin Preservation,” claims that topical application of a combination of Creatine and Carnitine treats uneven skin pigmentation.
Assay: 99.8%
CAS No.:  55965-97-4
INCI: Creatine Pyruvate
Appearance: white powder
Odor: Strong, unpleasant sour smell.
Solubility: water, heated to 43C (110F), to ensure that crystals dissolve
Suggested percentage:0.5% to 1.5%

Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China
[1]          B. Gualano, H. Roschel, A. H. Lancha-Jr, C. E. Brightbill, and E. S. Rawson, “In sickness and in health: the widespread application of creatine supplementation,” Amino Acids, vol. 43, no. 2, pp. 519–529, Aug. 2012.
[2]          R. I. Peirano, V. Achterberg, H.-J. Düsing, M. Akhiani, U. Koop, S. Jaspers, A. Krüger, H. Schwengler, T. Hamann, H. Wenck, F. Stäb, S. Gallinat, and T. Blatt, “Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is linked to effective antiwrinkle and antisagging efficacy in male subjects,” J. Cosmet. Dermatol., vol. 10, no. 4, pp. 273–281, Dec. 2011.
[3]          T. Wallimann, M. Tokarska-Schlattner, and U. Schlattner, “The creatine kinase system and pleiotropic effects of creatine,” Amino Acids, vol. 40, no. 5, pp. 1271–1296, May 2011.
[4]          F. Fischer, V. Achterberg, A. März, S. Puschmann, C.-D. Rahn, V. Lutz, A. Krüger, H. Schwengler, S. Jaspers, U. Koop, T. Blatt, H. Wenck, and S. Gallinat, “Folic acid and creatine improve the firmness of human skin in vivo,” J. Cosmet. Dermatol., vol. 10, no. 1, pp. 15–23, Mar. 2011.
[5]          E. Dupont, M. Journet, M.-L. Oula, J. Gomez, C. Léveillé, E. Loing, and D. Bilodeau, “An integral topical gel for cellulite reduction: results from a double-blind, randomized, placebo-controlled evaluation of efficacy,” Clin. Cosmet. Investig. Dermatol., vol. 7, pp. 73–88, 2014.
[6]          A. Knott, U. Koop, H. Mielke, K. Reuschlein, N. Peters, G.-M. Muhr, H. Lenz, U. Wensorra, S. Jaspers, L. Kolbe, T. Raschke, F. Stäb, H. Wenck, and S. Gallinat, “A novel treatment option for photoaged skin,” J. Cosmet. Dermatol., vol. 7, no. 1, pp. 15–22, Mar. 2008.
[7]          D. Maes, D. Collins, L. Declercq, R. Foyouzi-Yousseffi, D. Gan, T. Mammone, E. Pelle, K. Marenus, and H. Gedeon, “Improving cellular function through modulation of energy metabolism,” Int. J. Cosmet. Sci., vol. 26, no. 5, pp. 268–269, Oct. 2004.
[8]          M. Berneburg, T. Gremmel, V. Kürten, P. Schroeder, I. Hertel, A. von Mikecz, S. Wild, M. Chen, L. Declercq, M. Matsui, T. Ruzicka, and J. Krutmann, “Creatine supplementation normalizes mutagenesis of mitochondrial DNA as well as functional consequences,” J. Invest. Dermatol., vol. 125, no. 2, pp. 213–220, Aug. 2005.
[9]          H. Lenz, M. Schmidt, V. Welge, U. Schlattner, T. Wallimann, H.-P. Elsässer, K.-P. Wittern, H. Wenck, F. Stäb, and T. Blatt, “The creatine kinase system in human skin: protective effects of creatine against oxidative and UV damage in vitro and in vivo,” J. Invest. Dermatol., vol. 124, no. 2, pp. 443–452, Feb. 2005.
[10]        T. Blatt, H. Lenz, U. Koop, S. Jaspers, T. Weber, C. Mummert, K.-P. Wittern, F. Stäb, and H. Wenck, “Stimulation of skin’s energy metabolism provides multiple benefits for mature human skin,” BioFactors Oxf. Engl., vol. 25, no. 1–4, pp. 179–185, 2005.
 
0.5 to 1.5% added to water phase, then heated to 43C (110F), ensuring that crystals dissolve

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