Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
I wished i could order this in a smaller amount of 50 gr. Can i get informed when it is available ?
A. It will not be sold in smaller amounts. The review rating is meant to be for the product, not the size in which it is sold :-(.. ...»
I purposely waited a few months before writing my review. I am happy to report this product is great! I combined the DMAE product with the base creams resulting in tighter skin and lessened wrinkles, including areas around underarms... ...»
This ingredient has done more for my skin than anything else I've ever used.
I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic.
I will use this forever, no question... ...»
Any long delivery delays are caused by The Canada Border Services Agency.
I now ONLY offer EMS as a shipping option to Canada.
This appears to have resolved most of the delays caused by The Canada Border Services Agency.
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GABA (gamma-aminobutyric acid) is a neurotransmitter with purported dermatological benefits. Several patents indicated that GABA can be used as a wrinkle relaxer based on its inhibitory effect on muscles. Some patents also claim that GABA can dilate skin peripheral blood vessels, moisturize and prevent aging, suppress parakeratosis and shrink pores, as well as whitening the skin. However there is no scientific data to support these claims. On the other hand, a preliminary research study has shown that GABA can stimulate hyaluronic acid synthesis and protect the fibroblasts from oxidative stress. Another study showed that GABA was able to upregulate beta-defensin-2, which is an anti-microbial peptide, and filaggrin, which plays a role in normal barrier function of the skin. Lastly, GABA might be useful in combating inflammation associated with psoriasis based on preliminary findings that GABA receptors are expressed in white blood cells in psoriatic skin. Overall, the evidence of GABA in supporting skin health is very weak, and consumers are warned for its application.
Unsubstantiated benefits of GABA (Gamma-aminobutyric acid) in skin care:
Capillary health 
Lightening and brightening 
Moisturizing and hydration 
Pore refinement 
Reduce fine lines and wrinkles 
Restore barrier function 
Stimulate HA production 
Wrinkle relaxers 
Product Code: BulkActives Reward Points: 3 CAS#:
56-12-2 Net weight:
30g /1.06oz Availability: In Stock
About GABA (Gamma-aminobutyric acid) in DIY Skin Care
Gamma-aminobutyric acid (GABA) is a well-known neurotransmitter. In the mature brain of humans, it exerts inhibitory function on neurons when bind to GABA receptors, through regulating the chloride gradient across the cell membrane. GABA is synthesized by enzymes called glutamate decarboxylase, using glutamate as the substrate. Once synthesized, it is transported in little vesicles to the synapses of the neurons, and its action depends on its metabolism, expression, and activity level. GABA is important for brain development, and its dysfunction has been linked to a myriad of neurological disorders such as autism, Fragile X, Rett syndrome, Down syndrome, schizophrenia, Tourette's syndrome and neurofibromatosis.
GABA has been marketed as a wrinkle relaxer based on the claim that it can inhibit neuronal activity and hence relax muscles, limiting the “expression lines” resulted from muscle hyper-contraction such as in the peri-oral regions. There are several patents that indicate such function when used topically. Other patents that mentioned GABA’s benefits include dilation of skin peripheral blood vessels, moisturizing and age-preventing, suppressing parakeratosis and pore shrinking, and whitening effects. However, there have been no peer-reviewed study published to date (May, 2015) on these effects.
Research on dermatological use of GABA has been sporadic. It has been shown that glutamate decarboxylase exists in human dermal fibroblasts, and GABA can stimulate the synthesis of hyaluronic acid and enhances the survival rate of the fibroblasts when exposed to oxidative stress in vitro. GABA synthesized from fermentation of grape must using bacteria (Lactobacillus plantarum) has been shown to increase the level of beta-defensin-2, hyaluronan synthase, and filaggrin in reconstituted human skin tissue, suggesting that GABA might play a role in anti-microbial function, hydration, and proper barrier function of the skin. GABA receptors are expressed in a number of white blood cell types in psoriatic skin, and GABA has been implicated to be important in relieving inflammation associated with psoriasis. These studies provide new possibilities for the application of GABA, however consumers are encouraged to exercise precautions due to the fact that none of these studies has been replicated and substantiated.
Assay: 99.6% CAS No.: 56-12-2 INCI: Gamma-AminoButyric Acid Appearance: white powder Solubility: water Suggested percentage:No data available, up to customer's discretion
Storage: Cool, dry place. Do not freeze. Keep away from light and moisture! Country of origin: China
 G. Deidda, I. F. Bozarth, and L. Cancedda, “Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives,” Front. Cell. Neurosci., vol. 8, May 2014.
 O. D. Lacharriere and L. Breton, “Compositions and methods for treating wrinkles and/or fine lines of the skin,” US5976559 A, 02-Nov-1999.
 O. D. Lacharriere and L. Breton, “Compositions and methods for treating wrinkles and/or fine lines of the skin,” US5869068 A, 09-Feb-1999.
 H. Kyotaro and H. Minoru, “Cosmetic for preventing skin from aging,” 05-043448, 23-Feb-1993.
 T. Hiroshi, “Cosmetic for preventing aging of skin,” 05-117137, 14-May-1993.
 O. Tadatake, A. Takashi, and H. Kyotaro, “Cosmetic for preventing aging of skin,” 60-184005, 19-Sep-1985.
 M. Kaminuma, M. Suetsugu, T. Iida, and S. Inomata, “Parakeratosis inhibitor, pore -shrinking agent and external compositon for skin,” US20120232111 A1, 13-Sep-2012.
 S. Tatsuro and T. Hiroshi, “Skin-whitening cosmetic,” 05-229929, 09-Jul-1993.
 T. Hiroshi and S. Tatsuro, “Skin-beautifying cosmetic,” 05-194178, 08-Mar-1993.
 K. Ito, K. Tanaka, Y. Nishibe, J. Hasegawa, and H. Ueno, “GABA-synthesizing enzyme, GAD67, from dermal fibroblasts: evidence for a new skin function,” Biochim. Biophys. Acta, vol. 1770, no. 2, pp. 291–296, Feb. 2007.
 R. Di Cagno, F. Mazzacane, C. G. Rizzello, M. De Angelis, G. Giuliani, M. Meloni, B. De Servi, and M. Gobbetti, “Synthesis of gamma-aminobutyric acid (GABA) by Lactobacillus plantarum DSM19463: functional grape must beverage and dermatological applications,” Appl. Microbiol. Biotechnol., vol. 86, no. 2, pp. 731–741, Mar. 2010.
 R. Nigam, H. El-Nour, B. Amatya, and K. Nordlind, “GABA and GABA(A) receptor expression on immune cells in psoriasis: a pathophysiological role,” Arch. Dermatol. Res., vol. 302, no. 7, pp. 507–515, Sep. 2010.
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
BulkActives is a part-time business. Orders are processed on Saturdays and mailed on Mondays at the latest.