Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
I wished i could order this in a smaller amount of 50 gr. Can i get informed when it is available ?
A. It will not be sold in smaller amounts. The review rating is meant to be for the product, not the size in which it is sold :-(.. ...»
I purposely waited a few months before writing my review. I am happy to report this product is great! I combined the DMAE product with the base creams resulting in tighter skin and lessened wrinkles, including areas around underarms... ...»
This ingredient has done more for my skin than anything else I've ever used.
I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic.
I will use this forever, no question... ...»
Any long delivery delays are caused by The Canada Border Services Agency.
I now ONLY offer EMS as a shipping option to Canada.
This appears to have resolved most of the delays caused by The Canada Border Services Agency.
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Soy isoflavones are comparatively new in regards to cosmetic use, however, studies show they have multiple skin-benefitting properties.Isoflavones are structurally similar to estrogens and can activate estrogen signaling pathways, including collagen synthesis, to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and increase tissue hydration.Additionally isoflavones are powerful antioxidants that can halt and reverse the appearance of aging due to free radicals caused by sunlight and other environmental hazards.As such, soy isoflavones are useful in reducing redness of the skin and decreasing the appearance of dark spots.These properties make soy isoflavones ideal for use in anti-aging, moisturizing, and skin protecting creams.
Key benefits of Soy isoflavones on skin care:
Anti-inflammatory [6, 11, 12]
Antioxidant [3, 6]
Increase skin elasticity [1, 4, 5, 15]
Matrix metalloproteinase [MMP] inhibitors 
Moisturizing and hydration [5, 15]
Natural phytoestrogens [3, 15]
Reduce fine lines and wrinkles [1, 4, 5, 15]
Stimulate collagen production [1, 4, 5, 15]
Sun damage protection [3, 6, 11, 12, 14]
Sun damage repair [3, 6, 11, 12, 14]
Treat hyperpigmentation 
Product Code: BulkActives Reward Points: 5 Assay:
Total Isoflavones 40% CAS#:
574-12-9 Net weight:
30g /1.06oz Availability: In Stock
Aging in post-menopausal women is closely associated with decreased levels of hormones including the female sex hormone estrogen. Studies of these women indicate that the decrease in estrogen is associated with changes in the skin such as dryness, dermal atrophy, reduced mechanical tension, and the increased appearance of fine lines and wrinkles due to a decline in dermal collagen content . Such changes in the skin are potentiated by photoaging, which results from UV-induced oxidation in the skin. Damage from UV irradiation can also cause increased expression of matrix metalloproteinases [MMPs] in the skin, including MMP-1, MMP-2, MMP-3, and MMP-9 . These proteinases degrade the collagen network in the skin and thus contribute to the aged appearance.
Soy isoflavones are phytoestrogens, or plant-derived estrogens, which can bind to estrogen receptors and initiate signaling pathways related to maintaining dermal integrity. Particularly of interest, soy isoflavones can elicit such responses in the skin but do not increase the risk of uterine or breast cancers unlike most other estrogen replacement therapies . Independently of their estrogen receptor-binding abilities, soy isoflavones are powerful antioxidants capable of neutralizing and reversing photoaging effects .
The binding of estrogen to its receptors activates a variety of genes including those involving collagen production. A clinical study testing isoflavones to reverse the signs of post-menopausal skin aging found that after treatment with an isoflavone-containing cream twice daily for twelve weeks participants had improved skin dryness and roughness by 32.9% and 22%, respectively, compared to untreated skin. Wrinkles and skin looseness were also significantly reduced by 22% and 24%, respectively . A similar study testing topically applied isoflavones demonstrated a 7.5% increase in the number of collagen fibers after treatment for six months . Additionally, because collagen is capable of binding large amounts of water, it has been suggested that an indirect effect of isoflavone creams is increased hydration of the skin. This therefore also makes them useful in moisturizing creams.
The skin is highly susceptible to free radical attack caused by environmental elements such as sunlight, cigarette smoke, and pollution, all of which contribute to premature aging of the skin. Such environmental hazards can increase the rate of collagen degradation in skin, cause dermal inflammation, and lead to pigment abnormalities . The antioxidant properties of isoflavones halt and reverse these effects by neutralizing free radicals. Studies have demonstrated that isoflavones can impair the formation of free radicals and block oxidative stress-induced apoptosis of epidermal cells . Because free radicals drive melanogenesis, or the hyperpigmentation, in fibroblasts, the antioxidant properties of soy isoflavones are also believed to be able to decrease the appearance of dark spots and even out skin tone [7, 8].
Isoflavones are also known to inhibit tyrosine kinases by competing for the ATP-binding site. Through this mechanism, isoflavones can decrease MMP levels in the skin while increasing the levels of the body’s natural MMP inhibitors [9, 10]. In human epidermal cell cultures, isoflavones effectively inhibited UV-stimulated tyrosine kinases involved with initiation of inflammation [11, 12]. Thus, isoflavones have the capability to protect the integrity of the dermal matrix and to prevent UV-induced damage to the skin.
Interestingly, because dysregulation of tyrosine kinases and free radicals are each associated with driving carcinogenesis, soy isoflavones have been investigated for use in preventing or slowing skin cancer progression. Several studies have successfully demonstrated that treatment with isoflavones can reduce the number of skin tumors and slow the rate of growth of skin cancer [13, 14].
Storage: Store in cool and dry place. Keep away from direct strong light and heat. Country of origin: China
 Brincat M, Moniz C, Studd J, Darby A, Magos A, Emburey G, et al. Long‐term effects of the menopause and sex hormones on skin thickness. BJOG: An International Journal of Obstetrics & Gynaecology. 1985;92:256-9.
 Fisher GJ, Datta SC, Talwar HS, Wang Z-Q, Varani J, Kang S, et al. Molecular basis of sun-induced premature skin ageing and retinoid antagonism. 1996.
 Pinnell SR. Cutaneous photodamage, oxidative stress, and topical antioxidant protection. Journal of the American Academy of Dermatology. 2003;48:1-22.
 Sator P-G, Schmidt JB, Rabe T, Zouboulis CC. Skin aging and sex hormones in women – clinical perspectives for intervention by hormone replacement therapy. Experimental Dermatology. 2004;13:36-40.
 Accorsi-Neto A, Haidar M, Simões R, Simões M, Soares-Jr J, Baracat E. Effects of isoflavones on the skin of postmenopausal women: a pilot study. Clinics. 2009;64:505-10.
 Chan W-H, Yu J-S. Inhibition of UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermal carcinoma A 431 cells by genistein. Journal of cellular biochemistry. 2000;78:73-84.
 Pawelek J, Chakraborty A. The enzymology of melanogenesis. The pigmentary system. 1998:391-400.
 Paine C, Sharlow E, Liebel F, Eisinger M, Shapiro S, Seiberg M. An Alternative Approach to Depigmentation by Soybean Extracts via Inhibition of the PAR-2 Pathway. 2001;116:587-95.
 Puli S, Lai JC, Bhushan A. Inhibition of matrix degrading enzymes and invasion in human glioblastoma [U87MG] cells by isoflavones. Journal of Neuro-oncology. 2006;79:135-42.
 Kousidou OC, Mitropoulou T, Roussidis A, Kletsas D, Theocharis A, Karamanos N. Genistein suppresses the invasive potential of human breast cancer cells through transcriptional regulation of metalloproteinases and their tissue inhibitors. International journal of oncology. 2005;26:1101-9.
 Miller CC, Hale P, Pentland AP. Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Evidence for UVB-induced epidermal growth factor receptor activation. Journal of Biological Chemistry. 1994;269:3529-33.
 Isoherranen K, Punnonen K, Jansen C, Uotila P. Ultraviolet irradiation induces cyclooxygenase-2 expression in keratinocytes. British journal of dermatology. 1999;140:1017-22.
 Wei H, Bowen R, Zhang X, Lebwohl M. Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice. Carcinogenesis. 1998;19:1509-14.
 Moore JO, Wang Y, Stebbins WG, Gao D, Zhou X, Phelps R, et al. Photoprotective effect of isoflavone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis. Carcinogenesis. 2006;27:1627-35.
 Hall G, Phillips TJ. Estrogen and skin: The effects of estrogen, menopause, and hormone replacement therapy on the skin. Journal of the American Academy of Dermatology. 2005;53:555-68.
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
BulkActives is a part-time business. Orders are processed on Saturdays and mailed on Mondays at the latest.