Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
This lovely, simple, and affordable product has become something I don't want to be without. I am 47, with very sensitive and reactive dry skin. This cream doesn't feel particularly moisturizing and leaves something of a 'dry' finish on the skin after application, but it's had SUCH a positive impact on my face. The redness and papules from my rosacea and seb derm have reduced by a good 90%. It's been a magical barrier restorer and I panicked when it was temporarily out of stock. I would recomme.. ...»
This is the best product I have ever used on my skin and I tried a LOT of expansive brands. It helps with redness and overall skin tone. Please do not ever stop making this stuff... ...»
Tried this on my week-old rash from flea bites. Got an almost instant relief and rash healed in 2 days.
Tried it on my daughter who has eczema for a very long time. The rashes calmed down after a few days and her skin is now healing well. Really great product. Just put in order for another jar.... ...»
Really loving this product. I make the best Centella toner and most concentrated ever. 2 g of centella extract dissolved in 10g of alcohol(you have to stir a lot) plus 88 grams of water and you get a very concentrated toner. Creams, toners, ampoules... all have only 0,1% of triterpenes, this toner i make have 1,4%. I am loving it, will see the results. .. ...»
Just recently ordered this and LOVE! Green Tea EGCG truly is one of the most fantastic skincare actives out there. Very difficult to find good quality product (90%) and even harder to actually solubilize it! Love that it comes in pre-dissolved solution. I enjoy adding it at 1% (so 11% sol) to my serum formulations containing Niacinamide 5% + NAG 3%. Excellent for oily acne prone skin.
*Only gripe... because the Pre-Dissolved Solution is SO heavy in propanediol (10 parts Propanediol for 1 part E.. ...»
Wonderful base cream! Only multi-lamellar structured cream I've found on the market. Cream itself is lightweight (no oil) yet very conditioning/hydrating. Easily accepts water-soluble active ingredients as well as oil-soluble ones. I've even pushed the additional ingred % up to 20 (meaning 80% this cream, 20% added) without any separation issues. Ideal base cream for delivering actives. Personal favorite recipe calls for 5% straight Grapeseed Oil with 5% SebumREG oil active + Panthenol 1% + E Ac.. ...»
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
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This appears to have resolved most of the delays caused by The Canada Border Services Agency.
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The inflammatory response evolved as a way for the body to defend itself. Inflammation is initiated in response to the presence of an antigen, which may be an infectious agent or damaged tissue [including damage by UV irradiation]. Following recognition of an antigen by local immune cells [leukocytes], blood vessels may either dilate or constrict, depending on the context. This leads to increased vascular permeability and the accumulation of plasma proteins at the site of the antigen which can recruit circulating leukocytes to extravagate and respond to the insult. Through this mechanism a positive feedback loop is established as the immune cells secrete inflammatory signaling molecules [cytokines],recruiting more leukocytes from circulation [1, 2]. The “leaky” vasculature combined with the presence of leukocytes causes skin to appear flushed, a condition known as erythema. Further, the secretion of cytokines and pro-inflammatory compounds can cause itchiness and discomfort [3].
When phagocytic leukocytes such as macrophages respond during inflammation the phagocytic process causes reactive oxygen species [ROS] to be released. ROS can also be produced independently of leukocytes by UV irradiation. This is significant because ROS can damage cell membranes, and since the cells of the skin are rich in polyunsaturated fatty acids they are particularly susceptible to oxidative damage. ROS-induced cell death can thus initiate or contribute to a pro-inflammatory state, increasing leukocyte recruitment [4, 5]. Both ROS and cytokines can lead to cellular production of proteolytic enzymes which degrade the extracellular matrix, increasing the appearance of fine lines and wrinkles while decreasing the elasticity or the skin [6]. Together, inflammation resulting from environmental assaults [such as smoking or pollution], UV photodamage, or infection [such as acne vulgaris] results in aging of the skin and in skin abnormalities such as flushing and irritation.
Anti-inflammatory agents are now commonly being incorporated into skin care products to improve skin tone and texture while reducing the appearance of aging. Many plant extracts have been shown to attenuate inflammation, including boswelic acid which can inhibit the enzymatic pathway in leukocytes that produces leukotrienes, important inflammatory mediators. This blocks loss of collagen and elastic fibers while increasing fibroblastic synthesis of collagen [7, 8].
Dipotassium glycyerhizinate is a salt of an extract from the white licorice plant which can also inhibit leukotriene synthesis. Additionally, this compound slows down the metabolism of cortisol, a potent proinflammatory mediator and also can inhibit the synthesis of inflammatory histamines. Studies have demonstrate this compound is useful in treating both atopic dermatitis [AD] and psoriasis [9-13].
Fucoidan, a brown seaweed extract, also has implications for treatment of AD, allergic reactions, and wound healing. Fucoidans inhibit several enzymes involved in the inflammatory pathway while simultaneously stimulating dermal cells to synthesize collagen and accelerate re-epithelialization [14-21].
Pomegranate extracts, though widely known for their antioxidant properties, also have powerful anti-inflammatory effects. They have been shown to reduce erythema, decrease UV-induced cell death and protect against UV-induced inflammation via ROS [22, 23].
Soy isoflavones are also known mediators of UV-induced ROS and can inhibit the activity of certain enzymes which drive inflammation [24-26]. Plant sterols, hesperidin methyl chalcone [extracted from citrus fruits], and ginkgo biloba extracts are all known to regulate blood flow through skin capillaries which can decrease redness of the skin and reduce the recruitment of circulating leukocytes to the site of the stimulus [27-30].
Gynostemma, or jiaogulan, are polysaccharides extracted from a plant belonging to the cucumber family which decreases synthesis of inflammatory cytokines and is useful for treatment of psoriasis [31, 32]. Pine bark extracts, white willow bark salicylic acid extract, and grape extracts [resveratrol] are capable of acting as a skin protectant from UV light, both reducing damage if used as a pre-treatment and for alleviating the inflammation induced by UV irradiation [33-36].
Certain vitamins or vitamin-like compounds can also act as anti-inflammatory agents. Coenzyme Q10 is a vitamin-like compound which is oil-soluble and naturally synthesized by the body. Q10 levels naturally decline with age, but topical application of this compound to the skin have been shown to decrease inflammation induced by UV irradiation and other environmental hazards, increase collagen synthesis, and promote wound healing [37-39].
Provitamin B5, or D-panthenol, is involved in skin maintenance and growth. This compound has been shown to be beneficial for atopic dermatitis as it is protective against skin irritants and is as effective at treating AD as corticosteroids, the current standard of therapy [40, 41]. Further, D-panthenol is effective in reducing UV-induced erythema and thus can decrease redness in the skin [42].
Niacinamine [vitamin B3], supports barrier function and reduces leukocyte infiltration to the site of inflammation and has been shown to be beneficial in treatment of rosacea [43, 44]. Vitamin E, or mixed tocopherols, is a lipid-soluble vitamin with known sun-protectant properties also capable of neutralizing UV-induced oxidative damage. Mixed tocopherols can also inhibit the enzymes which produce reactive oxygen species in response to stress in both macrophages and epithelial cells [45, 46].
References
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[2] Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454[7203]:428-35.
[3] Hoffmann R, Schmelz M. Time course of UVA‐and UVB‐induced inflammation and hyperalgesia in human skin. European Journal of Pain. 1999;3[2]:131-9.
[4] Scharffetter-Kochanek K, Wlaschek M, Brenneisen P, Schauen M, Blaudschun R, Wenk J. UV-induced reactive oxygen species in photocarcinogenesis and photoaging. Biological chemistry. 1997;378[11]:1247-58.
[5] Trenam CW, Blake DR, Morris CJ. Skin Inflammation: Reactive Oxygen Species and the Role of Iron. J Investig Dermatol. 1992;99[6]:675-82.
[6] Pillai S, Oresajo C, Hayward J. Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation-induced matrix degradation – a review. International Journal of Cosmetic Science. 2005;27[1]:17-34.
[7] Calzavara‐Pinton P, Zane C, Facchinetti E, Capezzera R, Pedretti A. Topical Boswellic acids for treatment of photoaged skin. Dermatologic therapy. 2010;23[s1]:S28-S32.
[8] Siddiqui M. Boswellia serrata, a potential antiinflammatory agent: an overview. Indian journal of pharmaceutical sciences. 2011;73[3]:255.
[9] Panel CIRE. Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate. International journal of toxicology. 2007;26:79.
[10] Ojima M, Satoh K, Gomibuchi T, Itoh N, Kin S, Fukuchi S, et al. [The inhibitory effects of glycyrrhizin and glycyrrhetinic acid on the metabolism of cortisol and prednisolone--in vivo and in vitro studies]. Nihon Naibunpi Gakkai Zasshi. 1990;66[5]:584-96.
[11] Noriaki I, Hiroshi K, Yasuhiro H, Kimio Y, Atsushi I. Effects of glycyrrhizin and glycyrrhetinic acid on dexamethasone-induced changes in histamine synthesis of mouse mastocytoma P-815 cells and in histamine release from rat peritoneal mast cells. Biochemical pharmacology. 1989;38[15]:2521-6.
[12] Saeedi M, Morteza-Semnani K, Ghoreishi M. The treatment of atopic dermatitis with licorice gel. Journal of Dermatological Treatment. 2003;14[3]:153-7.
[13] Xiong H, Xu Y, Tan G, Han Y, Tang Z, Xu W, et al. Glycyrrhizin Ameliorates Imiquimod-Induced Psoriasis-like Skin Lesions in BALB/c Mice and Inhibits TNF-α-Induced ICAM-1 Expression via NF-κB/MAPK in HaCaT Cells. Cellular Physiology and Biochemistry. 2015;35[4]:1335-46.
[14] Ferrao AV, Mason RM. The effect of heparin on cell proliferation and type-I collagen synthesis by adult human dermal fibroblasts. Biochimica et Biophysica Acta [BBA]-Molecular Basis of Disease. 1993;1180[3]:225-30.
[15] Iwamoto K, Hiragun T, Takahagi S, Yanase Y, Morioke S, Mihara S, et al. Fucoidan suppresses IgE production in peripheral blood mononuclear cells from patients with atopic dermatitis. Arch Dermatol Res. 2011;303[6]:425-31.
[16] Kim TH, Lee EK, Lee MJ, Kim JH, Yang WS. Fucoidan inhibits activation and receptor binding of transforming growth factor-β1. Biochemical and Biophysical Research Communications. 2013;432[1]:163-8.
[17] Nakamura T, Suzuki H, Wada Y, Kodama T, Doi T. Fucoidan induces nitric oxide production via p38 mitogen-activated protein kinase and NF-κB-dependent signaling pathways through macrophage scavenger receptors. Biochemical and Biophysical Research Communications. 2006;343[1]:286-94.
[18] O’Leary R, Rerek M, Wood EJ. Fucoidan modulates the effect of transforming growth factor [TGF]-b1 on fibroblast proliferation and wound repopulation in in vitro models of dermal wound repair. Biol Pharm Bull. 2004;27[2]:266-70.
[19] Robert L, Fodil-Bourahla I, Bizbiz L, Robert AM. Effects of L-fucose and fucose-rich oligo- and polysaccharides [FROP-s] on collagen biosynthesis by human skin fibroblasts. Modulation of the effect of retinol, ascorbate and α-tocopherol. Biomedicine & Pharmacotherapy. 2004;58[1]:65-70.
[20] Sezer AD, Cevher E, Hatıpoğlu F, Oğurtan Z, Baş AL, Akbuğa J. Preparation of fucoidan-chitosan hydrogel and its application as burn healing accelerator on rabbits. Biological and Pharmaceutical Bulletin. 2008;31[12]:2326-33.
[21] Yang J-H. Topical Application of Fucoidan Improves Atopic Dermatitis Symptoms in NC/Nga Mice. Phytotherapy Research. 2012;26[12]:1898-903.
[22] Parveen R, Akhtar N, Mahmood T. Topical microemulsion containing Punica granatum extract: its control over skin erythema and melanin in healthy Asian subjects. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii. 2014;31[6]:351.
[23] Pacheco-Palencia LA, Noratto G, Hingorani L, Talcott ST, Mertens-Talcott SU. Protective effects of standardized pomegranate [Punica granatum L.] polyphenolic extract in ultraviolet-irradiated human skin fibroblasts. Journal of agricultural and food chemistry. 2008;56[18]:8434-41.
[24] Chan W-H, Yu J-S. Inhibition of UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermal carcinoma A 431 cells by genistein. Journal of cellular biochemistry. 2000;78[1]:73-84.
[25] Isoherranen K, Punnonen K, Jansen C, Uotila P. Ultraviolet irradiation induces cyclooxygenase-2 expression in keratinocytes. British journal of dermatology. 1999;140:1017-22.
[26] Miller CC, Hale P, Pentland AP. Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Evidence for UVB-induced epidermal growth factor receptor activation. Journal of Biological Chemistry. 1994;269[5]:3529-33.
[27] HIBATALLAH J, CARDUNER C, POELMAN MC. In‐vivo and In‐vitro Assessment of the Free‐radical‐scavenger Activity of Ginkgo Flavone Glycosides at High Concentration. Journal of pharmacy and pharmacology. 1999;51[12]:1435-40.
[28] Boelsma E, Lamers R, Hendriks HF, van Nesselrooij JH, Roza L. Evidence of the regulatory effect of Ginkgo biloba extract on skin blood flow and study of its effects on urinary metabolites in healthy humans. Planta medica. 2004;70[11]:1052-7.
[29] Bouskela E, Cyrino FZ, Marcelon G. Inhibitory effect of the Ruscus extract and of the flavonoid hesperidine methylchalcone on increased microvascular permeability induced by various agents in the hamster cheek pouch. Journal of cardiovascular pharmacology. 1993;22[2]:225-30.
[30] Boller S, Soldi C, Marques MC, Santos EP, Cabrini DA, Pizzolatti MG, et al. Anti-inflammatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation. Journal of ethnopharmacology. 2010;130[2]:262-6.
[31] Aktan F, Henness S, Roufogalis BD, Ammit AJ. Gypenosides derived from Gynostemma pentaphyllum suppress NO synthesis in murine macrophages by inhibiting iNOS enzymatic activity and attenuating NF-κB-mediated iNOS protein expression. Nitric oxide. 2003;8[4]:235-42.
[32] Li X-L, Wang Z-H, Zhao Y-X, Luo S-J, Zhang D-W, Xiao S-X, et al. Purification of a polysaccharide from Gynostemma pentaphyllum Makino and its therapeutic advantages for psoriasis. Carbohydrate polymers. 2012;89[4]:1232-7.
[33] Sime S, Reeve VE. Protection from Inflammation, Immunosuppression and Carcinogenesis Induced by UV Radiation in Mice by Topical Pycnogenol®¶. Photochemistry and photobiology. 2004;79[2]:193-8.
[34] Jackson RL, Greiwe JS, Schwen RJ. Ageing skin: oestrogen receptor β agonists offer an approach to change the outcome. Experimental dermatology. 2011;20[11]:879-82.
[35] Nwachukwu JC, Srinivasan S, Bruno NE, Parent AA, Hughes TS, Pollock JA, et al. Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. Elife. 2014;3:e02057.
[36] Khayyal MT, El-Ghazaly MA, Abdallah DM, Okpanyi SN, Kelber O, Weiser D. Mechanisms involved in the anti-inflammatory effect of a standardized willow bark extract. Arzneimittel-Forschung. 2004;55[11]:677-87.
[37] Fasano E, Serini S, Mondella N, Trombino S, Celleno L, Lanza P, et al. Antioxidant and anti-inflammatory effects of selected natural compounds contained in a dietary supplement on two human immortalized keratinocyte lines. BioMed research international. 2014;2014.
[38] Fuller B, Smith D, Howerton A, Kern D. Anti‐inflammatory effects of CoQ10 and colorless carotenoids. Journal of cosmetic dermatology. 2006;5[1]:30-8.
[39] Choi BS, Song HS, Kim HR, Park TW, Kim TD, Cho BJ, et al. Effect of coenzyme Q10 on cutaneous healing in skin-incised mice. Archives of pharmacal research. 2009;32[6]:907-13.
[40] Biro K, ThaÇi D, Ochsendorf FR, Kaufmann R, Boehncke WH. Efficacy of dexpanthenol in skin protection against irritation: a double‐blind, placebo‐controlled study. Contact dermatitis. 2003;49[2]:80-4.
[41] Udompataikul M, Limpa-o-Vart D. Comparative trial of 5% dexpanthenol in water-in-oil formulation with 1% hydrocortisone ointment in the treatment of childhood atopic dermatitis: a pilot study. Journal of drugs in dermatology: JDD. 2012;11[3]:366-74.
[42] Baschong W, Hüglin D, Röding J. D-panthenol loaded nanotopes< TM> providing enhanced anti-inflammatory efficacy: A study on human volunteers. SÖFW-journal. 1999;125[4]:18-20.
[43] Draelos ZD, Ertel K, Berge C, Amburgey M. Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea. CUTIS-NEW YORK-. 2005;76[2]:135.
[44] Navarrete-Solís J, Castanedo-Cázares JP, Torres-Álvarez B, Oros-Ovalle C, Fuentes-Ahumada C, González FJ, et al. A double-blind, randomized clinical trial of niacinamide 4% versus hydroquinone 4% in the treatment of melasma. Dermatology research and practice. 2011;2011.
[45] Jiang Q, Elson-Schwab I, Courtemanche C, Ames BN. γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proceedings of the National Academy of Sciences. 2000;97[21]:11494-9.
[46] Reiter E, Jiang Q, Christen S. Anti-inflammatory properties of α-and γ-tocopherol. Molecular aspects of medicine. 2007;28[5]:668-91.
What is Allantoin and Why is it Essential for DIY Skincare?
Allantoin is a naturally occurring compound found in many plants and mammals, prized in cosmetics for its skin-healing and anti-inflammatory properties. This versatile ingredient is ideal for DIY skincare enthusiasts looking to create effective, multi-functional products.
What are the Key Benefits of Allantoin in Homemade Skincare?
Anti-inflammatory Action: Soothes irritated skin and diminishes redness.
Antimicrobial Properties: Combats nail fungus and various skin infections.
Safe and Versatile: Suitable for a wide range of DIY skincare applications.
How Can You Use Allantoin in Your DIY Skincare Routine?
Incorporate allantoin into your homemade creams, lotions, and serums for enhanced healing, scar prevention, and overall skin health. Its gentle yet effective nature makes it perfect for both preventive care and treating existing skin concerns.
EcoFriendly, sustainable, synthetic Alpha Bisabolol , which offers all the benefits of natural Alpha Bisabolol, is now available.
For thousands of years, chamomile has been a prized component of many ancient therapies. The active ingredient of chamomile, α-bisabolol, is a lightly floral-scented essential oil extracted from the Candeia tree, a tropical relative of cammomile, in modern times. In order to produce 100 tons of α-bisabolol, 850 hectares of timber must be harvested . Due to deforestation amid a global high demand, synthetic sources of α-bisabolol are now available. New generations of the synthetic compound offer 85% α-bisabolol content and all of the benefits of the natural product. Easily absorbed by the skin, α-bisabolol is a potent anti-microbial agent, anti-inflammatory, and potent wound-care agent. It has valuable applications in soaps, lotions, soothing face creams, and wound-healing products
Key benefits of Sustainable Alpha Bisabolol in skin care:
What is Alpha Lipoic Acid (ALA) and Its Role in DIY Skincare?
Alpha-lipoic acid (ALA) is a naturally occurring antioxidant that also shows numerous attractive features for use in cosmetic skin care. It is known as a dietary supplement for a long time, but recent research suggests it may be more effective through other applications, such as skin creams. ALA neutralizes free radicals, thus helping to fight ageing and cancer. It is more effective in combating free radicals than common vitamins, such as vitamin C or E, hence lipoic acid is called the "universal antioxidant". In skin care, ALA was also shown to promote wound healing, treat and prevent diabetic ulcers. Cosmetics research suggests that ALA can promote collagen synthesis, thus reducing the visible effects of ageing on skin, and improving the appearance without any noticeable side effects.
What Are the Key Benefits of Alpha Lipoic Acid in Skin Care?
L-ascorbic acid (vitamin C) is an essential nutrient which has many cosmetic benefits. It is a remarkable antioxidant and can scavenge reactive oxygen species and other free radicals, protecting the skin from oxidative stress. It can stimulate collagen synthesis by promoting cross-linking and stabilizing collagen molecules, upregulating collagen genes, increasing the transcription of the tissue inhibitor of matrix metalloproteinase 1, and inducing fibroblast proliferation. It reduces pigmentation by suppressing tyrosinase, which is important for melanin production. It is an anti-inflammatory agent and can be used to treat inflammatory skin disease such as erythema. Together, L-ascorbic acid provides powerful anti-aging properties and has been shown to reduce wrinkles, improve elasticity, and protect against sun damage. Stability and absorption of L-ascorbic acid is a concern. While the anhydrous L-ascorbic acid might be the most stable form, adding vitamin E not only helps stabilizing L-ascorbic acid, but the two have synergistic effects on anti-aging. Used in: philosopy's turbo booster c powder and SkinCeuticals.
Key benefts of L-ascorbic acid in skin care:
Anti-inflammatory [31]
Antioxidant [4] [5] [6] [7] [8]
Increase skin elasticity [26]
Lightening and brightening [4] [22] [28] [29] [30]
Matrix metalloproteinases (MMP) inhibitors [19]
Moisturizing and hydration [21]
Reduce fine lines and wrinkles [7] [21] [22] [25] [26]
Resin from the Boswella serrata tree found in parts of Asia and Africa is commonly used in traditional Ayurvedic medicine for a variety of disorders associated with inflammation. It has been used medicinally for centuries and is now gaining support through research. The main ingredients of the resin are boswellic acids. Boswellic acids have anti-inflammatory effects when applied topically. Preparations using either the resin or pure boswellic acid extracted from the resin can help treat inflammatory disorders such as osteoarthritis, eczema, and psoriasis. The extract helps reduce sun damage, fine lines, and acne. It stimulates collagen production. Also, it aids in wound healing and inhibits tumor growth. Research shows boswella serrata extract has a variety of useful anti-inflammatory effects and can help alleviate the symptoms of a variety of conditions. This extract has been popularized as Boswelox™ by L’Oreal and its Wrinkle-de-crease.
NOTE: To assist you with solubility issues, we now also sell Boswellia serrata (Boswelic acid) as a liquid standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
16% solution gives 1% Boswelic Acid content in final product.
46% solution gives 3% Boswelic Acid content in final product.
66% solution gives 5% Boswelic Acid content in final product.
Carnosine is a compound from two amino acids, produced naturally in the human brain and muscles. Most likely, it performs a protective function – carnosine neutralizes metal ions and is a powerful antioxidant. It is used in skin care to combat oxidative damage to DNA and proteins, such as that caused by UV exposure. Furthermore, carnosine can protect proteins, primarily collagen, from glycation. These qualities make it a promising molecule in the fight against ageing, as carnosine not only protects cellular components, but can improve the visual appearance, reduce roughness and fine lines. It also maintains the barrier function of the skin, both by simple hydration and complex effects in wound healing. Carnosine applications are of special importance to diabetes patients, as it helps alleviate several complications of this disease, among them xerosis, rapid AGE production, and impaired wound healing.
Centella asiatica is a tropical plant that has been used extensively in Indian medicine. It has diverse applications for skin cosmetics: firstly, it is effective in wound care, as it promotes healing of simple, infected, non-healing, or burn wounds, as well as wounds in patients with diabetes, undergoing radiotherapy or steroid medication. Centella is also used for treating scars and preventing or reducing stretch marks. The extract of this plant promotes synthesis of collagen, hydroxyproline, hyaluronic acid and cell growth factors, thus helping to maintain the elasticity, strength and general appearance of healthy skin. It also protects the skin from ageing damage, such as glycation, and UV damage, likely by activating antioxidant synthesis.
NOTE: To assist you with solubility issues, we now also sell Centella asiatica as a standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
15% solution gives 1% triterpenes content in final product.
43% solution gives 3% triterpenes content in final product.
72% solution gives 5% triterpenes content in final product.
Coenzyme Q10 is a molecule naturally involved in energy metabolism in all human cells. Among its many benefits, the antioxidant properties are the most researched. This molecule can prevent oxidation damage to water-insoluble molecules, DNA mutations, collagen synthesis decrease, pigmentation, inflammation and other adverse effects associated with UV exposure and ageing. In combination with vitamin E or other antioxidants, an exceedingly strong antioxidative effect can be achieved. Furthermore, coenzyme Q10 has a unique capability to protect against infrared A radiation, which is also found in sunlight. The promotion of collagen synthesis makes this coenzyme useful in treating ageing-associated skin changes, such as wrinkle appearance. Finally, its anti-inflammatory effect is beneficial not only for UV-damaged skin, but also for wound healing support.
NOTE: To assist you with solubility issues, we now also sell CoQ10 (Coenzyme Q10) as a liquid standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
Dipotassium glycyrrhizinate is a salt of glycyrrhizic acid that exhibits several properties that make it useful for cosmetic purposes. Glycyrrhizic acid is also known as glycyrrhizinic acid or glycyrrhizin. It is extracted from licorice (Glycyrrhiza glabra). However, due to glycyrrhizic acid being poorly soluble in water, its potassium salt is frequently utilized instead in skin care products. Dipotassium glycyrrhizinate is a substance well known to the medical community because it has been investigated as potential treatment for several disorders. For example, in Japan it is used as treatment for chronic hepatitis due to its potent antiviral effects. Its beneficial properties can also be transferred to skin care because this licorice constituent displays prominent anti-inflammatory, anti-irritant, anti-aging, anti-psoriatic, anti-allergic and immune modulatory effects..
Key benefits of dipotassium glycyrrhizinate in skin care:
Dimethylaminoethanol [DMAE] is structurally similar to choline, an important component of cell membranes. Choline is a precursor to acetylcholine, which stimulates muscle contraction. DMAE is known to have skin tightening effects. In several clinical studies, it successfully reduced wrinkles, improved lip fullness, and tightened neck skin. Overall, DMAE has a skin lifting effect. These studies showed DMAE is safe for extended use and does not irritate skin. Pure DMAE is very basic, which may have negative effects on the skin. Thus DMAE bitratrate, the salt form of DMAE, is used in topical formulations as the pH is close to that of skin. DMAE is the active ingredient in Tricutan ( Dermyn Active Serum). Regretably, due to Candian law and PayPal regulations, this product may NOT be shipped to Canada.
Key benefits of DMAE bitartrate in skin care:
Wrinkle tightener [3] [7] [8] [9]
Anti-inflammatory [3] [6]
Moisturizing and hydration [8]
Antioxidant [3]
Reduce dark circles under eyes [8]
Reduce fine lines and wrinkles [3] [5] [7] [8] [9]
Ginkgo biloba is a unique tree species. Its leaf extract contains a diverse variety of molecules useful in cosmetics and pharmacology. Firstly, they are potent antioxidants, and can even activate the production of enzymes that neutralize free radicals. Combined with the anti-inflammatory effects, this extract provides an effective defense against UV radiation and ageing symptoms. Dermal applications of this extract can even lead to protection of other organs. Another major application of Ginkgo biloba is moisturizing the skin, which helps to increase its elasticity and visual appearance, even reducing the amount of wrinkles. Furthermore, this extract helps to maintain the barrier function of the skin – it reduces water loss through epidermis, thus reducing skin dryness and irritation. In combination with green tea extract, Ginkgo shows even stronger benefits in these areas.
NOTE: To assist you with solubility issues, we now also sell Ginkgo Biloba extract as a standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
N-acetyl glucosamine is a compound with a wealth of uses for improving skin condition. It is a known precursor to hyaluronic acid, a major component of skin structure. Hyaluronic acid is essential for hydration and n-acetyl glucosamine has been shown to increase moisture. N-acetyl glucosamine helps heal wounds, increase collagen, and reduce acne. It reduces hyperpigmentation, especially when combined with niacinamide, a member of the vitamin B3 family. It has anti-oxidant and anti-inflammatory properties which allow it to help heal and prevent sun damage. Overall, this compound can help prevent premature aging and reduce signs of aging, such as wrinkles, especially when combined with niacinamide.
Key benefits of Glucosamine in skin care:
Stimulate HA production [2] [3] [4] [5] [6] [7] [8] [9] 10]
Green tea has numerous benefits in almost all aspects of skin care. The main active ingredient, EGCG, is a potent antioxidant, and protects skin from UV damage. This results in reduced wrinkling, increased collagen content, smoother skin, thicker and more elastic epidermis and other visual benefits. Green tea also helps to moisturize the skin and improves the long-term barrier capabilities. Among the numerous clinical benefits are antibacterial and antifungal effects, which make green tea useful in wound care. Most important health effect is the prevention of melanoma and other types of skin cancer, resulting partly from the EGCG capability to neutralize free radicals and activate DNA repair. Since the extract also reduces inflammation and sebum secretion, it is an effective treatment against acne. Finally, green tea has also been proven to reduce hair loss and follicle death. Active ingredient in Teamine™ and ReVive™ lines.
NOTE:To assist you with solubility issues, we now also sell Green Tea EGCG in a standardized, pre-dissolved solution. Just add the liquid to your cream and mix well.
11% solution gives 1% EGCG content in final product.
33% solution gives 3% EGCG content in final product.
54% solution gives 5% EGCG content in final product.
Hesperidin is a a plant flavonoid, found naturally in citrus fruits. It has numerous biological benefits, but it is poorly absorbed and transported in the body, hence a modified version, hesperidin methyl chalcone (HMC), is used in cosmetics. The best known effect of HMC is reduction of capillary permeability. This can be used to reduce dark circles and bags under the eyes or even treat varicose veins. It is also known to reduce melanin synthesis, thus lightening the skin, and it also protects skin from UV-caused damage and cell ageing. Furthermore, HMC restores the barrier function of the skin, improving hydration, regulating pH and promoting skin cell proliferation. Finally, it has an anti-inflammatory effect, and can even be used to reduce various types of pain caused by inflammation.
NOTE: To assist you with solubility issues, we now also sell Hesperidin methyl chalcone as a liquid standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
11% solution gives 1% Hesperidin content in final product.
31% solution gives 3% Hesperidin content in final product.
51% solution gives 5% Hesperidin content in final product.
Key benefits of Hesperidin methyl chalcone in skin care:
Niacinamide, also known as nicotinamide, is a water soluble form of vitamin B3. Vitamin B3 is essential for maintaining skin health. Niacinamide increases production of important skin structural components such as collagen, ceramide, and keratin. This helps increase moisture and strengthen skin. Niacinamide is known to decrease hyperpigmentation, effectively lightening and brightening skin, especially when used together with n-acetyl glucosamine, a hyaluronic acid precursor. It reduces wrinkles and again, this effect is better with n-acetyl glucosamine. Niacinamide also effectively helps reduce acne and heal wounds. It has anti-oxidant and anti-inflammatory properties. Overall, niacinamide is a compound with many different uses that can increase overall skin health.
Oat Beta Glucan (β-glucans) are polysaccharides composed of glucose molecules in long linear polymers and they are naturally present in fungi, plants, algae and bacteria. Glucans interact with immune cells and have immunopharmacological properties. The results of studies showed that beta-glucan, despite its large molecular size may be capable of penetrating deep into the skin and delivering significant benefits for the skin. After the entery to skin, oat beta-glucan forms a thin film above the stratum corneum and epidermis and promotes sustained moisturization properties together with an improved, smoother appearance of the skin. Interaction between glucan and glucan receptors triggers reactions with fibroblasts that stimulate collagen synthesis. As a result of promoted collagen synthesis, elasticity of the skin is enhanced, wrinkle is reduced, with significant reduction of wrinkle depth and height, and overall roughness, aging process is largely delayed, and the negative effect of radiation is minimized. Glucan added to sunscreens helps in preservation of Langerhans cells so it can be use as an excellent photoprotective agent. It has been reported that topical glucans administration can suport wound healing and be useful for scar care by stimulating tissue granulation, collagen deposition, and re-epithelialization. Oat beta glucan also has anti-inflammatory antioxidant and free radicals scavenging capabilities.
Key benefits of Oat Beta Glucan (Beta 1-3, 1-4) in skin care:
Phytosterols are a family of plant-produced molecules with diverse health benefits. In cosmetics, the ability to stimulate collagen production is most interesting. Together with antioxidant activity and down-regulation of collagen degrading enzymes, these abilities help repair damage in photoaged skin. Phytosterols also have anti-inflammatory properties, which are useful in UV protection, dermatitis treatment, and even cancer prevention. They are widely used in burn wound care – phytosterols were found to improve healing, improve scar appearance and possess analgesic properties, reducing the need of opiate drugs. Antimicrobial activity of phytosterols is also important in skin care, as it can be utilized in both wound care and general fight against infections, such as Candida. Finally, phytosterols regulate transport of cholesterol and thus sebum production – this may present a good treatment option for acne and other sebum-related conditions.
NOTE:To assist you with solubility issues, we now also sell Phytosterol in a standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
11% solution gives 1% Phytosterols content in final product.
32% solution gives 3% Phytosterols content in final product.
53% solution gives 5% Phytosterols content in final product.
Resveratrol is a compound found in grapes and many other plants. It is currently investigated in many skincare applications. Resveratrol protects cells from oxidative stress – it is an antioxidant itself, and activates the synthesis of other such compounds. It also regulates inflammatory responses and even aids the distribution of cosmetical sunscreens, thus helping to prevent UV damage to the skin. Similarities in structure allow resveratrol to replace estrogen in post-menopausal women, helping to reduce collagen loss and reduce skin ageing symptoms. Additionally, it counters photoageing by inhibiting melanin synthesis, resulting in lighter skin and less pigmented spots. Even acne can be alleviated by applying resveratrol, as it has antibacterial properties and controls sebaceous cell growth. Finally, it is a promising agent in melanoma prevention, able to delay the emergence and reduce the size of skin tumors.
NOTE:To assist you with solubility issues, we now also sell Resveratrol in a standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
Salicylic acid is a hydroxyl acid compound originally derived from willow tree bark. It has many useful effects on skin, the most prominent being its use as an anti-acne treatment. It penetrates deep into pores, removing trapped oil that can cause blemishes. Salicylic acid is a keratolytic compound, meaning it exfoliates the skin and sloughs off dead skin cells, leaving smooth skin. This makes it useful for treating scaly skin, as well as calluses and warts. It also has anti-inflammatory and anti-bacterial properties. Salicylic acid has been shown to influence photodamage by reducing hyperpigmentation and providing protection against UV exposure.
NEW: We are excited to announce that we now also sell a WATER-SOLUBLE salicylic acid powder (assay 50%)!
Build effective Salicylic Acid formulations free from alcohol, discoloration, and recrystallization. WATER SOLUBLE salicylic acid increases water solubility of Salicylic Acid from 0.2% to 5%, and results in a pH of about 4. No need for organic solvents.
For higher strength formulations we also have Salicylic Acid (Beta Hydroxy Acid) as a pre-dissolved solution. Just add the liquid to your cream and mix well.
6.7% solution gives 1% Salicylic acid content in final product.
13.3% solution gives 2% Salicylic acid content in final product.
20% solution gives 3% Salicylic acid content in final product.
26.7% solution gives 4% Salicylic acid content in final product.
33.3% solution gives 5% Salicylic acid content in final product.
Sclerotium gum is an active ingredient obtained through fermentation from hardened fungal masses of various types of fungi. The most common source is a parasitic fungus named Sclerotium rolfsii. Due to its efficiency as a thickening agent, emulsifier and stabilizer, sclerotium gum is used in numerous applications in the industrial, food and pharmaceutical fields. Recent research showed that sclerotium gum is a compound perfectly suitable for topical delivery of pharmaceuticals and natural active ingredients. Besides providing the right viscosity and stability of the topical preparation, the gum also has multiple benefits for the skin. Sclerotium gum is high in polysaccharides, especially beta glucans, namely scleroglucan, and has multiple benefits for the skin: it protects the lipid barrier, prevents water loss, increases moisturization, protects and repair damaged skin, enhances the local immune response and increases collagen production and deposits.
Key benefits of Sclerotium Gum in skin care:
moisturizing and hydration [9][12][13]
anti-inflammatory [6] [10]
wound healing support [6] [10]
sun damage protection [10]
sun damage repair [10]
stimulate collagen production[11]
Anti-bacterial [11]
Antioxidant [10]
Restore barrier function [9][12][13]
Emulsion stabilizer
Improves flow of emulsions
Wide pH tolerance :: 5 to 12
Offers a nice feel to products
Viscosity not affected by high heat
Stable in extreme physical and chemical conditions
Creates smooth flowing gels / serums
Improves natural moisture levels in skin and hair
Gels the water phase for enhanced viscosity without stiffness
Sea Kelp bioFerment (also know as seakelp ferment) is a natural kelp extract that is obtained using traditional fermentation technology. Our Sea Kelp Bioferment can be used as a great nutritional active or as a skin care base for our other active ingredients. It is a perfect base for users with oily skin types as it moisturizes without supplying extra oil. It is also very effective for normal and dry skin, as it is a powerful nutritive moisturizer. From creams to serums to washes, it is the perfect active for almost any purpose.NEW Green Preservative formulation: Paraben AND Phenoxyethanol free. Now enriched with extra fucoxanthin and fucoidans
Natural Vitamin E Mixed Tocopherols is an active blend of natural mixed tocopherols containing naturally occurring d-alpha, d-beta, d-gamma and d-delta tocopherols. These are NATURAL tocopherols, they are NOT the synthetic, racemix dl-tocopherol or dl-tocopheryl acetate.
Tocopherol is the most commonly used form of vitamin E in cosmetic products. α-tocopherol, one of four types of tocopherol, is the most abundant form of vitamin E naturally found in the skin. α and γ forms are excreted in sebum [oil] and act as a barrier for the skin. The amount of tocopherol in the skin decreases over time due to sun exposure. Tocopherols are strong anti-oxidants. Anti-oxidants help protect against skin aging. Tocopherols use their anti-oxidant ability to protect against sun damage and repair sun damage. They increase collagen production and protect existing collagen by inhibiting matrix metalloproteinase [MMP] that degrades collagen. Mixed tocopherols have anti-inflammatory properties and accelerate wound healing.
Key benefits of Vitamin E Mixed Tocopherols in skin care:
Tocotrienol, a form of vitamin E, is known to be a natural powerful antioxidant that is quickly absorbed into the skin. It reduces damage involved with skin aging that is caused by harmful free radicals from UV light and ozone. Symptoms of skin aging include wrinkles, dryness, hyperpigmentation, and loss of elasticity. Tocotrienol increases collagen synthesis, which improves skin elasticity. It can also “unclog” skin burdened by excessive cholesterol. Toctrienol has anti-inflammatory properties and is able to reduce symptoms of allergic skin reactions. It can also help reduce the drying side effects of acne regimens such as benzoyl peroxide.
Natural Vitamin E Mixed Tocotrienols is an active blend of natural alpha tocopherol and alpha tocotrienol, beta tocotrienol, delta tocotrienol, and gamma tocotrienol.These are NATURAL tocotrienols, they are NOT synthetic.
Key Benefits of Vitamin E mixed Tocotrienols in skin care:
White willow bark extract has been used by many cultures to reduce pain and inflammation. It contains salicin, a natural form of salicylic acid known to have anti-inflammatory effects. Salicin can reduce signs of aging by reducing the appearance of pores, wrinkles, and pigmentation. It also softens and moisturizes the skin. Salicin contributes to white willow bark extract’s exfoliating and acne-reducing power. White willow bark extract also contains polyphenols that contribute anti-oxidant and anti-inflammatory effects. These can help protect against sun damage and premature aging when used with sunscreen. White willow bark extract is a natural alternative to salicylic acid that has additional properties to enhance skin health.
NOTE: To assist you with solubility issues, we now also sell White Willow bark extract as a standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
Key benefits of White Willow bark (salicin) in skin care:
In order for skin to be healthy we need a well maintained stratum corneum. A healthy stratum corneum offers protection against environmental stress and water loss. BulkActives’ multi lamellar cream imitates the skin’s own lipid structure and enhance the skin's natural barrier function.
BulkActives’ multi lamellar cream is formulated with a new generation, European, sugar based, liquid crystals emulsifying system based on sorbitan stearate with sucrose cocoate. It is formulated specifically for DIY Skin care customers. BulkActives’ multi lamellar cream can be used as is. However, it can easily accept both water, oil, and water soluble and oil soluble powders and liquids. BulkActives’ multi lamellar cream is a great carrier for active skin care ingredients. The multi lamellar structure is ideal for even and effective delivery of skin actives into the skin.
BulkActives’ multi lamellar cream is exclusively and professionally formulated, manufactured and packaged for us by the same biochemist who manufactures our seakelp bioferment, pumpkin bioferment, and lemon bioferment.
NOTE: Based on customer feedback we have reformulated our multi lamellar cream, making it "greener' and even more elegant! In this NEW formulation we have also replaced the xantham gum with Sclerotium Gum, the preservative system combines the extremely safe, yet effective, Sodium Levulinate and Sodium Anisate, with Potassium sorbate and citric acid. This means our cream now does NOT contain parabens or phenoxyethanol.
Multi Lamellar Base Cream with SeaKelp Bioferment and Sclerotium Gum (No Oil and No Polymer):
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
DISCLAIMER
We do NOT sell ready-made skin care products!
All our products are powders, liquids, flakes or gels, used for making your own skin care products.
All our products are cosmetic / technical grade only.
We do NOT sell pharmaceuticals, prescription drugs or nutritional supplements.
Any statements about our products have not been evaluated by the FDA.
Our active skin care ingredients are not intended to diagnose, treat, cure, or prevent any disease
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Delivery
BulkActives is a part-time business. Orders are processed and mailed on Saturdays.
Canadian Customers:
Any long delivery delays are caused by The Canada Border Services Agency.
I now ONLY offer EMS as a shipping option to Canada.
This appears to have resolved most of the delays caused by The Canada Border Services Agency.