Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
I am following the moisturizing cream + Zinc dispersion recipe and I am extremely satisfied. I do allow for a little time for it to absorb in & then I dab off anything that I feel looks a little white - but that's because I initially use a fairly thick coating on myself. I use a bit of foundation at times on top and there are no issues as far as weird colors or texture issues. I am so grateful for this entire website as a one-stop-shop for such effective skin care products, and now we can.. ...»
I purposely waited a few months before writing my review. I am happy to report this product is great! I combined the DMAE product with the base creams resulting in tighter skin and lessened wrinkles, including areas around underarms... ...»
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D panthenol (Dexpanthenol) is the stable alcohol form of pantothenic acid (vitamin B5). D panthenol is well absorbed through the skin where it is rapidly converted enzymatically to pantothenic acid, a component of coenzyme A (CoA), which is important in cellular skin metabolism. Application of D panthenol is commonly used in wound management because it stimulates skin regeneration via fibroblasts proliferation and promotes wound healing. Many clinical in vivo studies provide experimental evidence of the beneficial effects of topically applied D panthenol. Studies have proved that topical usage of D panthenol enhances skin barrier repair and reduces TEWL thus being an effective moisturizer. Last but not least, the anti-inflammatory properties of D panthenol make it effective in treating various dermatologic diseases or as an adjuvant in cosmetic therapies. D panthenol has zero toxicity and it is well tolerated both topically and orally thus appropriate for human consumption and use.
D panthenol (Dexpanthenol), also known as provitamin B5, is the stable alcohol form of pantothenic acid which is a key player in maintenance of epithelial function and skin regrowth, being a normal constituent of skin and hair.D panthenol is not found naturally, thus synthetic dexpanthenol is converted to pantothenic acid in the skin, stimulating skin regeneration in a manner comparable to vitamin A. This process of cell division and formation of new skin tissue restores skin elasticity and promotes wound healing .
Due to its anti-inflammatory properties and its solubility dexpanthenol is used in the treatment of various conditions such as: acnea vulgaris, alopecia, lupus, wound healing, with extrapolated research to other epithelial diseases such as celiac disease and other digestive tract conditions. D panthenol has very low toxicity and inexistent adverse reactions, making it suitable for human consumption and use 
D panthenol is water soluble and hydroscopic and has skin moisturization potential, especially when combined with the widely used moisturizing agent glycerol . D panthenol based formulations increased skin moisture in stratum corneum and had a significant effect on skin barrier function by decreasing TEWL (Transepidermal Water Loss) values and improving the skin barrier function in addition  Studies emphhasised that treatment with a dexpanthenol-containing cream significantly enhances skin barrier repair and stratum corneum hydration, while reducing skin roughness and inflammation.  .
D panthenol is responsible for in vitro and in vivo activation of fibroblast proliferation, which is of relevance in wound healing. Accelerated re-epithelization in wound healing, monitored by means of the transepidermal water loss as an indicator of the intact epidermal barrier function, has also been seen . In vivo wound–healing studies revealed considerable effects of dexpanthenol on gene regulation in comparison to placebo treatment in all samples. An upregulation of 95 genes could be detected after D panthenol treatment .
D panthenol exhibits protective effects against skin irritation with applications in contact dermatitis, a condition affecting a large pool of individuals both in domestic and professional situations. D panthenol exhibits protective effects against skin irritation, both in vitro and in vivo situations . Another application of D panthenol is the treatment of atopic dermatitis (AD), a common chronic relapsing disease particularly affecting children. The emollient used for protection of skin barrier function is the standard treatment for patients with AD. The topical treatment with D panthenol ointment is as effective as hydrocortisone, with no statistical difference between them. Concluding, dexpanthenol ointment may be used as alternative treatment in mild to moderate childhood AD therapy avoiding long term side effects of hydrocortisone . D panthenol is also involved in the process of reducing UV induced erythema. The efficacy of the active was assessed by colorimetry via the reduction of redness and by measuring the change in microcirculation by laser Doppler  .
Dexpanthenol has been shown to reduce acnea vulgaris and its effect. Under topical treatment the face became noticeably less oily and a decrease in facial sebum secretion occurred, facial pore size had become noticeably smaller, existing acne lesions had begun to heal, and the rate of new acne eruptions had slowed, finally getting the disease under control. It was shown that the gravity of the acne needs to be approached with proportional higher dexpanthenol dosage . D panthenol is also an adjuvant in healing post acne-treatment scars and inflammation. Dexpanthenol cream signifcantly improves mucocutaneous side effects associated with isotretinoin therapy 
The latest tendencies are to use the moisturizing and anti-inflammatory properties of dexpanthenol as adjuvant in cosmetic procedures. D panthenol based ointments were successfully used in reducing effects of chemical peeling and laser rejuvenation therapies .
Assay: 99% CAS#: 81-13-0 INCI: Panthenol Synonyms: D-Panthenol, dexpanthenol, D-pantothenyl alcohol, provitamin B5 Appearance: Pure D-Panthenol USP is a colourless, clear, highly viscous, hygroscopic liquid Solubility: D-Panthenol is readily miscible with water, ethanol, methanol and propylene glycol. Suggested percentage: 1 to 5% (too much will make your skin care product sticky) Stability: D-Panthenol is stable to air and light but not heat, If it is stored at around 20° C in the unopened, original containers, it has a shelf life of at least 12 months. In weakly acidic, aqueous solutions, D-Panthenol is considerably more stable than the salts of pantothenic acid. Storage: Store in cool and dry place in closed container. Keep away from direct strong light and heat. can solidify on prolonged storage. Manfacturer: BASF (Germany)
 L. Baumann, “Cosmeceutical Critique Compendium”, Skin and allergy news, 2006
 G.S. Kelly, “Pantothenic Acid”, Alternative Medicine Review, 16, pp 263-274, 2001
 D.L. Bissett, “Common cosmeceuticals”, Clinics in Dermatology, 27, pp 435–445, 2009
 F .B. Camargo, Jr., L.R. Gaspar, P.B.G. Maia Campos, “Skin moisturizing effects of panthenol-based formulations”, Journal of Cosmetic Science, no 62, pp 361–369, 2011
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 M. Udompataikul, D. Limpa-o-Vart, “Comparative trial of 5% dexpanthenol in water-in-oil formulation with 1% hydrocortisone ointment in the treatment of childhood atopic dermatitis: a pilot study”, Journal of Drugs in Dermatology”, 11, pp 366-374, 2012
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 H.D.Tauschel,C.Rudolph, “Untersuchungen zur perkutanen Wirksamkeit einer Heparin-Allantoin-Dexpanthenol-Kombination in spezieller Salbengrundlage: Antiinflammatorische Wirkung auf UV-Erytheme am Meerschweinchen”, Arzneimittel Forschung, 32, pp. 1096-1100, 1982
 H.L. Leung,“Pantothenic acid defciency as the pathogenesis of acne vulgaris”, Med Hypotheses, 44:490-492. 1995
 R. Romiti, N.Romiti, “Dexpanthenol cream signi!cantly improves mucocutaneous side effects associated with isotretinoin therapy”, Pediatric Dermatology, 19:368, 2002
 N.V. Gaidash, E.A. Karassyov, V.V. Mordortseva, “Personal experience in the use of dexpanthol for skin care after chemical peeling and photo-rejuvenation procedures”, Journal of Applied Cosmetology, 27, pp 111-115, 2009
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
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