Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Reviews
Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
Angela
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
Jessie Sandford
Very good product! Only been using it for a short time, its already made a difference. .. ...»
Bronwynne
muy satisfecho profesionales, y envio sin problemas ,ya que soy de españa producto bien envasado , un placer ser cliente porque dan comnfianza y calidad.gracias un saludo.. ...»
daniel
Wanting to try this, but.... Angela, what was that about effecting hormones? Could someone explain please..... ...»
Carla
I am following the moisturizing cream + Zinc dispersion recipe and I am extremely satisfied. I do allow for a little time for it to absorb in & then I dab off anything that I feel looks a little white - but that's because I initially use a fairly thick coating on myself. I use a bit of foundation at times on top and there are no issues as far as weird colors or texture issues. I am so grateful for this entire website as a one-stop-shop for such effective skin care products, and now we can.. ...»
Peggy
Excellent quality, very fine texture and disperses easily when used correctly. Arrived in just seven days to London, England and with a reasonable postage fee. Very pleased... ...»
D N Bay
I just placed my first order for SEaKelp Bioferment from Bulk Actives and was pleased to receive it very quickly.. ...»
Viki
I purposely waited a few months before writing my review. I am happy to report this product is great! I combined the DMAE product with the base creams resulting in tighter skin and lessened wrinkles, including areas around underarms... ...»
cjmluv
Very good product. It performed exactly how I expected. .. ...»
Ryan
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Buy Dipotassium Glycyrrhizinate (White Licorice) For Skin Care

Dipotassium glycyrrhizinate is a salt of glycyrrhizic acid that exhibits several properties that make it useful for cosmetic purposes. Glycyrrhizic acid is also known as glycyrrhizinic acid or glycyrrhizin. It is extracted from licorice (Glycyrrhiza glabra). However, due to glycyrrhizic acid being poorly soluble in water, its potassium salt is frequently utilized instead in skin care products. Dipotassium glycyrrhizinate is a substance well known to the medical community because it has been investigated as potential treatment for several disorders. For example, in Japan it is used as treatment for chronic hepatitis due to its potent antiviral effects. Its beneficial properties can also be transferred to skin care because this licorice constituent displays prominent anti-inflammatory, anti-irritant, anti-aging, anti-psoriatic, anti-allergic and immune modulatory effects..

Key benefits of dipotassium glycyrrhizinate in skin care:

  • anti-inflammatory [3] [4] [6] [8] [9] [10]
  • antioxidant [7] [9]
Dipotassium Glycyrrhizinate (White Licorice) skin care active ingredients
Product Code: BulkActives
Reward Points: 11
Assay: Dipotassium Glycyrrhizinate 98%
CAS#: 68797-35-3
Net weight: 30g /1.06oz
Availability: In Stock
Price: $22.70
Reward Points: 1135


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Dipotassium Glycyrrhizinate (White Licorice)

About Dipotassium Glycyrrhizinate (White Licorice) in DIY Skin Care

Licorice skin careSkin aging can be caused by several factors, including the negative influence of free radicals, trans-epidermal water loss and diminished collagen replacement, among others. Glycyrrhizin exerts anti-aging effects by affecting some of these physiological changes that take place in the human skin, including potent anti-oxidant properties [1],[7],[9]. Dipotassium glycyrrhizinate can be safely incorporated into various cosmetic products because it exhibits no toxicity, as concluded by experts who evaluated various glycyrrhizic acid derivatives [2].

Glycyrrhizin possesses anti-inflammatory properties due to its ability to slow down the metabolism of cortisol, which is a hormone that is implicated in the stress response, but also in the regulation of immune processes [3],[4]. Inflammation is caused by the release of several bioactive molecules, such as prostaglandins and leukotrienes. These pro-inflammatory molecules produce dilation of blood vessels and function as a signal for immune cells to concentrate in the specific area of the body where damage to the tissues, abnormal bacterial proliferation (infection) or irritation have occurred. Signs of skin inflammation (found in dermatitis) may include redness, swelling, itching, “burning” and even pain. Cortisol diminishes the immune response and thus contributes to inflammation resolution.

Dipotassium glycyrrhizinate exerts its anti-inflammatory effects by inhibiting the metabolism of cortisol, which leads to a prolonged half-life and remission of the immune response. Glycyrrhizin also has the ability to decrease the production of prostaglandin E2, which also facilitates the reduction of skin inflammation [6]. This compound (alone or in the form of licorice extract) is widely used in the treatment of atopic dermatitis as a potent anti-inflammatory agent [8], [9], [10].

Glycyrrhizin is currently investigated in clinical studies as a potential treatment for psoriasis [11]. An allergic reaction is accompanied by histamine release from mast cells (also known as degranulation), which causes skin allergy symptoms such as inflammation, itching or skin rash. Glycyrrhizin and its derivatives can ameliorate allergies by inhibiting the degranulation of mast cells, which limits the amount of histamine released into the bloodstream, and by improving the local immune response to an allergen, resulting in a faster resolution of symptoms [5],[7].

Glycyrrhizinic acid is soluble in ethanol only, whereas Dipotassium Glycyrrhizinate is water soluble, thus making it easier and less irritating to use.

Assay: 98%
CAS #: 68797-35-3
INCI: Dipotassium Glycyrrhizinate
Botanical source: glycyrrhiza glabra
Part used: root
Appearance: white powder
Solubility: water
Suggested percentage: No data available - up to customer's discretion.

Storage: Store in cool and dry place. Keep away from direct strong light and heat.
Country of origin: China
[1] Potential Role of Natural Compounds against Skin Aging. Tundis R, Loizzo MR, Bonesi M, Menichini F (2015)
 [2] Cosmetic Ingredient Review Expert Panel (2007).Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate .
 [3] Soma R, Ikeda M, Morise T, Miyamori I, Takeda R (1994) Effect of glycyrrhizin on cortisol metabolism in humans.
[4] Ojima M, Satoh K, Gomibuchi T, Itoh N, Kin S, Fukuchi S, Miyachi Y (1990). The inhibitory effects of glycyrrhizin and glycyrrhetinic acid on the metabolism of cortisol and prednisolone
[5] Imanishi N, Kawai H, Hayashi Y, Yatsunami K, Ichikawa A (1989). Effects of glycyrrhizin and glycyrrhetinic acid on dexamethasone-induced changes in histamine synthesis of mouse mastocytoma P-815 cells and in histamine release from rat peritoneal mast cells
[6] Glycyrrhizin inhibits prostaglandin E2 production by activated peritoneal macrophages from rats
Ohuchi K, Kamada Y, Levine L, Tsurufuji S (1981)
[7] Xiao-Lan Li, Ai-Guo Zhou, Li Zhang, and Wei-Jun Chen (2011). Antioxidant Status and Immune Activity of Glycyrrhizin in Allergic Rhinitis Mice
[8] M Trotta, E Peira, F Debernardi, M Gallarate (2002). Elastic liposomes for skin delivery of dipotassium glycyrrhizinate
[9]  Marjan Nassiri Asl and Hossein Hosseinzadeh (2008). Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds
[10] M Saeedi, K Morteza‐Semnani, and M‐R Ghoreishi (2003). The treatment of atopic dermatitis with licorice gel
[11] Xiong H, Xu Y, Tan G, Han Y, Tang Z, Xu W, Zeng F, Guo Q (2015). Glycyrrhizin Ameliorates Imiquimod-Induced Psoriasis-like Skin Lesions in BALB/c Mice and Inhibits TNF-α-Induced ICAM-1 Expression via NF-κB/MAPK in HaCaT Cells
 

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