Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
I am following the moisturizing cream + Zinc dispersion recipe and I am extremely satisfied. I do allow for a little time for it to absorb in & then I dab off anything that I feel looks a little white - but that's because I initially use a fairly thick coating on myself. I use a bit of foundation at times on top and there are no issues as far as weird colors or texture issues. I am so grateful for this entire website as a one-stop-shop for such effective skin care products, and now we can.. ...»
I purposely waited a few months before writing my review. I am happy to report this product is great! I combined the DMAE product with the base creams resulting in tighter skin and lessened wrinkles, including areas around underarms... ...»
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Dimethylaminoethanol [DMAE] is structurally similar to choline, an important component of cell membranes. Choline is a precursor to acetylcholine, which stimulates muscle contraction. DMAE is known to have skin tightening effects. In several clinical studies, it successfully reduced wrinkles, improved lip fullness, and tightened neck skin. Overall, DMAE has a skin lifting effect. These studies showed DMAE is safe for extended use and does not irritate skin. Pure DMAE is very basic, which may have negative effects on the skin. Thus DMAE bitratrate, the salt form of DMAE, is used in topical formulations as the pH is close to that of skin. DMAE is the active ingredient in Tricutan ( Dermyn Active Serum). Regretably, due to Candian law and PayPal regulations, this product may NOT be shipped to Canada.
Key benefits of DMAE bitartrate in skin care:
Wrinkle tightener    
Anti-inflammatory  
Moisturizing and hydration 
Reduce dark circles under eyes 
Reduce fine lines and wrinkles     
Product Code: BulkActives Reward Points: 3 Assay:
DMAE 37% CAS#:
5988-51-2 Net weight:
30g /1.06oz Availability: In Stock
2-Dimethylaminoethanol [DMAE] is a compound structurally similar to choline, a precursor to acetylcholine . DMAE can be methylated to form choline. Acetylcholine is mainly thought of as a neurotransmitter, but there is non-neuronal free acetylcholine present in skin. It is thought to have actions separate from its neuronal activity. Acetylcholine regulates basic cellular functions such as proliferation, differentiation, and locomotion . Additionally, choline is an important molecule in phospholipids, which make up cell membranes . Compromised cell membranes can be a sign of aging. DMAE is found naturally in fish such as salmon, but it is also present in small amounts in the human brain . It was originally supplemented orally to treat central nervous system disorders, but it essentially hardened areas of the brain, so focus shifted toward DMAE’s topical applications .
DMAE is a powerful anti-aging active ingredient. In a clinical study, skin treated with a 3% DMAE gel showed greater tensile strength . This is good for sagging, aged skin. In another clinical study, a 9% DMAE topical formulation increased collagen fiber thickness and dermal [deep skin layer] thickness . Dermal thickness decreases with aging, about 6% each decade. It also increased skin hydration and reduced wrinkles, under-eye dark circles, and overall had a “lifting” effect . This group reported no adverse effects of using topical DMAE over the course of a year. 3% DMAE is considered safe and effective at reducing wrinkles and improving lip shape and fullness and tightening neck skin . Also, topical application of DMAE does not irritate the skin. The effects of DMAE lasted at least two weeks. In another study, a formulation containing DMAE increased firmness in photoaged skin, skin with chronic damage due to sun exposure .
The mechanism of DMAE is currently unknown, although there are many possible theories. One is that DMAE increases the amount of acetylcholine deep in the skin, stimulating the muscles of the face. DMAE’s “lifting” effect is often attributed to its effects on the facial musculature. Other studies show DMAE is unable to increase levels of acetylcholine . Other theories are that DMAE has anti-inflammatory actions [3, 6] and that it increases collagen production . DMAE has also been shown to have free radical scavenging activity . Free radicals cause skin damage and promote premature skin aging. DMAE also helps decrease protein crosslinking, a characteristic of aging . Protein crosslinking can reduce the activity of proteins, which are essential for bodily functions.
Pure DMAE is extremely basic, meaning it has a pH well above 7, the approximate pH of skin. This makes pure DMAE unsatisfactory for skin care use. An in vitro [outside the body] study using fibroblasts [collagen-producing cells] shows pure DMAE reduces cell proliferation with increasing concentrations [2.5-10%] . This is likely because the basic pure DMAE caused a rapid change in pH that negatively affected the cells. Pure DMAE has also been shown to increase swelling indicative of vacuolization, a negative skin response, when applied to rabbit ears . Therefore, the salt form of DMAE, DMAE bitartrate is commonly used. In a comparison between pure DMAE and DMAE bitartrate, both showed stable behavior and had the same storage characteristics . DMAE bitartrate has a neutral pH of 7 compatible with skin.
"It has been demonstrated that DMAE causes some degree of skin tightening. However, despite speculation it remains unclear how DMAE firms the skin -- whether by stabilizing the membranes, boosting acetylcholine, reducing lipofuscin deposits or none of the above. Whatever the mechanism, the effect of DMAE is often noticeable although seldom dramatic.
Besides, even though DMAE can't fully reverse the existing facial sag, it may reduce its further progression. Some people report a cumulative effect with continued use of DMAE." Dr. G. Todorov. Will DMAE lift your face, or just your wallet?, Smartskincare.com.
DMAE is the active ingredient in Tricutan.
Scientists investigate anti-ageing attributes of Tricutan
"Swedish scientists say that dermatological research they have carried out on the anti-ageing ingredient Tricutan confirms that it can improve skin firmness and elasticity" 
Tricutan is the 'secret sauce' in Dermyn Active Serum
DMAE is VERY water soluble,
It is easy to DIY your own Dermyn! Just click on the FORMULATIONS/RECIPES tab!
Ingredients in Dermyn
Dimethyl Monoaminoethanol Bitartrate (DMAE)
Dimethyl Monoaminoethanol Bitartrate (DMAE)
PEG-16 Macadamia Glycerides
Ammonium Acryloyldimethyltaurate/VP Copolymer
Multi Lamellar Cream
Centella asiatica extract
Centella asiatica extract
Assay: DMAE 37%
A note about DMAE Anime: 'Pure' DMAE (amine ) is extremely alkaline and not suitable for DIY. Even if you have the anime form, it will still need to be neutralized to make it suitable for use on the skin. DMAE bitartrate, is already neutralized with tartaric acid. CAS#: 5988-51-2 Chemical name: 2-Dimethylaminoethanol (+)-bitartrate salt INCI: Dimethylaminoethanol Natural (Bitartrate) Appearance: white powder Solubility: water Suggested percentage: 3% to 5% (13.5% DMAE bitartrate to make a 5% DMAE product)
Storage: Cool, dry place. Do not freeze. Country of origin: China
 B. Clares, M.A. Ruiz, M.E. Morales, J.A. Tamayo, and V. Gallardo Lara, “Structural characterization and stability of dimethylaminoethanol and dimethylaminoethanol bitartrate for possible use in cosmetic firming,” J. Cosmet. Sci., vol. 61, 269–278, July 2010.
 A. Gragnani, F.B. Giannoccaro, C.S. Sobral, J.P. Franca, and L.M. Ferreira, “Dimethylaminoethanol Affects the Viability of Human Cultured Fibroblasts,” Aesth. Plast. Surg., vol. 31, pp. 711-718, 2007.
 R. Grossman, “The role of dimethylaminoethanol in clinical dermatology,” Am. J. Clin. Dermatol., vol. 6, issue 1, pp. 39-47, 2005.
 K.E. Haenke, “Dimethylethanolamine [DMAE] and Selected Salts and Esters: Review of Toxicological Literature,” pp. 1-131, November 2002.
 5. G. Morissette, L. Germain, and F. Marceau, “The antiwrinkle effect of topical concentrated 2- dimethylaminoethanol involves a vacuolar cytopathology,” Br. J. Dermatol., vol. 156, issue 3, pp. 433-439, March 2007.
 P.S. Prestes, R.B. Rigon, G.N. Guimaraes, M.L. Ozores Polacow, M.S. Mariani Pires-de- Campose, M. Chorilli, and G.R. Leonardi, “Development, physical-chemical stability and rheological behavior of silicones formulations containing Dimethylaminoethanol [DMAE],” Journal of Applied Pharmaceutical Science, vol. 3, no. 02, pp. 001-005, February 2013.
 B. Sommerfeld, “Randomised, placebo-controlled, double-blind, split-face study on the clinical efficacy of Tricutan on skin firmness,” Phytomedicine, vol 14, issue 11, pp. 711-715, November 2007.
 K.A. Tadini and M. Campos, “In vivo skin effects of dimethylaminoethanol [DMAE] based formulation,” Pharmazie, vol. 64, pp. 818-822, 2009.
 I. Uhoda, N. Faska, C. Robert, G. Cauwenbergh, and G.E. Pierard, “Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol [deanol] gel,” Skin Research and Technology, vol. 8, pp. 164-167, 2002.
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
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