Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
This is the best product I have ever used on my skin and I tried a LOT of expansive brands. It helps with redness and overall skin tone. Please do not ever stop making this stuff... ...»
Just recently ordered this and LOVE! Green Tea EGCG truly is one of the most fantastic skincare actives out there. Very difficult to find good quality product (90%) and even harder to actually solubilize it! Love that it comes in pre-dissolved solution. I enjoy adding it at 1% (so 11% sol) to my serum formulations containing Niacinamide 5% + NAG 3%. Excellent for oily acne prone skin.
*Only gripe... because the Pre-Dissolved Solution is SO heavy in propanediol (10 parts Propanediol for 1 part E.. ...»
This ingredient has done more for my skin than anything else I've ever used.
I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic.
I will use this forever, no question... ...»
I've been using Bulkactives green tea EGCG for four years. No complaints, it blends nicely my DIY anti-aging cream. I can feel a bit of toning and definitely notice the anti-inflammatory effects on my skin. Two observations that keep the rating 4 stars instead of 5: (1) A package of green tea contains significantly less weight/volume than the package of grape seed extract that I order from bulkactives. The two are combined in equal amounts in the anti-aging cream, so I find myself running o.. ...»
This is the best product I have ever used on my skin and I tried a LOT of expansive brands. It helps with redness and overall skin tone. Please do not ever stop making this stuff... ...»
Any long delivery delays are caused by The Canada Border Services Agency.
I now ONLY offer EMS as a shipping option to Canada.
This appears to have resolved most of the delays caused by The Canada Border Services Agency.
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We take NO responsibility for delivery issues caused by customers entering the wrong address in the checkout page
We sell COSMETIC RAW MATERIALS, which are meant to be used at an appropriate percentage in a cosmetic formulation of your devising. Please do not order our products unless you know how to formulate creams and lotions with it!
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Please READ this before placing an order, and select the CORRECT shipping option for your country at checkout!
Due to Wuhan Pneumonia Virus (aka Covid-19) border restrictions and a reduction or cancellation of flights by airlines, we CAN ONLY ship to the counries listed below!
We have also been advised to expect delivery delays at your end, and yes, that INCLUDES USA customers!!!
UK customers, we are finally ABLE to ship to the UK.
We CAN ship to:
Registered Airmail and EMS:
NORTH AMERICA: USA (NOT including Hawaii and Guam), UK
ASIA: China, Japan, Korea, Vietnam,Thailand, Malaysia, Singapore, Hong Kong, Macau, Philippines
EUROPE: France, Netherlands, Germany, Poland, Denmark, Norway, Finland
EMS only ! (Do NOT select Registered Airmail at checkout)
NORTH AMERICA: Canada
EUROPE: Belgium, Switzerland, Sweden, Czech, Italy
OCEANIA: New Zealand, Australia
Registered Airmail only!
Cambodia, Spain, Austria, Slovakia, Bahrain, Turkey, Saudi Arabia, United Arab Emirates, Lithuania
IMPORTANT: If your country is NOT in the above lists, then we CANNOT ship to you at the moment.
If your country does not accept Registered Airmail, then do NOT select it from the shipping options at checkout!
Carnitine is a naturally occurring substance, necessary for fat and glucose metabolism in human body cells. Primary function of carnitine in pharmacy is the reduction of advanced glycation end products (AGEs). AGEs are proteins, damaged by reactions with sugars, therefore glycation is most prominent in diabetes patients. It also occurs in many other diseases, as well as natural ageing processes. Dermal carnitine applications reduce the level of glycated collagen and promote synthesis of new protein. Since it is involved in lipid metabolism, carnitine is used for acne treatment. It effectively reduces sebum secretion and skin oiliness. Carnitine preparations also improve other aspects of the skin, such as tonicity, and reduce cellulite. Finally, it aids skin regeneration after damage, such as burns, and promotes blood vessel formation. Regretably, due to Candian law and PayPal regulations, this product may NOT be shipped to Canada.
Carnitine (also L-carnitine or CA) is a naturally occurring substance, necessary for the cellular metabolism of glucose, fat and related compounds. Since these metabolic processes occur in most cells of the body, carnitine deficiency is associated with a wide range of diseases, such as muscle weakness, cardiac hypertrophy and accelerated atherosclerosis [1], [2]. Most importantly, carnitine helps to reduce protein glycation levels.
Glycation is a detrimental protein change that occurs in typical ageing processes. It involves a non-specific reaction between various sugars and proteins, especially collagen [3]. The damage brought on by such reactions is irreversible and results in dysfunctional protein aggregates, called advanced glycation end products (AGEs). AGE formation proceeds faster under elevated blood sugar levels, typically caused by diabetes, but they are also involved in the development of other disorders, among them osteoporosis, Alzheimer’s disease and cancer [1]. Carnitine was shown to be successful at inhibiting collagen glycation in rats that were fed on a high-sugar diet [3].
Furthermore, it reduced the AGE levels even more than commercially used antiglycation agent aminoguanidine, and also enhanced glucose metabolism in the diaphragm. Research on humans also confirms this conclusion, indicating that carnitine successfully reduces AGE levels in skin [1]. It is even suggested for management of adverse chemo- and radiotherapy effects. Recent studies have found that carnitine reduces therapy-caused damage to various organs and possibly even fatigue from chemotherapy [2].
In skin care, carnitine is a favored ingredient for several purposes.
Due to its role in lipid metabolism, it is known to inhibit sebum secretion and thus reduce skin oiliness. Applying 2 %-carnitine containing cream for 3 weeks was enough to significantly reduce both lipid content and sebum production in human sebaceous glands [4]. The same effect is utilized in anti-acne preparations with carnitine. In a study of mild to moderately severe acne, volunteers used a face cleanser with carnitine for 8 weeks. Total lesion count, sebum production, bacterial colonization, were all reduced; pustule count decreased 5 times, and general life quality of the subjects (measured by a questionnaire test) was improved [5].
Carnitine can also improve skin appearance in other ways. It is involved in skin cell proliferation, as it was shown to increase epidermal thickness both in healthy skin and during regeneration after wounds [6], [7]. Using a carnitine-containing preparation for 12 weeks resulted in various esthetic improvements of the skin, such as decreased cellulite and improved tonicity [6]. It is also known to promote wound healing, likely due to increased collagen synthesis, skin cell migration or energy release [7]–[9]. This effect is especially important in patients using steroids, as these medications can reduce the activity of immune processes necessary for wound healing [8]. The healing process can also be disrupted by diabetes, but preparations containing carnitine were effective in such models as well, promoting skin regeneration and faster healing [9]. Benefits of carnitine are not limited to simple wounds – larger burns were also investigated. Carnitine successfully reduced tissue necrosis, promoted cell proliferation, and increased the formation of new blood vessels [10], [11]. The positive effects on skin cells is enhanced even more when carnitine is combined with retinol (a form of vitamin A) or vitamin C [6], [10].
Carnitine exists in two forms: L-Carnitine and D-Carnitine. Only the L-Carnitine form is desirous as the D-Carnitine form is physiologically inactive and can inhibit the uptake and functions of the natural isomer L-Carnitine. BulkActives' Carnitine is L carnitine.
Storage: Keep tightly closed, in cool place. Hygroscopic. Country of origin: China
[1] K. Fukami, S.-I. Yamagishi, K. Sakai, Y. Kaida, T. Adachi, R. Ando, and S. Okuda, “Potential inhibitory effects of L-carnitine supplementation on tissue advanced glycation end products in patients with hemodialysis,” Rejuvenation Res., vol. 16, no. 6, pp. 460–466, Dec. 2013.
[2] H. A. Khan and A. S. Alhomida, “A review of the logistic role of L-carnitine in the management of radiation toxicity and radiotherapy side effects,” J. Appl. Toxicol. JAT, vol. 31, no. 8, pp. 707–713, Nov. 2011.
[3] P. Rajasekar and C. V. Anuradha, “L-Carnitine inhibits protein glycation in vitro and in vivo: evidence for a role in diabetic management,” Acta Diabetol., vol. 44, no. 2, pp. 83–90, Jun. 2007.
[4] R. I. Peirano, T. Hamann, H.-J. Düsing, M. Akhiani, U. Koop, T. Schmidt-Rose, and H. Wenck, “Topically applied L-carnitine effectively reduces sebum secretion in human skin,” J. Cosmet. Dermatol., vol. 11, no. 1, pp. 30–36, Mar. 2012.
[5] I. Angelova-Fischer, F. Rippke, T. W. Fischer, G. Neufang, and D. Zillikens, “A double-blind, randomized, vehicle-controlled efficacy assessment study of a skin care formulation for improvement of mild to moderately severe acne,” J. Eur. Acad. Dermatol. Venereol. JEADV, vol. 27 Suppl 2, pp. 6–11, Jul. 2013.
[6] R. Roure, T. Oddos, A. Rossi, F. Vial, and C. Bertin, “Evaluation of the efficacy of a topical cosmetic slimming product combining tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol, In vitro, ex vivo and in vivo studies,” Int. J. Cosmet. Sci., vol. 33, no. 6, pp. 519–526, Dec. 2011.
[7] T. Karsidag, J. A. Asensio, F. Kabukcuoglu, and S. Tuzun, “Preliminary study comparing the effects of locally and systemically applied L-carnitine on the healing of full-thickness skin defects,” Scand. J. Surg. SJS Off. Organ Finn. Surg. Soc. Scand. Surg. Soc., vol. 99, no. 3, pp. 147–152, 2010.
[8] A. Akkus, K. Aydinuraz, C. Daphan, O. Saygun, O. Caglayan, M. Edremitlioglu, and F. Agalar, “Effect of carnitine on cutaneous wound healing in immunosuppressed rats,” J. Surg. Res., vol. 155, no. 2, pp. 301–305, Aug. 2009.
[9] L. Gennero, R. De Siena, T. Denysenko, M. A. Roos, G. F. Calisti, M. Martano, S. Fiobellot, M. Panzone, S. Reguzzi, L. Gabetti, A. Vercelli, G. Cavallo, E. Ricci, and G. P. Pescarmona, “A novel composition for in vitro and in vivo regeneration of skin and connective tissues,” Cell Biochem. Funct., vol. 29, no. 4, pp. 311–333, Jun. 2011.
[10] E. Arslan, Y. Basterzi, A. Aksoy, C. Majka, S. Unal, A. Sari, and F. Demirkan, “The additive effects of carnitine and ascorbic acid on distally burned dorsal skin flap in rats,” Med. Sci. Monit. Int. Med. J. Exp. Clin. Res., vol. 11, no. 6, pp. BR176–180, Jun. 2005.
[11] E. Arslan, A. Milcan, S. Unal, F. Demirkan, A. Polat, O. Bagdatoglu, A. Aksoy, and G. Polat, “The effects of carnitine on distally-burned dorsal skin flap: an experimental study in rats,” Burns J. Int. Soc. Burn Inj., vol. 29, no. 3, pp. 221–227, May 2003.
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
DISCLAIMER
We do NOT sell ready-made skin care products!
All our products are powders, liquids, flakes or gels, used for making your own skin care products.
All our products are cosmetic / technical grade only.
We do NOT sell pharmaceuticals, prescription drugs or nutritional supplements.
Any statements about our products have not been evaluated by the FDA.
Our active skin care ingredients are not intended to diagnose, treat, cure, or prevent any disease
SHIPPING
Please write your correct address:
We take NO responsibility for delivery issues caused by customers entering the wrong address in the checkout page
Delivery
BulkActives is a part-time business. Orders are processed and mailed on Saturdays.
Canadian Customers:
Any long delivery delays are caused by The Canada Border Services Agency.
I now ONLY offer EMS as a shipping option to Canada.
This appears to have resolved most of the delays caused by The Canada Border Services Agency.