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Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
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- ALL PRODUCTS
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ACTIVES
- - anti-acne
- - anti-androgenetic alopecia
- - anti-bacterial
- - anti-blackheads
- - anti-inflammatory
- - antioxidant
- - capillary health
- - exfoliating
- - glycation inhibitor and repair
- - increase cellular energy production
- - increase skin elasticity
- - lightening and brightening
- - matrix metalloproteinases (MMP) inhibitors
- - moisturizing and hydration
- - natural phyto estrogens
- - nutrition
- - oil/sebum control
- - pore refinement
- - reduce dark circles under the eyes
- - reduce fine lines and wrinkles
- - reduce rosacea
- - restore barrier function
- - scar care
- - stimulate collagen production
- - stimulate HA production
- - sun damage protection
- - sun damage repair
- - treat hyperpigmentation
- - wound healing support
- - wrinkle relaxers
- - wrinkle tighteners
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Reviews
This is great stuff.
I add it to my liquid face soap and it does an excellent job in preventing acne and gently exfoliating the skin... ...»
Marie
Very good product. It performed exactly how I expected. .. ...»
Ryan
This is the best product I have ever used on my skin and I tried a LOT of expansive brands. It helps with redness and overall skin tone. Please do not ever stop making this stuff... ...»
Helena
I' m not sure about this: "11% solution gives 1% EGCG content in final product." What is the weight of final product? .. ...»
Vesna Hanich
It is true, this product does leave the skin silky smooth! I can highly recommend using it in your masks... ...»
Mati Fuller
I am 69 and I have used this product for two years almost every day at a high dose, adding it to my antioxidant day cream, with excellent results. For me it has a very high quality and effectiveness: reduction of wrinkles, hydrated skin, unified color without blemishes ... A product of 10, the same score that I give to John for the quality of the products he sells, his excellent description / use and the bibliographic contribution.En .. ...»
María Jesus
Tried this on my week-old rash from flea bites. Got an almost instant relief and rash healed in 2 days.
Tried it on my daughter who has eczema for a very long time. The rashes calmed down after a few days and her skin is now healing well. Really great product. Just put in order for another jar.... ...»
Eliz
This is great stuff.
I add it to my liquid face soap and it does an excellent job in preventing acne and gently exfoliating the skin... ...»
Marie
Really loving this product. I make the best Centella toner and most concentrated ever. 2 g of centella extract dissolved in 10g of alcohol(you have to stir a lot) plus 88 grams of water and you get a very concentrated toner. Creams, toners, ampoules... all have only 0,1% of triterpenes, this toner i make have 1,4%. I am loving it, will see the results. .. ...»
Francisco
Just recently ordered this and LOVE! Green Tea EGCG truly is one of the most fantastic skincare actives out there. Very difficult to find good quality product (90%) and even harder to actually solubilize it! Love that it comes in pre-dissolved solution. I enjoy adding it at 1% (so 11% sol) to my serum formulations containing Niacinamide 5% + NAG 3%. Excellent for oily acne prone skin.
*Only gripe... because the Pre-Dissolved Solution is SO heavy in propanediol (10 parts Propanediol for 1 part E.. ...»
Victor
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Important Stuff
All customers PLEASE read:
the FAQ and Delivery Info pages!
Canadian Customers:
Any long delivery delays are caused by The Canada Border Services Agency.
I now ONLY offer EMS as a shipping option to Canada.
This appears to have resolved most of the delays caused by The Canada Border Services Agency.
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Delivery
BulkActives is a part-time business. Orders are processed and mailed on Saturdays. (TimeZone Order Deadline Chart)
What we sell
We sell COSMETIC RAW MATERIALS, which are meant to be used at an appropriate percentage in a cosmetic formulation of your devising. Please do not order our products unless you know how to formulate creams and lotions with it!
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Sample Recipes
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Please READ this before placing an order, and select the CORRECT shipping option for your country at checkout!
Due to Wuhan Pneumonia Virus (aka Covid-19) border restrictions and a reduction or cancellation of flights by airlines, we CAN ONLY ship to the counries listed below!
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UK customers, we are finally ABLE to ship to the UK.
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IMPORTANT: If your country is NOT in the above lists, then we CANNOT ship to you at the moment.
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Buy GABA (Gamma-aminobutyric acid) For Skin Care
GABA (gamma-aminobutyric acid) is a neurotransmitter with purported dermatological benefits. Several patents indicated that GABA can be used as a wrinkle relaxer based on its inhibitory effect on muscles. Some patents also claim that GABA can dilate skin peripheral blood vessels, moisturize and prevent aging, suppress parakeratosis and shrink pores, as well as whitening the skin. However there is no scientific data to support these claims. On the other hand, a preliminary research study has shown that GABA can stimulate hyaluronic acid synthesis and protect the fibroblasts from oxidative stress. Another study showed that GABA was able to upregulate beta-defensin-2, which is an anti-microbial peptide, and filaggrin, which plays a role in normal barrier function of the skin. Lastly, GABA might be useful in combating inflammation associated with psoriasis based on preliminary findings that GABA receptors are expressed in white blood cells in psoriatic skin. Overall, the evidence of GABA in supporting skin health is very weak, and consumers are warned for its application.
Unsubstantiated benefits of GABA (Gamma-aminobutyric acid) in skin care:
- Anti-bacterial [11]
- Anti-inflammatory [12]
- Anti-oxidant [10]
- Capillary health [4][5][6]
- Lightening and brightening [8][9]
- Moisturizing and hydration [4][5][6][11]
- Pore refinement [7]
- Reduce fine lines and wrinkles [2][3][4][5]
- Restore barrier function [11]
- Stimulate HA production [10]
- Wrinkle relaxers [2][3][4][5]
Product Code: BulkActives
CAS#: 56-12-2
Net weight: 30g /1.06oz
Availability: In Stock
CAS#: 56-12-2
Net weight: 30g /1.06oz
Availability: In Stock
Price: $6.00
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GABA (Gamma-aminobutyric acid)
About GABA (Gamma-aminobutyric acid) in DIY Skin Care
Gamma-aminobutyric acid (GABA) is a well-known neurotransmitter. In the mature brain of humans, it exerts inhibitory function on neurons when bind to GABA receptors, through regulating the chloride gradient across the cell membrane. GABA is synthesized by enzymes called glutamate decarboxylase, using glutamate as the substrate. Once synthesized, it is transported in little vesicles to the synapses of the neurons, and its action depends on its metabolism, expression, and activity level. GABA is important for brain development, and its dysfunction has been linked to a myriad of neurological disorders such as autism, Fragile X, Rett syndrome, Down syndrome, schizophrenia, Tourette's syndrome and neurofibromatosis.[1]GABA has been marketed as a wrinkle relaxer based on the claim that it can inhibit neuronal activity and hence relax muscles, limiting the “expression lines” resulted from muscle hyper-contraction such as in the peri-oral regions. There are several patents that indicate such function when used topically.[2][3][4][5] Other patents that mentioned GABA’s benefits include dilation of skin peripheral blood vessels,[4][5][6] moisturizing and age-preventing,[4][5][6] suppressing parakeratosis and pore shrinking,[7] and whitening effects.[8][9] However, there have been no peer-reviewed study published to date (May, 2015) on these effects.
Research on dermatological use of GABA has been sporadic. It has been shown that glutamate decarboxylase exists in human dermal fibroblasts, and GABA can stimulate the synthesis of hyaluronic acid and enhances the survival rate of the fibroblasts when exposed to oxidative stress in vitro.[10] GABA synthesized from fermentation of grape must using bacteria (Lactobacillus plantarum) has been shown to increase the level of beta-defensin-2, hyaluronan synthase, and filaggrin in reconstituted human skin tissue,[11] suggesting that GABA might play a role in anti-microbial function, hydration, and proper barrier function of the skin. GABA receptors are expressed in a number of white blood cell types in psoriatic skin, and GABA has been implicated to be important in relieving inflammation associated with psoriasis.[12] These studies provide new possibilities for the application of GABA, however consumers are encouraged to exercise precautions due to the fact that none of these studies has been replicated and substantiated.
Assay: 99.6%
CAS No.: 56-12-2
INCI: Gamma-AminoButyric Acid
Appearance: white powder
Solubility: water
Suggested percentage: No data available, up to customer's discretion
Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China
CAS No.: 56-12-2
INCI: Gamma-AminoButyric Acid
Appearance: white powder
Solubility: water
Suggested percentage: No data available, up to customer's discretion
Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China
[1] G. Deidda, I. F. Bozarth, and L. Cancedda, “Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives,” Front. Cell. Neurosci., vol. 8, May 2014.
[2] O. D. Lacharriere and L. Breton, “Compositions and methods for treating wrinkles and/or fine lines of the skin,” US5976559 A, 02-Nov-1999.
[3] O. D. Lacharriere and L. Breton, “Compositions and methods for treating wrinkles and/or fine lines of the skin,” US5869068 A, 09-Feb-1999.
[4] H. Kyotaro and H. Minoru, “Cosmetic for preventing skin from aging,” 05-043448, 23-Feb-1993.
[5] T. Hiroshi, “Cosmetic for preventing aging of skin,” 05-117137, 14-May-1993.
[6] O. Tadatake, A. Takashi, and H. Kyotaro, “Cosmetic for preventing aging of skin,” 60-184005, 19-Sep-1985.
[7] M. Kaminuma, M. Suetsugu, T. Iida, and S. Inomata, “Parakeratosis inhibitor, pore -shrinking agent and external compositon for skin,” US20120232111 A1, 13-Sep-2012.
[8] S. Tatsuro and T. Hiroshi, “Skin-whitening cosmetic,” 05-229929, 09-Jul-1993.
[9] T. Hiroshi and S. Tatsuro, “Skin-beautifying cosmetic,” 05-194178, 08-Mar-1993.
[10] K. Ito, K. Tanaka, Y. Nishibe, J. Hasegawa, and H. Ueno, “GABA-synthesizing enzyme, GAD67, from dermal fibroblasts: evidence for a new skin function,” Biochim. Biophys. Acta, vol. 1770, no. 2, pp. 291–296, Feb. 2007.
[11] R. Di Cagno, F. Mazzacane, C. G. Rizzello, M. De Angelis, G. Giuliani, M. Meloni, B. De Servi, and M. Gobbetti, “Synthesis of gamma-aminobutyric acid (GABA) by Lactobacillus plantarum DSM19463: functional grape must beverage and dermatological applications,” Appl. Microbiol. Biotechnol., vol. 86, no. 2, pp. 731–741, Mar. 2010.
[12] R. Nigam, H. El-Nour, B. Amatya, and K. Nordlind, “GABA and GABA(A) receptor expression on immune cells in psoriasis: a pathophysiological role,” Arch. Dermatol. Res., vol. 302, no. 7, pp. 507–515, Sep. 2010.
[2] O. D. Lacharriere and L. Breton, “Compositions and methods for treating wrinkles and/or fine lines of the skin,” US5976559 A, 02-Nov-1999.
[3] O. D. Lacharriere and L. Breton, “Compositions and methods for treating wrinkles and/or fine lines of the skin,” US5869068 A, 09-Feb-1999.
[4] H. Kyotaro and H. Minoru, “Cosmetic for preventing skin from aging,” 05-043448, 23-Feb-1993.
[5] T. Hiroshi, “Cosmetic for preventing aging of skin,” 05-117137, 14-May-1993.
[6] O. Tadatake, A. Takashi, and H. Kyotaro, “Cosmetic for preventing aging of skin,” 60-184005, 19-Sep-1985.
[7] M. Kaminuma, M. Suetsugu, T. Iida, and S. Inomata, “Parakeratosis inhibitor, pore -shrinking agent and external compositon for skin,” US20120232111 A1, 13-Sep-2012.
[8] S. Tatsuro and T. Hiroshi, “Skin-whitening cosmetic,” 05-229929, 09-Jul-1993.
[9] T. Hiroshi and S. Tatsuro, “Skin-beautifying cosmetic,” 05-194178, 08-Mar-1993.
[10] K. Ito, K. Tanaka, Y. Nishibe, J. Hasegawa, and H. Ueno, “GABA-synthesizing enzyme, GAD67, from dermal fibroblasts: evidence for a new skin function,” Biochim. Biophys. Acta, vol. 1770, no. 2, pp. 291–296, Feb. 2007.
[11] R. Di Cagno, F. Mazzacane, C. G. Rizzello, M. De Angelis, G. Giuliani, M. Meloni, B. De Servi, and M. Gobbetti, “Synthesis of gamma-aminobutyric acid (GABA) by Lactobacillus plantarum DSM19463: functional grape must beverage and dermatological applications,” Appl. Microbiol. Biotechnol., vol. 86, no. 2, pp. 731–741, Mar. 2010.
[12] R. Nigam, H. El-Nour, B. Amatya, and K. Nordlind, “GABA and GABA(A) receptor expression on immune cells in psoriasis: a pathophysiological role,” Arch. Dermatol. Res., vol. 302, no. 7, pp. 507–515, Sep. 2010.
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