Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Reviews
Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
Angela
Very good product! Only been using it for a short time, its already made a difference. .. ...»
Bronwynne
muy satisfecho profesionales, y envio sin problemas ,ya que soy de españa producto bien envasado , un placer ser cliente porque dan comnfianza y calidad.gracias un saludo.. ...»
daniel
Wanting to try this, but.... Angela, what was that about effecting hormones? Could someone explain please..... ...»
Carla
I purposely waited a few months before writing my review. I am happy to report this product is great! I combined the DMAE product with the base creams resulting in tighter skin and lessened wrinkles, including areas around underarms... ...»
cjmluv
Powered ingredient easy to blend, dissolves easily, no gritty feel, product does however transfer this chemical transdermally and should be thought about prior to mixing as it does effect hormones. Gives skin a quick firm appearance in personal formulations and was a great experimental addition to personal products. The DIY provided on this site is the way to go to try out this product. A little goes a long way... ...»
Angela
Just recently ordered this and LOVE! Green Tea EGCG truly is one of the most fantastic skincare actives out there. Very difficult to find good quality product (90%) and even harder to actually solubilize it! Love that it comes in pre-dissolved solution. I enjoy adding it at 1% (so 11% sol) to my serum formulations containing Niacinamide 5% + NAG 3%. Excellent for oily acne prone skin. *Only gripe... because the Pre-Dissolved Solution is SO heavy in propanediol (10 parts Propanediol for 1 part E.. ...»
Victor
Wonderful base cream! Only multi-lamellar structured cream I've found on the market. Cream itself is lightweight (no oil) yet very conditioning/hydrating. Easily accepts water-soluble active ingredients as well as oil-soluble ones. I've even pushed the additional ingred % up to 20 (meaning 80% this cream, 20% added) without any separation issues. Ideal base cream for delivering actives. Personal favorite recipe calls for 5% straight Grapeseed Oil with 5% SebumREG oil active + Panthenol 1% + E Ac.. ...»
Vic
excellence product, very good and made my skin soft and smooth just like baby's skin. Thank you john.. ...»
nky
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
Jessie Sandford
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Hesperidin methyl chalcone

Hesperidin is a a plant flavonoid, found naturally in citrus fruits. It has numerous biological benefits, but it is poorly absorbed and transported in the body, hence a modified version, hesperidin methyl chalcone (HMC), is used in cosmetics. The best known effect of HMC is reduction of capillary permeability. This can be used to reduce dark circles and bags under the eyes or even treat varicose veins. It is also known to reduce melanin synthesis, thus lightening the skin, and it also protects skin from UV-caused damage and cell ageing. Furthermore, HMC restores the barrier function of the skin, improving hydration, regulating pH and promoting skin cell proliferation. Finally, it has an anti-inflammatory effect, and can even be used to reduce various types of pain caused by inflammation.

NOTE: To assist you with solubility issues, we now also sell Hesperidin methyl chalcone as a liquid standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
  • 11% solution gives 1% Hesperidin content in final product.
  • 31% solution gives 3% Hesperidin content in final product.
  • 51% solution gives 5% Hesperidin content in final product.

Key benefits of Hesperidin methyl chalcone in skin care:

  • Sun damage protection [8] [11]
  • Capillary health [4] [5] [12]
  • Lightening & brightening [7] [8]
  • Reduce dark circles under the eyes [6]
  • Restore barrier function [1] [9] [10]
  • Anti-inflammatory [2] [5]
Product Code: BulkActives
Reward Points: 5
Assay: 98%
CAS#: 24292-52-2
Net weight: 30g /1.06oz & 100g / 3.53oz
Availability:
Standardized preDissolved solution 100g - Options In Stock
Standardized Powder 30g - Options In Stock
Price: $11.70
Reward Points: 520


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About Hesperidin methyl chalcone in DIY Skin Care

Plants are the major source of many complex compounds with cosmetical and pharmaceutical benefits called flavonoids. Hesperidin is one such molecule, composed of a flavone hesperetin bound to a sugar. It is found naturally in peels of orange and other citrus fruits. It has a wide range of protective effects, among them anti-inflammatory, antioxidant, antibacterial, antiviral properties, skin whitening effect, epidermal barrier strengthening, and even cancer suppression [1]. Interestingly, many of the benefits of orange juice consumption have been linked to their high hesperidin content [2].

However, pure hesperidin has poor solubility in water, therefore its absorption and distribution inside the body are ineffective [2]. Hesperidin methyl chalcone (HMC) is produced by a simple chemical reaction (adding methyl groups) of hesperidin. Experiments have shown that such changes greatly improve the absorption of related compounds. Furthermore, their health benefits can be even stronger: certain flavones that have a cancer-preventive effect showed 8-10 time stronger effect in the methylated form, likely due to better absorption and transport in the body [3]. Therefore, it is logical that the effects of hesperidin methyl chalcone should be similar to unmodified hesperidin or even more notable.

The action of hesperidin methyl chalcone on capillaries has been known for almost 40 years. It is able to reduce their permeability, thus reducing loss of various molecules through their walls [4]. Many molecules produced during inflammation have an opposite activity, therefore HMC exhibits anti-inflammatory properties [5]. Furthermore, it is able to reduce inflammation-associated pain of various types [2]. In cosmetics, this ability is used in several related products to reduce dark bags and puffiness under the eyes, with reported 65 % reduction of bag volume after 28 days of using HMC [6].

HMC is also a promising cosmeceutical in lightening and brightening skin tone. Hesperidin is able to inhibit melanin synthesis, thus reducing skin darkening, and has an anti-yellowing effect [7]. Hesperetin was also found to be an effective whitening agent, having significant photoprotective effect on the skin [8].

Regarding other uses in cosmetics, hesperidin helps to restore the barrier function of damaged skin. A cream containing 2 % hesperidin restores the hydration of damaged skin up to 50 % of healthy level as soon as 2 hours after damage. Furthermore, it stimulates the proliferation of epidermal cells, resulting in increased skin thickness [1]. This is especially useful for patients using glucocorticoids (steroids), as they can negatively affect the barrier function of skin, and this damage is fully reversed by hesperiding-containing cream [9]. Loss of barrier function is also associated with ageing skin. Additionally, ageing causes skin pH to increase; hesperidin applications can reduce both of these symptoms [10].

The protective effect of hesperetin-related compounds was also shown using fermented citrus peel. UV irradiation of skin cells increases collagen degradation and causes cell ageing. However, application of the fermented peel counteracted these processes, increasing collagen synthesis, decreasing its degradation, and even reducing the levels of markers typically associated with cell senescence [11].

Finally, HMC is useful for patients with varicose veins. Together with Ruscus plant extract, it reduces both the negative symptoms, such as pain and cramps, and the underlying physiological damage associated with this condition [12]. These changes significantly improve the quality of life of the patients [13]. Interestingly, it is believed that HMC is safe to use even in very high doses, since no adverse effects were observed in patients consuming as much as 15 g daily [2].
 
NOTE: To assist you with solubility issues, we now also sell Hesperidin methyl chalcone as a liquid standardized pre-dissolved solution. Just add the liquid to your cream and mix well.

Hesperidin methyl chalcone Standardized Powder

Assay: 98%
CAS No.:  24292-52-2
INCI: Hesperidin methyl chalcone
Appearance: powder
Solubility: water, propanediol (heated)
Suggested percentage: 2 to 10%

Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China

Hesperidin methyl chalcone Standardized Pre Dissolved Solution - 10%

Assay: 9.8 % Hesperidin methyl chalcone
CAS#: 504-63-2, 24292-52-2
INCI:1,3-Propanediol, Hesperidin methyl chalcone
Appearance: liquid

Solubility: add to cream
Suggested percentage:
11% solution gives 1% Hesperidin content in final product.
31% solution gives 3% Hesperidin content in final product.
51% solution gives 5% Hesperidin content in final product.

Storage: Store in fridge, do not freeze
Country of origin for raw material: China
Country of manufacture: Taiwan
[1]          M. Hou, M. Man, W. Man, W. Zhu, M. Hupe, K. Park, D. Crumrine, P. M. Elias, and M.-Q. Man, “Topical hesperidin improves epidermal permeability barrier function and epidermal differentiation in normal murine skin,” Exp. Dermatol., vol. 21, no. 5, pp. 337–340, May 2012.
[2]          F. A. Pinho-Ribeiro, M. S. N. Hohmann, S. M. Borghi, A. C. Zarpelon, C. F. S. Guazelli, M. F. Manchope, R. Casagrande, and W. A. Verri Jr., “Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: Role of TRPV1, oxidative stress, cytokines and NF-κB,” Chem. Biol. Interact., vol. 228, pp. 88–99, Feb. 2015.
[3]          T. Walle, “Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption,” Mol. Pharm., vol. 4, no. 6, pp. 826–832, Dec. 2007.
[4]          J. P. Tarayre and H. Lauressergues, “Advantages of a combination of proteolytic enzymes, flavonoids and ascorbic acid in comparison with non-steroid anti-inflammatory agents,” Arzneimittelforschung., vol. 27, no. 6, pp. 1144–1149, 1977.
[5]          E. Bouskela, F. Z. Cyrino, and G. Marcelon, “Inhibitory effect of the Ruscus extract and of the flavonoid hesperidine methylchalcone on increased microvascular permeability induced by various agents in the hamster cheek pouch,” J. Cardiovasc. Pharmacol., vol. 22, no. 2, pp. 225–230, Aug. 1993.
[6]          Sederma, “Cosmetic or dermopharmaceutical compositions which are used to reduce bags and circles under the eyes.,” EP1474100.
[7]          W. Zhu and J. Gao, “The Use of Botanical Extracts as Topical Skin-Lightening Agents for the Improvement of Skin Pigmentation Disorders,” J. Investig. Dermatol. Symp. Proc., vol. 13, no. 1, pp. 20–24, 2008.
[8]          Y.-B. Huang, K.-F. Lee, C.-T. Huang, Y.-H. Tsai, and P.-C. Wu, “The effect of component of cream for topical delivery of hesperetin,” Chem. Pharm. Bull. (Tokyo), vol. 58, no. 5, pp. 611–614, May 2010.
[9]          G. Man, T. M. Mauro, P. L. Kim, M. Hupe, Y. Zhai, R. Sun, D. Crumrine, C. Cheung, A. Nuno-Gonzalez, P. M. Elias, and M.-Q. Man, “Topical hesperidin prevents glucocorticoid-induced abnormalities in epidermal barrier function in murine skin,” Exp. Dermatol., vol. 23, no. 9, pp. 645–651, Sep. 2014.
[10]        G. Man, T. M. Mauro, Y. Zhai, P. L. Kim, C. Cheung, M. Hupe, D. Crumrine, P. M. Elias, and M.-Q. Man, “Topical Hesperidin Enhances Epidermal Function in an Aged Murine Model,” J. Invest. Dermatol., Nov. 2014.
[11]        J. T. Bae, H. J. Ko, G. B. Kim, H. B. Pyo, and G. S. Lee, “Protective effects of fermented Citrus unshiu peel extract against ultraviolet-A-induced photoageing in human dermal fibrobolasts,” Phytother. Res. PTR, vol. 26, no. 12, pp. 1851–1856, Dec. 2012.
[12]        P. Boyle, C. Diehm, and C. Robertson, “Meta-analysis of clinical trials of Cyclo 3 Fort in the treatment of chronic venous insufficiency,” Int. Angiol. J. Int. Union Angiol., vol. 22, no. 3, pp. 250–262, Sep. 2003.
[13]        J. J. Guex, L. Avril, E. Enrici, E. Enriquez, C. Lis, and C. Taïeb, “Quality of life improvement in Latin American patients suffering from chronic venous disorder using a combination of Ruscus aculeatus and hesperidin methyl-chalcone and ascorbic acid (quality study),” Int. Angiol. J. Int. Union Angiol., vol. 29, no. 6, pp. 525–532, Dec. 2010

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