Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
This is a fantastic product. Highly moisturizing and smooths out lines and wrinkles. It works quickly and is evening out skin tone as well. I think its a must have product and I certainly will be purchasing it again.. ...»
This is the best product I have ever used on my skin and I tried a LOT of expansive brands. It helps with redness and overall skin tone. Please do not ever stop making this stuff... ...»
I' m not sure about this: "11% solution gives 1% EGCG content in final product." What is the weight of final product? .. ...»
Vesna Hanich
I am 69 and I have used this product for two years almost every day at a high dose, adding it to my antioxidant day cream, with excellent results. For me it has a very high quality and effectiveness: reduction of wrinkles, hydrated skin, unified color without blemishes ... A product of 10, the same score that I give to John for the quality of the products he sells, his excellent description / use and the bibliographic contribution.En .. ...»
María Jesus
This is great stuff. I add it to my liquid face soap and it does an excellent job in preventing acne and gently exfoliating the skin... ...»
Really loving this product. I make the best Centella toner and most concentrated ever. 2 g of centella extract dissolved in 10g of alcohol(you have to stir a lot) plus 88 grams of water and you get a very concentrated toner. Creams, toners, ampoules... all have only 0,1% of triterpenes, this toner i make have 1,4%. I am loving it, will see the results. .. ...»
Just recently ordered this and LOVE! Green Tea EGCG truly is one of the most fantastic skincare actives out there. Very difficult to find good quality product (90%) and even harder to actually solubilize it! Love that it comes in pre-dissolved solution. I enjoy adding it at 1% (so 11% sol) to my serum formulations containing Niacinamide 5% + NAG 3%. Excellent for oily acne prone skin. *Only gripe... because the Pre-Dissolved Solution is SO heavy in propanediol (10 parts Propanediol for 1 part E.. ...»
excellence product, very good and made my skin soft and smooth just like baby's skin. Thank you john.. ...»
Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
Very good product! Only been using it for a short time, its already made a difference. .. ...»
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Ascorbyl Tetraisopalmitate

Ascorbyl tetraisopalmitate (Tetrahexyldecyl Ascorbate) is a molecule derived from vitamin C and isopalmitic acid. Pure vitamin C has several drawbacks for cosmeceutical use, most important of which is the low stability. Chemically modified vitamin molecules are more stable, and pure vitamin is released from the derivatives inside the body. Therefore, the effects of Ascorbyl Tetraisopalmitate are similar to those of vitamin C, most importantly it is able to act as an antioxidant. Ascorbyl tetraisopalmitate reduces the production of oxidizing agents, which contribute to cell damage after exposure to UV or chemical hazards. This effect is even stronger in the modified molecule than in pure vitamin C. Additionally, Ascorbyl Tetraisopalmitate protects against DNA damage and skin darkening caused by UV exposure. Finally, skin visual appearance is also improved by Ascorbyl tetraisopalmitate, as it promotes collagen synthesis and acts as a hydrating agent in reducing skin roughness.

Key benefits of Ascorbyl tetraisopalmitate in skin care:

  • Sun damage protection [1] [2] [7]
  • Sun damage repair [2]
  • Antioxidant [1] [6]
  • Moisturizing and hydration [5]
  • Stimulate collagen production [2]
  • Lightening & brightening [1]
  • treat hyperpigmentation [1]
Product Code: BulkActives
Assay: 99%
CAS#: 183476-82-6
Net weight: 50g / 1.76oz & 1kg / 35.27oz
50g / 1.76oz - Options Out of Stock
1kg / 35.27oz - Options In Stock
Price: $86.90

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About Ascorbyl Tetraisopalmitate in DIY Skin Care

Ascorbyl tetraisopalmitate (also tetra-isopalmitoyl ascorbate, or Tetrahexyldecyl Ascorbate) is a molecule derived from vitamin C. It is produced by combining one molecule of vitamin C (ascorbic acid) with four molecules of tetraisopalmitic acid, a fatty acid found in butter and other sources. Although it was developed only recently, its safety for human use has been thoroughly tested [1], [2]. While pure vitamin C has many clinical and cosmetical benefits, it degrades easily and its delivery through skin is ineffective. Furthermore, sudden high doses of ascorbic acid may be toxic to cells, so several modified versions of this vitamin have been developed [3], [4]. Inside the body cells, any modifications are removed and pure vitamin C is released. In the case of Ascorbyl tetraisopalmitate, more than 80 % of the vitamin C content is released successfully [1]. An additional benefit of Tetrahexyldecyl Ascorbate is that it is soluble in lipids, such as oils, and thus its uptake through the skin is easier. The pH of this derivative (around 4.0-6.0) is also more compatible with skin than that of pure ascorbic acid [5].

In this way, Ascorbyl tetraisopalmitate retains all the beneficial effects of vitamin C. For example, while the Tetrahexyldecyl Ascorbate molecule itself is not able to act as an antioxidant, it is proven to protect skin cells from oxidizing stress. It reduces the levels of free radicals, produced by certain chemicals or UV radiation, proving that vitamin C is effectively released [1], [6]. It is also able to protect the skin cell DNA from mutations caused by UV exposure and increase the cell viability [2].

Ascorbyl tetraisopalmitate was also shown to improve the physical appearance of the skin. A formulation with Tetrahexyldecyl Ascorbate acts as a moisturizer, improving the smoothness of the skin. It was also shown to increase the thickness of epithelial layer in mice [5]. Vitamin C is well known for the ability to activate collagen synthesis, and Ascorbyl tetraisopalmitate also retains this effect. In fact, the derivative had an even stronger effect, compared with the same concentrations of vitamin C [2]. Furthermore, it was shown to inhibit the collagen-degrading enzymes, thus it additionally helps maintain higher skin collagen content and improved visual appearance [2].

Furthermore, a cream containing 3 % Tetrahexyldecyl Ascorbate was shown to reduce skin darkening. This is explained by the fact that skin cells, treated with Ascorbyl tetraisopalmitate, do not activate melanocytes (pigment-producing cells) in response to UV radiation [1]. Preparation with Tetrahexyldecyl Ascorbate and flavonoids (a group of plant-produced molecules) had an even stronger effect, reducing skin damage and inflammatory response after UV exposure [7]. Using a combination of several antioxidants also increase the stability and thus the shelf-life of final product. Therefore, researchers suggest combining Ascorbyl tetraisopalmitate with plant extracts and other vitamins [7], [8]

About Vitamin C derivatives in Skin Care

 "Most vitamin C derivatives on the market, including ascorbyl palmitate and magnesuim ascorbyl phosphate, consist of the ascorbic acid fragment (ascorbyl) and a fragment of another acid (e.g. palmitate or phosphate). Recent research indicates that new vitamin C derivatives, such as Tetrahexyldecyl Ascorbate, consisting of multiple chemical fragments bound to a single ascorbic acid fragment may work even better. These new derivatives are more stable compared to both vitamin C and older derivatives. Furthermore, some of these newcomers (particularly the so-called tetrasubstituted lipophilic ascorbates) also appear to be more powerful boosters of collagen synthesis."  
Dr. G. Todorov, Vitamin C Derivatives,

Anhydrous vitamin C Combo 

"There is some evidence that combining water soluble and oil-soluble forms of vitamin C may provide synergistic skin benefits through broader antioxidant protection and better penetration."
Dr. G. Todorov, Anhydrous Vitamin C Combo,

L-ascorbic acid with Ascorbyl Tetraisopalmitate in a waterless silicone base
 "Ten patients having facial photodamage were recruited for a double-blind pilot study of a newly formulated vitamin C ,complex having 10% ascorbic acid, a water soluble acid, and 7% tetrahexyldecyl ascorbate, a lipid soluble analog. Both of these are combined in an anhydrous polysilicone gel base, which acts as a 'dermal patch,' releasing the water soluble acid slowly and the lipid soluble analog rapidly. The active vitamin C complex was applied to one side of the face and the inactive placebo base was applied to the opposite side of the face once a day."
Source: Fitzpatrick RE, Rostan EF. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage. Dermatology Associates of San Diego County, Inc. 92024, USA. Read more
CAS# :183476-82-6
INCI Name: Ascorbyl Tetraisopalmitate
Appearance: Colorless to pale yellow liquid
Suggested percentage: .5% to 7%
  • Excellent solubility in carrier oils, mineral oils, ethanol, silicone. 
  • Insoluble in water, propylene glycol, glycerin.
Stability: Best at pH 5.5
Inorganic Organic balance (IOB) : 0.274
HLB: 2.74 (IOB 0.274 x 10 = HLB 2.74)

Storage: Cool place. Do not freeze.
Country of origin: Japan
[1]          Y. Ochiai, S. Kaburagi, K. Obayashi, N. Ujiie, S. Hashimoto, Y. Okano, H. Masaki, M. Ichihashi, and H. Sakurai, “A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative properties,” J. Dermatol. Sci., vol. 44, no. 1, pp. 37–44, Oct. 2006.
[2]          L. Xiao, K. Kaneyasu, Y. Saitoh, Y. Terashima, Y. Kowata, and N. Miwa, “Cytoprotective effects of the lipoidic-liquiform pro-vitamin C tetra-isopalmitoyl-ascorbate (VC-IP) against ultraviolet-A ray-induced injuries in human skin cells together with collagen retention, MMP inhibition and p53 gene repression,” J. Cell. Biochem., vol. 106, no. 4, pp. 589–598, Mar. 2009.
[3]          I. Yamamoto, N. Muto, K. Murakami, and J. Akiyama, “Collagen synthesis in human skin fibroblasts is stimulated by a stable form of ascorbate, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid,” J. Nutr., vol. 122, no. 4, pp. 871–877, Apr. 1992.
[4]          K. Murakami, N. Muto, K. Fukazawa, and I. Yamamoto, “Comparison of ascorbic acid and ascorbic acid 2-O-alpha-glucoside on the cytotoxicity and bioavailability to low density cultures of fibroblasts,” Biochem. Pharmacol., vol. 44, no. 11, pp. 2191–2197, Dec. 1992.
[5]          P. M. B. G. Maia Campos, M. D. Gianeti, F. B. Camargo, and L. R. Gaspar, “Application of tetra-isopalmitoyl ascorbic acid in cosmetic formulations: stability studies and in vivo efficacy,” Eur. J. Pharm. Biopharm. Off. J. Arbeitsgemeinschaft Für Pharm. Verfahrenstechnik EV, vol. 82, no. 3, pp. 580–586, Nov. 2012.
[6]          P. Jurkovic, M. Sentjurc, M. Gasperlin, J. Kristl, and S. Pecar, “Skin protection against ultraviolet induced free radicals with ascorbyl palmitate in microemulsions,” Eur. J. Pharm. Biopharm. Off. J. Arbeitsgemeinschaft Für Pharm. Verfahrenstechnik EV, vol. 56, no. 1, pp. 59–66, Jul. 2003.
[7]          P. M. B. G. Maia Campos, M. D. Gianeti, A. Kanashiro, Y. M. Lucisano-Valim, and L. R. Gaspar, “In vitro antioxidant and in vivo photoprotective effects of an association of bioflavonoids with liposoluble vitamins,” Photochem. Photobiol., vol. 82, no. 3, pp. 683–688, Jun. 2006.
[8]          M. D. Gianeti, L. R. Gaspar, F. B. de Camargo, and P. M. B. G. M. Campos, “Benefits of combinations of vitamin A, C and E derivatives in the stability of cosmetic formulations,” Mol. Basel Switz., vol. 17, no. 2, pp. 2219–2230, 2012.
[9]          Fitzpatrick RE, Rostan EF. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage. Dermatol Surg. 2002 Mar;28(3):231-6. PubMed PMID: 11896774..

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