Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Reviews
This ingredient has done more for my skin than anything else I've ever used. I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic. I will use this forever, no question... ...»
Marie
Excellent base Ceramide 2, 3, 6II Lamellar Liquid Crystal PRE emulsion! It went very well for me and my daughter, she has atopic dermatitis. Literally on the third day of applying the cream (which is made up of Multi Lamellar Base Cream V2 Carrier Oil Free, NO Polymer 60%, 10% black currant oil, rice bran oil 5%, 1% of the complex of ceramides and water), the skin of my daughter got clean and healthy. I have noticeably narrowed pores, face was moist and disappeared on my forehead shine. Now Mul.. ...»
Lidia
I've been using Bulkactives green tea EGCG for four years. No complaints, it blends nicely my DIY anti-aging cream. I can feel a bit of toning and definitely notice the anti-inflammatory effects on my skin. Two observations that keep the rating 4 stars instead of 5: (1) A package of green tea contains significantly less weight/volume than the package of grape seed extract that I order from bulkactives. The two are combined in equal amounts in the anti-aging cream, so I find myself running o.. ...»
Theresa Andrews
Another great find on bulkactives. Mixed with de mineralized water, you have the basis to add to any serum, mix with your moisturiser, to simply use on it's own. Love it... ...»
Jan
Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
Angela
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
Jessie Sandford
Many thanks for the Silicone DM. This product is lovely quality; it is light, silky, and leaves no residue at all. I use it in the base recipe for a mouldable polymer that I then use to make a simulated 'Amber' for bead making. At the end of this process I have a silky, translucent polymer plus the most gorgeous hands in the studio ! My thanks again, Helen.. ...»
HELEN pEAKE
Very good product! Only been using it for a short time, its already made a difference. .. ...»
Bronwynne
muy satisfecho profesionales, y envio sin problemas ,ya que soy de españa producto bien envasado , un placer ser cliente porque dan comnfianza y calidad.gracias un saludo.. ...»
daniel
Wanting to try this, but.... Angela, what was that about effecting hormones? Could someone explain please..... ...»
Carla
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Buy GABA (Gamma-aminobutyric acid) For Skin Care

GABA (gamma-aminobutyric acid) is a neurotransmitter with purported dermatological benefits. Several patents indicated that GABA can be used as a wrinkle relaxer based on its inhibitory effect on muscles. Some patents also claim that GABA can dilate skin peripheral blood vessels, moisturize and prevent aging, suppress parakeratosis and shrink pores, as well as whitening the skin. However there is no scientific data to support these claims. On the other hand, a preliminary research study has shown that GABA can stimulate hyaluronic acid synthesis and protect the fibroblasts from oxidative stress. Another study showed that GABA was able to upregulate beta-defensin-2, which is an anti-microbial peptide, and filaggrin, which plays a role in normal barrier function of the skin. Lastly, GABA might be useful in combating inflammation associated with psoriasis based on preliminary findings that GABA receptors are expressed in white blood cells in psoriatic skin. Overall, the evidence of GABA in supporting skin health is very weak, and consumers are warned for its application.

Unsubstantiated benefits of GABA (Gamma-aminobutyric acid) in skin care:

  • Anti-bacterial [11]
  • Anti-inflammatory [12]
  • Anti-oxidant [10]
  • Capillary health [4][5][6]
  • Lightening and brightening [8][9]
  • Moisturizing and hydration [4][5][6][11]
  • Pore refinement [7]
  • Reduce fine lines and wrinkles [2][3][4][5]
  • Restore barrier function [11]
  • Stimulate HA production [10]
  • Wrinkle relaxers [2][3][4][5]
GABA (Gamma-aminobutyric acid) skin care active ingredients
Product Code: BulkActives
Reward Points: 3
CAS#: 56-12-2
Net weight: 30g /1.06oz
Availability: In Stock
Price: $5.10
Reward Points: 255


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GABA (Gamma-aminobutyric acid)

About GABA (Gamma-aminobutyric acid) in DIY Skin Care

Gamma-aminobutyric acid (GABA) is a well-known neurotransmitter. In the mature brain of humans, it exerts inhibitory function on neurons when bind to GABA receptors, through regulating the chloride gradient across the cell membrane. GABA is synthesized by enzymes called glutamate decarboxylase, using glutamate as the substrate. Once synthesized, it is transported in little vesicles to the synapses of the neurons, and its action depends on its metabolism, expression, and activity level. GABA is important for brain development, and its dysfunction has been linked to a myriad of neurological disorders such as autism, Fragile X, Rett syndrome, Down syndrome, schizophrenia, Tourette's syndrome and neurofibromatosis.[1]

GABA has been marketed as a wrinkle relaxer based on the claim that it can inhibit neuronal activity and hence relax muscles, limiting the “expression lines” resulted from muscle hyper-contraction such as in the peri-oral regions. There are several patents that indicate such function when used topically.[2][3][4][5] Other patents that mentioned GABA’s benefits include dilation of skin peripheral blood vessels,[4][5][6] moisturizing and age-preventing,[4][5][6] suppressing parakeratosis and pore shrinking,[7] and whitening effects.[8][9] However, there have been no peer-reviewed study published to date (May, 2015) on these effects.

Research on dermatological use of GABA has been sporadic. It has been shown that glutamate decarboxylase exists in human dermal fibroblasts, and GABA can stimulate the synthesis of hyaluronic acid and enhances the survival rate of the fibroblasts when exposed to oxidative stress in vitro.[10] GABA synthesized from fermentation of grape must using bacteria (Lactobacillus plantarum) has been shown to increase the level of beta-defensin-2, hyaluronan synthase, and filaggrin in reconstituted human skin tissue,[11] suggesting that GABA might play a role in anti-microbial function, hydration, and proper barrier function of the skin. GABA receptors are expressed in a number of white blood cell types in psoriatic skin, and GABA has been implicated to be important in relieving inflammation associated with psoriasis.[12] These studies provide new possibilities for the application of GABA, however consumers are encouraged to exercise precautions due to the fact that none of these studies has been replicated and substantiated.
Assay: 99.6%
CAS No.: 56-12-2
INCI: Gamma-AminoButyric Acid
Appearance: white powder
Solubility: water
Suggested percentage: No data available, up to customer's discretion

Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China
[1]          G. Deidda, I. F. Bozarth, and L. Cancedda, “Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives,” Front. Cell. Neurosci., vol. 8, May 2014.
[2]          O. D. Lacharriere and L. Breton, “Compositions and methods for treating wrinkles and/or fine lines of the skin,” US5976559 A, 02-Nov-1999.
[3]          O. D. Lacharriere and L. Breton, “Compositions and methods for treating wrinkles and/or fine lines of the skin,” US5869068 A, 09-Feb-1999.
[4]          H. Kyotaro and H. Minoru, “Cosmetic for preventing skin from aging,” 05-043448, 23-Feb-1993.
[5]          T. Hiroshi, “Cosmetic for preventing aging of skin,” 05-117137, 14-May-1993.
[6]          O. Tadatake, A. Takashi, and H. Kyotaro, “Cosmetic for preventing aging of skin,” 60-184005, 19-Sep-1985.
[7]          M. Kaminuma, M. Suetsugu, T. Iida, and S. Inomata, “Parakeratosis inhibitor, pore -shrinking agent and external compositon for skin,” US20120232111 A1, 13-Sep-2012.
[8]          S. Tatsuro and T. Hiroshi, “Skin-whitening cosmetic,” 05-229929, 09-Jul-1993.
[9]          T. Hiroshi and S. Tatsuro, “Skin-beautifying cosmetic,” 05-194178, 08-Mar-1993.
[10]        K. Ito, K. Tanaka, Y. Nishibe, J. Hasegawa, and H. Ueno, “GABA-synthesizing enzyme, GAD67, from dermal fibroblasts: evidence for a new skin function,” Biochim. Biophys. Acta, vol. 1770, no. 2, pp. 291–296, Feb. 2007.
[11]        R. Di Cagno, F. Mazzacane, C. G. Rizzello, M. De Angelis, G. Giuliani, M. Meloni, B. De Servi, and M. Gobbetti, “Synthesis of gamma-aminobutyric acid (GABA) by Lactobacillus plantarum DSM19463: functional grape must beverage and dermatological applications,” Appl. Microbiol. Biotechnol., vol. 86, no. 2, pp. 731–741, Mar. 2010.
[12]        R. Nigam, H. El-Nour, B. Amatya, and K. Nordlind, “GABA and GABA(A) receptor expression on immune cells in psoriasis: a pathophysiological role,” Arch. Dermatol. Res., vol. 302, no. 7, pp. 507–515, Sep. 2010.

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