Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Reviews
Excellent quality, very fine texture and disperses easily when used correctly. Arrived in just seven days to London, England and with a reasonable postage fee. Very pleased... ...»
D N Bay
This ingredient has done more for my skin than anything else I've ever used. I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic. I will use this forever, no question... ...»
Marie
I've been using Bulkactives green tea EGCG for four years. No complaints, it blends nicely my DIY anti-aging cream. I can feel a bit of toning and definitely notice the anti-inflammatory effects on my skin. Two observations that keep the rating 4 stars instead of 5: (1) A package of green tea contains significantly less weight/volume than the package of grape seed extract that I order from bulkactives. The two are combined in equal amounts in the anti-aging cream, so I find myself running o.. ...»
Theresa Andrews
Awesome Product and thanks for such a nice Product description .. ...»
Stephen
Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
Angela
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
Jessie Sandford
Many thanks for the Silicone DM. This product is lovely quality; it is light, silky, and leaves no residue at all. I use it in the base recipe for a mouldable polymer that I then use to make a simulated 'Amber' for bead making. At the end of this process I have a silky, translucent polymer plus the most gorgeous hands in the studio ! My thanks again, Helen.. ...»
HELEN pEAKE
Very good product! Only been using it for a short time, its already made a difference. .. ...»
Bronwynne
muy satisfecho profesionales, y envio sin problemas ,ya que soy de españa producto bien envasado , un placer ser cliente porque dan comnfianza y calidad.gracias un saludo.. ...»
daniel
Wanting to try this, but.... Angela, what was that about effecting hormones? Could someone explain please..... ...»
Carla
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Buy Carnitine (L-Carnitine) For Skin Care

Carnitine is a naturally occurring substance, necessary for fat and glucose metabolism in human body cells. Primary function of carnitine in pharmacy is the reduction of advanced glycation end products (AGEs). AGEs are proteins, damaged by reactions with sugars, therefore glycation is most prominent in diabetes patients. It also occurs in many other diseases, as well as natural ageing processes. Dermal carnitine applications reduce the level of glycated collagen and promote synthesis of new protein. Since it is involved in lipid metabolism, carnitine is used for acne treatment. It effectively reduces sebum secretion and skin oiliness. Carnitine preparations also improve other aspects of the skin, such as tonicity, and reduce cellulite. Finally, it aids skin regeneration after damage, such as burns, and promotes blood vessel formation.  Regretably, due to Candian law and PayPal regulations, this product may NOT be shipped to Canada.

Key beneftis of Carnitine in skin care:

  • Oil/sebum control [4] [5]
  • Glycation inhibition and repair [1] [3]
  • Increase cellular energy production [1] [3]
  • Anti-acne [5]
  • Restore barrier function [6] [7]
  • Wound-healing support [8]
Carnitine (L-Carnitine) skin care active ingredients
Product Code: BulkActives
Reward Points: 3
Assay: 99%
CAS#: 3040-38-8
Net weight: 30g /1.06oz
Availability: In Stock
Price: $6.60
Reward Points: 330


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Carnitine (L-Carnitine)

About L Carnitine in DIY Skin Care

Carnitine (also L-carnitine or CA) is a naturally occurring substance, necessary for the cellular metabolism of glucose, fat and related compounds. Since these metabolic processes occur in most cells of the body, carnitine deficiency is associated with a wide range of diseases, such as muscle weakness, cardiac hypertrophy and accelerated atherosclerosis [1], [2]. Most importantly, carnitine helps to reduce protein glycation levels.

Glycation is a detrimental protein change that occurs in typical ageing processes. It involves a non-specific reaction between various sugars and proteins, especially collagen [3]. The damage brought on by such reactions is irreversible and results in dysfunctional protein aggregates, called advanced glycation end products (AGEs). AGE formation proceeds faster under elevated blood sugar levels, typically caused by diabetes, but they are also involved in the development of other disorders, among them osteoporosis, Alzheimer’s disease and cancer [1]. Carnitine was shown to be successful at inhibiting collagen glycation in rats that were fed on a high-sugar diet [3].

Furthermore, it reduced the AGE levels even more than commercially used antiglycation agent aminoguanidine, and also enhanced glucose metabolism in the diaphragm. Research on humans also confirms this conclusion, indicating that carnitine successfully reduces AGE levels in skin [1]. It is even suggested for management of adverse chemo- and radiotherapy effects. Recent studies have found that carnitine reduces therapy-caused damage to various organs and possibly even fatigue from chemotherapy [2].

In skin care, carnitine is a favored ingredient for several purposes.

Due to its role in lipid metabolism, it is known to inhibit sebum secretion and thus reduce skin oiliness. Applying 2 %-carnitine containing cream for 3 weeks was enough to significantly reduce both lipid content and sebum production in human sebaceous glands [4]. The same effect is utilized in anti-acne preparations with carnitine. In a study of mild to moderately severe acne, volunteers used a face cleanser with carnitine for 8 weeks. Total lesion count, sebum production, bacterial colonization, were all reduced; pustule count decreased 5 times, and general life quality of the subjects (measured by a questionnaire test) was improved [5].

Carnitine can also improve skin appearance in other ways. It is involved in skin cell proliferation, as it was shown to increase epidermal thickness both in healthy skin and during regeneration after wounds [6], [7]. Using a carnitine-containing preparation for 12 weeks resulted in various esthetic improvements of the skin, such as decreased cellulite and improved tonicity [6]. It is also known to promote wound healing, likely due to increased collagen synthesis, skin cell migration or energy release [7]–[9]. This effect is especially important in patients using steroids, as these medications can reduce the activity of immune processes necessary for wound healing [8]. The healing process can also be disrupted by diabetes, but preparations containing carnitine were effective in such models as well, promoting skin regeneration and faster healing [9]. Benefits of carnitine are not limited to simple wounds – larger burns were also investigated. Carnitine successfully reduced tissue necrosis, promoted cell proliferation, and increased the formation of new blood vessels [10], [11]. The positive effects on skin cells is enhanced even more when carnitine is combined with retinol (a form of vitamin A) or vitamin C [6], [10].

Carnitine exists in two forms: L-Carnitine and D-Carnitine.  Only the L-Carnitine form is desirous as the D-Carnitine form is physiologically inactive and can inhibit the uptake and functions of the natural isomer L-Carnitine. BulkActives' Carnitine is L carnitine. 

 
Assay: 99%
CAS#: 3040-38-8
INCI: Acetyl Carnitine
Appearance: white powder
Solubility: water, Dimethyl isosorbide
Suggested percentage: 2%

Storage: Keep tightly closed, in cool place. Hygroscopic. 
Country of origin: China
[1]          K. Fukami, S.-I. Yamagishi, K. Sakai, Y. Kaida, T. Adachi, R. Ando, and S. Okuda, “Potential inhibitory effects of L-carnitine supplementation on tissue advanced glycation end products in patients with hemodialysis,” Rejuvenation Res., vol. 16, no. 6, pp. 460–466, Dec. 2013.
[2]          H. A. Khan and A. S. Alhomida, “A review of the logistic role of L-carnitine in the management of radiation toxicity and radiotherapy side effects,” J. Appl. Toxicol. JAT, vol. 31, no. 8, pp. 707–713, Nov. 2011.
[3]          P. Rajasekar and C. V. Anuradha, “L-Carnitine inhibits protein glycation in vitro and in vivo: evidence for a role in diabetic management,” Acta Diabetol., vol. 44, no. 2, pp. 83–90, Jun. 2007.
[4]          R. I. Peirano, T. Hamann, H.-J. Düsing, M. Akhiani, U. Koop, T. Schmidt-Rose, and H. Wenck, “Topically applied L-carnitine effectively reduces sebum secretion in human skin,” J. Cosmet. Dermatol., vol. 11, no. 1, pp. 30–36, Mar. 2012.
[5]          I. Angelova-Fischer, F. Rippke, T. W. Fischer, G. Neufang, and D. Zillikens, “A double-blind, randomized, vehicle-controlled efficacy assessment study of a skin care formulation for improvement of mild to moderately severe acne,” J. Eur. Acad. Dermatol. Venereol. JEADV, vol. 27 Suppl 2, pp. 6–11, Jul. 2013.
[6]          R. Roure, T. Oddos, A. Rossi, F. Vial, and C. Bertin, “Evaluation of the efficacy of a topical cosmetic slimming product combining tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol, In vitro, ex vivo and in vivo studies,” Int. J. Cosmet. Sci., vol. 33, no. 6, pp. 519–526, Dec. 2011.
[7]          T. Karsidag, J. A. Asensio, F. Kabukcuoglu, and S. Tuzun, “Preliminary study comparing the effects of locally and systemically applied L-carnitine on the healing of full-thickness skin defects,” Scand. J. Surg. SJS Off. Organ Finn. Surg. Soc. Scand. Surg. Soc., vol. 99, no. 3, pp. 147–152, 2010.
[8]          A. Akkus, K. Aydinuraz, C. Daphan, O. Saygun, O. Caglayan, M. Edremitlioglu, and F. Agalar, “Effect of carnitine on cutaneous wound healing in immunosuppressed rats,” J. Surg. Res., vol. 155, no. 2, pp. 301–305, Aug. 2009.
[9]          L. Gennero, R. De Siena, T. Denysenko, M. A. Roos, G. F. Calisti, M. Martano, S. Fiobellot, M. Panzone, S. Reguzzi, L. Gabetti, A. Vercelli, G. Cavallo, E. Ricci, and G. P. Pescarmona, “A novel composition for in vitro and in vivo regeneration of skin and connective tissues,” Cell Biochem. Funct., vol. 29, no. 4, pp. 311–333, Jun. 2011.
[10]        E. Arslan, Y. Basterzi, A. Aksoy, C. Majka, S. Unal, A. Sari, and F. Demirkan, “The additive effects of carnitine and ascorbic acid on distally burned dorsal skin flap in rats,” Med. Sci. Monit. Int. Med. J. Exp. Clin. Res., vol. 11, no. 6, pp. BR176–180, Jun. 2005.
[11]        E. Arslan, A. Milcan, S. Unal, F. Demirkan, A. Polat, O. Bagdatoglu, A. Aksoy, and G. Polat, “The effects of carnitine on distally-burned dorsal skin flap: an experimental study in rats,” Burns J. Int. Soc. Burn Inj., vol. 29, no. 3, pp. 221–227, May 2003.
 

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