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Buy Ascorbic Acid -L (ultra fine powder) For Skin Care

L-ascorbic acid (vitamin C) is an essential nutrient which has many cosmetic benefits. It is a remarkable antioxidant and can scavenge reactive oxygen species and other free radicals, protecting the skin from oxidative stress. It can stimulate collagen synthesis by promoting cross-linking and stabilizing collagen molecules, upregulating collagen genes, increasing the transcription of the tissue inhibitor of matrix metalloproteinase 1, and inducing fibroblast proliferation. It reduces pigmentation by suppressing tyrosinase, which is important for melanin production. It is an anti-inflammatory agent and can be used to treat inflammatory skin disease such as erythema. Together, L-ascorbic acid provides powerful anti-aging properties and has been shown to reduce wrinkles, improve elasticity, and protect against sun damage. Stability and absorption of L-ascorbic acid is a concern. While the anhydrous L-ascorbic acid might be the most stable form, adding vitamin E not only helps stabilizing L-ascorbic acid, but the two have synergistic effects on anti-aging. Used in: philosopy's turbo booster c powder and SkinCeuticals.

Key benefts of L-ascorbic acid in skin care:

Anti-inflammatory ^[31]
Antioxidant^{[4] [5] [6] [7] [8]}
Increase skin elasticity ^[26]
Lightening and brightening^{[4] [22] [28] [29] [30]}
Matrix metalloproteinases (MMP) inhibitors ^[19]
Moisturizing and hydration ^[21]
Reduce fine lines and wrinkles ^{[7] [21] [22] [25] [26]}
Ttimulate collagen production^{[5] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24]}
Sun damage protection ^{[9] [11]}
Sun damage repair ^{[6] [22] [26]}
Teat hyperpigmentation ^{[4] [9] [22] [25] [28] [29] [30]}
Wrinkle relaxers ^[22]

Product Code: BulkActives
CAS#: 50-81-7
Net weight: 30g /1.06oz
Availability: In Stock

Price: $7.10

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Description specifications references recipes/usage Reviews (4) Related Products (42)

Ascorbic Acid -L (ultra fine powder)

About L Ascorbic Acid / Vitamin C in DIY Skin Care

L-ascorbic acid (AA), the active form of vitamin C, is a remarkable anti-aging substance due to its anti-oxidative, collagen-producing, and pigment-reducing effects. Humans have to get AA from food sources, however since its active transport from our digestive system is low, it is hard to achieve optimal skin level of AA from food alone.[1] AA level decreases with sunlight and pollution quite dramatically,[1] and topical supplementation of AA can provide an ideal solution especially considering the fact that keratinocytes can actively take up AA and maintain its level efficiently.[2]
AA protects against oxidative stress by scavenging reactive oxygen species and other free radicals that are a result of normal daily function, UV radiation, and/or pollutants.[3] This was evident in human skin both in vitro[4][5] and in vivo.[6][7] Interestingly, AA does not function alone as an antioxidant. Rather, AA is able to recycle oxidized a-tocopherol (which is produced constantly on the cell membrane) and hence regenerate vitamin E[8], augmenting the skin’s anti-oxidative capacity. AA and vitamin E work synergistically, as shown both in human skin cells[9][10] and a randomized, double-blind trial[11].

AA is an essential cofactor for two enzymes involved in collagen synthesis, lysyl hydroxylase (for cross-linking collagen molecules) and prolyl hydroxylase (for stabilizing collagen).[12] AA increases collagen synthesis in vitro,[5][13][14][15][16][17] ex vivo,[18] in a controlled clinical trial,[19] double-blind controlled trials,[20][21] as well as a randomized double-blind controlled trial.[22] It has been shown that the stimulatory effect of AA on collagen synthesis is at the DNA level,[23][24] not just post-translational. In addition, AA application increased the mRNA of tissue inhibitor of the collagen-degrading matrix metalloproteinase 1.[19] Furthermore, AA stimulates fibroblast proliferation[15], further contributing to wrinkle reduction, as seen in a controlled trial,[25] and randomized double-blind controlled trials.[21][22][26]

In addition to anti-oxidative function, AA combats pigmentation also by suppressing tyrosinase, an enzyme that is crucial for melanin formation.[27] AA inhibits pigmentation in vitro,[4] in vivo,[9][28][29] in a controlled trial,[25] a randomized double-blind trial,[30] and a randomized double-blind controlled trial,[22] while providing sun damage protection[9][11] and repair.[6][22][26]
AA is anti-inflammatory[31] and has been used to treat erythema in a randomized controlled study.[32] AA was also effective at treating striae alba (stretch marks)[33] and can possibly provide would healing support. Interestingly, AA has also been shown to increase certain sphingolipids in vitro,[34] such as ceramides, and might be helpful in maintaining the barrier function of the skin.
AA is highly unstable under the exposure of water, air, and light (because it is such an excellent antioxidant). There are many strategies for increasing the stability and absorption of AA, one of which is altering its chemical structure.[3] However, for any of the AA derivatives to be effective, they need to be able to release or be converted back to AA in the skin.[3] Adding vitamin A,[35] vitamin E[35][36] and/or cinnamic acids derivatives (such as p-coumaric acid, ferulic acid, caffeic acid, and sinapinic acid)[37] help stabilize AA, and it has been suggested that the anhydrous form of AA is the most stable.[38]

C+E+Ferulic in DIY Skin care

"SkinCeuticals antioxidant combination of C+E+Ferulic delivers an unprecedented 8 times the skin's natural protection against photoaging - neutralizing free radicals, helping build collagen, and providing unmatched antioxidant protection. Containing 15% pure L-ascorbic acid and 1% alpha tocopherol, the addition of 0.5%Ferulic acid doubles the already synergistic benefits of the original high-potency formula, C+E, transforming it into an unrivaled super-antioxidant combination."

C E Ferulic is a revolutionary antioxidant combination that delivers advanced protection against photoaging by neutralizing free radicals, boosting collagen synthesis, and providing unmatched antioxidant protection. More protection means more youthful looking skin and better defense against environmental aging.

Provides advanced environmental protection against UVA, UVB and infrared radiation A
Stimulates collagen synthesis to improve signs of aging
Increases firmness and replenishes lipids to reduce wrinkles
Once absorbed, this serum can’t be washed or rubbed off. It remains effective for a minimum of 72 hours, making it an excellent addition to sunscreen.

The addition of ferulic acid to 15% pure L-ascorbic acid (vitamin C) and 1% alpha tocopherol (vitamin E) increases the environmental protection.

This antioxidant combination enhances protection against damaging UV rays to better prevent visible signs of aging.
Stimulates collagen production to help diminish the appearance of photodamage.

Key ingredients of Vitamin C, Vitamin E, and Ferulic Acid serum:

15% L-ascorbic acid: Neutralizes free radicals and promotes collagen synthesis.
1% alpha tocopherol (vitamin E): Neutralizes free radicals, provides the healing process.
0.5% ferulic acid: This plant-based antioxidant neutralizes free radicals, inhibits UV-induced melanogenesis, and has anti-inflammatory properties.

Assay: 99.8%
CAS#: 50-81-7
INCI: L-Ascorbic Acid
Description: powder
Mesh size: 100% through 100, 95% though 200 (US standard sieve) - Ultra-fine powder.
Our 100% pure L-Ascorbic Acid is an ultra- fine powder. It feels like ICING SUGAR. It does not require grinding and will EASILY dissolve in water up to 25% , it also disperses very well in a silicone base.
Solubility: water
pH: 2.2 - 2.5 (at 5% in water)
Suggested percentage: 10% to 15% (20% if you can handle it)
Stability: L-Ascorbic Acid is very unstable. As soon as you put it in water, it will start oxidizing. It is best used fresh every day. It can be made substantially more stable if your formula contains a large percentage of ethanol. Ferulic Acid will also help stabilize it.

Shelf Life: The manufacturer's stated "best use" date is two years from date of manufacture, if the container is unopened and stored away from heat, light and air. We repackage this product in foil bags. Over time, constant opening and closing of the bag will eventually allow the l-ascorbic acid to adsorb the moisture in the air and it will begin to oxidize. This will be noticeable as it takes on a yellow color in solution.

Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: Japan

[1]          K. E. Burke, “Interaction of vitamins C and E as better cosmeceuticals,” Dermatol. Ther., vol. 20, no. 5, pp. 314–321, Oct. 2007.
[2]          M. V. Catani, I. Savini, A. Rossi, G. Melino, and L. Avigliano, “Biological role of vitamin C in keratinocytes,” Nutr. Rev., vol. 63, no. 3, pp. 81–90, Mar. 2005.
[3]          N. P. J. Stamford, “Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives,” J. Cosmet. Dermatol., vol. 11, no. 4, pp. 310–317, Dec. 2012.
[4]          U. Panich, V. Tangsupa-a-nan, T. Onkoksoong, K. Kongtaphan, K. Kasetsinsombat, P. Akarasereenont, and A. Wongkajornsilp, “Inhibition of UVA-mediated melanogenesis by ascorbic acid through modulation of antioxidant defense and nitric oxide system,” Arch. Pharm. Res., vol. 34, no. 5, pp. 811–820, May 2011.
[5]          H. J. Park, S. M. Ock, H. J. Kim, H. J. Park, Y. B. Lee, J. M. Choi, C. S. Cho, J. Y. Lee, B. K. Cho, and D. H. Cho, “Vitamin C attenuates ERK signalling to inhibit the regulation of collagen production by LL-37 in human dermal fibroblasts,” Exp. Dermatol., vol. 19, no. 8, pp. e258–e264, Aug. 2010.
[6]          J. Murray, D. Darr, J. Reich, and S. Pinnell, “Topical vitamin-C treatment reduces ultraviolet-B radiation-induced erythema in human skin,” in Journal of Investigative Dermatology, 1991, vol. 96, pp. 587–587.
[7]          T. Raschke, U. Koop, H.-J. Düsing, A. Filbry, K. Sauermann, S. Jaspers, H. Wenck, and K.-P. Wittern, “Topical activity of ascorbic acid: from in vitro optimization to in vivo efficacy,” Skin Pharmacol. Physiol., vol. 17, no. 4, pp. 200–206, Aug. 2004.
[8]          A. C. Chan, “Partners in defense, vitamin E and vitamin C,” Can. J. Physiol. Pharmacol., vol. 71, no. 9, pp. 725–731, Sep. 1993.
[9]          W. C. Quevedo, T. J. Holstein, J. Dyckman, and C. J. McDonald, “The responses of the human epidermal melanocyte system to chronic erythemal doses of UVR in skin protected by topical applications of a combination of vitamins C and E,” Pigment Cell Res. Spons. Eur. Soc. Pigment Cell Res. Int. Pigment Cell Soc., vol. 13, no. 3, pp. 190–192, Jun. 2000.
[10]        K. E. Burke, “Interaction of vitamins C and E as better cosmeceuticals,” Dermatol. Ther., vol. 20, no. 5, pp. 314–321, Oct. 2007.
[11]        F. Dreher, B. Gabard, D. A. Schwindt, and H. I. Maibach, “Topical melatonin in combination with vitamins E and C protects skin from ultraviolet-induced erythema: a human study in vivo,” Br. J. Dermatol., vol. 139, no. 2, pp. 332–339, Aug. 1998.
[12]        K. I. Kivirikko and R. Myllylä, “Post-translational processing of procollagens,” Ann. N. Y. Acad. Sci., vol. 460, pp. 187–201, 1985.
[13]        C. L. Phillips, S. Tajima, and S. R. Pinnell, “Ascorbic acid and transforming growth factor-beta 1 increase collagen biosynthesis via different mechanisms: coordinate regulation of pro alpha 1(I) and Pro alpha 1(III) collagens,” Arch. Biochem. Biophys., vol. 295, no. 2, pp. 397–403, Jun. 1992.
[14]        J. C. Geesin, D. Darr, R. Kaufman, S. Murad, and S. R. Pinnell, “Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast,” J. Invest. Dermatol., vol. 90, no. 4, pp. 420–424, Apr. 1988.
[15]        C. L. Phillips, S. B. Combs, and S. R. Pinnell, “Effects of ascorbic acid on proliferation and collagen synthesis in relation to the donor age of human dermal fibroblasts,” J. Invest. Dermatol., vol. 103, no. 2, pp. 228–232, Aug. 1994.
[16]        N. Boyera, I. Galey, and B. A. Bernard, “Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts,” Int. J. Cosmet. Sci., vol. 20, no. 3, pp. 151–158, Jun. 1998.
[17]        M. D. Kaplan, S. J. Moloney, W. R. Troy, M. S. Dickens, and S. R. Pinnell, “A new stabilized ascorbic acid solution: Percutaneous absorption and effect on relative collagen synthesis,” J Cutan. Ag Cosm Derm, vol. 1, pp. 88–92, 1988.
[18]        G. K. Heber, B. Markovic, and A. Hayes, “An immunohistological study of anhydrous topical ascorbic acid compositions on ex vivo human skin,” J. Cosmet. Dermatol., vol. 5, no. 2, pp. 150–156, Jun. 2006.
[19]        B. V. Nusgens, P. Humbert, A. Rougier, A. C. Colige, M. Haftek, C. A. Lambert, A. Richard, P. Creidi, and C. M. Lapière, “Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis,” J. Invest. Dermatol., vol. 116, no. 6, pp. 853–859, Jun. 2001.
[20]        B. V. Nusgens, P. Humbert, A. Rougier, A. Richard, and C. M. Lapière, “Stimulation of collagen biosynthesis by topically applied vitamin C,” Eur. J. Dermatol. EJD, vol. 12, no. 4, pp. XXXII–XXXIV, Aug. 2002.
[21]        R. E. Fitzpatrick and E. F. Rostan, “Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage,” Dermatol. Surg. Off. Publ. Am. Soc. Dermatol. Surg. Al, vol. 28, no. 3, pp. 231–236, Mar. 2002.
[22]        P. G. Humbert, M. Haftek, P. Creidi, C. Lapière, B. Nusgens, A. Richard, D. Schmitt, A. Rougier, and H. Zahouani, “Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo,” Exp. Dermatol., vol. 12, no. 3, pp. 237–244, Jun. 2003.
[23]        S. Tajima and S. R. Pinnell, “Ascorbic acid preferentially enhances type I and III collagen gene transcription in human skin fibroblasts,” J. Dermatol. Sci., vol. 11, no. 3, pp. 250–253, Mar. 1996.
[24]        S. Belin, F. Kaya, S. Burtey, and M. Fontes, “Ascorbic Acid and gene expression: another example of regulation of gene expression by small molecules?,” Curr. Genomics, vol. 11, no. 1, pp. 52–57, Mar. 2010.
[25]        T.-H. Xu, J. Z. S. Chen, Y.-H. Li, Y. Wu, Y.-J. Luo, X.-H. Gao, and H.-D. Chen, “Split-face study of topical 23.8% L-ascorbic acid serum in treating photo-aged skin,” J. Drugs Dermatol. JDD, vol. 11, no. 1, pp. 51–56, Jan. 2012.
[26]        S. S. Traikovich, “Use of topical ascorbic acid and its effects on photodamaged skin topography,” Arch. Otolaryngol. Head Neck Surg., vol. 125, no. 10, pp. 1091–1098, Oct. 1999.
[27]        H. Ando, H. Kondoh, M. Ichihashi, and V. J. Hearing, “Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase,” J. Invest. Dermatol., vol. 127, no. 4, pp. 751–761, Apr. 2007.
[28]        S. Kim, S. Y. Oh, and S. H. Lee, “Comparative Study of Glycolic Acid Peeling vs. Vitamin C-iontophoresis in Melasma,” Korean J. Dermatol., vol. 39, no. 12, pp. 1356–1363, Dec. 2001.
[29]        S.-W. Hwang, D.-J. Oh, D. Lee, J.-W. Kim, and S.-W. Park, “Clinical efficacy of 25% L-ascorbic acid (C’ensil) in the treatment of melasma,” J. Cutan. Med. Surg., vol. 13, no. 2, pp. 74–81, Apr. 2009.
[30]        L. E. Espinal-Perez, B. Moncada, and J. P. Castanedo-Cazares, “A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma,” Int. J. Dermatol., vol. 43, no. 8, pp. 604–607, Aug. 2004.
[31]        J. M. Cárcamo, A. Pedraza, O. Bórquez-Ojeda, and D. W. Golde, “Vitamin C suppresses TNF alpha-induced NF kappa B activation by inhibiting I kappa B alpha phosphorylation,” Biochemistry (Mosc.), vol. 41, no. 43, pp. 12995–13002, Oct. 2002.
[32]        T. S. Alster and T. B. West, “Effect of topical vitamin C on postoperative carbon dioxide laser resurfacing erythema,” Dermatol. Surg. Off. Publ. Am. Soc. Dermatol. Surg. Al, vol. 24, no. 3, pp. 331–334, Mar. 1998.
[33]        K. Ash, J. Lord, M. Zukowski, and D. H. McDaniel, “Comparison of topical therapy for striae alba (20% glycolic acid/0.05% tretinoin versus 20% glycolic acid/10% L-ascorbic acid),” Dermatol. Surg. Off. Publ. Am. Soc. Dermatol. Surg. Al, vol. 24, no. 8, pp. 849–856, Aug. 1998.
[34]        Y. Uchida, M. Behne, D. Quiec, P. M. Elias, and W. M. Holleran, “Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte cultures,” J. Invest. Dermatol., vol. 117, no. 5, pp. 1307–1313, Nov. 2001.
[35]        M. D. Gianeti, L. R. Gaspar, F. B. de Camargo, and P. M. B. G. M. Campos, “Benefits of combinations of vitamin A, C and E derivatives in the stability of cosmetic formulations,” Mol. Basel Switz., vol. 17, no. 2, pp. 2219–2230, 2012.
[36]        I. Ahmad, M. A. Sheraz, S. Ahmed, R. Bano, and F. H. M. Vaid, “Photochemical interaction of ascorbic acid with riboflavin, nicotinamide and alpha-tocopherol in cream formulations,” Int. J. Cosmet. Sci., vol. 34, no. 2, pp. 123–131, Apr. 2012.
[37]        J. Zielinski and S. Pinnell, Stabilized ascorbic acid compositions and methods therefor. Google Patents, 2005.
[38]        C. M. Burgess, Ed., Cosmetic Dermatology. Berlin/Heidelberg: Springer-Verlag, 2005.