Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Reviews
I wished i could order this in a smaller amount of 50 gr. Can i get informed when it is available ? -------------------- A. It will not be sold in smaller amounts. The review rating is meant to be for the product, not the size in which it is sold :-(.. ...»
Diana
Excellent quality, very fine texture and disperses easily when used correctly. Arrived in just seven days to London, England and with a reasonable postage fee. Very pleased... ...»
D N Bay
The best, most potent and most stable form of Vitamin C. Makes quite a difference to the appearance of mature, photo-damaged skin - don't expect results over night but with consistent use your skin will look more even and radiant!.. ...»
Judy
Very good product. It performed exactly how I expected. .. ...»
Ryan
This ingredient has done more for my skin than anything else I've ever used. I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic. I will use this forever, no question... ...»
Marie
I bought this product before and I am here to buy it again! A high quality product for really good price... .. Thanks!.. ...»
Raisa
Love the fine powder ascorbic acid. I use it in a recipe for skin care along with hyaluronic acid. I'm 65 years old and absolutely no one believes it 'cause I've been doing this for years... ...»
Kathy
As all products from bulkactives, this is a really great and high-quality DYI ingredient. Along with John's friendly, reliable and very efficient service, it makes a purchase from bulkactives a very pleasant experience... ...»
Sandra
Purchased this some time ago from BulkActives and here to buy some more! Great stuff!!!!.. ...»
Kathy
I've been using Bulkactives green tea EGCG for four years. No complaints, it blends nicely my DIY anti-aging cream. I can feel a bit of toning and definitely notice the anti-inflammatory effects on my skin. Two observations that keep the rating 4 stars instead of 5: (1) A package of green tea contains significantly less weight/volume than the package of grape seed extract that I order from bulkactives. The two are combined in equal amounts in the anti-aging cream, so I find myself running o.. ...»
Theresa Andrews
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Ascorbyl Glucoside in Skin Care (AA2G, stable Vitamin C)

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Buy Ascorbyl Glucoside (Ascorbic Acid 2- Glucoside) For Skin Care

Ascorbyl glucoside (AA-2G) is a vitamin derivative, produced biologically by the reaction between glucose and vitamin C. This addition confers greater stability, compared to relatively unstable pure ascorbic acid, thus allowing for wide usage in pharmacy and cosmetics. AA-2G retains the antioxidant properties of the unmodified vitamin, therefore it is used to prevent radiation damage, cell senescence and skin darkening. It also promotes collagen synthesis, as well as cell proliferation – these mechanisms help improve the appearance of the skin and reduce wrinkles. Furthermore, since AA-2G does not release ascorbic acid instantly, all the listed positive effects are sustained longer and the possibility of adverse effects is reduced, compared to using pure ascorbic acid. All these qualities make AA-2G the most attractive vitamin C derivative for cosmetic use.

Key benefits of Ascorbyl glucoside (AA-2G)  in skin care:

  • Antioxidant [10] [16]
  • Lightening and brightening [14]
  • Treat hyperpigmentation [14]
  • Sun damage repair [10] [16]
  • Sun dammage protection [7] [9]
  • Stimulate collagen production [3] [13]
  • Reduce fine lines and wrinkles [12]
Ascorbyl Glucoside (Ascorbic Acid 2- Glucoside) skin care active ingredients
Product Code: BulkActives
Reward Points: 11
CAS#: 129499-78-1
Net weight: 15g / 0.53oz
Availability: In Stock
Price: $25.00
Reward Points: 1085


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Ascorbyl Glucoside (Ascorbic Acid 2- Glucoside)

About Ascorbyl Glucoside (Ascorbic Acid 2- Glucoside) in DIY Skin Care

Ascorbyl glucoside (scientific name ascorbic acid 2-O-alpha-glucoside, AA-2G) is a stable derivative of ascorbic acid, commonly known as vitamin C. Commercially, AA-2G is produced directly in biological systems, simply by reacting glucose with an ascorbic acid molecule [1]. It is also formed naturally in animals, during simultaneous digestion of vitamin C and carbohydrates [2]. While ascorbic acid has numerous cosmetical and pharmaceutical benefits, it is relatively unstable, and degrades even at neutral pH and body temperature [3]. Addition of glucose serves to protect this molecule. Upon entering the body, ascorbyl glucoside is easily digested back into ascorbic acid and glucose, resulting in stable vitamin C delivery without any toxic effects [1]. It has also been shown that this compound is metabolized fully, and the amount of vitamin C gained from AA-2G or pure ascorbic acid is equivalent [4]. In fact, this modification allows for more controlled release of the vitamin, while pure ascorbic acid can lead to cell toxicity if absorbed suddenly and in large quantities [3], [5]. As a tradeoff, absorption of modified vitamins through skin is less effective, but AA-2G in this respect surpasses other molecules [6].

Vitamin C is widely known for its antioxidant properties. It functions in neutralizing free radicals, such as reactive oxygen species, that can form due to radiation or other factors. This activity is important in preventing cancer, ageing-related diseases and radiotherapy damage [7]. Ascorbyl glucoside shares similar qualities. As an antioxidant, AA-2G was found to perform similarly or even better than ascorbic acid, for example, in protecting skin cells from ultraviolet radiation [8], [9]. It was also observed to protect cells against damage from high-energy radiation, similar to that used in radiotherapy [7]. Recent research confirmed that AA-2G protects skin cells not only from oxidative stress (free radicals), but also from cellular senescence [10]. Ascorbyl glucoside even  has a positive effect on immunity, as it promotes antibody synthesis in lymphocytes [11]. Again, ascorbic acid has similar benefits, but also causes adverse side effects that are not observed when using AA-2G [11].

The importance of vitamin C in collagen synthesis is well known since the times of scurvy – besides activating synthesis in various ways, it functions as a necessary cofactor for the relevant enzymes. This has led to its use in anti-wrinkle cosmeceuticals. For example, a cream containing 3 % ascorbic acid has been shown to significantly reduce facial wrinkles and ageing-related damage [12]. Activity of AA-2G is similar, as it promotes collagen accumulation, cell proliferation and formation of tissue structure [3]. Furthermore, this molecule has a longer-lasting effect, compared to pure vitamin C. One study found that ascorbic acid stimulation of collagen synthesis ceased after 3 days, while a similar amount of ascorbyl glucoside maintained active collagen synthesis for 5 days [3]. Under different conditions, similar difference was observed, with ascorbyl glucoside remaining active for at least 8 days and ascorbic acid being depleted after 5 days [13].

Another application of AA-2G in cosmetics is control of skin pigmentation. Due to its antioxidant properties, this compound reduces the rate of melanin synthesis, thus preventing skin darkening after UV exposure. This effect, together with reduced inflammation, was demonstrated by applying a cream containing 2 % ascorbic acid or related molecules, and AA-2G was found to be even more effective than unmodified vitamin C [14]. It was also found that the whitening activity of AA-2G increases greatly when combined together with resveratrol [15].
 

WARNING

  • Ascorbyl Glucoside is VERY acidic.
  • Ascorbyl Glucoside is ONLY stable at pH 5-7
  • After preparing an Ascorbyl Glucoside stock solution, neutralize it tp pH 5.5 by using Triethanolamineand then add it to the formulation.

 
Chemical Name: Ascorbic Acid 2-Glucoside (AAG2TM)
INCI: Ascorbyl Glucoside
CAS#: 129499-78-1
Appearance: fine white powder
Solubility: water
Suggested percentage: 2 %
 pH:  2.1 -2.8 (at 2% in water)
Stability:  
  • highly stable in solution even at high temperatures and in the presence of metal ions.
  • Stable at pH 5-7
  • After preparing an Ascorbyl Glucoside stock solution, neutralize it tp pH 5 by using Triethanolamineand then add it to the formulation.
 Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: Japan 
 
[1]          I. Yamamoto and N. Muto, “Bioavailability and biological activity of L-ascorbic acid 2-O-alpha-glucoside,” J. Nutr. Sci. Vitaminol. (Tokyo), vol. Spec No, pp. 161–164, 1992.
[2]          N. Muto, Y. Ban, M. Akiba, and I. Yamamoto, “Evidence for the in vivo formation of ascorbic acid 2-O-alpha-glucoside in guinea pigs and rats,” Biochem. Pharmacol., vol. 42, no. 3, pp. 625–631, Jul. 1991.
[3]          I. Yamamoto, N. Muto, K. Murakami, and J. Akiyama, “Collagen synthesis in human skin fibroblasts is stimulated by a stable form of ascorbate, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid,” J. Nutr., vol. 122, no. 4, pp. 871–877, Apr. 1992.
[4]          H. Wakamiya, E. Suzuki, I. Yamamoto, M. Akiba, M. Otsuka, and N. Arakawa, “Vitamin C activity of 2-O-alpha-D-glucopyranosyl-L-ascorbic acid in guinea pigs,” J. Nutr. Sci. Vitaminol. (Tokyo), vol. 38, no. 3, pp. 235–245, Jun. 1992.
[5]          K. Murakami, N. Muto, K. Fukazawa, and I. Yamamoto, “Comparison of ascorbic acid and ascorbic acid 2-O-alpha-glucoside on the cytotoxicity and bioavailability to low density cultures of fibroblasts,” Biochem. Pharmacol., vol. 44, no. 11, pp. 2191–2197, Dec. 1992.
[6]          Y. Kumano, T. Sakamoto, M. Egawa, I. Iwai, M. Tanaka, and I. Yamamoto, “In vitro and in vivo prolonged biological activities of novel vitamin C derivative, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), in cosmetic fields,” J. Nutr. Sci. Vitaminol. (Tokyo), vol. 44, no. 3, pp. 345–359, Jun. 1998.
[7]          D. Mathew, C. K. K. Nair, J. A. Jacob, N. Biswas, T. Mukherjee, S. Kapoor, and T. V. Kagiya, “Ascorbic acid monoglucoside as antioxidant and radioprotector,” J. Radiat. Res. (Tokyo), vol. 48, no. 5, pp. 369–376, Sep. 2007.
[8]          E. Miyai, M. Yanagida, J. Akiyama, and I. Yamamoto, “Ascorbic acid 2-O-alpha-glucoside-induced redox modulation in human keratinocyte cell line, SCC: mechanisms of photoprotective effect against ultraviolet light B,” Biol. Pharm. Bull., vol. 20, no. 6, pp. 632–636, Jun. 1997.
[9]          E. Miyai, M. Yanagida, J. Akiyama, and I. Yamamoto, “Ascorbic acid 2-O-alpha-glucoside, a stable form of ascorbic acid, rescues human keratinocyte cell line, SCC, from cytotoxicity of ultraviolet light B,” Biol. Pharm. Bull., vol. 19, no. 7, pp. 984–987, Jul. 1996.
[10]        M. Taniguchi, N. Arai, K. Kohno, S. Ushio, and S. Fukuda, “Anti-oxidative and anti-aging activities of 2-O-α-glucopyranosyl-L-ascorbic acid on human dermal fibroblasts,” Eur. J. Pharmacol., vol. 674, no. 2–3, pp. 126–131, Jan. 2012.
[11]        M. Tanaka, N. Muto, E. Gohda, and I. Yamamoto, “Enhancement by ascorbic acid 2-glucoside or repeated additions of ascorbate of mitogen-induced IgM and IgG productions by human peripheral blood lymphocytes,” Jpn. J. Pharmacol., vol. 66, no. 4, pp. 451–456, Dec. 1994.
[12]        T. Raschke, U. Koop, H.-J. Düsing, A. Filbry, K. Sauermann, S. Jaspers, H. Wenck, and K.-P. Wittern, “Topical activity of ascorbic acid: from in vitro optimization to in vivo efficacy,” Skin Pharmacol. Physiol., vol. 17, no. 4, pp. 200–206, Aug. 2004.
[13]        Y. Kumano, T. Sakamoto, M. Egawa, M. Tanaka, and I. Yamamoto, “Enhancing effect of 2-O-alpha-D-glucopyranosyl-L-ascorbic acid, a stable ascorbic acid derivative, on collagen synthesis,” Biol. Pharm. Bull., vol. 21, no. 7, pp. 662–666, Jul. 1998.
[14]        E. Miyai, I. Yamamoto, J. Akiyama, and M. Yanagida, “Inhibitory Effect of Ascorbic Acid 2-O-alpha-Glucoside on the Pigmentation of Skin by Exposure to Ultraviolet Light.,” Nishi Nihon Hifuka, vol. 58, no. 3, pp. 439–443, 1996.
[15]        DSM IP Assets B.V., “Use of resveratrol and ascorbyl-2-glucoside,” EP 2522328 A1.
[16]        W.-Y. Huang, P.-C. Lee, L.-K. Huang, L.-P. Lu, and W. C. Liao, “Stability studies of ascorbic acid 2-glucoside in cosmetic lotion using surface response methodology,” Bioorg. Med. Chem. Lett., vol. 23, no. 6, pp. 1583–1587, Mar. 2013.
 
  • After preparing an Ascorbyl Glucoside stock solution, neutralize it tp pH 5.5 by using Triethanolamineand then add it to the formulation.
  • If the formulation needs heating, cool down the formulations to 40-50°C and then add the neutralized  Ascorbyl Glucoside solution. Please avoid heating at high temperatures (above 40°C) for prolonged periods.
  • Adding buffers, chelating agents and antioxidants, and shielding from strong light are also useful in preventing Ascorbyl Glucoside from decomposition during formulation.
  • The stability of Ascorbyl Glucosideis influenced by pH. Please avoid leaving it under prolonged conditions of strong acidity or alkalinity (pH 2-4 and 9-12).

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