Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
This lovely, simple, and affordable product has become something I don't want to be without. I am 47, with very sensitive and reactive dry skin. This cream doesn't feel particularly moisturizing and leaves something of a 'dry' finish on the skin after application, but it's had SUCH a positive impact on my face. The redness and papules from my rosacea and seb derm have reduced by a good 90%. It's been a magical barrier restorer and I panicked when it was temporarily out of stock. I would recomme.. ...»
Candace Carnahan
This is the best product I have ever used on my skin and I tried a LOT of expansive brands. It helps with redness and overall skin tone. Please do not ever stop making this stuff... ...»
I' m not sure about this: "11% solution gives 1% EGCG content in final product." What is the weight of final product? .. ...»
Vesna Hanich
Tried this on my week-old rash from flea bites. Got an almost instant relief and rash healed in 2 days. Tried it on my daughter who has eczema for a very long time. The rashes calmed down after a few days and her skin is now healing well. Really great product. Just put in order for another jar.... ...»
Really loving this product. I make the best Centella toner and most concentrated ever. 2 g of centella extract dissolved in 10g of alcohol(you have to stir a lot) plus 88 grams of water and you get a very concentrated toner. Creams, toners, ampoules... all have only 0,1% of triterpenes, this toner i make have 1,4%. I am loving it, will see the results. .. ...»
Just recently ordered this and LOVE! Green Tea EGCG truly is one of the most fantastic skincare actives out there. Very difficult to find good quality product (90%) and even harder to actually solubilize it! Love that it comes in pre-dissolved solution. I enjoy adding it at 1% (so 11% sol) to my serum formulations containing Niacinamide 5% + NAG 3%. Excellent for oily acne prone skin. *Only gripe... because the Pre-Dissolved Solution is SO heavy in propanediol (10 parts Propanediol for 1 part E.. ...»
Wonderful base cream! Only multi-lamellar structured cream I've found on the market. Cream itself is lightweight (no oil) yet very conditioning/hydrating. Easily accepts water-soluble active ingredients as well as oil-soluble ones. I've even pushed the additional ingred % up to 20 (meaning 80% this cream, 20% added) without any separation issues. Ideal base cream for delivering actives. Personal favorite recipe calls for 5% straight Grapeseed Oil with 5% SebumREG oil active + Panthenol 1% + E Ac.. ...»
Excellent quality, very fine texture and disperses easily when used correctly. Arrived in just seven days to London, England and with a reasonable postage fee. Very pleased... ...»
D N Bay
This ingredient has done more for my skin than anything else I've ever used. I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic. I will use this forever, no question... ...»
This product is amazing! I'm new to diy moisturizing cream and I've done quite a bit of research. However, I found info. at BulkActives that I have not seen anywhere else, especially with the hyaluronic acid. This product is of high quality, my friend is a chemist and he ran some tests, very high quality. It has done wonders for my skin, not only in the way it looks more healthy but it just feels so smooth and hydrated. I'm still experimenting with some recipes so I will return. Your service is .. ...»
Karen S.
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Grape Seed Proanthocyanidins

Grape seed extract is a mixture of complex molecules, mostly proanthocyanidins. These molecules are very strong antioxidants, even surpassing vitamins C and E, and also show anti-inflammatory activity. Due to these properties, grape seed extract is a promising drug in combating cancer. It is capable of protecting the skin from melanoma and other cancer types, prevents already formed tumors from spreading, and can even reverse the damage in cancer-forming cells. It also reduces the cosmetical damage of UV exposure, such as increased pigmentation, thus lightening the skin. Grape seed extract is also useful in regulating sebum secretion. Finally, wound healing is strongly supported by applying this extract, as it helps tissue regeneration and provides a powerful defense against resistant bacteria.

NOTE: To assist you with solubility issues, we now also sell Grape Seed Proanthocyanidins as a liquid standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
  • 11% solution gives 1% Proanthocyanidins content in final product.
  • 31% solution gives 3% Proanthocyanidins content in final product.
  • 52% solution gives 5% Proanthocyanidins content in final product.

Key benefits of Grape seed Proanthocyanidins in skin care:

  • Sun damage protection [1] [3] [5] [8] [10]
  • Sun damage repair [4] [6]
  • Antioxidant [1] [2]
  • Oil/sebum control [11] [12]
  • Lightening & brightening [11]
  • Wound healing support [14] [15]
  • Anti-inflammatory [1]
Product Code: BulkActives
Assay: 95.56% Proanthocyanidins
CAS#: 84929-27-1
Net weight: 30g /1.06oz & 150g / 8.82oz
Standardized preDissolved solution 150g - Options In Stock
Standardized Powder 30g - Options In Stock
Price: $6.50

Available Options

* Property:
(Stock: 34)
(Stock: 15)

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About Grape Seed Proanthocyanidins in DIY Skin Care

Grape Seed Proanthocyanidins Skin CareGrape seed extract is produced by purifying the most beneficial components from grape seeds. Among these components, most is known about proanthocyanidins – these molecules are produced in plants by combining several smaller molecules called flavonoids. Flavonoids are known for their antioxidant capabilities, and in proanthocyanidins this effect is even stronger, exceeding vitamins C and E [1]. This activity makes them useful in protecting all systems of the body – they reduce UV damage in skin, ethanol damage on liver, ageing damage in brain and other negative symptoms associated with oxidation. Together with several other compounds found in grapes, proanthocyanidins are very promising anticancer drugs, as they were shown to reduce the growth of diverse cancer types [2].

In skincare, the most important function of grape seed extract is protecting against sun damage. Solar UV is the primary cause of non-melanoma skin cancer, and it has been shown that applying grape seed extract before exposure significantly reduces the damage to cells [3]. It is proven that proanthocyanidins are responsible for this protective action, as they enhance DNA repair in the damaged area [4]. Similar results, leading to decreased cell death, were also found in another study [5]. In fact, grape seed extract can even be used to treat skin cancer, as it is able to restore the genes in tumor cells to their healthy state [6]. Similarly, melanoma cells can become less invasive, and thus less dangerous, after treatment with this extract [7]. Application of grape seed extract on healthy volunteers’ skin, irradiated with UV, also reduced the cell damage that may lead to cancer [8]. Furthermore, this extract inhibits the inflammatory processes that typically start after UV exposure. This also leads to reduced cancer risk [1].

The antioxidative abilities of flavonoids are useful not only in response to UV. Using a cream with these and other antioxidants for 21 days, significant reduction in wrinkles was observed, as well as protection from UV – this indicates potential anti-ageing effects of this extract [9]. New research also indicates that a cream containing grape seed extracts is able to protect against infrared A radiation – no other formulation has been proven to achieve this [10]. These effects suggest that grape seed extract would be a valuable addition to any sunscreen, since no adverse effects of this extract have been observed [9].

Grape seed extract also has other cosmetic benefits. In volunteers applying 2 % extract-containing cream, skin elasticity was significantly improved, together with decreased sebum secretion and melanin content (pigmentation) [11]. Using a complex formulation with extracts from grapes and other sources, numerous skin benefits were observed, among them increased hydration, collagen content, and sebum reduction [12]. However, the large proanthocyanidin molecules are absorbed rather slowly through skin. To enhance this process, it is advised to use this extract in high water content formulations, or apply together with hydrating agents [13].

Finally, wound healing process is also aided by applying this extract. Not only do the wounds heal faster, but the regenerated tissue shows better structure and larger collagen amounts [14]. Again, 2 % was the concentration of extract that gave the best results in these experiments [15]. Additionally, grape seed extract is known to have strong antibacterial and antiviral properties. It is even able to destroy antibiotic-resistant bacteria, proving its usefulness in wound care [16].


NOTE: To assist you with solubility issues, we now also sell Grape Seed Proanthocyanidins as a liquid standardized pre-dissolved solution. Just add the liquid to your cream and mix well.

Grape Seed Proanthocyanidins Standardized Powder

Assay: 95.56% Proanthocyanidins
CAS#: 84929-27-1
INCI: Grape (Vitis Vinifera) Seed extract
Botanical source: Vitis vinifera (Grape)
Appearance: powder
Solubility: non-denatured ethanol, 1,3-Propanediol
Suggested percentage:1 to 10%

Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China

Grape Seed Proanthocyanidins) Standardized Pre Dissolved Solution - 10%

Assay: 9.7% Proanthocyanidins
CAS#: 504-63-2, 84929-27-1
INCI:1,3-Propanediol, Grape (Vitis Vinifera) Seed extract
Appearance: dark bred/brown liquid

Solubility: add to cream
Suggested percentage:
11% solution gives 1% Proanthocyanidins content in final product.
31% solution gives 3% Proanthocyanidins content in final product.
52% solution gives 5% Proanthocyanidins content in final product.

Storage: Store in fridge, do not freeze
Country of origin for raw material: China
Country of manufacture: Taiwan
[1]          S. K. Katiyar, “Grape seed proanthocyanidines and skin cancer prevention: inhibition of oxidative stress and protection of immune system,” Mol. Nutr. Food Res., vol. 52 Suppl 1, pp. S71–76, Jun. 2008.
[2]          M. Nassiri-Asl and H. Hosseinzadeh, “Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds,” Phytother. Res. PTR, vol. 23, no. 9, pp. 1197–1204, Sep. 2009.
[3]          A. Filip, D. Daicoviciu, S. Clichici, T. Mocan, A. Muresan, and I. D. Postescu, “Photoprotective effects of two natural products on ultraviolet B-induced oxidative stress and apoptosis in SKH-1 mouse skin,” J. Med. Food, vol. 14, no. 7–8, pp. 761–766, Aug. 2011.
[4]          M. Vaid, S. D. Sharma, and S. K. Katiyar, “Proanthocyanidins inhibit photocarcinogenesis through enhancement of DNA repair and xeroderma pigmentosum group A-dependent mechanism,” Cancer Prev. Res. Phila. Pa, vol. 3, no. 12, pp. 1621–1629, Dec. 2010.
[5]          M. Perde-Schrepler, G. Chereches, I. Brie, C. Tatomir, I. D. Postescu, L. Soran, and A. Filip, “Grape seed extract as photochemopreventive agent against UVB-induced skin cancer,” J. Photochem. Photobiol. B, vol. 118, pp. 16–21, Jan. 2013.
[6]          M. Vaid, R. Prasad, T. Singh, V. Jones, and S. K. Katiyar, “Grape seed proanthocyanidins reactivate silenced tumor suppressor genes in human skin cancer cells by targeting epigenetic regulators,” Toxicol. Appl. Pharmacol., vol. 263, no. 1, pp. 122–130, Aug. 2012.
[7]          M. Vaid, T. Singh, and S. K. Katiyar, “Grape seed proanthocyanidins inhibit melanoma cell invasiveness by reduction of PGE2 synthesis and reversal of epithelial-to-mesenchymal transition,” PloS One, vol. 6, no. 6, p. e21539, 2011.
[8]          X.-Y. Yuan, W. Liu, J.-C. Hao, W.-J. Gu, and Y.-S. Zhao, “Topical grape seed proanthocyandin extract reduces sunburn cells and mutant p53 positive epidermal cell formation, and prevents depletion of Langerhans cells in an acute sunburn model,” Photomed. Laser Surg., vol. 30, no. 1, pp. 20–25, Jan. 2012.
[9]          C. C. Felippi, D. Oliveira, A. Ströher, A. R. Carvalho, E. A. M. A. Van Etten, M. Bruschi, and R. P. Raffin, “Safety and efficacy of antioxidants-loaded nanoparticles for an anti-aging application,” J. Biomed. Nanotechnol., vol. 8, no. 2, pp. 316–321, Apr. 2012.
[10]        S. Grether-Beck, A. Marini, T. Jaenicke, and J. Krutmann, “Effective Photoprotection of Human Skin against Infrared A Radiation by Topically Applied Antioxidants: Results from a Vehicle Controlled, Double-Blind, Randomized Study,” Photochem. Photobiol., vol. 91, no. 1, pp. 248–250, Jan. 2015.
[11]        A. Sharif, N. Akhtar, M. S. Khan, A. Menaa, B. Menaa, B. A. Khan, and F. Menaa, “Formulation and evaluation on human skin of a water-in-oil emulsion containing Muscat hamburg black grape seed extract,” Int. J. Cosmet. Sci., Nov. 2014.
[12]        M. Haftek, S. Mac-Mary, M.-A. Le Bitoux, P. Creidi, S. Seité, A. Rougier, and P. Humbert, “Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin,” Exp. Dermatol., vol. 17, no. 11, pp. 946–952, Nov. 2008.
[13]        O. V. Zillich, U. Schweiggert-Weisz, P. Eisner, and M. Kerscher, “Polyphenols as active ingredients for cosmetic products,” Int. J. Cosmet. Sci., Feb. 2015.
[14]        S. Khanna, M. Venojarvi, S. Roy, N. Sharma, P. Trikha, D. Bagchi, M. Bagchi, and C. K. Sen, “Dermal wound healing properties of redox-active grape seed proanthocyanidins,” Free Radic. Biol. Med., vol. 33, no. 8, pp. 1089–1096, Oct. 2002.
[15]        A. A. Hemmati, N. Aghel, I. Rashidi, and A. Gholampur-Aghdami, “Topical grape (Vitis vinifera) seed extract promotes repair of full thickness wound in rabbit,” Int. Wound J., vol. 8, no. 5, pp. 514–520, Oct. 2011.
[16]        A. Al-Habib, E. Al-Saleh, A.-M. Safer, and M. Afzal, “Bactericidal effect of grape seed extract on methicillin-resistant Staphylococcus aureus (MRSA),” J. Toxicol. Sci., vol. 35, no. 3, pp. 357–364, Jun. 2010.

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