Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Reviews
Excellent quality, very fine texture and disperses easily when used correctly. Arrived in just seven days to London, England and with a reasonable postage fee. Very pleased... ...»
D N Bay
This ingredient has done more for my skin than anything else I've ever used. I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic. I will use this forever, no question... ...»
Marie
This product is amazing! I'm new to diy moisturizing cream and I've done quite a bit of research. However, I found info. at BulkActives that I have not seen anywhere else, especially with the hyaluronic acid. This product is of high quality, my friend is a chemist and he ran some tests, very high quality. It has done wonders for my skin, not only in the way it looks more healthy but it just feels so smooth and hydrated. I'm still experimenting with some recipes so I will return. Your service is .. ...»
Karen S.
I've been using Bulkactives green tea EGCG for four years. No complaints, it blends nicely my DIY anti-aging cream. I can feel a bit of toning and definitely notice the anti-inflammatory effects on my skin. Two observations that keep the rating 4 stars instead of 5: (1) A package of green tea contains significantly less weight/volume than the package of grape seed extract that I order from bulkactives. The two are combined in equal amounts in the anti-aging cream, so I find myself running o.. ...»
Theresa Andrews
Awesome Product and thanks for such a nice Product description .. ...»
Stephen
I have been buying from bulkactives for some time and have never been disappointed. My most recent purchases have been the hyaluronic acid and the dispenser bottle. the bottle is great. The inner container rises with use, ensuring that you use most of the product. Much better than having residue sit at bottom of bottle to be wasted. I've used only one batch of hyaloronic acid formula, so too early to report. I mix it with ascorbic L and ferulic acid, according to recipe on this site. So f.. ...»
Suzanne Ryan
Another great find on bulkactives. Mixed with de mineralized water, you have the basis to add to any serum, mix with your moisturiser, to simply use on it's own. Love it... ...»
Jan
Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
Angela
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
Jessie Sandford
Many thanks for the Silicone DM. This product is lovely quality; it is light, silky, and leaves no residue at all. I use it in the base recipe for a mouldable polymer that I then use to make a simulated 'Amber' for bead making. At the end of this process I have a silky, translucent polymer plus the most gorgeous hands in the studio ! My thanks again, Helen.. ...»
HELEN pEAKE
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We sell  COSMETIC RAW MATERIALS, which are meant to be used at an appropriate percentage in a cosmetic formulation of your devising. Please do not order our products unless you know how to formulate creams and lotions with it!  

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Hyaluronic Acid (sodium hyaluronate powder)

Hyaluronic acid [HA] is a fundamental element of the extracellular matrix.  Due to its amazing capacity to retain water, HA is a highly desirable ingredient in moisturizing creams.  Further, because HA can stimulate dermal fibroblast proliferation and migration, it is also ideal for use in wrinkle-reducing and anti-aging formulas.  HA can be purchased at various molecular weights with different molecular weights eliciting different effects on the skin.  For use in wound-healing support or restoring barrier function, high molecular weight is the best option.  For the best results in anti-aging and moisturizing creams, low molecular weight HA is the ideal choice due to increased penetration of the HA through the skin.  Warning: Customers in countries with a dry climate may find that hyaluronic acid has a drying effect, instead of moisturizing. It is theorized that this is due to the HA drawing moisturize away from the skin.
 

Key benefits of Hyaluronic acid in skin care:

  • Moisturizing and hydration [2] [6] [7]
  • Reduce fine lines and wrinkles [2] [7] [8]
  • Increase skin elasticity [2] [4] [7]
  • Wound healing support [1] [10] [11]
  • Restoring barrier function [9]
Product Code: BulkActives
Reward Points: 5
CAS#: 9067-32-7
Net weight: 5g / 0.18oz
Availability: In Stock
Price: $11.30
Reward Points: 455


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About Hyaluronic Acid (sodium hyaluronate powder) in DIY Skin Care

The epidermis is the outer layer of the skin which serves to protect the body from water loss and from the environment.  Immediately beneath the epidermis is a matrix comprised of structural elements collagen and fibrin which provide the basic support for the matrix.  Hyaluronic acid fills in this structured system to provide insulation to the matrix and to maintain mechanical integrity.  HA is a polymer composed of long chains of non-sulfated glycosaminoglycans and is produced by dermal fibroblasts.  In a complicated feedback loop HA regulates dermal fibroblast proliferation and migration, stimulating its own production or degradation depending on the stimuli present [1, 2].  HA is also capable of initiating these and other important cellular signaling pathways depending on the size of molecular weight HA present.  Because HA is made of linked glycosaminoglycans, it can be considered high or low, comparatively, in molecular weight with masses ranging from 20 to over 4,000 kDa.  Interestingly, the high and low molecular weight HA species can have opposing effects.  High molecular weight HA signals that the integrity of the extracellular matrix is maintained and everything is status quo, whereas very low molecular weight HA [20 kDa and below] signals matrix damage and initiates a proinflammatory response.  Thus, in order to avoid increasing inflammation in the skin low or high molecular weight HA [50 kDa and greater] is generally preferred [3, 4]. 

While collagen and fibrin provide the general structure and organization for the skin, HA is what fills in the remaining space and gives healthy skin the ideal supple and elastic feel and smoothes out fine lines or wrinkles.  On the other hand, degradation of HA, resulting from wound or aging, is what leads to the appearance of fine lines and wrinkles.  HA is capable of binding massive amounts of water.  In fact, it’s water-binding capacity is greater than any other natural or synthetic polymer [5], a property which makes it attractive for use in topical applications to increase hydration of the skin, in anti-aging cosmetic creams, and to provide wound healing support [6, 7].  However, to most efficiently perform the desired function the choice of molecular weight HA for use should be made with care.  To best moisturize the skin and reduce the appearance of aging, HA must be able to penetrate through the epidermis.  Studies have demonstrated that in order to penetrate the thick outer layer of skin molecular weight HA species that are considered low, but not low enough to stimulate inflammation, are ideal [7]. 

50 kDa HA species have been demonstrated to most efficiently penetrate the skin in comparison to 300, 800, and 1,500 kDa species.  In human volunteers, topical solutions containing 50 kDa significantly decreased the roughness of the skin whereas 300 kDa HA had no effect.  Further, the appearance of wrinkles in these subjects was markedly decreased [8].  It is also known that high molecular weight HA can stimulate activation of approximately 40 genes in keratinocytes which are related to regulation of dermal cells and the formation of cell-cell tight junctions, on intercellular bridges.  A recent study demonstrated that low molecular weight HA is not only capable of activating all of these genes but also affects the expression of 80 more genes all of which are related to improved skin appearance, function, and structure.  The increase is believed to be directly related to the ability of low molecular weight HA to more efficiently penetrate the epidermis [4, 8].  Considering these results, for use in moisturizers and anti-aging cream low molecular weight cream is the optimal choice. 

For additional information, please refer to our link here: Low Molecular Weight (50kDa) Hyaluronic Acid

While low molecular weight HA is certainly most ideal for moisturizing and anti-aging cosmetics, high molecular weight HA remains the conventionally utilized species.  High molecular weight species forms lightweight gels that, when combined with an emulsifier and oil can form a serum which can limit water evaporation from the skin.  This not only improves the feel of the epidermis but also supports the function of the epidermal barrier, causing skin to feel protected and healthier [9].  Other studies have demonstrated that such gels when applied to dermal wounds can expedite wound healing [10, 11].  A recent in vivo study demonstrated that HA gels applied topically to chemically-induced wounds on the skin of rats were successfully able to increase the rate of wound closure.  Further, HA stimulated fibroblast migration to the site of the wound, leading to increased collagen regeneration and rates of re-epithelialization [11]. 
 

Hyaluronic acid in dry climates

"there is a controversy whether concentrated HA formulas should be used as a moisturizer in dry climate. When air humidity is very low, HA may preferentially pull water from the skin rather than from the air, thus producing the opposite effect." [ Dr. G. Todorov. Hyaluronic acid for skin hydration and possibly a lot more.1999-2015. SmartSkinCare.com]

To properly use a hyaluronic acid serum, it needs to be applied onto damp skin and then "sealed" in with a layer of a good moisturizer on top. If applying the hyaluronic acid in this manner still makes your skin feel a bit dry or taut, the hyaluronic acid is probably pulling moisture out of your skin instead of pulling moisture from the air and into your skin.

Note that the combination of Niacinamide and Glucosamine has been proven to actually increase Hyaluronic acid synthesis in the skin, thereby moisturizing from the inside, rather than putting moisture on top of the skin.

For further detailed and unbiased information about topical Hyaluronic acid in skin care we suggest you read these two excellent articles by Dr. Todorov from smartskincare.com:
Hyaluronic acid: Skin matrix health is not just about proteins and Hyaluronic acid for skin hydration and possibly a lot more

 

Hyaluronic acid in dry climates

"there is a controversy whether concentrated HA formulas should be used as a moisturizer in dry climate. When air humidity is very low, HA may preferentially pull water from the skin rather than from the air, thus producing the opposite effect." [ Dr. G. Todorov. Hyaluronic acid for skin hydration and possibly a lot more.1999-2015. SmartSkinCare.com]

To properly use a hyaluronic acid serum, it needs to be applied onto damp skin and then "sealed" in with a layer of a good moisturizer on top. If applying the hyaluronic acid in this manner still makes your skin feel a bit dry or taut, the hyaluronic acid is probably pulling moisture out of your skin instead of pulling moisture from the air and into your skin.

Note that the combination of Niacinamide and Glucosamine has been proven to actually increase Hyaluronic acid synthesis in the skin, thereby moisturizing from the inside, rather than putting moisture on top of the skin.
CAS#: 9067-32-7
INCI: sodium hyaluronate
Source: biotechnology (bacterial fermentation)
Grade: cosmetic grade
Molecular weight: 1 320 000 daltons ( 1.32x106  daltons)
Appearance: white powder
Solubility: water (this pure powder dissolves very well in water, some mixing may be required.)
Suggested percentage: 0.5 to 1%

Storage: cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China

Manufacturing company: Our supplier is a "high-tech enterprise confirmed by the Science and Technology Department of Hebei Province. It has three purifying and production workshops set up in accordance with the requirements of the National GMP Standard, and has quality equipment and advanced inspection means. It now has the annual capacity to produce 5000kgs of high pure sodium hyaluronate and 1000kgs of sodium hyaluronate for medical use. It is approved for IS09001 quality System Certification. "
[1]          Brown M, Jones SA. Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin. Journal of the European Academy of Dermatology and Venereology. 2005;19[3]:308-18.
[2]          Price RD, Berry M, Navsaria HA. Hyaluronic acid: the scientific and clinical evidence. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2007;60[10]:1110-9.
[3]          Gariboldi S, Palazzo M, Zanobbio L, Selleri S, Sommariva M, Sfondrini L, et al. Low molecular weight hyaluronic acid increases the self-defense of skin epithelium by induction of β-defensin 2 via TLR2 and TLR4. The Journal of Immunology. 2008;181[3]:2103-10.
[4]          Farwick M, Gauglitz G, Pavicic T, Köhler T, Wegmann M, Schwach-Abdellaoui K, et al. Fifty-kDa hyaluronic acid upregulates some epidermal genes without changing TNF-α expression in reconstituted epidermis. Skin pharmacology and physiology. 2011;24[4]:210-7.
[5]          Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, et al. Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate. International journal of toxicology. 2009;28[4 suppl]:5-67.
[6]          Weindl G, Schaller M, Schafer-Korting M, Korting H. Hyaluronic acid in the treatment and prevention of skin diseases: molecular biological, pharmaceutical and clinical aspects. Skin Pharmacology and Physiology. 2004;17[5]:207-13.
[7]          Brown TJ, Alcorn D, Fraser JRE. Absorption of hyaluronan applied to the surface of intact skin. Journal of investigative dermatology. 1999;113[5]:740-6.
[8]          Farwick M, Lersch P, Strutz G. Low molecular weight hyaluronic acid: its effects on epidermal gene expression & skin ageing. SÖFW Journal. 2008;134[11]:17.
[9]          Draelos ZD. New treatments for restoring impaired epidermal barrier permeability: skin barrier repair creams. Clinics in dermatology. 2012;30[3]:345-8.
[10]        Price RD, Das-Gupta V, Leigh IM, Navsaria HA. A comparison of tissue-engineered hyaluronic acid dermal matrices in a human wound model. Tissue engineering. 2006;12[10]:2985-95.
[11]        Al Bayaty F, Abdulla M, Hassan MA, Masud M. Wound healing potential by hyaluronate gel in streptozotocin-induced diabetic rats. Scientific Research and Essays. 2010;5[18]:2756-60.
 

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