Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Reviews
Excellent quality, very fine texture and disperses easily when used correctly. Arrived in just seven days to London, England and with a reasonable postage fee. Very pleased... ...»
D N Bay
This ingredient has done more for my skin than anything else I've ever used. I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic. I will use this forever, no question... ...»
Marie
This product is amazing! I'm new to diy moisturizing cream and I've done quite a bit of research. However, I found info. at BulkActives that I have not seen anywhere else, especially with the hyaluronic acid. This product is of high quality, my friend is a chemist and he ran some tests, very high quality. It has done wonders for my skin, not only in the way it looks more healthy but it just feels so smooth and hydrated. I'm still experimenting with some recipes so I will return. Your service is .. ...»
Karen S.
I've been using Bulkactives green tea EGCG for four years. No complaints, it blends nicely my DIY anti-aging cream. I can feel a bit of toning and definitely notice the anti-inflammatory effects on my skin. Two observations that keep the rating 4 stars instead of 5: (1) A package of green tea contains significantly less weight/volume than the package of grape seed extract that I order from bulkactives. The two are combined in equal amounts in the anti-aging cream, so I find myself running o.. ...»
Theresa Andrews
Awesome Product and thanks for such a nice Product description .. ...»
Stephen
I have been buying from bulkactives for some time and have never been disappointed. My most recent purchases have been the hyaluronic acid and the dispenser bottle. the bottle is great. The inner container rises with use, ensuring that you use most of the product. Much better than having residue sit at bottom of bottle to be wasted. I've used only one batch of hyaloronic acid formula, so too early to report. I mix it with ascorbic L and ferulic acid, according to recipe on this site. So f.. ...»
Suzanne Ryan
Another great find on bulkactives. Mixed with de mineralized water, you have the basis to add to any serum, mix with your moisturiser, to simply use on it's own. Love it... ...»
Jan
Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
Angela
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
Jessie Sandford
Many thanks for the Silicone DM. This product is lovely quality; it is light, silky, and leaves no residue at all. I use it in the base recipe for a mouldable polymer that I then use to make a simulated 'Amber' for bead making. At the end of this process I have a silky, translucent polymer plus the most gorgeous hands in the studio ! My thanks again, Helen.. ...»
HELEN pEAKE
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Buy Vitamin E Natural Mixed Tocopherols For Skin Care

Natural Vitamin E Mixed Tocopherols is an active blend of natural mixed tocopherols containing naturally occurring d-alpha, d-beta, d-gamma and d-delta tocopherols. These are NATURAL tocopherols, they are NOT the synthetic, racemix dl-tocopherol or dl-tocopheryl acetate. 

Tocopherol is the most commonly used form of vitamin E in cosmetic products. α-tocopherol, one of four types of tocopherol, is the most abundant form of vitamin E naturally found in the skin. α and γ forms are excreted in sebum [oil] and act as a barrier for the skin. The amount of tocopherol in the skin decreases over time due to sun exposure. Tocopherols are strong anti-oxidants. Anti-oxidants help protect against skin aging. Tocopherols use their anti-oxidant ability to protect against sun damage and repair sun damage. They increase collagen production and protect existing collagen by inhibiting matrix metalloproteinase [MMP] that degrades collagen. Mixed tocopherols have anti-inflammatory properties and accelerate wound healing.
 

Key benefits of Vitamin E Mixed Tocopherols in skin care:

  • Antioxidant [1-15]
  • Sun damage protection [2, 4, 7, 8, 9, 14, 15]
  • Sun damage repair [12]
  • Anti-inflammatory [2, 5, 10, 14]
  • Wound Healing Support [5]
  • Matrix Metalloproteinase [MMP] inhibitors [11]
  • Stimulate collagen production [5]
  • Reduces fine lines and wrinkles [3]
Vitamin E Natural Mixed Tocopherols skin care active ingredients
Product Code: BulkActives
Reward Points: 5
Assay: 95% mixed Tocopherols
CAS#: 1406-18-4
Net weight: 14g / 0.49oz
Availability:
14g / 0.49oz - Options In Stock
50g / 1.76oz - Options In Stock
Price: $10.40
Reward Points: 545


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Vitamin E Natural Mixed Tocopherols

About Vitamin E Mixed Tocopherols  in DIY Skin Care

Tocopherol is a common form of vitamin E used for therapeutic purposes. Tocopherols are depleted in skin after UV exposure. This depletion in the amount of tocopherol is associated with skin aging. There are four forms of tocopherol-α, β, γ, and δ. α and γ forms are excreted in sebum (oil), mostly on the forehead and cheeks (12). α-tocopherol is the most abundant natural form of vitamin E, followed by γ-tocopherol. There is a ten-fold difference in the amount of tocopherol in the skin when it is applied topically rather than through diet, showing it is most effective when supplemented topically (1).
 
Tocopherol's primary function is as an antioxidant. Each form of tocopherol has anti-oxidant abilities, but with varying degrees (α>β>γ>δ) (13). Tocopherols decrease levels of lipid degradation associated with harmful free radicals from UV exposure, which is associated with skin aging (15). Lipids are waxy molecules necessary for to retain moisture and skin barrier function. In a clinical study, α-tocopherol in a rinse off formula absorbed into the skin and protected the skin barrier against lipid degradation (9). Application of tocopherol also increases the amounts of other natural antioxidants (12) Vitamin E works in conjunction with vitamin C. In a clinical study, it was found that vitamin C regenerates α-tocopherol so it can continue acting as an antioxidant (4). Studies show γ-tocopherol is more effective than α-tocopherol at protecting against lipid degradation (2). The anti-oxidant properties of tocopherols help protect against sunburn, photoaging (chronic skin damage due to sun exposure), and skin sensitivity.
 
The effect of tocopherol is thought to be greater when using mixed tocopherols, as α, β, γ, and δ forms have slightly different functions. A study using α-tocopherol, mixed tocopherols, and α-tocopherol acetate, a derivative of α-tocopherol commonly used in cosmetic products, showed that mixed tocopherols and α-tocopherol had anti-oxidant ability, while α-tocopherol acetate showed none (7). α, δ, and γ-tocopherol inhibited photodamage, showing mixed tocopherols are a beneficial sunscreen additive (8).
 
Tocopherols also benefit the immune system. They increase levels of cyclic amp (cAMP), which helps regulate inflammatory responses. They have also been shown to decrease levels of inflammatory proteins (5). γ-tocopherol reduces inflammation by inhibiting COX-2, a protein that produces prostaglandins, immune mediators (14). Studies show γ-tocopherol and δ-tocopherol’s anti-inflammatory effects are greater than that of α-tocopherol and this is not related to its anti-oxidant function (2, 10). Thus, mixed tocopherols may help treat inflammatory skin disorders such as eczema.
 
In a study using rats, application of creams containing 0.6% and 0.29% tocopherol helped with delayed wound healing characteristic of diabetes (5). Wounds treated with tocopherol closed quicker and had more protein, which is a measure of wound healing. Also, the amount of collagen formation in the wound was higher in the treated rats.
 
Additionally, tocopherol decreases collagen breakdown (1, 7). Tocopherol protects fibroblasts, collagen producing cells, from death by UV exposure (7). Loss of elasticity associated with this is seen in aged skin. α-tocopherol also inhibits matrix metalloproteinase 1 (MMP1), which degrades collagen and deteriorates skin (11). Thus, tocopherol protects collagen. α-tocopherol was also shown to decrease skin wrinkling in mice (3). It also protects against telomere shortening (6). Telomeres are “tails” on the end of DNA necessary for proper cell replication. Telomere shortening is involved in skin aging.


You can read more about the role of Vitamin E in Skin care here: Vitamin E reborn: how to correctly use tocopherols and tocotrienols for skin and health.


 
Assay: 95% Alpha-, Beta-, Gamma-, and Delta-Tocopherols
CAS No.: 1406-18-4
INCI: Tocopherol
Source: soybean oil
Appearance: oil
Solubility: oil
Suggested percentage: 0.5% to 1%

Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: USA


 
[1] M.J. Abla and A.K. Banga, “Formulation of Tocopherol Nanocarriers and In Vitro Delivery into Human Skin,” International Journal of Cosmetic Science, vol. 36, pp. 239-246, 2014.
[2] Q. Jiang, I. Elson-Schwab, C. Courtemanche, and B.N. Ames, “gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells,” Proc Natl Acad Sci, vol. 97, issue 21, pp. 11494-11499, October 2000.
[3] B.A. Jurkiewicz, D.L. Bissett, and G.R. Buettner, “Effect of Topically Applied Tocopherol on Ultraviolet Radiation-Mediated Free Radical Damage in Skin,” The Society for Investigative                Dermatology, vol. 104, no. 4, pp. 484-488, April 1995.
[4] B.E. Konig, M. Placzek, and B. Przybilla, “Protective effect against sunburn of combined systemic ascorbic acid [vitamin C] and d-α-tocopherol [vitamin E],” Journal of the American Academy of Dermatology, vol. 38, pp. 45-48, 1998.
[5] T.S. Lin, A.A. Latiff, N.A.A. Hamid, W.Z.W. Ngah, and M. Mazlan, “Evaluation of Topical Tocopherol Cream on Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats,” Evidence-Based Complementary and Alternative Medicine, pp. 1-6, 2012.
[6] S. Makpol, A. Zainuddin, N.A. Rahim, Y.A. Yusof, and W.Z. Ngah, “Alpha-tocopherol modulates   hydrogen peroxide-induced DNA damage and telomere shortening of human skin fibroblasts derived from differently aged individuals,” Planta Med, vol. 76, no. 9, pp. 869-875, 2010.
[7] V.M. Di Mambro, A.E.C.S. Azzolini, Y.M.L. Valim, and M.J.V. Fonseca, “Comparison of antioxidant activities of tocopherols alone and in pharmaceutical formulations,” International Journal of Pharmaceutics, vol. 262, pp. 93-99, 2003.
[8] M. McVean and D.C. Liebler, “Prevention of DNA photodamage by vitamin E compounds and sunscreens: roles of ultraviolet absorbance and cellular uptake,” Mol Carcinog., vol. 24, issue 3, pp. 169-176, March 1999.
[9] S.E. Mudiyanselage, A. Tavakkol, T.G. Polefka, Z. Nabi, P. Elsner, and J.J. Thiele, “Vitamin E delivery to human skin by a rinse-off product: penetration of alpha-tocopherol versus wash-out effects of skin surface lipids,” Skin Pharmacol. Physiol., vol. 18, no. 1, pp. 20-26, 2005.
[10] E. Reiter, Q. Jiang, and S. Christen, “Anti-inflammatory properties of α- and γ-tocopherol,” Mol Aspects Med., vol. 28, issue 5, pp. 668-691, 2007.
[11] R. Ricciarelli, P. Maroni, N. Ozer, J.M. Zingg, and A. Azzi, “Age-dependent increase of collagenase expression can be reduced by α-tocopherol via protein kinase C inhibition,” Free Radical  Biology and Medicine, vol. 27, issue 7, pp. 729-737, October 1999. 
[12] J.J. Thiele, S.U. Weber, and L. Packer, “Sebaceous Gland Secretion is a Major Physiologic Route of  Vitamin E Delivery to the Skin,” The Society for Investigative Dermatology, vol. 113. no. 6, pp.  1006- 1010, 1999.
[13] C. Weber, M. Podda, M. Rallis, J. J. Thiele, M.G. Traber, and L. Packer, “Efficacy of Topically Applied Tocopherols and Tocotrienols in Protection of Murine Skin from Oxidative Damage                Induced by UV-Irradiation” Free Radical Biology & Medicine, Vol. 22, No. 5, pp. 761–769, 1997.
[14] E. Yoshida, T. Watanabe, J. Takata, A. Yamazaki, Y. Karube, and S. Kobayashi, “Topical Application of a Novel, Hydrophillic γ-Tocopherol Derivative Reduces Photo-Inflammation in Mice Skin,”Journal of Investigative Dermatology, vol. 126, pp. 1633-1640, 2006.
[15] K.S. Yuen and G.M. Halliday, “α-Tocopherol, an Inhibitor of Epidermal Lipid Peroxidation, Prevents Ultraviolet Radiation from Suppressing the Skin Immune System,” Photochemistry                and Photobiology, vol. 65, issue 3, pp. 587-592, 1997.
 

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