Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Love the fine powder ascorbic acid. I use it in a recipe for skin care along with hyaluronic acid. I'm 65 years old and absolutely no one believes it 'cause I've been doing this for years... ...»
Purchased this some time ago from BulkActives and here to buy some more! Great stuff!!!!.. ...»
I started experimenting with DIY skin care about 5-6 months ago, then I found Bulk Actives. A one shop DIY shop. LLA powder is beautiful to work with, easy to dissolve, and price is absolutely to die for. Mixed with other powders and oils it is a great serum. .. ...»
Very finely milled powder, great quality. I don't have difficulty dissolving it in my regular toner. I add FE, HA and Vit E with the mixture to make a serum. Shipping time is as promised. Thank you BulkActives! .. ...»
This is a fantastic product. Highly moisturizing and smooths out lines and wrinkles. It works quickly and is evening out skin tone as well. I think its a must have product and I certainly will be purchasing it again.. ...»
This lovely, simple, and affordable product has become something I don't want to be without. I am 47, with very sensitive and reactive dry skin. This cream doesn't feel particularly moisturizing and leaves something of a 'dry' finish on the skin after application, but it's had SUCH a positive impact on my face. The redness and papules from my rosacea and seb derm have reduced by a good 90%. It's been a magical barrier restorer and I panicked when it was temporarily out of stock. I would recomme.. ...»
Candace Carnahan
This is the best product I have ever used on my skin and I tried a LOT of expansive brands. It helps with redness and overall skin tone. Please do not ever stop making this stuff... ...»
I' m not sure about this: "11% solution gives 1% EGCG content in final product." What is the weight of final product? .. ...»
Vesna Hanich
It is true, this product does leave the skin silky smooth! I can highly recommend using it in your masks... ...»
Mati Fuller
I am 69 and I have used this product for two years almost every day at a high dose, adding it to my antioxidant day cream, with excellent results. For me it has a very high quality and effectiveness: reduction of wrinkles, hydrated skin, unified color without blemishes ... A product of 10, the same score that I give to John for the quality of the products he sells, his excellent description / use and the bibliographic contribution.En .. ...»
María Jesus
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Gynostemma (Jiaogulan)

Gynostemma pentaphyllum / Jiaogulan is a plant native to Eastern Asia. It has been used in traditional Chinese medicine for centuries, and recently it has come to the focus of many researchers due to its anti-cancer properties. The extract of this plant contains high amounts of flavonoids and gypenosides, noted for their antioxidant effects. In skin cells, this extract was shown to prevent UV-induced damage and cell death. Furthermore, it is able to reduce the levels of matrix metalloproteinases (enzymes responsible for collagen degradation), thus its applications are likely beneficial for skin collagen maintenance. It is also investigated as a promising drug against skin reddening and inflammation, observed in diseases like psoriasis.

NOTE: To assist you with solubility issues, we now also sell Gynostemma (Jiaogulan) as a liquid standardized pre-dissolved solution. Just add the liquid to your cream and mix well.

  • 11% solution gives 1% Gypenosides content in final product.
  • 32% solution gives 3% Gypenosides content in final product.
  • 53% solution gives 5% Gypenosides content in final product.

Key benefits of Gynostemma Jiaogulan in skin care:

  • Sun damage protection [4] [10]
  • sun damage repair [2] [3] [5] [6]
  • Antioxidant [2] [3] [5] [6]
  • Anti-inflammatory [2] [7]
Product Code: BulkActives
Assay: 95% Gypenosides
CAS#: 80321-63-7
Net weight: 30g /1.06oz & 150g / 8.82oz
Standardized preDissolved solution 150g - Options In Stock
Standardized pre-dissolved solution 50g - Options In Stock
Standardized Powder 30g - Options In Stock
Price: $11.60

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About Gynostemma / Jiaogulan in DIY Skin Care

Gynostemma  Jiaogulan skin careGynostemma pentaphyllum, also known as jiaogulan, is a plant from the cucumber family, growing naturally in China and other parts of East Asia. Although it has been used for centuries in Chinese traditional medicine, the actual components and mechanisms responsible for the medicinal activity of this plant are still being investigated. Recently, it has attracted more attention from the science community due to its potential in preventing various types of cancer [1].

Most research is focused on gypenosides – these molecules belong to a class of compounds called saponins, often found in plants. However, gypenosides found in Gynostemma can inhibit inflammation, prevent cardiovascular disease, protect from oxidative stress, and have other health benefits, thus contributing to the many medicinal properties of Gynostemma extract [2].

Among the best known properties of gypenosides is their antioxidant effect. Under oxidative damage, cell membranes tend to become less fluid, disrupting many processes in the cell. Gypenosides can reverse this change, effectively protecting the cells from injury and death [3]. In fact, they are known to prevent various types of oxidative damage, and even reduce the likelihood of DNA mutations [4]. Furthermore, Gynostemma pentaphyllum extract contains additional molecules with strong antioxidant properties, such as flavonoids and even polysaccharides (sugars) that are able to neutralize free radicals [5], [6]. The polysaccharides found in Gynostemma are also promising for treatment of skin diseases, such as psoriasis – they reduce the production of inflammatory signals that lead to this disease [7].

Gypenosides have an additional effect on matrix metalloproteinase enzymes. These enzymes are known to degrade collagen – under UV exposure, for example, the levels of these enzymes increase, resulting in skin damage and aged appearance [8]. Gypenosides were shown to reduce the amounts of these metalloproteinases, thus preventing collagen degradation and even tumor cell migration [9].

The overall skin benefits of Gynostemma pentaphyllum extract were confirmed in a study with mouse dermal cells. After UV exposure of 3 h, complete cell death was observed among these cells. However, application of Gynostemma extract at various concentrations up to 5 mg of material per mL resulted in strongly increased lifetime of the cells, most likely due to the neutralization of oxidative agents produced under UV [10].

Many cosmeceutical preparations suffer from poor absorption through skin. While dermal transport of gypenosides has not been investigated yet, a related molecule called ginsenoside has been studied well, and it was shown to be transported easily even at low concentrations [11]. Since the molecules of gypenosides have similar size and structure, it is reasonable to conclude that their absorption is equally effective. Furthermore, no adverse effect of Gynostemma extract has been observed, even at high doses [12].

NOTE: To assist you with solubility issues, we now also sell Gynostemma (Jiaogulan) as a liquid standardized pre-dissolved solution. Just add the liquid to your cream and mix well.

Gynostemma (Jiaogulan) Standardized Powder

Assay: 95% Gypenosides
CAS#: 80321-63-7
INCI: Gynostemma Pentaphyllum Extract
Botanical source: Gynostemma pentaphyllum (Jiaogulan)
Appearance: powder
Solubility: 1,3 Propanediol
Suggested percentage: 1 to 10%

Storage: Store in cool and dry place. Keep away from direct strong light and heat.
Country of origin: China

Gynostemma (Jiaogulan) Standardized Pre Dissolved Solution - 10%

Assay: 9.5% Gypenosides
CAS#: 504-63-2, 80321-63-7
INCI:1,3-Propanediol, Gynostemma Pentaphyllum Extract
Appearance: dark red/brown liquid

Solubility: add to cream
Suggested percentage:
11% solution gives 1% Gypenosides content in final product.
32% solution gives 3% Gypenosides content in final product.
53% solution gives 5% Gypenosides content in final product.

Storage: Store in fridge, do not freeze
Country of origin for raw material: China
Country of manufacture: Taiwan
[1]          C. Kulwat, N. Lertprasertsuke, P. Leechanachai, P. Kongtawelert, and U. Vinitketkumnuen, “Antimutagenicity and DT-diaphorase inducing activity of Gynostemma pentaphyllum Makino extract,” J. Med. Investig. JMI, vol. 52, no. 3–4, pp. 145–150, Aug. 2005.
[2]          F. Aktan, S. Henness, B. D. Roufogalis, and A. J. Ammit, “Gypenosides derived from Gynostemma pentaphyllum suppress NO synthesis in murine macrophages by inhibiting iNOS enzymatic activity and attenuating NF-kappaB-mediated iNOS protein expression,” Nitric Oxide Biol. Chem. Off. J. Nitric Oxide Soc., vol. 8, no. 4, pp. 235–242, Jun. 2003.
[3]          L. Li, L. Jiao, and B. H. Lau, “Protective effect of gypenosides against oxidative stress in phagocytes, vascular endothelial cells and liver microsomes,” Cancer Biother., vol. 8, no. 3, pp. 263–272, 1993.
[4]          Y. Quan, Y. Yang, H. Wang, B. Shu, Q.-H. Gong, and M. Qian, “Gypenosides attenuate cholesterol-induced DNA damage by inhibiting the production of reactive oxygen species in human umbilical vein endothelial cells,” Mol. Med. Rep., vol. 11, no. 4, pp. 2845–2851, Apr. 2015.
[5]          K.-C. Tsui, T.-H. Chiang, J.-S. Wang, L.-J. Lin, W.-C. Chao, B.-H. Chen, and J.-F. Lu, “Flavonoids from Gynostemma pentaphyllum exhibit differential induction of cell cycle arrest in H460 and A549 cancer cells,” Mol. Basel Switz., vol. 19, no. 11, pp. 17663–17681, 2014.
[6]          Y. Niu, P. Shang, L. Chen, H. Zhang, L. Gong, X. Zhang, W. Yu, Y. Xu, Q. Wang, and L. L. Yu, “Characterization of a novel alkali-soluble heteropolysaccharide from tetraploid Gynostemma pentaphyllum Makino and its potential anti-inflammatory and antioxidant properties,” J. Agric. Food Chem., vol. 62, no. 17, pp. 3783–3790, Apr. 2014.
[7]          X.-L. Li, Z.-H. Wang, Y.-X. Zhao, S.-J. Luo, D.-W. Zhang, S.-X. Xiao, and Z.-H. Peng, “Purification of a polysaccharide from Gynostemma pentaphyllum Makino and its therapeutic advantages for psoriasis,” Carbohydr. Polym., vol. 89, no. 4, pp. 1232–1237, Aug. 2012.
[8]          G. J. Fisher, T. Quan, T. Purohit, Y. Shao, M. K. Cho, T. He, J. Varani, S. Kang, and J. J. Voorhees, “Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin,” Am. J. Pathol., vol. 174, no. 1, pp. 101–114, Jan. 2009.
[9]          K.-W. Lu, M.-L. Tsai, J.-C. Chen, S.-C. Hsu, T.-C. Hsia, M.-W. Lin, A.-C. Huang, Y.-H. Chang, S.-W. Ip, H.-F. Lu, and J.-G. Chung, “Gypenosides inhibited invasion and migration of human tongue cancer SCC4 cells through down-regulation of NFkappaB and matrix metalloproteinase-9,” Anticancer Res., vol. 28, no. 2A, pp. 1093–1099, Apr. 2008.
[10]        S. N. Lobo, Y. Q. Qi, and Q. Z. Liu, “The Effect of Gynostemma pentaphyllum Extract on Mouse Dermal Fibroblasts,” ISRN Dermatol., vol. 2014, p. 202876, 2014.
[11]        Y. Kimura, M. Sumiyoshi, and M. Sakanaka, “Effects of ginsenoside Rb₁ on skin changes,” J. Biomed. Biotechnol., vol. 2012, p. 946242, 2012.
[12]        N. Chiranthanut, S. Teekachunhatean, A. Panthong, P. Khonsung, D. Kanjanapothi, and N. Lertprasertsuk, “Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino,” J. Ethnopharmacol., vol. 149, no. 1, pp. 228–234, Aug. 2013.

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