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Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
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ACTIVES
- - anti-acne
- - anti-androgenetic alopecia
- - anti-bacterial
- - anti-blackheads
- - anti-inflammatory
- - antioxidant
- - capillary health
- - exfoliating
- - glycation inhibitor and repair
- - increase cellular energy production
- - increase skin elasticity
- - lightening and brightening
- - matrix metalloproteinases (MMP) inhibitors
- - moisturizing and hydration
- - natural phyto estrogens
- - nutrition
- - oil/sebum control
- - pore refinement
- - reduce dark circles under the eyes
- - reduce fine lines and wrinkles
- - reduce rosacea
- - restore barrier function
- - scar care
- - stimulate collagen production
- - stimulate HA production
- - sun damage protection
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Reviews
This lovely, simple, and affordable product has become something I don't want to be without. I am 47, with very sensitive and reactive dry skin. This cream doesn't feel particularly moisturizing and leaves something of a 'dry' finish on the skin after application, but it's had SUCH a positive impact on my face. The redness and papules from my rosacea and seb derm have reduced by a good 90%. It's been a magical barrier restorer and I panicked when it was temporarily out of stock. I would recomme.. ...»
Candace Carnahan
This is the best product I have ever used on my skin and I tried a LOT of expansive brands. It helps with redness and overall skin tone. Please do not ever stop making this stuff... ...»
Helena
I' m not sure about this: "11% solution gives 1% EGCG content in final product." What is the weight of final product? .. ...»
Vesna Hanich
It is true, this product does leave the skin silky smooth! I can highly recommend using it in your masks... ...»
Mati Fuller
I am 69 and I have used this product for two years almost every day at a high dose, adding it to my antioxidant day cream, with excellent results. For me it has a very high quality and effectiveness: reduction of wrinkles, hydrated skin, unified color without blemishes ... A product of 10, the same score that I give to John for the quality of the products he sells, his excellent description / use and the bibliographic contribution.En .. ...»
María Jesus
Tried this on my week-old rash from flea bites. Got an almost instant relief and rash healed in 2 days.
Tried it on my daughter who has eczema for a very long time. The rashes calmed down after a few days and her skin is now healing well. Really great product. Just put in order for another jar.... ...»
Eliz
This is great stuff.
I add it to my liquid face soap and it does an excellent job in preventing acne and gently exfoliating the skin... ...»
Marie
Really loving this product. I make the best Centella toner and most concentrated ever. 2 g of centella extract dissolved in 10g of alcohol(you have to stir a lot) plus 88 grams of water and you get a very concentrated toner. Creams, toners, ampoules... all have only 0,1% of triterpenes, this toner i make have 1,4%. I am loving it, will see the results. .. ...»
Francisco
Just recently ordered this and LOVE! Green Tea EGCG truly is one of the most fantastic skincare actives out there. Very difficult to find good quality product (90%) and even harder to actually solubilize it! Love that it comes in pre-dissolved solution. I enjoy adding it at 1% (so 11% sol) to my serum formulations containing Niacinamide 5% + NAG 3%. Excellent for oily acne prone skin.
*Only gripe... because the Pre-Dissolved Solution is SO heavy in propanediol (10 parts Propanediol for 1 part E.. ...»
Victor
Wonderful base cream! Only multi-lamellar structured cream I've found on the market. Cream itself is lightweight (no oil) yet very conditioning/hydrating. Easily accepts water-soluble active ingredients as well as oil-soluble ones. I've even pushed the additional ingred % up to 20 (meaning 80% this cream, 20% added) without any separation issues. Ideal base cream for delivering actives. Personal favorite recipe calls for 5% straight Grapeseed Oil with 5% SebumREG oil active + Panthenol 1% + E Ac.. ...»
Vic
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Sample Recipes
Near The End
BulkActives has been in business since 2005, we might have disappeared from google search results,
but we're still hanging on, just, mainly thanks to the support of some loyal customers.
However, like many, COVID hit us hard, and we're having a lot of trouble recovering.
Right now, we have not restocked many powders, however, are looking at continuing with selling only our flagship products:
seakelp and pre-dissolved powders, and some of the essentials.
Allantoin: The Ultimate DIY Skincare Ingredient for Healing and Anti-Aging
What is Allantoin and Why is it Essential for DIY Skincare?
Allantoin is a naturally occurring compound found in many plants and mammals, prized in cosmetics for its skin-healing and anti-inflammatory properties. This versatile ingredient is ideal for DIY skincare enthusiasts looking to create effective, multi-functional products.
What are the Key Benefits of Allantoin in Homemade Skincare?
- Wound Healing Support: Accelerates skin repair and visibly reduces scar size.
- Anti-inflammatory Action: Soothes irritated skin and diminishes redness.
- Antimicrobial Properties: Combats nail fungus and various skin infections.
- Safe and Versatile: Suitable for a wide range of DIY skincare applications.
How Can You Use Allantoin in Your DIY Skincare Routine?
Incorporate allantoin into your homemade creams, lotions, and serums for enhanced healing, scar prevention, and overall skin health. Its gentle yet effective nature makes it perfect for both preventive care and treating existing skin concerns.
Product Code: BulkActives
HS Code: 29332100
Assay: 99.6%
CAS#: 97-59-6
Net weight: 30g /1.06oz
Availability: In Stock
HS Code: 29332100
Assay: 99.6%
CAS#: 97-59-6
Net weight: 30g /1.06oz
Availability: In Stock
Price: $4.75
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Discover the Power of Allantoin in Your Homemade Skincare Recipes
Allantoin: The Powerhouse Ingredient for DIY Skincare Enthusiasts
Allantoin, the final product of nitrogen metabolism in most mammals (except primates), is a skincare superstar naturally found in plants like sugar beets and wheat sprouts [1]. While historically extracted from comfrey plant roots and leaves, its widespread use in cosmetics and pharmaceuticals has led to synthetic production [2].
How Prevalent is Allantoin in Skincare Products?
This versatile agent is featured in over 1300 cosmetic preparations, with concentrations ranging from 0.0001% to 2.0% [3]. Its 70-year history in cosmetics spans a wide range of clinical skincare products, addressing conditions such as wounds, ulcers, burns, dermatitis, psoriasis, impetigo, and acne [2]–[5].
What Makes Allantoin a Must-Have in DIY Skincare?
- Antiphlogistic: Reduces inflammation
- Antioxidant: Combats free radical damage associated with aging and cancer
- Keratolytic: Effective against unwanted keratin formations like warts
- Cell Proliferation Inducer: Promotes tissue repair and even peripheral nerve regeneration [1], [2]
How Does Allantoin Promote Wound Healing in DIY Formulations?
Recent research has unveiled allantoin's mechanism in regulating inflammatory reactions [4]. Clinical studies have demonstrated its efficacy:
- A 1994 study showed that allantoin-containing mixtures improved thoracic surgery scar appearance and reduced width in over 90% of patients [6].
- Early application can significantly decrease scar size, improve color, and reduce painfulness [7].
- Allantoin-based treatments reduced scar incidence after laser tattoo removal [8].
Can Allantoin Be Used as an Antimicrobial in Homemade Products?
Absolutely! Allantoin exhibits potent antimicrobial effects:
- Combined with benzalkonium chloride and surfactants, it effectively treats onychomycosis (toenail fungal infections) with a 90% improvement rate [9].
- Allantoin-based hand sanitizers outperform alcohol-based alternatives in preventing infection spread among children [10], [11].
- It has shown promise in experimental treatments for trichomoniasis [2], [12].
How Can DIY Skincare Enthusiasts Combine Allantoin with Other Ingredients?
Allantoin synergizes well with other natural extracts:
- Often paired with onion (Allium cepa) extract for enhanced wound healing [6]–[8].
- Combined with Vitis vinifera extract, glycyrrhenetic acid, and telmesteine in Atopiclair, a non-steroidal anti-inflammatory for allergic skin conditions [13].
- Effective even when used as the sole active ingredient in wound healing formulations [4].
Is Allantoin Safe for DIY Skincare Use?
Research consistently reports no adverse side effects, and the safety of allantoin has been extensively confirmed [3]. This makes it an ideal ingredient for DIY skincare enthusiasts looking to create safe, effective, and multi-functional products at home.
Assay: 99.6%
CAS No.: 97-59-6
Source: synthetic...note that, although Allantoin is found in the leaves of the comfrey plant and in the urine of most mammals, commercial allantoin is usually produced synthetically
Appearance: white powder
Solubility: water (0.5 at 25C)
Suggested percentage:0.5% to 2%
Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China
CAS No.: 97-59-6
Source: synthetic...note that, although Allantoin is found in the leaves of the comfrey plant and in the urine of most mammals, commercial allantoin is usually produced synthetically
Appearance: white powder
Solubility: water (0.5 at 25C)
Suggested percentage:0.5% to 2%
Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China
[1] National Center for Biotechnology Information, “PubChem Compound Summary for CID 204, allantoin.”
[2] C. Thornfeldt, “Cosmeceuticals Containing Herbs: Fact, Fiction, and Future,” Dermatol. Surg., vol. 31, pp. 873–881, Mar. 2006.
[3] L. C. Becker, W. F. Bergfeld, D. V. Belsito, C. D. Klaassen, J. G. Marks, R. C. Shank, T. J. Slaga, P. W. Snyder, and F. Alan Andersen, “Final report of the safety assessment of allantoin and its related complexes,” Int. J. Toxicol., vol. 29, no. 3 Suppl, p. 84S–97S, May 2010.
[4] L. U. Araújo, A. Grabe-Guimarães, V. C. F. Mosqueira, C. M. Carneiro, and N. M. Silva-Barcellos, “Profile of wound healing process induced by allantoin,” Acta Cirúrgica Bras. Soc. Bras. Para Desenvolv. Pesqui. Em Cir., vol. 25, no. 5, pp. 460–466, Oct. 2010.
[5] D. M. Ashcroft, A. L. Po, H. C. Williams, and C. E. Griffiths, “Systematic review of comparative efficacy and tolerability of calcipotriol in treating chronic plaque psoriasis,” BMJ, vol. 320, no. 7240, pp. 963–967, Apr. 2000.
[6] G. H. Willital and H. Heine, “Efficacy of Contractubex gel in the treatment of fresh scars after thoracic surgery in children and adolescents,” Int. J. Clin. Pharmacol. Res., vol. 14, no. 5–6, pp. 193–202, 1994.
[7] G. H. Willital and J. Simon, “Efficacy of early initiation of a gel containing extractum cepae, heparin, and allantoin for scar treatment: an observational, noninterventional study of daily practice,” J. Drugs Dermatol. JDD, vol. 12, no. 1, pp. 38–42, Jan. 2013.
[8] W. S. Ho, S. Y. Ying, P. C. Chan, and H. H. Chan, “Use of onion extract, heparin, allantoin gel in prevention of scarring in chinese patients having laser removal of tattoos: a prospective randomized controlled trial,” Dermatol. Surg. Off. Publ. Am. Soc. Dermatol. Surg. Al, vol. 32, no. 7, pp. 891–896, Jul. 2006.
[9] P. S. Wadhams, J. Griffith, P. Nikravesh, and D. Chodosh, “Efficacy of a surfactant, allantoin, and benzalkonium chloride solution for onychomycosis. Preliminary results of treatment with periodic debridement,” J. Am. Podiatr. Med. Assoc., vol. 89, no. 3, pp. 124–130, Mar. 1999.
[10] A. Moadab, K. F. Rupley, and P. Wadhams, “Effectiveness of a nonrinse, alcohol-free antiseptic hand wash,” J. Am. Podiatr. Med. Assoc., vol. 91, no. 6, pp. 288–293, Jun. 2001.
[11] C. G. White, F. S. Shinder, A. L. Shinder, and D. L. Dyer, “Reduction of illness absenteeism in elementary schools using an alcohol-free instant hand sanitizer,” J. Sch. Nurs. Off. Publ. Natl. Assoc. Sch. Nurses, vol. 17, no. 5, pp. 258–265, Oct. 2001.
[12] L. duBouchet, M. R. Spence, M. F. Rein, M. R. Danzig, and W. M. McCormack, “Multicenter comparison of clotrimazole vaginal tablets, oral metronidazole, and vaginal suppositories containing sulfanilamide, aminacrine hydrochloride, and allantoin in the treatment of symptomatic trichomoniasis,” Sex. Transm. Dis., vol. 24, no. 3, pp. 156–160, Mar. 1997.
[13] S. Veraldi, P. De Micheli, R. Schianchi, and L. Lunardon, “Treatment of pruritus in mild-to-moderate atopic dermatitis with a topical non-steroidal agent,” J. Drugs Dermatol. JDD, vol. 8, no. 6, pp. 537–539, Jun. 2009.
[2] C. Thornfeldt, “Cosmeceuticals Containing Herbs: Fact, Fiction, and Future,” Dermatol. Surg., vol. 31, pp. 873–881, Mar. 2006.
[3] L. C. Becker, W. F. Bergfeld, D. V. Belsito, C. D. Klaassen, J. G. Marks, R. C. Shank, T. J. Slaga, P. W. Snyder, and F. Alan Andersen, “Final report of the safety assessment of allantoin and its related complexes,” Int. J. Toxicol., vol. 29, no. 3 Suppl, p. 84S–97S, May 2010.
[4] L. U. Araújo, A. Grabe-Guimarães, V. C. F. Mosqueira, C. M. Carneiro, and N. M. Silva-Barcellos, “Profile of wound healing process induced by allantoin,” Acta Cirúrgica Bras. Soc. Bras. Para Desenvolv. Pesqui. Em Cir., vol. 25, no. 5, pp. 460–466, Oct. 2010.
[5] D. M. Ashcroft, A. L. Po, H. C. Williams, and C. E. Griffiths, “Systematic review of comparative efficacy and tolerability of calcipotriol in treating chronic plaque psoriasis,” BMJ, vol. 320, no. 7240, pp. 963–967, Apr. 2000.
[6] G. H. Willital and H. Heine, “Efficacy of Contractubex gel in the treatment of fresh scars after thoracic surgery in children and adolescents,” Int. J. Clin. Pharmacol. Res., vol. 14, no. 5–6, pp. 193–202, 1994.
[7] G. H. Willital and J. Simon, “Efficacy of early initiation of a gel containing extractum cepae, heparin, and allantoin for scar treatment: an observational, noninterventional study of daily practice,” J. Drugs Dermatol. JDD, vol. 12, no. 1, pp. 38–42, Jan. 2013.
[8] W. S. Ho, S. Y. Ying, P. C. Chan, and H. H. Chan, “Use of onion extract, heparin, allantoin gel in prevention of scarring in chinese patients having laser removal of tattoos: a prospective randomized controlled trial,” Dermatol. Surg. Off. Publ. Am. Soc. Dermatol. Surg. Al, vol. 32, no. 7, pp. 891–896, Jul. 2006.
[9] P. S. Wadhams, J. Griffith, P. Nikravesh, and D. Chodosh, “Efficacy of a surfactant, allantoin, and benzalkonium chloride solution for onychomycosis. Preliminary results of treatment with periodic debridement,” J. Am. Podiatr. Med. Assoc., vol. 89, no. 3, pp. 124–130, Mar. 1999.
[10] A. Moadab, K. F. Rupley, and P. Wadhams, “Effectiveness of a nonrinse, alcohol-free antiseptic hand wash,” J. Am. Podiatr. Med. Assoc., vol. 91, no. 6, pp. 288–293, Jun. 2001.
[11] C. G. White, F. S. Shinder, A. L. Shinder, and D. L. Dyer, “Reduction of illness absenteeism in elementary schools using an alcohol-free instant hand sanitizer,” J. Sch. Nurs. Off. Publ. Natl. Assoc. Sch. Nurses, vol. 17, no. 5, pp. 258–265, Oct. 2001.
[12] L. duBouchet, M. R. Spence, M. F. Rein, M. R. Danzig, and W. M. McCormack, “Multicenter comparison of clotrimazole vaginal tablets, oral metronidazole, and vaginal suppositories containing sulfanilamide, aminacrine hydrochloride, and allantoin in the treatment of symptomatic trichomoniasis,” Sex. Transm. Dis., vol. 24, no. 3, pp. 156–160, Mar. 1997.
[13] S. Veraldi, P. De Micheli, R. Schianchi, and L. Lunardon, “Treatment of pruritus in mild-to-moderate atopic dermatitis with a topical non-steroidal agent,” J. Drugs Dermatol. JDD, vol. 8, no. 6, pp. 537–539, Jun. 2009.
- Allantoin is compatible with most ingredients used in personal care formulations.
- Water solubility at monograph-approved levels is an issue.
- Suspending the material in a thick base is the best way to resolve this issue.
- When conducting stability testing, care must be taken to look for Allantoin recrystallization.
- To incorporate 0.5% Allantoin, or more, into an emulsion product, the emulsion is made and Allantoin is added during the cooling process below 50 °C.
- Good agitation is required to thoroughly disperse the Allantoin to achieve a suitable suspension.
- Addition of Allantoin at 0.5% or more or at temperatures above 50 °C in aqueous systems can cause solubilization and recrystallization upon cooling into larger particles which are perceptible during product use.
- Soluble in the aqueous phase
- Insoluble in commonly used oils
- Add to water and dissolve at 50°C
- Alternatively add at 25°C under stirring
- A pH between 4 and 8 is recommended
Solubility of Allantoin in different solvents
| Solvent | Temp | Concentration |
| Water | 20°C | ca. 0.4% |
| Water | 75°C | ca. 4.0% |
| Ethanol | 20°C | ca. 0.1% |
| 5% Glycerin in water | 20°C. | ca 0.8% |
| Propylenglycol | 25°C | ca. 0.3% |
| 50% Isopropanol in water | 25°C | ca. 0.3% |
| Sodium Lauryl Sulfate (30%) | 20°C | ca. 0.8% |
References
1 DiSalvo, R.M. Allantoin. in: Chemistry and Manufacture ofCosmetics, Vol 3, 29-34 (2002)
2 Eggensperger, H. Allantoin und seine Derivate. in: Multiaktive
Wirkstoffe für Kosmetika, 9-33 (1995)
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