Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Reviews
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
Jessie Sandford
Many thanks for the Silicone DM. This product is lovely quality; it is light, silky, and leaves no residue at all. I use it in the base recipe for a mouldable polymer that I then use to make a simulated 'Amber' for bead making. At the end of this process I have a silky, translucent polymer plus the most gorgeous hands in the studio ! My thanks again, Helen.. ...»
HELEN pEAKE
I am following the moisturizing cream + Zinc dispersion recipe and I am extremely satisfied. I do allow for a little time for it to absorb in & then I dab off anything that I feel looks a little white - but that's because I initially use a fairly thick coating on myself. I use a bit of foundation at times on top and there are no issues as far as weird colors or texture issues. I am so grateful for this entire website as a one-stop-shop for such effective skin care products, and now we can.. ...»
Peggy
I just placed my first order for SEaKelp Bioferment from Bulk Actives and was pleased to receive it very quickly.. ...»
Viki
I have a blind faith of this Pre Liposome Microemulsion, especially it is made in Japan & of Squalane & Lecithin which I am fond of. I mixed it with Palmitoyl oligopeptide and palmitoyl tetrapeptide-7 peptides liposome emulsion & some other water actives like Glucosamine, Niacinamide, Glutathione etc and the serum was very smooth and moisturizing. As it claims, it penetrates into the skin very well. I will mix it with oil soluble actives in my next batch. .. ...»
RRR
This is an excellent additive for increased absorption into the skin. I personally incorporate it with the ceramide lamellar crystal emulsion and multi lamellar base cream V2. The final product delivers a soothing, calming, super moisturizing liquid that penetrates the skin and helps the healing of severe skin issues such as mine (ichthyosis, keratosis). I highly recommend this formulation for those who are not getting any relief from other products and prescription topicals. My skin is finally .. ...»
Nora
I am very happy with my purchase of SKB from BulkActives. Good quality and packaged well. I use SKB in my Vitamin C serum. Will buy from them again. Can't beat the price either! .. ...»
DBallings
Excellent cold emulsifier. Easy to use and a little goes a long way. Gives product a soft luxurious feel excellent for high end personal skin care products. Wish it came in a larger size..... ...»
Angela
Very easy to use. I like it as a thickener for ready emulsion if it is too liquid. Using it as a single emulsifier keep in mind to add less actives... ...»
Nat
I have been a regular customer of BulkActives SeaKelp. I've used it for years after washing my hair. I put a little in my hair and it makes it comb out tangles extremely easy. My hair is about to my midback. My hair is what I would call in pristine condition I think because of this. My hair is dyed so it's not like it is virgin hair. I also blow dry on occasion and use a straightener daily. This is my holy grail and hair products. I believe it keeps my hair "young". Their SeaK.. ...»
Carol P
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Buy EPE9010 (Ethylhexylglycerin + Phenoxyethanol) For Skin Care

EPE9010 is a liquid cosmetic preservative based on phenoxyethanol and ethylhexylglycerin. The addition of ethylhexylglycerin affects the interfacial tension at the cell membrane of microorganisms, improving the preservative activity of phenoxyethanol. It has a broad, balanced spectrum of effect against bacteria, yeasts and mould fungi. Ethylhexylglycerin and  Phenoxyethanol is stable to hydrolysis, temperature and pH. As a result of the good solubility of Ethylhexylglycerin and Phenoxyethanol, an easy dispersion in the various systems even at low temperature is possible. Ethylhexylglycerin (and) Phenoxyethanol is effective in pH-ranges up to 12 (acidic to alkaline). Gels preserved with Ethylhexylglycerin and Phenoxyethanol stay clear and transparent.

Phenoxyethanol is safe and effective at the designated levels in personal care products and cosmetics. It has a long history of effective preservation of these products, and its safety has been extensively documented on human health. Based on available data, the CIR Expert Panel has concluded that ethylhexylglycerin,is safe for use in cosmetical products. The alkyl glyceryl ethers, including ethylhexylglycerin, may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Regulation of the European Union.

Ethylhexylglycerin (and) Phenoxyethanol in skin care:

  • Innovative cosmetic preservative based on phenoxyethanol
  • Paraben free, non-formaldehyde releasing,
  • globally approved
  • stable to hydrolysis, temperature and pH
  • Effective in pH-ranges up to 12
  • broad, balanced spectrum of effect against bacteria,yeasts and mould fungi
  • effective even in low use-concentrations
  • ethylhexylglycerin improves the preservative activity of phenoxyethanol
  • Gels preserved with EPE9010 stay clear and transparent.
  • Oil soluble and soluble in glycerin
  • A high load of surfactants can lead to loss in effectiveness

Quick guide to our preservatives:

  • For facial washes, body washes, and shampoos: EK300
  • For acidic creams/lotions (L ascorbic): EK300 or EPE9010
  • For alkaline creams/lotions (SAP): EPE9010
EPE9010 (Ethylhexylglycerin + Phenoxyethanol) skin care active ingredients
Product Code: BulkActives
Reward Points: 4
CAS#: 122-99-6
Net weight: 50g / 1.76oz
Availability: In Stock
Price: $8.70
Reward Points: 435


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EPE9010 (Ethylhexylglycerin + Phenoxyethanol)

About  Ethylhexylglycerin and Phenoxyethanol in DIY Skin Care

Phenoxyethanol is a well-known, accepted cosmetic preservative. EPE9010 breaks new ground: an innovative, multifunctional additive enhances the efficacy of phenoxyethanol. The addition of ethylhexylglycerin affects the interfacial tension at the cell membrane of microorganisms, improving the preservative activity of phenoxyethanol

Ethylhexylglycerin (and) Phenoxyethanol is used at a recommended use-concentration of 0.5 - 1.0 %. In accordance with the conditions stipulated in Directive 76/768/EEC, Ethylhexylglycerin (and) Phenoxyethanol may be used in cosmetic preparations (leave-on and rinse-off) in a use-concentration up to a maximum of 1.1 %.

As active substance, phenoxyethanol (90 %) is used in Ethylhexylglycerin (and) Phenoxyethanol. As an auxiliary compound, the formulation additionally contains ethylhexylglycerin in a concentration of 10 %. Both substances have undergone extensive toxicological testing. On the basis of the results, with the given upper concentration limit of 1.1 %, Ethylhexylglycerin (and) Phenoxyethanol can be considered safe for the preservation of cosmetics and toiletries.

Furthermore a skin tolerability study (occlusive patch test) of  Ethylhexylglycerin (and) Phenoxyethanol compared to phenoxyethanol showed that there is no difference in skin tolerability between Ethylhexylglycerin (and) Phenoxyethanol and phenoxyethanol. During the entire test period no reactions neither to phenoxyethanol nor to  used in the maximum use concentrations could be observed. This skin tolerability test has been carried out on Caucasian skin in Germany and on Japanese skin in Japan.
  • Innovative cosmetic preservative based on phenoxyethanol
  • Paraben free, non-formaldehyde releasing,
  • globally approved
  • stable to hydrolysis, temperature and pH
  • Effective in pH-ranges up to 12
  • broad, balanced spectrum of effect against bacteria,yeasts and mould fungi
  • effective even in low use-concentrations
  • ethylhexylglycerin improves the preservative activity of phenoxyethanol
  • Gels preserved with EPE9010 stay clear and transparent. 


The Efficacy and Safety of Phenoxyethanol and Ethylhexylglycerin in Skin Care Products

Phenoxyethanol 

Phenoxyethanol is an aromatic ether alcohol [glycol ether] also known as 2-phenoxyethanol, phenoxetol, or ethylene glycol monophenyl ether. [1-2] Phenoxyethanol is an oily, slightly viscous liquid, colorless, to off-white in appearance. It has a faint aromatic or rose-like odor. It is practically insoluble in mineral oil, slightly soluble in water, and soluble in alcohol and ether, and in alkaline solutions. [2-4] It is also stable in acid solutions. [4]
 
Introduced in the 1950s, it has had a long history of safe use as a cosmetic preservative. [5] In cosmetics and personal care products, phenoxyethanol is used in the formulation of skin care products and can also be found in eye makeup, fragrances, blushers, foundations and makeup bases, lipstick, cuticle softeners, bath soaps and detergents, baby products, suntan and sunscreen products, and face, body and foot powders. Cosmetic grades are of high purity and do not impart free phenol, odor or color to the final formulation. [6] Although the phenoxyethanol used in personal care is typically synthetic, it does occur naturally in green tea. The natural form has been employed to preserve “natural” personal care products. In addition to its function as a preservative, phenoxyethanol is used as a solvent for low water-soluble cosmetic ingredients such as fragrances and other preservative actives. [7] It is also listed as an ingredient for many United States vaccines by the Center for Disease Control. In Japan and the EU, its usage level in cosmetic products is restricted to concentrations of up to 1%. [8-9] In recent years, the use of phenoxyethanol has expanded due to its low sensitization potential and global approval. [5]
 
Phenoxyethanol is compatible with most cosmetic raw materials used in rinse-off and leave-on products. Its thermal stability [up to 85°C] facilitates viability through numerous manufacturing processes and use in a broad range of products types. It has functional activity and efficacy at a pH range of 3 to 10, and is typically well-dispersed throughout a formulation, although changes in viscosity have been observed in some formulations, depending on the thickening mechanism and use level. [10]
 
Phenoxyethanol acts as a bactericide, by inhibiting synthesis of nucleic acids in bacteria, as well as acting on bacterial cell walls by causing them to become more permeable to potassium ions.
[11] Phenoxyethanol has a broad range of antimicrobial activity, but the greatest activity is against gram-negative organisms. It is particularly effective against Pseudomonas aeruginosa [minimum inhibitory concentration MIC, 0.32%]. At higher concentrations, it is effective against gram-positive organisms [MIC, Staphylococcus aureus, 0.85%] and yeasts [MIC, Candida albicans, 0.54%]. [12-13] Phenoxyethanol is also effective as a broad-spectrum preservative when  used  in  combination  with  other  preservatives  such  as  neomycin  and  streptomycin

[antibiotics], isothiazolinones, organic acids and parahydroxybenzoic acids [in order to protect against fungi], hexachlorophane, tribromosalicylanilide or aminacrine hydrochloride, and with the parabens. [14-15,10].
 
The safety profile of 2-phenoxyethanol has been extensively investigated in pre-clinical studies assessing the endpoints of acute and repeated dose toxicity, genotoxicity, reproductive toxicity, developmental toxicity, dermal irritation and sensitization, skin penetration and toxicokinetics. Clinical studies have evaluated its potential for irritation, sensitization and phototoxicity. In 1990, phenoxyethanol was reviewed by the Cosmetic Ingredient Review [CIR] Expert Panel in the United States. Undiluted phenoxyethanol was a strong eye irritant, but was nonirritating when tested at 2.2%. Phenoxyethanol at 2.0% was a slight irritant to rabbit skin, but was neither an irritant nor sensitizer to guinea pig skin. In dermal treatment studies, phenoxyethanol was neither teratogenic, embryotoxic, or fetotoxic at doses which were maternally toxic. Phenoxyethanol was nonmutagenic in the Ames test, with and without metabolic activition, and in the mouse micronucleus test. In clnical studies phenoxyethanol was shown to be neither a primary nor a cumulative skin irritant and demonstrated to not be a sensitizer and or phototoxic. Phenoxyethanol was therefore concluded to be safe as a cosmetic ingredient in the present practices of use and concentration, generally < 1%. [16]
 
There are some researches that show a possible risk of phenoxyethanol usage, but this researches do not have strong evidence. German research in 1999., concluded that phenoxyethanol has neurotoxic potential, but in a concentration-dependent manner. The EPA [Environmental Protection Agency] data sheets show chromosomal changes and genetic mutation effects in testing as well as testicular atrophy and interference with reproductivity in mice for other glycol ethers, although phenoxyethanol is not mentioned in the abstract. [23-24]
 
Although, The Food and Drug Administration has warned that the chemical is toxic to infants via ingestion, and can depress the central nervous system and may cause vomiting and diarrhea. Combined with chlorphenesin, these two chemicals can cause respiratory depression in infants. Chlorphenesin relaxes skeletal muscle and can depress the central nervous system and cause slow or shallow breathing in infants. Since these chemicals are often present in cosmetics, caution should be exercised. [25]
 
In 2007, the CIR Expert Panel reviewed studies that had become available since its initial review, along with updated information on use. The panel reconfirmed that phenoxyethanol is safe in the present practices of use and concentration [< 1%], and did not reopen the safety assessment. Among the new data presented were clinical patch-test results from a study conducted by the North American Contact Dermatitis Group on patients with skin disorders showing a very low frequency, 0.2%, of positive allergic responses to phenoxyethanol at 1%. [17-18]

Phenoxyethanol is also approved by the European Commission for use in cosmetics at concentrations up to 1%. [19] A review of phenoxyethanol was conducted in 2011. by the Agence Nationale de Sécurité du Médicament et des Produits de Santé in France. [20] This report concluded that phenoxyethanol should be limited to 0.4% in products intended for children under three and prohibited in products intended for the diaper area. However, the risk assessment was not conducted according to the Notes of Guidance issued by the European Union’s Scientific Committee on Consumer Safety [SCCS]. [21] In October 2013, the European Commission issued a public call for relevant scientific information on phenoxyethanol safety, and a mandate for SCCS review is expected in the near future. A comprehensive dossier was submitted to the SCCS in December 2013. to support the use of phenoxyethanol in all categories of personal care products, including products for children under three, at levels up to 1%. [22]
 
 Phenoxyethanol is safe and effective at the designated levels in personal care products and cosmetics. It has a long history of effective preservation of these products, and its safety has been extensively documented on human health.
 

 Ethylhexylglycerin 

 Ethylhexylglycerin is an alkyl glyceryl ether. This means that the ethylhexyl group is bound to glycerin at one end by an ether linkage. Although they are also alkyl glyceryl ethers, Batyl Alcohol and Chimyl Alcohol [may also be called Cetyl Glyceryl Ether] have traditionally been used as cosmetic labeling names for these alkyl glyceryl ethers. Glyceryl Lauryl Ether and Isostearyl Glyceryl Ether are also alkyl glyceryl ethers that may be used in cosmetic products. Ethylhexylglycerin and the other alkyl glyceryl ether ingredients may be used in bath products, body and hand products, cleansing products, deodorants, eye makeup, foundations, hair care products and suntan products. [26]
 
 Ethylhexylglycerin is a globally approved, versatile and multifunctional additive as well as a very effective deodorant active. [27-29] As an emollient and mild humectant, it improves the skin feel of cosmetic formulations. It can compensate disadvantages of glycerine-containing emulsions. It reliably inhibits the growth and multiplication of odour-causing bacteria, while at the same time not affecting the beneficial skin flora. Additionally, it can boost the efficacy of traditional preservatives such as parabens or phenoxyethanol, thus minimising the preservative load and act as an antimicrobial stabiliser in combination with other cosmetic ingredients. [30-
31] It is a high purity, colourless and almost odourless liquid, with excellent properties for use in cosmetic formulations. Ethylhexylglycerin was introduced to the cosmetic market as a commercial product [Sensiva® SC 50] in the year 1992. as a skin care additive and deodorant active. As a new substance it is listed on the ELINCS file. [32]

Ethylhexylglycerin becomes a very stable molecule when it is stabilized with tocopherol. The safety of Sensiva® SC 50, the stabilized quality of ethylhexylglycerin, has been tested and proven in comprehensive toxicity studies by Schülke. The constant purity guarantees that no degradation products develop during storage for a minimum of three years. Unstabilized, aged ethylhexylglycerin shows many breakdown products that can develop during storage. Unidentified impurities with unknown toxicological profile can negatively influence the safety of
the product. [38]
 
Although ethylhexylglycerin is generally considered safe, it has been found to be an irritant to the skin in two studies, causing allergic contact dermatitis in people with sensitive skin: A Belgian study by the Department of Dermatology at the University Hospital and a study in the Contact Dermatitis Journal. [33-34]
 
But there are also studies that show safety of ethylhexylglycerin use. The Cosmetic Ingredient Review panel has published 4 predictive dermatotoxicologic reports describing tests with cosmetic products containing ethylhexylglycerin in the concentration range from 0.4% to 0.995%. Three repeated insult patch tests including 103 to 111 volunteers and 1 modified Draize test performed in 600 volunteers concluded that the tested products under the conditions of study did not cause irritation or sensitization. [35]
 
At the Department of Dermatology, Odense University Hospital and Allergy Centre, ethylhexylglycerin 5% in petrolatum, based on Sensiva SC50, has been included in the baseline series for more than a year. Of 785 consecutively patch-tested dermatitis patients, 1 [0.13%] had a strong positive [++] reaction at day 3 and + reaction at day 7. It was a 35-year-old woman with persistent atopic dermatitis now characterized by head and neck dermatitis requiring repeated short-term treatments with prednisolone. She also had mucosal atopy and positive skin prick tests to animal dander and dust mites. During the patch test procedure in a quiet phase, she experienced a flare up of facial dermatitis. Subsequent interview disclosed that she had used a face cream containing ethylhexylglycerin. The patient had discarded the product some time ago, so it was not patch tested. Among the 785 tested patients, there were not irritant reactions and only 6 doubtful [+?] reactions without known clinical relevance. Of the 6 patients, 1 had a positive nickel patch test, and the 5 were negative at testing with the baseline series. [36]
 
The CIR Expert Panel reviewed the safety of alkyl glyceryl ethers including ethylhexylglycerin, chimyl alcohol [also called cetyl glyceryl ether], batyl alcohol, glyceryl lauryl ether and isostearyl glyceryl ether. Data reviewed indicated that about 50% of the ethylhexylglycerin placed on the skin may be absorbed. Large oral doses of ethylhexylglycerin for 13-weeks resulted in effects on the liver. Lower doses did not cause any adverse effects. Ethylhexylglycerin was not genotoxic, reproductive or developmental toxic. Undiluted ethylhexylglycerin is an eye irritant, while a 5% concentration only causes mild eye irritation.

Undiluted ethylhexylglycerin and chimyl alcohol are mild skin irritants. Ethylhexylglycerin is not a dermal sensitizer. [26]
 
Based on the available data, the CIR Expert Panel concluded that ethylhexylglycerin,is safe for use in cosmetical products. The alkyl glyceryl ethers, including ethylhexylglycerin, may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Regulation of the European Union. [26,37]
 

Quick guide to our preservatives:

  • For facial washes, body washes, and shampoos: EK300
  • For acidic creams/lotions (L ascorbic): EK300 or EPE9010
  • For alkaline creams/lotions (SAP): EPE9010
CAS#: 122-99-6
INCI: Ethylhexylglycerin (and) Phenoxyethanol
DATA SHEET: download here
Appearance: clear, colourless,nearly colourless liquid
Odour: characteristic
Flash point (DIN 51 758): > 100 °C
Solubility:  Dissolve 1% EPE9010 (Ethylhexylglycerin + Phenoxyethanol) IN 6% Propanediol, add to final formulation and mix well.

Temperature stability:
  • Stable to temperature.
  • easy dispersion at low temperature
pH stability: effective in pH-ranges up to 12
Suggested percentage:  1.1%

Chemical compatibility:
  • Good compatibility with salts.
  • Can be used in pH-ranges up to 12.
  • A high load of surfactants can lead to loss in effectiveness.
  • Good compatibility with the ingredients of cosmetics. No discolourations have been detected.
  • Shows no interaction with sulphite ions.
  • Shows no interaction with pigments such as TiO2.
Storage: at room temperature.
 
[1] Estrin, N. F., Crosley. P.A., and Haynes, C.R. [1982]. CTFA Cosmetic Ingredient Dictionary. 3rd Ed. Washington, DC: The Cosmetic, Toiletry, and Fragrance Assn.
[2] Windholz, M. [1983]. The Merck Index, 10th ed. Rahway, NJ: Merck and Co., Inc., p. 7130
[3] Hunting, A. L. L. [1983]. Encyclopedia of Shampoo Ingredrents. Cranford, NJ: Micelle Press, Inc., p. 317.
[4] Hawley, C.C. [1971]. The Condensed Chemical Dictionary, 8th ed. New York: Van Nostrand Reinhold Co. p. 366.
[5] DC Steinberg, Preservatives for Cosmetics, 3rd ed, Allured Business Media, Carol Stream, IL USA [2012] p5
[6] Cosmetics Info: Phenoxyethanol, 2015. Retrieved [May 20, 2015] from http://www.cosmeticsinfo.org/ingredient/phenoxyethanol
[7] W Paulus, ed, Directory of Microbicides for the Protection of Materials–A Handbook, Springer Verlag, New York [2005]
[8] Tokunaga H, Takeuchi O, Ko R, Uchino T, Ando M [2003]. 市販化粧水中のフェノキシエ タノールおよびパラベン類の分析法に関する研究" [Studies for analyzing phenoxyethanol and parabens in commercial lotions] [PDF]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo Hōkoku [in Japanese] [121]: 25–9. PMID 14740401
[9] European Commission Health and Consumers, Substance: 2-Phenoxyethanol. Retrieved from http://ec.europa.eu/consumers/cosmetics/cosing/index.cfm?fuseaction=search.details&id=28157&back=4
[10] John Krowka, PhD, and Linda Loretz, PhD, Personal Care Products Council; Karolina Brzuska and Jose Filipe Almeida, PhD, Cosmetics Europe; Megan Diehl and Stanley J. Gonsior, The Dow Chemical Company; Andress Johnson, PhD, and Stephané Sellam, Thor Specialties; and Steffen Bade, PhD, and Samantha Champ, BASF [Apr 23, 2014]. Phenoxyethanol as a Safe and Important Preservative in Personal Care. Retrieved [May 21, 2015] from http://www.cosmeticsandtoiletries.com/research/chemistry/Phenoxyethanol-as-a-Safe-and- Important-Preservative-in-Personal-Carepremium-256198651.html?c=n
[11] Gilbert et al., Microbios. 1977;19[75]:17-26; Microbios. 1977;19[76]:125-41.
[12] Hall, A.L. [1981]. Phenoxyethanol cosmetically acceptable preservative. Cosmet. Toilet. [March]: 83-5.
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[14] Cameron, J. [1974]. Preservative systems compatible with DPT [diptheria, pertussis, tetanus]-polio [Salk] and TABTD [typhoid A,B, tetanus, diptheria]-polio [Salk] vaccines. Dev. Biol. Stand. 24, 155-65.
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Click here to download all available sample recipes in a RAR file

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Solubility: Dissolve 1% EPE9010 (Ethylhexylglycerin + Phenoxyethanol) IN 6% Propanediol, add to final formulation and mix well.

Temperature stability:
  • Stable to temperature.
  • easy dispersion at low temperature
pH stability: effective in pH-ranges up to 12
Suggested percentage: 0.5%  to 1.1%

Chemical compatibility:
  • Good compatibility with salts.
  • Can be used in pH-ranges up to 12.
  • A high load of surfactants can lead to loss in effectiveness.
  • Good compatibility with the ingredients of cosmetics. No discolourations have been detected.
  • Shows no interaction with sulphite ions.
  • Shows no interaction with pigments such as TiO2.
  • Oil soluble and soluble in glycerin

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