Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
I am 69 and I have used this product for two years almost every day at a high dose, adding it to my antioxidant day cream, with excellent results. For me it has a very high quality and effectiveness: reduction of wrinkles, hydrated skin, unified color without blemishes ... A product of 10, the same score that I give to John for the quality of the products he sells, his excellent description / use and the bibliographic contribution.En .. ...»
María Jesus
excellence product, very good and made my skin soft and smooth just like baby's skin. Thank you john.. ...»
I wished i could order this in a smaller amount of 50 gr. Can i get informed when it is available ? -------------------- A. It will not be sold in smaller amounts. The review rating is meant to be for the product, not the size in which it is sold :-(.. ...»
I bought this product before and I am here to buy it again! A high quality product for really good price... .. Thanks!.. ...»
As all products from bulkactives, this is a really great and high-quality DYI ingredient. Along with John's friendly, reliable and very efficient service, it makes a purchase from bulkactives a very pleasant experience... ...»
I mixed it with some other water actives like Glucosamine, Niacinamide, Glutathione etc into the Pre Liposome Microemulsion and the serum was very smooth and moisturizing. As it claims, it penetrates into the skin very well. I will mix it with oil soluble actives in my next batch. .. ...»
Excellent product! Easy to use. Add to your cream or oil, mix, and that's it! After applying cream with peptides, my skin was really smooth and nourishing. Very happy that BulkActives offers such high quality product for really good price... ...»
Great product! I've added this emulsion to different DYI combinations to include serums and creams with wonderful results. It's a light, smooth product that mixes easily into my formulations. As earlier reviewer mentioned, I especially like the emulsion when mixed with the incredible multi-lamellar IV cream. Also, can't beat the price for such a quality product... ...»
Hi, Ordered this about 5 weeks ago, so I been waiting to DIY and try the product before I left a review. I mixed Palmitoyl oligopeptide and palmitoyl tetrapeptide-7 Liposome Emulsion, 3/4 tsp, with 3tsps distilled water and 3/4 tsp of rose hip oil. It makes a beautiful light weight serum that I apply at night. You can feel tightening within a few minutes. The tightening subsides in half hour or so and then I apply a moisturiser. Another excellent buy from Bulk Actives. .. ...»
Jan Greenwood
This peptide emulsion is perfect! I just add water, mix it, and i have a super elegant light serum for the delicate skin around my eyes. I also add it to the multi - lamellar cream for the rest of my face... ...»
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Buy Carnosine (L-Carnosine) For Skin Care

Carnosine is a compound from two amino acids, produced naturally in the human brain and muscles. Most likely, it performs a protective function – carnosine neutralizes metal ions and is a powerful antioxidant. It is used in skin care to combat oxidative damage to DNA and proteins, such as that caused by UV exposure. Furthermore, carnosine can protect proteins, primarily collagen, from glycation. These qualities make it a promising molecule in the fight against ageing, as carnosine not only protects cellular components, but can improve the visual appearance, reduce roughness and fine lines. It also maintains the barrier function of the skin, both by simple hydration and complex effects in wound healing. Carnosine applications are of special importance to diabetes patients, as it helps alleviate several complications of this disease, among them xerosis, rapid AGE production, and impaired wound healing.

Key benefits Carnosine in skin care:

  • Glycation inhibitor and repair [1] [9]
  • Sun damage protection [3] [4]
  • Sun damage repair [3] [4]
  • Wound healing support [11] [12]
  • Moisturizing & hydration [13] [14]
  • Antioxidant [4] [5] [6]
  • Restore barrier function [8]
Carnosine (L-Carnosine) skin care active ingredients
Product Code: BulkActives
Assay: 99.8
CAS#: 305-84-0
Net weight: 15g / 0.53oz
Availability: In Stock
Price: $18.70

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Carnosine (L-Carnosine)

About Carnosine in DIY Skin Care

Carnosine is a molecule composed of two amino acids, β-alanine and histidine. It is naturally abundant in brain and muscle tissues, but, although it was discovered in the year 1900, its function in the body is still unclear [1]. It might regulate the pH of muscle cells, neutralize metal ions or act as an antioxidant, and it gained a lot of interest recently as some studies show it might be used in treating cancer, Alzheimer’s disease and even cell ageing [2].

Carnosine has been shown to protect human skin cells against UV radiation. Together with some other forms of radiation, UV causes mutations in DNA and protein damage that often lead to cancer. To combat this, use of DNA-protecting molecules in skin cosmetics was proposed [3]. Carnosine falls among these molecules due to its antioxidant properties. In a study on human skin cells, carnosine was shown to reduce the oxidative damage caused by the UV on both DNA and proteins [4]. It is also able to activate synthesis of other naturally produced antioxidants, such as glutathione peroxidase [5]. Carnosine and related molecules have even stronger antioxidative capability than vitamin E [6]. However, it is advisable to apply these two antioxidants together, not only for synergistic protective effects – vitamin E improves the delivery of carnosine, resulting in higher levels of this molecule in target tissue [7].

In the recent years, commercial sunscreen products started to include carnosine, and the benefits of it have been proven in studies of UV-irradiated skin. Compared to traditional sunscreens, carnosine-containing creams successfully prevented UV damage and resulted in a significantly better state of both DNA and protein (less oxidative damage) after the irradiation [3]. In a trial on volunteers with sensitive skin, carnosine showed a protective effect on skin barrier function (reduced water loss and perceived dryness after 28 days of usage). Biochemical experiments suggest that the cream achieved this by improving the skin and neural cell response to UV radiation [8].

Carnosine is also able to reduce the effects of glycation. This process occurs naturally during ageing and produces damaged forms of proteins, called advanced glycation end products (AGEs). Collagen is among the proteins most affected by this, and its glycation may be responsible for loss of elasticity or other negative consequences of skin ageing. Carnosine is a competitive target for glycation, thus protecting valuable proteins from it [9], [10]. Results from volunteer studies indicate that carnosine improves skin visual parameters, maintains firmness, reduces roughness, fine lines and oily appearance [7].

Another major application of carnosine in skin care is wound healing. A preparation with carnosine was shown to promote collagen synthesis, cell proliferation and migration, which result in faster wound closure [11]. Just like glycation protection, this benefit of carnosine is even more important for diabetes patients, as wound healing is impaired under this disease. Skin applications of carnosine have successfully activated healing in diabetic mice wounds [12]. Xerosis, another skin-affecting complication of diabetes, is also alleviated by applying a cream with carnosine, as this molecule has a hydrating effect [13]. This cream also increases skin thickness, blood circulation and quality of life in xerosis patients [14].
Assay: 99.8%
CAS#: 305-84-0
INCI: L Carnosine
Appearance: white powder
Solubility: water
Suggested percentage: 1% to 5%

Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China
[1]          A. A. Boldyrev, S. C. Gallant, and G. T. Sukhich, “Carnosine, the protective, anti-aging peptide,” Biosci. Rep., vol. 19, no. 6, pp. 581–587, Dec. 1999.
[2]          C. Renner, N. Zemitzsch, B. Fuchs, K. D. Geiger, M. Hermes, J. Hengstler, R. Gebhardt, J. Meixensberger, and F. Gaunitz, “Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model,” Mol. Cancer, vol. 9, p. 2, 2010.
[3]          E. Emanuele, J. M. Spencer, and M. Braun, “An experimental double-blind irradiation study of a novel topical product (TPF 50) compared to other topical products with DNA repair enzymes, antioxidants, and growth factors with sunscreens: implications for preventing skin aging and cancer,” J. Drugs Dermatol. JDD, vol. 13, no. 3, pp. 309–314, Mar. 2014.
[4]          E. Emanuele, M. Bertona, F. Sanchis-Gomar, H. Pareja-Galeano, and A. Lucia, “Protective effect of trehalose-loaded liposomes against UVB-induced photodamage in human keratinocytes,” Biomed. Rep., vol. 2, no. 5, pp. 755–759, Sep. 2014.
[5]          M. Y. Kim, E. J. Kim, Y.-N. Kim, C. Choi, and B.-H. Lee, “Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats,” Nutr. Res. Pract., vol. 5, no. 5, pp. 421–428, Oct. 2011.
[6]          M. A. Babizhayev, “Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products,” Life Sci., vol. 78, no. 20, pp. 2343–2357, Apr. 2006.
[7]          M. A. Babizhayev, A. I. Deyev, E. L. Savel’yeva, V. Z. Lankin, and Y. E. Yegorov, “Skin beautification with oral non-hydrolized versions of carnosine and carcinine: Effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and skin aging,” J. Dermatol. Treat., vol. 23, no. 5, pp. 345–384, Oct. 2012.
[8]          G. de C. Dieamant, M. D. C. Velazquez Pereda, S. Eberlin, C. Nogueira, R. M. Werka, and M. L. de S. Queiroz, “Neuroimmunomodulatory compound for sensitive skin care: in vitro and clinical assessment,” J. Cosmet. Dermatol., vol. 7, no. 2, pp. 112–119, Jun. 2008.
[9]          V. P. Reddy, M. R. Garrett, G. Perry, and M. A. Smith, “Carnosine: a versatile antioxidant and antiglycating agent,” Sci. Aging Knowl. Environ. SAGE KE, vol. 2005, no. 18, p. pe12, May 2005.
[10]        C. Rona, F. Vailati, and E. Berardesca, “The cosmetic treatment of wrinkles,” J. Cosmet. Dermatol., vol. 3, no. 1, pp. 26–34, Jan. 2004.
[11]        Q. Wessels, E. Pretorius, C. M. Smith, and H. Nel, “The potential of a niacinamide dominated cosmeceutical formulation on fibroblast activity and wound healing in vitro,” Int. Wound J., vol. 11, no. 2, pp. 152–158, Apr. 2014.
[12]        I. Ansurudeen, V. G. Sunkari, J. Grünler, V. Peters, C. P. Schmitt, S.-B. Catrina, K. Brismar, and E. A. Forsberg, “Carnosine enhances diabetic wound healing in the db/db mouse model of type 2 diabetes,” Amino Acids, vol. 43, no. 1, pp. 127–134, Jul. 2012.
[13]        A. Federici, G. Federici, and M. Milani, “An urea, arginine and carnosine based cream (Ureadin Rx Db ISDIN) shows greater efficacy in the treatment of severe xerosis of the feet in Type 2 diabetic patients in comparison with glycerol-based emollient cream. A randomized, assessor-blinded, controlled trial,” BMC Dermatol., vol. 12, p. 16, 2012.
[14]        G. Ciammaichella, G. Belcaro, M. Dugall, M. Hosoi, R. Luzzi, E. Ippolito, and M. R. Cesarone, “Product evaluation of Ureadin Rx Db (ISDIN) for prevention and treatment of mild-to-moderate xerosis of the foot in diabetic patients. Prevention of skin lesions due to microangiopathy,” Panminerva Med., vol. 54, no. 1 Suppl 4, pp. 35–42, Dec. 2012.

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