PACKAGING & EQUIPMENT:
Skin Care Categories
We accept payment via PayPal
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
New & Updates
Attention: BulkActives is a part-time business.
Orders are processed on Saturdays and mailed on Mondays at the latest, usually earlier.
Free original software: Recipe creator
NEW! Safe, mild and gentle SURFACTANTS for DIY facial wash, body wash & shampoo:
Alpha Bisabolol as a penetration enhancer (PDF)
A. C. Williams and B. W. Barry. Skin Absorption Enhancers. Crit. Rev. Ther. Drug
Syst. 9(3-4):305-330 (1992).
P. A. Cornwell and B.W. Barry. Determination of the Mode of Action of Sesquiterpene Skin Penetration Enhancers. J. Phann. Pharrnacol. 43:56P (1991).
R. Kadir and B. W. Barry. Alpha-Bisabolol, a Possible Safe Penetration Enhancer for Dermal and Transdermal Therapeutics. Int. J. Phann. 70:87-94 (1991).
T. K. Ghosh and A. K. Banga. Methods of Enhancement of Transdermal Drug Delivery. Part 2B. Chemical Permeation Enhancers. Phann. Tech. 17:68-76 (1993).
α-Bisabolol, a possible safe penetration enhancer for dermal and transdermal therapeuticsRon Kadir and Brian W. Barry.
Enhancement of transdermal penetration of dapiprazole through hairless mouse skin
D. Montia, M. F. Saettonea, , B. Giannaccinia and D. Galli-Angelib
"One long-standing approach for improving transdermal drug delivery uses penetration enhancers (also called sorption promoters or accelerants) which penetrate into skin to reversibly decrease the barrier resistance. Numerous compounds have been evaluated for penetration enhancing activity, including sulphoxides (such as dimethylsulphoxide, DMSO), Azones (e.g. laurocapram), pyrrolidones (for example 2-pyrrolidone, 2P), alcohols and alkanols (ethanol, or decanol), glycols (for example propylene glycol, PG, a common excipient in topically applied dosage forms), surfactants (also common in dosage forms) and terpenes. Many potential sites and modes of action have been identified for skin penetration enhancers; the intercellular lipid matrix in which the accelerants may disrupt the packing motif, the intracellular keratin domains or through increasing drug partitioning into the tissue by acting as a solvent for the permeant within the membrane. Further potential mechanisms of action, for example with the enhancers acting on desmosomal connections between corneocytes or altering metabolic activity within the skin, or exerting an influence on the thermodynamic activity/solubility of the drug in its vehicle are also feasible, and are also considered in this review."
Skin absorption enhancers.
"When we try to maximize drug flux through the skin, we usually meet major difficulties because of the impervious nature of the stratum corneum. A popular solution incorporates penetration enhancers into transdermal products. Such materials ideally possess the sole property of reversibly reducing the barrier resistance of the horny layer, allowing the drug to reach the living tissues at a greater rate. This article considers examples of accelerant action that support a general concept explaining enhancer activity in human skin. The core of the proposal is that enhancers usually work by one or more of three main mechanisms: alteration of the lipid or protein domains of the stratum corneum or increase in tissue partitioning of a drug, a coenhancer, water, or any combination of these three chemicals. We may usefully refer to the overall hypothesis as the lipid-protein-partitioning (LPP) concept."
Advanced Skin Care Research on Alpha Bisabolol: Studies have shown that the most important effects of Alpha Bisabolol for the use in cosmetics are anti-inflammatory, wound-healing, anti-bacterial and anti-mycotic.
DISCLAIMER:Any statements about products sold by BulkActives have not been evaluated by the FDA. Products sold by BulkActives are not intended to be used as nutritional supplements. Products sold by BulkActives are not intended to diagnose, treat, cure, or prevent any disease.
Due to a severe world wide shortage of the raw material, this product is now extremely expensive and difficult to source.
New generation, 100% pure, synthetic products are an option, but they are crazy $$$$