Skin Care Research: Glucosamine (N-acetyl-D) for Homemade Skin Care Recipes

Glucosamine: an ingredient with skin and other benefits

Bissett, Donald L., Source: Journal of Cosmetic Dermatology, Volume 5, Number 4, December 2006, pp. 309-315(7)

"Both glucosamine and its derivative N-acetyl glucosamine are amino-monosaccharides that serve key biochemical functions on their own and as substrate precursors for the biosynthesis of polymers such as glycosaminoglycans (e.g., hyaluronic acid) and for the production of proteoglycans. Glucosamine has an excellent safety profile and has been shown to provide benefits in several clinical disorders. Glucosamine compounds have been reported to have several beneficial effects on the skin or skin cells. Because of its stimulation of hyaluronic acid synthesis, glucosamine has been shown to accelerate wound healing, improve skin hydration, and decrease wrinkles. In addition, as an inhibitor of tyrosinase activation, it inhibits melanin production and is useful in treatment of disorders of hyperpigmentation. Mechanistically, glucosamine also has both anti-inflammatory and chondroprotective effects. Clinical trials have shown benefit in using oral glucosamine supplementation to improve symptoms and slow the progression of osteoarthritis in humans. Glucosamine has also been used to prevent and treat osteoarthritis in animals. Based on other observations, glucosamine has been suggested for additional clinical uses, including treatment of inflammatory bowel disease, migraine headaches, and viral infections. The current clinical uses for topical and oral glucosamine compounds and the mechanistic rationale for these uses are reviewed here." Read more

Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine

Donald L Bissett, PhD, Larry R Robinson, PhD, Patricia S Raleigh, BS, Kukizo Miyamoto, PhD,Tomohiro Hakozaki, MS, Jim Li, MS, MA, & Gary R Kelm, PhD

Procter & Gamble Company, Cincinnati, Ohio, USA

"Glucosamine has been reported to inhibit melanin production in melanocyte culture. It thus has a potential to reduce hyperpigmentation via topical use. Due to stability limitations of glucosamine, we chose to clinically evaluate the stable derivative N-acetyl glucosamine (NAG). Based on in vitro Franz cell testing, NAG is a good skin penetrant. In an 8-week, double-blind, placebo-controlled, left-right randomized, split-face clinical test, topical 2% NAG reduced the appearance of facial hyperpigmentation. In a second clinical study involving the topical combination of 2% NAG with 4% niacinamide, an agent previously shown to be clinically active, the effect on hyperpigmentation was greater. Both of these agents are well tolerated by the skin. This high tolerance coupled with relative ease of formulation and stability in solution make NAG, especially in combination with niacinamide, a suitable cosmetic ingredient for use in skin care products dealing with issues of skin hyperpigmentation." Read more

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Advanced skin care research has shown that Glucosamine (N-acetyl-D) is useful for HA production, collagen production, and for its skin lightening and brightening qualities. It is known to reduce the appearance of facial hyperpigmentation.

N-acetyl glucosamine research

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