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BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
New & Updates
Attention: BulkActives is a part-time business.
Orders are processed on Saturdays and mailed on Mondays at the latest, usually earlier.
Free original software: Recipe creator
NEW! Safe, mild and gentle SURFACTANTS for DIY facial wash, body wash & shampoo:
Alpha Lipoic Acid (RS-ALA)
INCI: 1,2-dithiolane-3-pentanoic acid (thioctic acid)
Solubility: oil (mixes in a cream), propolyne glycol
Suggested percentage:3% to 5%
Irritation: Alpha Lipoic Acid, is an acid and it may irritate. Start of with small amounts. A slight tingling/burning feeling upon application is common, this should go away after a few minutes. If not, remove from face and use a smaller percentage.
Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China
DISCLAIMER:Any statements about products sold by BulkActives have not been evaluated by the FDA. Products sold by BulkActives are not intended to be used as nutritional supplements. Products sold by BulkActives are not intended to diagnose, treat, cure, or prevent any disease.
References - Full Abstracts here
12. Matsugo S, Bito T, Konishi T.. Photochemical stability of lipoic acid and its impact on skin ageing. Free Radic Res. 2011 Aug;45(8):918-24. Epub 2011 Jun 9. PMID: 21651453
11. Tsuji-Naito K, Ishikura S, Akagawa M, Saeki H. α-Lipoic acid induces collagen biosynthesis involving prolyl hydroxylase expression via activation of TGF-β-Smad signaling in human dermal fibroblasts. Connect Tissue Res. 2010 Oct;51(5):378-87. PMID: 20604712
10. Wada N, Wakami H, Konishi T, Matsugo S. The Degradation and Regeneration of alpha-Lipoic Acid under the Irradiation of UV Light in the Existence of Homocysteine. J Clin Biochem Nutr. 2009 May;44(3):218-22. Epub 2009 Apr 25. PMID: 19430609
9. Davis GD, Masilamoni JG, Arul V, Kumar MS, Baraneedharan U, Paul SF, Sakthivelu IV, Jesudason EP, Jayakumar R. Radioprotective effect of DL-alpha-lipoic acid on mice skin fibroblasts.. Cell Biol Toxicol. 2009 Aug;25(4):331-40. Epub 2008 Jun 13. PMID: 18553143
8. Petersen Shay K, Moreau RF, Smith EJ, Hagen TM. Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. IUBMB Life. 2008 Jun;60(6):362-7. PMID: 18409172
7. Ho YS, Lai CS, Liu HI, Ho SY, Tai C, Pan MH, Wang YJ. Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and anti-oxidation. Biochem Pharmacol. 2007 Jun 1;73(11):1786-95. Epub 2006 Dec 10. PMID: 17403519
6. Lin JY, Lin FH, Burch JA, Selim MA, Monteiro-Riviere NA, Grichnik JM, Pinnell SR. Alpha-lipoic acid is ineffective as a topical antioxidant for photoprotection of skin. J Invest Dermatol. 2004 Nov;123(5):996-8. PMID: 15482491
5. Beitner H. Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin. Br J Dermatol. 2003 Oct;149(4):841-9. PMID: 14616378
4. Podda M, Zollner TM, Grundmann-Kollmann M, Thiele JJ, Packer L, Kaufmann R. Activity of alpha-lipoic acid in the protection against oxidative stress in skin. Curr Probl Dermatol. 2001;29:43-51. PMID: 11225200
3. Biewenga GP, Haenen GR, Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol. 1997 Sep;29(3):315-31. PMID: 9378235
2. Podda M, Rallis M, Traber MG, Packer L, Maibach HI. Kinetic study of cutaneous and subcutaneous distribution following topical application of [7,8-14C]rac-alpha-lipoic acid onto hairless mice. Biochem Pharmacol. 1996 Aug 23;52(4):627-33. PMID: 8759036
1. Handelman GJ, Han D, Tritschler H, Packer L. Alpha-lipoic acid reduction by mammalian cells to the dithiol form, and release into the culture medium. Biochem Pharmacol. 1994 May 18;47(10):1725-30. PMID: 8204089
Alpha Lipoic Acid in Skin Care - Research
Topically applied Alpha Lipoic Acid may:
prevent or reduce UVA and UVB sun damage:     
act as an anti oxidant     
increase collagen production 
act as an anti inflammatory