Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients,  for DIY skin care and cosmetics, and homemade skin care products. 

BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.

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Ascorbyl Tetraisopalmitate / Tetrahexyldecyl Ascorbate

Product details

 

Appearance: Colorless to pale yellow liquid

CAS# 183476-82-6

INCI Name: Tetrahexyldecyl Ascorbate

Chem. Name: Ascorbyl Tetraisopalmitate

Suggested percentage: .5% to 7%
Solubility: excellent solubility in carrier oils, mineral oils, ethanol, siliconeInsoluble in water, propylene glycol, glycerin.

Inorganic Organic balance (IOB) : 0.274 H

LB: 2.74 (IOB 0.274 x 10 = HLB 2.74)

 

  • This oil soluble product can easily be added to a base cream or lotion.
  • It can also be emulsified with Gelmaker PLUS and a 1% HA mixture to create a very light 'serum'.
  • Combine with L-ascorbic acid in a silicone base for an Anhydrous Vitamin C combo.

 

Storage: Cool place. Do not freeze.

Country of origin: Japan

 

Anhydrous vitamin C combo 

 

L-ascorbic acid with Ascorbyl Tetraisopalmitate

in a waterless silicone base

 

References:

 

 

"Ten patients having facial photodamage were recruited for a double-blind pilot study of a newly formulated vitamin C ,complex having 10% ascorbic acid, a water soluble acid, and 7% tetrahexyldecyl ascorbate, a lipid soluble analog.


Both of these are combined in an anhydrous polysilicone gel base, which acts as a 'dermal patch,' releasing the water soluble acid slowly and the lipid soluble analog rapidly. The active vitamin C complex was applied to one side of the face and the inactive placebo base was applied to the opposite side of the face once a day." Fitzpatrick RE, Rostan EF. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage. Dermatology Associates of San Diego County, Inc. 92024, USA. Read more

About Vitamin C derivatives

 

"There is some evidence that combining water soluble and oil-soluble forms of vitamin C may provide synergistic skin benefits through broader antioxidant protection and better penetration." Dr. G. Todorov, Anhydrous Vitamin C Combo, smartskincare.com

 

 

"Most vitamin C derivatives on the market, including ascorbyl palmitate and magnesuim ascorbyl phosphate, consist of the ascorbic acid fragment (ascorbyl) and a fragment of another acid (e.g. palmitate or phosphate). Recent research indicates that new vitamin C derivatives, such as Tetrahexyldecyl Ascorbate, consisting of multiple chemical fragments bound to a single ascorbic acid fragment may work even better. These new derivatives are more stable compared to both vitamin C and older derivatives. Furthermore, some of these newcomers (particularly the so-called tetrasubstituted lipophilic ascorbates) also appear to be more powerful boosters of collagen synthesis."  Dr. G. Todorov, Vitamin C Derivatives, smartskincare.com

Ascorbyl Tetraisopalmitate, also known as Tetrahexyldecyl Ascorbate, is a Vitamin C ester with better improved absorption and stability qualities. It is used as an antioxidant, a whitening agent (for skin lightening and brightening), in anti-acne formulations, and it promotes collagen production. Unlike absorbic acid, it will not exfoliate of cause irritation.

DISCLAIMER:Any statements about products sold by BulkActives have not been evaluated by the FDA.  Products sold by BulkActives are not intended to be used as nutritional supplements. Products sold by BulkActives are not intended to diagnose, treat, cure, or prevent any disease.

Ascorbyl Tetraisopalmitate / Tetrahexyldecyl Ascorbate Formulating ideas:

 

 Anhydrous vitamin C combo (L-ascorbic acid with Ascorbyl tetraisopalmitate in a waterless silicone base)


 BulkActives: ingredients for DIY skin care and cosmetics
Ascorbyl Tetraisopalmitate
(Tetrahexyldecyl Ascorbate)






Ascorbyl Tetraisopalmitate / Tetrahexyldecyl Ascorbate in skin care:

 

  • anti-acne
  • antioxidant
  • collagen production
  • lightening & brightening
  • reduce fine lines and wrinkles
  • sun damage repair

References (full abstracts here)

 

4: Xiao L, Kaneyasu K, Saitoh Y, Terashima Y, Kowata Y, Miwa N. Cytoprotective effects of the lipoidic-liquiform pro-vitamin C tetra-isopalmitoyl-ascorbate (VC-IP) against ultraviolet-A ray-induced injuries in human skin cells together with collagen retention, MMP inhibition and p53 gene repression. J Cell Biochem. 2009 Mar 1;106(4):589-98. PubMed PMID: 19165821.

 

3: Ochiai Y, Kaburagi S, Obayashi K, Ujiie N, Hashimoto S, Okano Y, Masaki H, Ichihashi M, Sakurai H. A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative properties. J Dermatol Sci. 2006 Oct;44(1):37-44. Epub 2006 Aug 28. PubMed PMID: 16935471.

 

2: Maia Campos PM, Gianeti MD, Kanashiro A, Lucisano-Valim YM, Gaspar LR. In vitro antioxidant and in vivo photoprotective effects of an association of bioflavonoids with liposoluble vitamins. Photochem Photobiol. 2006 May-Jun;82(3):683-8. PubMed PMID: 16542108.

 

1: Fitzpatrick RE, Rostan EF. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage. Dermatol Surg. 2002 Mar;28(3):231-6. PubMed PMID: 11896774.