Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
ACTIVES:
anti-acne
anti-androgenetic alopecia
anti-inflammatory
antioxidant
cellular energy production
stimulate collagen production
natural phyto estrogens
nutrition
oil/sebum control
wrinkle relaxers
wrinkle tighteners
FUNCTIONALS:
chelating agents
skin care bases
PACKAGING & EQUIPMENT:
Skin Care Categories
We accept payment via PayPal
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
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Attention: BulkActives is a part-time business.
Orders are processed on Saturdays and mailed on Mondays at the latest, usually earlier.
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Ascorbyl Tetraisopalmitate / Tetrahexyldecyl Ascorbate
Product details
Appearance: Colorless to pale yellow liquid
CAS# 183476-82-6
INCI Name: Tetrahexyldecyl Ascorbate
Chem. Name: Ascorbyl Tetraisopalmitate
Suggested percentage: .5% to 7%
Solubility: excellent solubility in carrier oils, mineral oils, ethanol, silicone. Insoluble in water, propylene glycol, glycerin.
Inorganic Organic balance (IOB) : 0.274 H
LB: 2.74 (IOB 0.274 x 10 = HLB 2.74)
Storage: Cool place. Do not freeze.
Country of origin: Japan
Anhydrous vitamin C combo
L-ascorbic acid with Ascorbyl Tetraisopalmitate
in a waterless silicone base
References:
Stable topical ascorbic acid compositions. (Enter this patent number: 6146664 , in the search field).
"Ten patients having facial photodamage were recruited for a double-blind pilot study of a newly formulated vitamin C ,complex having 10% ascorbic acid, a water soluble acid, and 7% tetrahexyldecyl ascorbate, a lipid soluble analog.
Both of these are combined in an anhydrous polysilicone gel base, which acts as a 'dermal patch,' releasing the water soluble acid slowly and the lipid soluble analog rapidly. The active vitamin C complex was applied to one side of the face and the inactive placebo base was applied to the opposite side of the face once a day." Fitzpatrick RE, Rostan EF. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage. Dermatology Associates of San Diego County, Inc. 92024, USA. Read more
About Vitamin C derivatives
"There is some evidence that combining water soluble and oil-soluble forms of vitamin C may provide synergistic skin benefits through broader antioxidant protection and better penetration." Dr. G. Todorov, Anhydrous Vitamin C Combo, smartskincare.com
"Most vitamin C derivatives on the market, including ascorbyl palmitate and magnesuim ascorbyl phosphate, consist of the ascorbic acid fragment (ascorbyl) and a fragment of another acid (e.g. palmitate or phosphate). Recent research indicates that new vitamin C derivatives, such as Tetrahexyldecyl Ascorbate, consisting of multiple chemical fragments bound to a single ascorbic acid fragment may work even better. These new derivatives are more stable compared to both vitamin C and older derivatives. Furthermore, some of these newcomers (particularly the so-called tetrasubstituted lipophilic ascorbates) also appear to be more powerful boosters of collagen synthesis." Dr. G. Todorov, Vitamin C Derivatives, smartskincare.com
Ascorbyl Tetraisopalmitate, also known as Tetrahexyldecyl Ascorbate, is a Vitamin C ester with better improved absorption and stability qualities. It is used as an antioxidant, a whitening agent (for skin lightening and brightening), in anti-acne formulations, and it promotes collagen production. Unlike absorbic acid, it will not exfoliate of cause irritation.
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DISCLAIMER:Any statements about products sold by BulkActives have not been evaluated by the FDA. Products sold by BulkActives are not intended to be used as nutritional supplements. Products sold by BulkActives are not intended to diagnose, treat, cure, or prevent any disease.
Ascorbyl Tetraisopalmitate / Tetrahexyldecyl Ascorbate Formulating ideas:
Anhydrous vitamin C combo (L-ascorbic acid with Ascorbyl tetraisopalmitate in a waterless silicone base)
Ascorbyl Tetraisopalmitate / Tetrahexyldecyl Ascorbate in skin care:
References (full abstracts here)
4: Xiao L, Kaneyasu K, Saitoh Y, Terashima Y, Kowata Y, Miwa N. Cytoprotective effects of the lipoidic-liquiform pro-vitamin C tetra-isopalmitoyl-ascorbate (VC-IP) against ultraviolet-A ray-induced injuries in human skin cells together with collagen retention, MMP inhibition and p53 gene repression. J Cell Biochem. 2009 Mar 1;106(4):589-98. PubMed PMID: 19165821.
3: Ochiai Y, Kaburagi S, Obayashi K, Ujiie N, Hashimoto S, Okano Y, Masaki H, Ichihashi M, Sakurai H. A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative properties. J Dermatol Sci. 2006 Oct;44(1):37-44. Epub 2006 Aug 28. PubMed PMID: 16935471.
2: Maia Campos PM, Gianeti MD, Kanashiro A, Lucisano-Valim YM, Gaspar LR. In vitro antioxidant and in vivo photoprotective effects of an association of bioflavonoids with liposoluble vitamins. Photochem Photobiol. 2006 May-Jun;82(3):683-8. PubMed PMID: 16542108.
1: Fitzpatrick RE, Rostan EF. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage. Dermatol Surg. 2002 Mar;28(3):231-6. PubMed PMID: 11896774.