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BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
New & Updates
Attention: BulkActives is a part-time business.
Orders are processed on Saturdays and mailed on Mondays at the latest, usually earlier.
Free original software: Recipe creator
NEW! Safe, mild and gentle SURFACTANTS for DIY facial wash, body wash & shampoo:
Suggested percentage: 4% Glucosamine with 2% Niacinamide. No other data available - up to customer's discretion. (One DIYer is succesfully using 10% NAG in water with Propylene Glycol.)
Storage: Store in cool and dry place. Keep away from direct strong light and heat.
Country of origin: China
DISCLAIMER:Any statements about products sold by BulkActives have not been evaluated by the FDA. Products sold by BulkActives are not intended to be used as nutritional supplements. Products sold by BulkActives are not intended to diagnose, treat, cure, or prevent any disease.
How it works
N-acetyl glucosamine and niacinamide block melanin production by interfering in the process at two different points - reducing formation and appearance of age spots.
A key enzyme in melanin biosynthesis is tyrosinase. It is initially produced in the cell as an inactive pro-enzyme, which is then glycosylated to the active form.
N-acetyl Glucosamine and Niacinamide
What it does
Both N-acetyl glucosamine and niacinamide significantly reduce: amount and appearance of hyperpigmentation,melanized hyperpigmented spots and uneven melanin distribution, melanin content in skin cells in culture
Zoom to P&G article and pictures
References (Full abstracts here)
14: Leyden JJ, Shergill B, Micali G, Downie J, Wallo W. Natural options for the management of hyperpigmentation. J Eur Acad Dermatol Venereol. 2011 Oct;25(10):1140-5. doi: 10.1111/j.1468-3083.2011.04130.x. Epub 2011 May 31. PubMed PMID: 21623927.
13: Hwang JS, Lee HY, Lim TY, Kim MY, Yoon TJ. Disruption of tyrosinase glycosylation by N-acetylglucosamine and its depigmenting effects in guinea pig skin and in human skin. J Dermatol Sci. 2011 Sep;63(3):199-201. Epub 2011 Jun 12. PubMed PMID: 21723097.
12: Callender VD, St Surin-Lord S, Davis EC, Maclin M. Postinflammatory hyperpigmentation: etiologic and therapeutic considerations. Am J Clin Dermatol. 2011 Apr 1;12(2):87-99. doi: 10.2165/11536930-000000000-00000. Review. PubMed PMID: 21348540.
11: Davis EC, Callender VD. Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color. J Clin Aesthet Dermatol. 2010 Jul;3(7):20-31. PubMed PMID: 20725554; PubMed Central PMCID: PMC2921758.
10: Kimball AB, Kaczvinsky JR, Li J, Robinson LR, Matts PJ, Berge CA, Miyamoto K, Bissett DL. Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial. Br J Dermatol. 2010 Feb 1;162(2):435-41. Epub 2009 Aug 28. PubMed PMID: 19845667.
9: Bissett DL, Robinson LR, Raleigh PS, Miyamoto K, Hakozaki T, Li J, Kelm GR. Reduction in the appearance of facial hyperpigmentation by topical N-undecyl-10-enoyl-L-phenylalanine and its combination with niacinamide. J Cosmet Dermatol. 2009 Dec;8(4):260-6. PubMed PMID: 19958429.
8: Tu CX, Zhang RX, Zhang XJ, Huang T. Exogenous N-acetylglucosamine increases hyaluronan production in cultured human dermal fibroblasts. Arch Dermatol Res. 2009 Aug;301(7):549-51. Epub 2009 Feb 27. PubMed PMID: 19247681.
7: Mammone T, Gan D, Fthenakis C, Marenus K. The effect of N-acetyl-glucosamine on stratum corneum desquamation and water content in human skin. J Cosmet Sci. 2009 Jul-Aug;60(4):423-8. PubMed PMID: 19691938.
6: Grimes PE. Management of hyperpigmentation in darker racial ethnic groups. Semin Cutan Med Surg. 2009 Jun;28(2):77-85. Review. PubMed PMID: 19608057.
5: Bissett DL, Farmer T, McPhail S, Reichling T, Tiesman JP, Juhlin KD, Hurley GJ, Robinson MK. Genomic expression changes induced by topical N-acetyl glucosamine in skin equivalent cultures in vitro. J Cosmet Dermatol. 2007 Dec;6(4):232-8. PubMed PMID: 18047607.
4: Draelos ZD. Skin lightening preparations and the hydroquinone controversy. Dermatol Ther. 2007 Sep-Oct;20(5):308-13. Review. PubMed PMID: 18045355.
3: Bissett DL, Robinson LR, Raleigh PS, Miyamoto K, Hakozaki T, Li J, Kelm GR. Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine. J Cosmet Dermatol. 2007 Mar;6(1):20-6. Review. PubMed PMID: 17348991.
2: Bissett DL. Glucosamine: an ingredient with skin and other benefits. J Cosmet Dermatol. 2006 Dec;5(4):309-15. Review. PubMed PMID: 17716251.
1: Sayo T, Sakai S, Inoue S. Synergistic effect of N-acetylglucosamine and retinoids on hyaluronan production in human keratinocytes. Skin Pharmacol Physiol. 2004 Mar-Apr;17(2):77-83. PubMed PMID: 14976384.
Topically applied Glucosamine (N-acetyl-D) may:
lighten and brighten skin (treat melsama/hyper pigmentation):          
increase hyaluronic acid production:   
repair and treat sun damage:      
moisturize and hydrate