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BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
New & Updates
Attention: BulkActives is a part-time business.
Orders are processed on Saturdays and mailed on Mondays at the latest, usually earlier.
Free original software: Recipe creator
NEW! Safe, mild and gentle SURFACTANTS for DIY facial wash, body wash & shampoo:
Grape Seed Extract (95% Proanthocyanidins)
Assay: 95.56% Proanthocyanidins
Suggested percentage: .5 to 3%
Storage: Store in cool and dry place. Keep away from direct strong light and heat.
Country of origin: China
About Grape seed Proanthocyanidins
Grape Seed extract (Grape Seed Proanthocyandins) in skin care - research
Topically applied Grape Seed Proanthocyandins may:
act as an anti-inflammatory:     
act as an anti oxidant:        
repair and treat sun damage:     
prevent or reduce UVA and UVB sun damage:          
increase skin elasticity: 
support wound healing:   
DISCLAIMER:Any statements about products sold by BulkActives have not been evaluated by the FDA. Products sold by BulkActives are not intended to be used as nutritional supplements. Products sold by BulkActives are not intended to diagnose, treat, cure, or prevent any disease.
References (Full abstracts here)
14: Yuan XY, Liu W, Hao JC, Gu WJ, Zhao YS. Topical Grape Seed Proanthocyandin Extract Reduces Sunburn Cells and Mutant p53 Positive Epidermal Cell Formation, and Prevents Depletion of Langerhans Cells in an Acute Sunburn Model. Photomed Laser Surg. 2011 Nov 21. [Epub ahead of print] PubMed PMID: 22103910.
13: Afaq F, Katiyar SK. Polyphenols: Skin Photoprotection and Inhibition of Photocarcinogenesis. Mini Rev Med Chem. 2011 Oct 28. [Epub ahead of print] PubMed PMID: 22070679.
12: Hemmati AA, Aghel N, Rashidi I, Gholampur-Aghdami A. Topical grape (Vitis vinifera) seed extract promotes repair of full thickness wound in rabbit. Int Wound J. 2011 Oct;8(5):514-20. doi: 10.1111/j.1742-481X.2011.00833.x. Epub 2011 Aug 4. PubMed PMID: 21816000.
11: Filip A, Daicoviciu D, Clichici S, Mocan T, Muresan A, Postescu ID. Photoprotective effects of two natural products on ultraviolet B-induced oxidative stress and apoptosis in SKH-1 mouse skin. J Med Food. 2011 Jul-Aug;14(7-8):761-6. Epub 2011 Apr 6. PubMed PMID: 21470043.
10: Hanausek M, Spears E, Walaszek Z, Kowalczyk MC, Kowalczyk P, Wendel C, Slaga TJ. Inhibition of murine skin carcinogenesis by freeze-dried grape powder and other grape-derived major antioxidants. Nutr Cancer. 2011;63(1):28-38. PubMed PMID: 21108125.
9: Nichols JA, Katiyar SK. Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms. Arch Dermatol Res. 2010 Mar;302(2):71-83. Epub 2009 Nov 7. Review. PubMed PMID: 19898857; PubMed Central PMCID: PMC2813915.
8: Vitseva O, Varghese S, Chakrabarti S, Folts JD, Freedman JE. Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates. J Cardiovasc Pharmacol. 2005 Oct;46(4):445-51. PubMed PMID: 16160595.
7: Shi J, Yu J, Pohorly JE, Kakuda Y. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food. 2003 Winter;6(4):291-9. Review. PubMed PMID: 14977436.
6: Khanna S, Venojarvi M, Roy S, Sharma N, Trikha P, Bagchi D, Bagchi M, Sen CK. Dermal wound healing properties of redox-active grape seed proanthocyanidins. Free Radic Biol Med. 2002 Oct 15;33(8):1089-96. PubMed PMID: 12374620.
5: Sen CK, Khanna S, Gordillo G, Bagchi D, Bagchi M, Roy S. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm. Ann N Y Acad Sci. 2002 May;957:239-49. Review. PubMed PMID: 12074976.
4: Bagchi D, Bagchi M, Stohs SJ, Das DK, Ray SD, Kuszynski CA, Joshi SS, Pruess HG. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology. 2000 Aug 7;148(2-3):187-97. PubMed PMID: 10962138.
3: Bomser J, Singletary K, Meline B. Inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin ornithine decarboxylase and protein kinase C by polyphenolics from grapes. Chem Biol Interact. 2000 Jun 15;127(1):45-59. PubMed PMID: 10903418.
2: Zhao J, Wang J, Chen Y, Agarwal R. Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent. Carcinogenesis. 1999 Sep;20(9):1737-45. PubMed PMID: 10469619.
1: Bomser JA, Singletary KW, Wallig MA, Smith MA. Inhibition of TPA-induced tumor promotion in CD-1 mouse epidermis by a polyphenolic fraction from grape seeds. Cancer Lett. 1999 Jan 29;135(2):151-7. PubMed PMID: 10096423.
Proanthocyanidins, also called "OPCs" for oligomeric procyanidins or "PCOs" for procyanidolic oligomers, are a class of nutrients belonging to the flavonoid family.
Proanthocyanidins can be found in many plants, most notably pine bark and grape seed.