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BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
New & Updates
Attention: BulkActives is a part-time business.
Orders are processed on Saturdays and mailed on Mondays at the latest, usually earlier.
Free original software: Recipe creator
NEW! Safe, mild and gentle SURFACTANTS for DIY facial wash, body wash & shampoo:
Assay: 80% - Silymarin 80%, Silybin 30%
Botanical source: Silybum marianum (L) Gaertn.
Used part: seeds
Solubility notes: I use Silymarin in a serum that contains non-denatured ethanol. According to the MSDS, 0.5mg will dissolve in warm water. According to my experience (and the MSDS) it will dissolve completely in non-denatured ethanol, or a combination of water and non-denatured ethanol.
Suggested percentage: 2% to 5%
Storage: Store in cool and dry place. Keep away from direct strong light and heat.
Country of origin: China
DISCLAIMER:Any statements about products sold by BulkActives have not been evaluated by the FDA. Products sold by BulkActives are not intended to be used as nutritional supplements. Products sold by BulkActives are not intended to diagnose, treat, cure, or prevent any disease.
References (full abstracts here)
23: Couteau C, Cheignon C, Paparis E, Coiffard LJ. Silymarin, a molecule of interest for topical photoprotection. Nat Prod Res. 2011 Dec 8. [Epub ahead of print] PubMed PMID: 22149904.
22: Becker-Schiebe M, Mengs U, Schaefer M, Bulitta M, Hoffmann W. Topical use of a silymarin-based preparation to prevent radiodermatitis : results of a prospective study in breast cancer patients. Strahlenther Onkol. 2011 Aug;187(8):485-91. Epub 2011 Jul 22. PubMed PMID: 21786113.
21: Katiyar SK, Mantena SK, Meeran SM. Silymarin protects epidermal keratinocytes from ultraviolet radiation-induced apoptosis and DNA damage by nucleotide excision repair mechanism. PLoS One. 2011;6(6):e21410. Epub 2011 Jun 22. PubMed PMID: 21731736; PubMed Central PMCID: PMC3120878.
20: Vaid M, Katiyar SK. Molecular mechanisms of inhibition of photocarcinogenesis by silymarin, a phytochemical from milk thistle (Silybum marianum L. Gaertn.) (Review). Int J Oncol. 2010 May;36(5):1053-60. Review. PubMed PMID: 20372777; PubMed Central PMCID: PMC2852174.
19: Kang JS, Yoon WK, Han MH, Lee H, Lee CW, Lee KH, Han SB, Lee K, Yang KH, Park SK, Kim HM. Inhibition of atopic dermatitis by topical application of silymarin in NC/Nga mice. Int Immunopharmacol. 2008 Oct;8(10):1475-80. Epub 2008 Jun 30. PubMed PMID: 18593606.
18: Berardesca E, Cameli N, Cavallotti C, Levy JL, Piérard GE, de Paoli Ambrosi G. Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation. J Cosmet Dermatol. 2008 Mar;7(1):8-14. PubMed PMID: 18254805.
17: Katiyar SK, Meleth S, Sharma SD. Silymarin, a flavonoid from milk thistle (Silybum marianum L.), inhibits UV-induced oxidative stress through targeting infiltrating CD11b+ cells in mouse skin. Photochem Photobiol. 2008 Mar-Apr;84(2):266-71. Epub 2007 Nov 28. PubMed PMID: 18221354; PubMed Central PMCID: PMC2394725.
16: Han MH, Yoon WK, Lee H, Han SB, Lee K, Park SK, Yang KH, Kim HM, Kang JS. Topical application of silymarin reduces chemical-induced irritant contact dermatitis in BALB/c mice. Int Immunopharmacol. 2007 Dec 15;7(13):1651-8. Epub 2007 Sep 14. PubMed PMID: 17996674.
15: Svobodová A, Zdarilová A, Walterová D, Vostálová J. Flavonolignans from Silybum marianum moderate UVA-induced oxidative damage to HaCaT keratinocytes. J Dermatol Sci. 2007 Dec;48(3):213-24. Epub 2007 Aug 3. PubMed PMID: 17689055.
14: Toklu HZ, Tunali-Akbay T, Erkanli G, Yüksel M, Ercan F, Sener G. Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injury. Burns. 2007 Nov;33(7):908-16. Epub 2007 May 22. PubMed PMID: 17521818.
13: Baumann L. Botanical ingredients in cosmeceuticals. J Drugs Dermatol. 2007 Nov;6(11):1084-8. Review. PubMed PMID: 18038494.
12: Gu M, Singh RP, Dhanalakshmi S, Agarwal C, Agarwal R. Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice. Cancer Res. 2007 Apr 1;67(7):3483-91. PubMed PMID: 17409458.
11: Gu M, Singh RP, Dhanalakshmi S, Mohan S, Agarwal R. Differential effect of silibinin on E2F transcription factors and associated biological events in chronically UVB-exposed skin versus tumors in SKH-1 hairless mice. Mol Cancer Ther. 2006 Aug;5(8):2121-9. PubMed PMID: 16928834.
10: Gu M, Dhanalakshmi S, Mohan S, Singh RP, Agarwal R. Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin. Carcinogenesis. 2005 Aug;26(8):1404-13. Epub 2005 Apr 14. PubMed PMID: 15831527.
9: Katiyar SK. Silymarin and skin cancer prevention: anti-inflammatory, antioxidant and immunomodulatory effects (Review). Int J Oncol. 2005 Jan;26(1):169-76. Review. PubMed PMID: 15586237.
8: Mallikarjuna G, Dhanalakshmi S, Singh RP, Agarwal C, Agarwal R. Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling. Cancer Res. 2004 Sep 1;64(17):6349-56. PubMed PMID: 15342425.
7: Dhanalakshmi S, Mallikarjuna GU, Singh RP, Agarwal R. Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. Carcinogenesis. 2004 Aug;25(8):1459-65. Epub 2004 Mar 19. PubMed PMID: 15033902.
6: Pinnell SR. Cutaneous photodamage, oxidative stress, and topical antioxidant protection. J Am Acad Dermatol. 2003 Jan;48(1):1-19; quiz 20-2. Review. PubMed PMID: 12522365.
5: Katiyar SK. Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin. Int J Oncol. 2002 Dec;21(6):1213-22. PubMed PMID: 12429970.
4: Zhao J, Lahiri-Chatterjee M, Sharma Y, Agarwal R. Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin. Carcinogenesis. 2000 Apr;21(4):811-6. PubMed PMID: 10753220.
3: Zhao J, Sharma Y, Agarwal R. Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1alpha expression in SENCAR mouse epidermis: implications in the prevention of stage I tumor promotion. Mol Carcinog. 1999 Dec;26(4):321-33. PubMed PMID: 10569809.
2: Zi X, Mukhtar H, Agarwal R. Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: inhibition of mRNA expression of an endogenous tumor promoter TNF alpha. Biochem Biophys Res Commun. 1997 Oct 9;239(1):334-9. PubMed PMID: 9345320.
1: Agarwal R, Katiyar SK, Lundgren DW, Mukhtar H. Inhibitory effect of silymarin, an anti-hepatotoxic flavonoid, on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice. Carcinogenesis. 1994 Jun;15(6):1099-103. PubMed PMID: 8020140.
Silymarin, is the active ingredient of the fruit of the milk thistle.
Silymarin is a mixture of at least seven flavolignans and one flavonoid.
The most abundant and potent costituents in silymarin is silybin (also called silibinin).
Silymarin in skin care - research
Topically applied silymarin may:
act as an anti-inflammatory:      
help with acne (rosacea): 
act as an anti oxidant:        
repair and treat sun damage:  
prevent or reduce UVA and UVB sun damage: