Anti-Blackheads in skin care
Blackheads are a common occurrence in individuals suffering from acne, the most common skin affliction, affecting 85% of teenagers . Acne however may last or re-emerge later in life; particularly, this condition plagues many menopausal or post-menopausal women .
The most common form of acne is caused by hair follicles clogged by sebum, a waxy substance secreted by sebaceous glands. As this process is hormonally regulated, acne commonly occurs during puberty [3-5]. Additionally, a genetic predisposition to overproduction of sebum or hormonal imbalances can also lead to acne .
Blackheads are a common feature of acne, although these can arise independently of acne and the inflammation associated with it. The difference between a blackhead and a pimple, or whitehead, is that the pore is open and oxygen can get in, causing the sebum to become oxidized. While this is often associated with hormonal imbalances including during puberty or menopause, the use of certain topical oils or excessive application of makeup can also cause blackheads .
Any compound which can treat acne is also effective at decreasing blackheads. For a complete description of anti-acne agents, see our link here: https://www.bulkactives.com/actives/anti-acne/ To treat blackheads specifically, the most effective treatment approaches are exfoliation and decreasing sebum secretion. Exfoliants can remove blackheads already existing in the skin, remove sebum to decrease the number of blackheads which will form, and can remove dead skin cells which can block pores and cause or contribute to new blackheads or acne lesions [8, 9]. Several natural products have been identified which can induce the cells in sebaceous glands to decrease the amount of sebum produced.
The highly lipophilic compound salicylic acid efficiently penetrates skin to remove excess sebum and exfoliate. Clinical studies show that salicylic acid decreases blackheads and can reduce the pore sebum content in follicles [6-8]. Sialicin, a derivative of siacylic acid extracted from the bark of white willow trees also acts as an anti-inflammatory and antibacterial agent [10-12]. Sialicin may also be preferred over its parent compound due to the fact that no side effects are associated with topical use . Other compounds that can reduce sebum accumulation in the skin are baobab oils, carnitine, D-panthenol,
 Krowchuk DP. Managing Adolescent Acne. Pediatrics in review. 2005;26(7):251.
 Kligman A. Postmenopausal acne. Cutis. 1991;47(6):425-6.
 Mashkevich G. Cosmetic Dermatology: Principles & Practice, Leslie Baumann, MD. Facial plastic surgery. 2010;26(01):059-.
 Zouboulis CC. Acne and sebaceous gland function. Clinics in dermatology. 2004;22(5):360-6.
 Thiboutot D. Acne: hormonal concepts and therapy. Clinics in dermatology. 2004;22(5):419-28.
 Bhate K, Williams HC. Epidemiology of acne vulgaris. British Journal of Dermatology. 2013;168(3):474-85.
 Fulton Jr JE. Acne: Its causes and treatments. International Journal of Cosmetic Surgery and Aesthetic Dermatology. 2002;4(2):95-105.
 Tsai TC, Hantash BM. Cosmeceutical agents: A comprehensive review of the literature. Clinical Medicine: Dermatology. 2008;1(1).
 Neill US. Skin care in the aging female: myths and truths. The Journal of clinical investigation. 2012;122(2):473.
 Levy LL, Emer JJ. Emotional benefit of cosmetic camouflage in the treatment of facial skin conditions: personal experience and review. Clinical, cosmetic and investigational dermatology. 2012;5:173.
 Gopaul R, Knaggs H, Lephart J. Salicin regulates the expression of functional ‘youth gene clusters’ to reflect a more youthful gene expression profile. International journal of cosmetic science. 2011;33(5):416-20.
 Khayyal MT, El-Ghazaly MA, Abdallah DM, Okpanyi SN, Kelber O, Weiser D. Mechanisms involved in the anti-inflammatory effect of a standardized willow bark extract. Arzneimittel-Forschung. 2004;55(11):677-87.