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This appears to have resolved most of the delays caused by The Canada Border Services Agency.
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BulkActives is a part-time business. Orders are processed and mailed on Saturdays. (TimeZone Order Deadline Chart)
We sell COSMETIC RAW MATERIALS, which are meant to be used at an appropriate percentage in a cosmetic formulation of your devising. Please do not order our products unless you know how to formulate creams and lotions with it!
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 Burke, K.E., Interaction of vitamins C and E as better cosmeceuticals. Dermatol Ther, 2007. 20(5): p. 314-21.
 Manosroi, A., et al., Antioxidant activities and skin hydration effects of rice bran bioactive compounds entrapped in niosomes. J Nanosci Nanotechnol, 2011. 11(3): p. 2269-77.
 McDaniel, D.H., et al., Idebenone: a new antioxidant - Part I. Relative assessment of oxidative stress protection capacity compared to commonly known antioxidants. J Cosmet Dermatol, 2005.
4(1): p. 10-7.
 Rohr, M., et al., Influence of repetitive UVA stimulation on skin protection capacity and antioxidant efficacy. Skin Pharmacol Physiol, 2011. 24(6): p. 300-4.
 Yoshida, A., et al., Direct assessment by electron spin resonance spectroscopy of the antioxidant effects of French maritime pine bark extract in the maxillofacial region of hairless mice. J Clin Biochem Nutr, 2011. 49(2): p. 79-86.
Alpha-lipoic acid (ALA) is a naturally occurring antioxidant that also shows numerous attractive features for use in cosmetic skin care. It is known as a dietary supplement for a long time, but recent research suggests it may be more effective through other applications, such as skin creams. ALA neutralizes free radicals, thus helping to fight ageing and cancer. It is more effective in combating free radicals than common vitamins, such as vitamin C or E, hence lipoic acid is called the “universal antioxidant”. In skin care, ALA was also shown to promote wound healing, treat and prevent diabetic ulcers. Cosmetics research suggests that ALA can promote collagen synthesis, thus reducing the visible effects of ageing on skin, and improving the appearance without any noticeable side effects. Alpha Lipoic Acid is a key active ingredient in Perricone MD products
L-ascorbic acid (vitamin C) is an essential nutrient which has many cosmetic benefits. It is a remarkable antioxidant and can scavenge reactive oxygen species and other free radicals, protecting the skin from oxidative stress. It can stimulate collagen synthesis by promoting cross-linking and stabilizing collagen molecules, upregulating collagen genes, increasing the transcription of the tissue inhibitor of matrix metalloproteinase 1, and inducing fibroblast proliferation. It reduces pigmentation by suppressing tyrosinase, which is important for melanin production. It is an anti-inflammatory agent and can be used to treat inflammatory skin disease such as erythema. Together, L-ascorbic acid provides powerful anti-aging properties and has been shown to reduce wrinkles, improve elasticity, and protect against sun damage. Stability and absorption of L-ascorbic acid is a concern. While the anhydrous L-ascorbic acid might be the most stable form, adding vitamin E not only helps stabilizing L-ascorbic acid, but the two have synergistic effects on anti-aging. Used in: philosopy's turbo booster c powder and SkinCeuticals.
Ascorbyl tetraisopalmitate (Tetrahexyldecyl Ascorbate) is a molecule derived from vitamin C and isopalmitic acid. Pure vitamin C has several drawbacks for cosmeceutical use, most important of which is the low stability. Chemically modified vitamin molecules are more stable, and pure vitamin is released from the derivatives inside the body. Therefore, the effects of Tetrahexyldecyl Ascorbate are similar to those of vitamin C, most importantly it is able to act as an antioxidant. Ascorbyl tetraisopalmitate reduces the production of oxidizing agents, which contribute to cell damage after exposure to UV or chemical hazards. This effect is even stronger in the modified molecule than in pure vitamin C. Additionally, Tetrahexyldecyl Ascorbate protects against DNA damage and skin darkening caused by UV exposure. Finally, skin visual appearance is also improved by Ascorbyl tetraisopalmitate, as it promotes collagen synthesis and acts as a hydrating agent in reducing skin roughness.
Centella asiatica is a tropical plant that has been used extensively in Indian medicine. It has diverse applications for skin cosmetics: firstly, it is effective in wound care, as it promotes healing of simple, infected, non-healing, or burn wounds, as well as wounds in patients with diabetes, undergoing radiotherapy or steroid medication. Centella is also used for treating scars and preventing or reducing stretch marks. The extract of this plant promotes synthesis of collagen, hydroxyproline, hyaluronic acid and cell growth factors, thus helping to maintain the elasticity, strength and general appearance of healthy skin. It also protects the skin from ageing damage, such as glycation, and UV damage, likely by activating antioxidant synthesis.
NOTE: To assist you with solubility issues, we now also sell Centella asiatica as a standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
Coenzyme Q10 is a molecule naturally involved in energy metabolism in all human cells. Among its many benefits, the antioxidant properties are the most researched. This molecule can prevent oxidation damage to water-insoluble molecules, DNA mutations, collagen synthesis decrease, pigmentation, inflammation and other adverse effects associated with UV exposure and ageing. In combination with vitamin E or other antioxidants, an exceedingly strong antioxidative effect can be achieved. Furthermore, coenzyme Q10 has a unique capability to protect against infrared A radiation, which is also found in sunlight. The promotion of collagen synthesis makes this coenzyme useful in treating ageing-associated skin changes, such as wrinkle appearance. Finally, its anti-inflammatory effect is beneficial not only for UV-damaged skin, but also for wound healing support.
NOTE: To assist you with solubility issues, we now also sell Fucoidan as a standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
GABA (gamma-aminobutyric acid) is a neurotransmitter with purported dermatological benefits. Several patents indicated that GABA can be used as a wrinkle relaxer based on its inhibitory effect on muscles. Some patents also claim that GABA can dilate skin peripheral blood vessels, moisturize and prevent aging, suppress parakeratosis and shrink pores, as well as whitening the skin. However there is no scientific data to support these claims. On the other hand, a preliminary research study has shown that GABA can stimulate hyaluronic acid synthesis and protect the fibroblasts from oxidative stress. Another study showed that GABA was able to upregulate beta-defensin-2, which is an anti-microbial peptide, and filaggrin, which plays a role in normal barrier function of the skin. Lastly, GABA might be useful in combating inflammation associated with psoriasis based on preliminary findings that GABA receptors are expressed in white blood cells in psoriatic skin. Overall, the evidence of GABA in supporting skin health is very weak, and consumers are warned for its application.
Unsubstantiated benefits of GABA (Gamma-aminobutyric acid) in skin care:
Gamma-oryzanol is an ingredient produced from rice bran. It contains several related molecules, build on a ferulic acid backbone, all of which share antioxidant properties. They are particularly useful in protecting lipids, such as oils, which makes oryzanol an attractive ingredient in oil-containing preparations. Furthermore, it helps reduce skin darkening from UV exposure, as well as ageing-related skin symptoms, such as roughness and wrinkling. Since gamma-oryzanol activates sebum glands, it can be used for alleviating various conditions causing dry skin. In respect to collagen degradation, oryzanol can slow down this process even more efficiently than vitamin C, thus resulting in thicker and smoother skin. At the moment, even more possible applications of oryzanol are being investigated, such as treating hair loss or preventing damage from chemotherapy. As gamma oryzanol is oil soluble, it is an ideal active to use instead of pure ferulic acid (which is alcohol soluble).
Ginkgo biloba is a unique tree species. Its leaf extract contains a diverse variety of molecules useful in cosmetics and pharmacology. Firstly, they are potent antioxidants, and can even activate the production of enzymes that neutralize free radicals. Combined with the anti-inflammatory effects, this extract provides an effective defense against UV radiation and ageing symptoms. Dermal applications of this extract can even lead to protection of other organs. Another major application of Ginkgo biloba is moisturizing the skin, which helps to increase its elasticity and visual appearance, even reducing the amount of wrinkles. Furthermore, this extract helps to maintain the barrier function of the skin – it reduces water loss through epidermis, thus reducing skin dryness and irritation. In combination with green tea extract, Ginkgo shows even stronger benefits in these areas.
NOTE: To assist you with solubility issues, we now also sell Ginkgo Biloba extract as a standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
NOTE: To assist you with solubility issues, we now also sell Gynostemma (Jiaogulan) as a liquid standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
NOTE: To assist you with solubility issues, we now also sell Pomegranate Extract as a standardized pre-dissolved solution. Just add the liquid to your cream and mix well.
Glucan is a polymer, produced from glucose molecules in fungi, seaweed and other organisms. Many types of this polymer exist, but yeast beta-glucan has the optimal structure and size for biological activity. It has significant effects in wound healing – glucan is already used to treat burn patients, as it promotes regeneration of the skin, reduces pain and improves scar appearance. Furthermore, it is able to activate the immune system to fight against infections, making it additionally useful in open wound care. Additionally, it helps the skin to maintain its barrier function after damage by chemicals, such as detergents. The antioxidant properties of this polymer help protect the skin cells against UV or other sources of oxidative damage. Skin ageing symptoms, such as darkening, sunburn and collagen degradation, can also be reduced by applying this compound.