penetration enhancers

Dimethyl Isosorbide (Arlasolve DMI)

Dimethyl isosorbide [DMI] is a solvent made from starch. It increases the solubility of many different active ingredients and increases their penetration into the skin. This reduces the amount of an active ingredient needed to have an effect, which is particularly good for reducing the irritation of harsher actives. Increasing skin penetration also increases the activity of a formulation, in several cases. Dimethyl isosorbide improves the overall properties of formulations, including skin feel and consistency. It can be used in many different types of products and is compatible with many compounds, including non-ionic surfactants.

Key benefits of Dimethyl Isosorbide (Arlasolve DMI) in skin care

Enhanced penetration of actives to the epidermis, enabling targeted delivery [1] [2] [5] [6] [7] [8] [9]
A lower level of skin irritation with a reduction in the required concentration level of aggressive actives [4] [8]
Improved formulation shelf stability [8]
Miscibility with most organic solvents and non-ionic surfactants.[8]
Incorporation within many product forms, including clear gels [4]
A long history of safe usage.
Ability to transport water soluble actives into skin, without recrystallization of the active [4] [8]

$18.60

Pre Liposome Microemulsion Base

Pre Liposome Microemulsion Preparation Base, is especially suited as carrier for active ingredients in light lotions or serums. Pre Liposome Microemulsion Base is a micro-emulsion premix based on hydrogenated soybean lecithin and olive squalane. Pre Liposome Microemulsion Preparation Base forms clear to translucent preparations with excellent texture just by diluting with water. BulkActives' Pre Liposome Microemulsion Base allows to prepare clear / translucent formulations with various oily ingredients, such as oil-soluble vitamins, vegetable oils, esters, hydrocarbons and silicone oils. Larger amounts of oily ingredients can be incorporated in the product without the texture being affected by high surfactant levels. Hydrogenated soybean lecithin works as a natural emulsifier and promotes penetration of actives into the skin. Liposomes are synthetic microscopic vesicles with an external, fully enclosed double lipid membrane of phospholipids. Liposomes are not active themselves, but function in creams as carriers of active substances to enhance penetration into the skin's fatty layers.

Pre Liposome Microemulsion Base in skin care:

penetration enhancer
base serum/lotion
emulsifier

$36.65

Multi Lamellar Base Cream with SeaKelp Bioferment and Sclerotium Gum (No Oil and No Polymer)

In order for skin to be healthy we need a well maintained stratum corneum. A healthy stratum corneum offers protection against environmental stress and water loss. BulkActives’ multi lamellar cream imitates the skin’s own lipid structure and enhance the skin's natural barrier function.

BulkActives’ multi lamellar cream is formulated with a new generation, European, sugar based, liquid crystals emulsifying system based on sorbitan stearate with sucrose cocoate. It is formulated specifically for DIY Skin care customers. BulkActives’ multi lamellar cream can be used as is. However, it can easily accept both water, oil, and water soluble and oil soluble powders and liquids. BulkActives’ multi lamellar cream is a great carrier for active skin care ingredients. The multi lamellar structure is ideal for even and effective delivery of skin actives into the skin.

BulkActives’ multi lamellar cream is exclusively and professionally formulated, manufactured and packaged for us by the same biochemist who manufactures our seakelp bioferment, pumpkin bioferment, and lemon bioferment.

NOTE: Based on customer feedback we have reformulated our multi lamellar cream, making it "greener' and even more elegant! In this NEW formulation we have also replaced the xantham gum with Sclerotium Gum, the preservative system combines the extremely safe, yet effective, Sodium Levulinate and Sodium Anisate, with Potassium sorbate and citric acid. This means our cream now does NOT contain parabens or phenoxyethanol.

Multi Lamellar Base Cream with SeaKelp Bioferment and Sclerotium Gum (No Oil and No Polymer):

Multi-lamellar cream offers outstanding moisturization
skin barrier repair and maintenance
optimized delivery of actives

Benefits of Liquid crystal systems:

Improved dissolution of poorly water soluble actives .
Liquid crystals can protect and facilitate the transport of fragile molecules e.g. proteins
Controlled active release:
Multilayers reduce the interfacial transport of actives dissolved in oil phase
Active delivery can be tailored depending on the active
Oleosome structure may enhance delivery of oil soluble ingredients
Hydrosome structure may enhance delivery of water soluble actives
Prolonged hydration potential:
Up to 50% water bound up in swollen water layers.
This water is less prone to evaporation.
In-vivo tests moisturization lasts 3 times longer
Effective Transepidermal Water Loss (TWEL)
Structure similar to skin

To thicken these creams after adding actives dissolved in waters add a few drops of Gelmaker Ultra (polymer emulsifier)

$20.80